ライフサイエンスコーパス: sodium stibogluconate

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1 e phosphatase (PTPase) assays, we found that sodium stibogluconate, a drug used in treatment of leish

2 the antileishmanial T cell repertoire where sodium stibogluconate alone had no effect.

3 o, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-

4 ntified and the sensitivity of L donovani to sodium stibogluconate assessed at each passage.

5 ly, pharmacological inhibition of SHP-1 with sodium stibogluconate augmented the function of all engi

6 B/c mice with imipramine in combination with sodium stibogluconate cleared organ Sb(R)LD parasites an

7 ably, pharmacologic inhibition of SHP-1 with sodium stibogluconate counteracted CD20 mAb-induced NK h

8 f SHP-2 and PTP1B required 100 micrograms/ml sodium stibogluconate, demonstrating differential sensit

9 term treatment with the antileishmanial drug sodium stibogluconate failed to significantly alter the

10 ork study, 110 patients with VL treated with sodium stibogluconate, failure rate was 59%.

11 sages, isolated parasites were refractory to sodium stibogluconate in in-vitro drug sensitivity assay

12 fective as the standard antileishmanial drug sodium stibogluconate in treatment of cutaneous leishman

13 , the cure rate of antimonial compounds (eg, sodium stibogluconate) in the treatment of visceral leis

14 Sodium stibogluconate inhibited 99% of SHP-1 activity at

15 These data represent the first evidence that sodium stibogluconate inhibits PTPases and augments cyto

16 d when treated with the antileishmanial drug sodium stibogluconate, <10% of mice were cured when the

17 ted IL-13(-/-) mice also responded poorly to sodium stibogluconate-mediated chemotherapy compared wit

18 tavalent state as a complex in drugs such as sodium stibogluconate (Pentostam) and meglumine antimona

19 SHP-1 enzymatic activity via the cancer drug sodium stibogluconate potently augmented Treg suppressor

20 In this study, we show that sodium stibogluconate (SSG) and IFN-alpha synergized to

21 Based on finding that sodium stibogluconate (SSG) inhibited SHP-1, the anti-RC

22 ent antimony-carbohydrate complexes, such as sodium stibogluconate (SSG), has been reported to prolon

23 tion and the activity of the SHP-1 inhibitor sodium stibogluconate that induced IFN-gamma(+) cells fo

24 Sodium stibogluconate was offered to 11 patients in the

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