ライフサイエンスコーパス: social isolation

1 rs (such as parental depression, stress, and social isolation).

2 h wounding and infection may be more likely (social isolation).

3 ic and contextual factors that contribute to social isolation.

4 ocial anxiety-like behavior after early-life social isolation.

5 treatment alleviates anxiety symptoms after social isolation.

6 ed with substantial levels of disability and social isolation.

7 ange in total GABA(A)-R number occurs during social isolation.

8 economic status, psychological distress, and social isolation.

9 e adopted a mouse model involving protracted social isolation.

10 s drug intoxication, maternal separation, or social isolation.

11 all measures of functioning examined except social isolation.

12 latory activity when rat pups were tested in social isolation.

13 we observe synaptic changes following acute social isolation.

14 n vitro, for 2 weeks in adult mice following social isolation.

15 idance behavior in mice undergoing prolonged social isolation.

16 from no SI states was the chronic stress of social isolation.

17 se, a painful loss, exposure to violence, or social isolation.

18 their patients find strategies for avoiding social isolation.

19 endent manner, and this effect is blocked by social isolation.

20 d not contribute to the risk associated with social isolation.

21 ar context to understand the consequences of social isolation.

22 r mouse model of depression, prolonged adult social isolation.

23 rrel monkeys and macaque monkeys showed that social isolation [2, 3], deafness [2], cross-fostering [

24 Mice subjected to social isolation (3-4 weeks) exhibit enhanced contextual

25 In a mouse model of chronic social isolation, a known risk factor for depressive ill

26 In contrast, during social isolation, a separate test for anxiety,beta4-/- m

27 pocampus of piglets at 12 days of age, while social isolation affected frontal cortex regardless of a

28 After 6 weeks of social isolation, ALLO and 5alpha-DHP biosynthesis rates

29 Social isolation also exacerbated CA/CPR-induced depress

30 nt (CRE)-LacZ reporter mice, that protracted social isolation also reduces CRE-dependent transcriptio

31 se in group housed mice, which suggests that social isolation alters emotional responses by reducing

32 roendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of thes

33 The intervention improved depression and social isolation, although the relative improvement in t

34 ron activation restores RGL quiescence after social isolation, an experience that induces RGL activat

35 hat were not reported in controls, including social isolation and aggression.

36 ntal risk factors for schizophrenia, such as social isolation and childhood trauma, also affect presy

37 skewing, which may both propagate perceived social isolation and contribute to its associated health

38 idity and mortality independent of objective social isolation and health behavior.

39 Both social isolation and loneliness are associated with incr

40 Both social isolation and loneliness were associated with inc

41 sess the extent to which the associations of social isolation and loneliness with mortality were attr

42 The associations of social isolation and loneliness with premature mortality

43 , subjective wellbeing, less depression, low social isolation and loneliness, more close relationship

44 riety of adverse life circumstances, such as social isolation and low socioeconomic status, mammalian

45 the extent to which the association between social isolation and mortality is mediated by loneliness

46 ty, atonic episodes, restricted mobility) to social isolation and placidity.

47 ical factors such as stress, depression, and social isolation and progression of cancer.

48 es were age, sex, education, marital status, social isolation and social support, chronic medical con

49 ersonality factors and character traits, (4) social isolation, and (5) chronic life stress.

50 self-rated health, impaired quality of life, social isolation, and depressive symptoms.

51 the medial prefrontal cortex, social reward, social isolation, and drug use.

52 s (energy, pain, emotional reactions, sleep, social isolation, and mobility) and seven aspects of dai

53 roblems, life events, neighborhood problems, social isolation, and social support.

54 ated with functional impairment, feelings of social isolation, and suicidal ideation.

55 nisms underlying the exacerbating effects of social isolation are unclear.

56 chological factors, including depression and social isolation, are important determinants of cardiova

57 monstrated that a rodent model of adolescent social isolation (aSI) produces robust and persistent in

58 n stabilize fragile brokerage relationships: social isolation, broker capture, and organizational gra

59 Our observations demonstrate that social isolation, but not acute physical stress has sex-

60 , as social interaction can be rewarding and social isolation can be aversive.

61 Social isolation can exacerbate the negative consequence

62 We found that postweaning social isolation caused a decrease of in vivo firing act

63 physiological studies found that postweaning social isolation caused a presynaptic impairment of exci

64 In this study, we tested whether postweaning social isolation caused abnormal activity of MeA neurons

65 In rodents, postweaning social isolation causes a range of deficits in sexual an

66 The hazard ratio for all-cause mortality for social isolation compared with no social isolation was 1

67 tic analyses in a macaque model of perceived social isolation confirmed CTRA activation and identifie

68 ary perspective, these findings suggest that social isolation could be adaptive in some contexts and

69 Social isolation decreased gene expression (P < 0.05) in

70 In these experiments, peri-ischemic social isolation decreases poststroke survival rate and

71 people with SMI are strongly associated with social isolation, depression, cognitive impairment, and

72 rcentile), and controlling for indicators of social isolation did not affect the finding.

73 Mice undergoing prolonged social isolation display impaired myelination in the pre

74 In a rat model, we examined how social isolation during adolescence impacts stress react

75 eported criminality, substance use problems, social isolation, early sexual behavior, and psychiatric

76 n be observed in animals that have undergone social isolation, especially in species having important

77 Mice housed in social isolation exhibit a decreased response to gamma-a

78 Surprisingly, social isolation facilitated accumulation of stem cells,

79 ontinence has been associated with increased social isolation, falls, fractures, and admission to lon

80 umber of hours spent caregiving, depression, social isolation, financial stress, and lack of choice i

81 in peer activities, placing them at risk for social isolation from their peers and psychosocial adjus

82 m rats reared in either groups of five or in social isolation from weaning.

83 s of age, gender, education, marital status, social isolation, functional impairment, financial strai

84 s, rearing rodents in persistent postweaning social isolation has been established as a widely used a

85 Social isolation has been recognized as a major risk fac

86 Social isolation has dramatic long-term physiological an

87 pensity to intense psychological pain (e.g., social isolation, hopelessness), often in the context of

88 presents the emotional pathway through which social isolation impairs health.

89 gnitive problems, neighborhood problems, and social isolation in 1994 all were significant predictors

90 Using a model of protracted social isolation in adult rats, we observed increased an

91 ehavioral abnormalities induced by prolonged social isolation in adult rodents.

92 and others have previously demonstrated that social isolation in mice induced behavioral, transcripti

93 Protracted social isolation in mice may provide a model to investig

94 the effects of acute morphine dependence and social isolation in non-anxious Sprague Dawley (SD) rats

95 Social isolation in old age has been associated with ris

96 Social isolation in rodents has been used extensively to

97 We assessed social isolation in terms of contact with family and fri

98 esent study investigated the hypothesis that social isolation increases aggression by increasing the

99 These data support the hypothesis that social isolation increases aggression by increasing the

100 hat may be involved suggest that (a) chronic social isolation increases the activation of the hypotha

101 Furthermore, early-life social isolation increases the levels of corticotropin-r

102 Social isolation induced both anxiety- and anhedonia-lik

103 at inhibiting SK channels normalizes chronic social isolation-induced anxiety/depressive-like behavio

104 hether oxidative stress is implicated in the social isolation-induced exacerbation of schizophrenia-l

105 nsequences; however, the mechanisms by which social isolation influences disease outcome are largely

106 Social isolation is a passive, naturalistic form of chro

107 The present study suggests that in men, social isolation is not only an important risk factor fo

108 loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB

109 ngitudinal research indicates that perceived social isolation (loneliness) is a risk factor for morbi

110 al response in people experiencing perceived social isolation (loneliness), we conducted integrative

111 re transcriptionally sensitive to subjective social isolation (loneliness).

112 , which may contribute to the development of social isolation, loneliness, and consequent cognitive d

113 depression, as were being female, older age, social isolation, low education, financial strain, and f

114 ough traffic exposure, noise, air pollution, social isolation, low physical activity, and sedentary b

115 Social isolation, male sex, and older age were associate

116 Older adults with social isolation, medical comorbidity, and physical impa

117 ortex and hippocampus, protracted (>4 weeks) social isolation of adult male mice alters the subunit e

118 Protracted social isolation of adult mice induced behavioral, trans

119 iety of psychosocial reactions, ranging from social isolation of clinical depression and attempted su

120 These data suggest that post-weaning social isolation of female rats sensitizes a DR-basolate

121 revious studies have shown that post-weaning social isolation of male rats leads to sensitization of

122 Thus, protracted social isolation of mice combined with tests of fear con

123 Results suggest that social isolation of non- and early-weaned piglets may im

124 Here, we show that social isolation of rats during a critical period of ado

125 Social isolation of rats during the early part of develo

126 Post-weaning social isolation of rats produces psychological and phys

127 ress-induced behavioral deficits, we imposed social isolation on a genetically vulnerable mouse model

128 sent study was to investigate the effects of social isolation on neuronal damage, neuroinflammation,

129 SD paradigm in mice to assess the impact of social isolation on sleep, wakefulness and delta electro

130 s to investigate the effects of post-weaning social isolation on subsequent responses of an anxiety-r

131 estigated the effects of age, weaning and/or social isolation on the expression of genes regulating g

132 owever, little is known about the effects of social isolation on the function of MeA neurons.

133 LX) stereospecifically reverse the effect of social isolation on the PTB-induced loss of righting ref

134 The increase in FSL following either social isolation or acute physical stress was blocked by

135 y risk factors for secondary depression (eg, social isolation or exclusion, and unemployment), our fi

136 ions (47 [36%]), family problems (44 [34%]), social isolation or withdrawal (33 [25%]), child abuse o

137 ment of multiple comorbid medical illnesses, social isolation, polypharmacy, and factors associated w

138 Postweaning social isolation (PWSI) augmented the ROS levels in KO m

139 al magnetic resonance imaging of postweaning social isolation rats (N = 23) 9 weeks after isolation.

140 ty in posterior brain regions of postweaning social isolation rats.

141 for demographic factors and baseline health, social isolation remained significantly associated with

142 Chronic social isolation renders 5-HT neurons insensitive to SK2

143 These results show that social isolation results from a combination of intrinsic

144 Early social isolation results in adult behavioral and cogniti

145 Similarly, rats reared in social isolation (SI) during adolescence exhibit augment

146 Social isolation (SI) increases stroke-related mortality

147 Social isolation (SI) of male mice lasting >4 weeks is a

148 mRNA expression was unchanged by protracted social isolation (Si).

149 Many of these behaviors were exacerbated by social isolation stress.

150 ese behavioral phenotypes are exacerbated by social isolation stress.

151 er of the aru mutant are restored upon adult social isolation, suggesting a causal relationship betwe

152 ted contextual fear responses resulting from social isolation, suggesting that selective activation o

153 strain, depression, hostility, anxiety, and social isolation tend to cluster in certain individuals.

154 me of the interviewees experienced even more social isolation than they did before.

155 tely leading to new approaches to combat the social isolation that often ensues.

156 studies on SD were conducted in a setting of social isolation, the impact of the social contextual se

157 Hsp60 levels, low socioeconomic status, and social isolation, together with an association with psyc

158 tality for social isolation compared with no social isolation was 1.73 (95% CI 1.65-1.82) after adjus

159 Adolescent social isolation was associated with a significant incre

160 By contrast, social isolation was not explained by the identity of an

161 n) leading to communication difficulties and social isolation (Weinstein & Ventry).

162 ofiles; specifically, social subordinance or social isolation were associated in our study with hyper

163 ious primate, we found that some measures of social isolation were modestly repeatable within individ

164 physical functioning, vitality, emotion, and social isolation were significantly worse in patients co

165 levated Depression score may be a marker for social isolation, which could play a role in immune func

166 ticoid receptor (GR) antagonist RU486 during social isolation, which implicates the role for glucocor

167 stressors such as inescapable tailshock and social isolation, while no changes in IL-1 have been obs

168 The association of social isolation with mortality was unchanged when lonel