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1 from phase 2 and 3 studies of ledipasvir and sofosbuvir.
2 eiving 12 weeks of treatment with ledipasvir/sofosbuvir.
3 genetically stable in cell cultures without sofosbuvir.
4 who received at least one dose of ledipasvir-sofosbuvir.
5 e at 12 weeks after completion of ledipasvir-sofosbuvir.
6 atasvir, beclabuvir, dasabuvir, MK-3682, and sofosbuvir.
7 data from 1788 patients receiving ledipasvir-sofosbuvir (282 for 8 weeks, 910 for 12 weeks, 510 for 2
8 (duration of infection <12 months) received sofosbuvir 400 mg daily and weight-based ribavirin (<75
12 ed the combination of ledipasvir (90 mg) and sofosbuvir (400 mg) (ledipasvir/sofosbuvir) once daily,
13 llular carcinoma, received up to 48 weeks of sofosbuvir (400 mg) and ribavirin before liver transplan
14 ned to an all-oral fixed-dose combination of sofosbuvir (400 mg) and velpatasvir (100 mg) once daily
18 ive 12 or 24 weeks of ledipasvir (90 mg) and sofosbuvir (400 mg) once daily (combination tablet), plu
19 :1) to receive either ledipasvir (90 mg) and sofosbuvir (400 mg) or ledipasvir, sofosbuvir, and ribav
20 cg/kg/wk), ribavirin (1000-1200 mg/day), and sofosbuvir (400 mg/day) (n = 24 in the final analysis).
21 to groups given simeprevir (150 mg/day) and sofosbuvir (400 mg/day) (n = 58 in the final analysis) o
23 or 2 HCV infection were randomly assigned to sofosbuvir, 400 mg, and velpatasvir, 25 or 100 mg, with
24 V genotypes 1 to 6 were randomly assigned to sofosbuvir, 400 mg, with velpatasvir, 25 or 100 mg, for
26 All patients were treated with ledipasvir-sofosbuvir (90 mg and 400 mg) plus weight-based ribaviri
29 nts, 16 of 25 (64%) receiving ledipasvir and sofosbuvir alone achieved SVR12 compared with all 26 pat
31 nder the curve and maximum concentration for sofosbuvir and GS-331007 in adolescents were within pred
32 R12) with regimens containing ledipasvir and sofosbuvir and identify factors associated with treatmen
36 ieve an ultrarapid response were switched to sofosbuvir and ledipasvir for either 8 weeks or 12 weeks
37 fore, we assessed the efficacy and safety of sofosbuvir and ledipasvir in renal transplant patients w
39 uvir, MK-3682, dasabuvir, or combinations of sofosbuvir and ledipasvir or sofosbuvir and velpatasvir
40 b, or 4 were treated with the combination of sofosbuvir and ledipasvir without ribavirin for 8 or 12
41 the end of treatment (SVR12) with ledipasvir/sofosbuvir and only a small effect in patients with HCV
42 uvir plus ribavirin, 87.0% in patients given sofosbuvir and pegylated-interferon plus ribavirin, and
43 no significant difference between ledipasvir/sofosbuvir and PrOD regimens), 86.2% (95% CI, 84.6%-87.7
45 The patients were treated for 24 weeks with sofosbuvir and ribavirin and underwent sampling longitud
48 of this study was to assess the efficacy of sofosbuvir and ribavirin for 6 weeks in individuals with
54 hose with genotype 2 infection (treated with sofosbuvir and ribavirin), 74.8% (95% CI, 72.2%-77.3%) o
57 and safety of the NS5B polymerase inhibitor sofosbuvir and the NS5A inhibitor velpatasvir for HCV in
61 combinations of sofosbuvir and ledipasvir or sofosbuvir and velpatasvir had decreased efficacy agains
62 elpatasvir (100 mg) once daily for 12 weeks, sofosbuvir and velpatasvir plus oral ribavirin (weight-b
64 ed the efficacy of 8 weeks of treatment with sofosbuvir and velpatasvir plus the pangenotypic NS3/4A
65 cirrhosis given a fixed-dose combination of sofosbuvir and velpatasvir with and without ribavirin.
67 re, during, and after antiviral therapy with sofosbuvir and velpatasvir, we found that intrahepatic M
69 orld effectiveness of sofosbuvir, ledipasvir/sofosbuvir, and paritaprevir/ritonavir/ombitasvir and da
70 0 mg) and sofosbuvir (400 mg) or ledipasvir, sofosbuvir, and ribavirin (dosed according to the Japane
71 essed the safety and efficacy of ledipasvir, sofosbuvir, and ribavirin in patients with HCV genotype
72 he pan-genotypic combination of daclatasvir, sofosbuvir, and ribavirin was safe and well tolerated.
74 riority in SVR12 was assessed for simeprevir+sofosbuvir at 12 and 8 weeks versus a composite historic
75 enotypic NS5A inhibitor) in combination with sofosbuvir at 400 mg once daily (NS5B inhibitor) and rib
79 ctively evaluated the efficacy and safety of sofosbuvir-based direct-acting antiviral therapy, indivi
81 patients with HCV-MCS who were treated with sofosbuvir-based regimens and historical controls treate
84 h HCV genotype 3 discontinued ledipasvir and sofosbuvir because of an adverse event (diverticular per
85 ent with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor velpatasvir.
88 genotype 1 infection; the dose of ledipasvir-sofosbuvir currently used in adults was well tolerated i
89 ived interferon-free regimens, most commonly sofosbuvir + daclatasvir (8/12), for a total of 24 weeks
90 vir; and two [33%] of six patients receiving sofosbuvir, daclatasvir, and asunaprevir) and headache (
91 sofosbuvir, daclatasvir, and simeprevir; or sofosbuvir, daclatasvir, and asunaprevir) until six pati
93 sofosbuvir plus daclatasvir for 24 weeks or sofosbuvir, daclatasvir, and ribavirin for 12 weeks are
94 osbuvir, ledipasvir, and asunaprevir; six to sofosbuvir, daclatasvir, and simeprevir; and eight to so
95 aprevir; one [17%] of six patients receiving sofosbuvir, daclatasvir, and simeprevir; and two [33%] o
96 ps (sofosbuvir, ledipasvir, and asunaprevir; sofosbuvir, daclatasvir, and simeprevir; or sofosbuvir,
97 d the broadly used, off-label combination of sofosbuvir, daclatasvir, simeprevir, and ribavirin in di
98 For genotype 2, sofosbuvir-ribavirin and sofosbuvir-daclatasvir cost $110 000 and $691 000 per QA
99 r/simeprevir would be expected in 31.4%, for sofosbuvir/daclatasvir in 36.8%, and for sofosbuvir/ledi
100 sofosbuvir/ribavirin, ledipasvir/sofosbuvir, sofosbuvir/daclatasvir, sofosbuvir/simeprevir, ombitasvi
101 ted the efficacy and safety of daclatasvir + sofosbuvir (DCV + SOF) for 12 weeks by antiretroviral (A
109 -naive and -experienced patients, ledipasvir-sofosbuvir for 12 weeks is highly effective for the trea
112 eved by 96% of patients receiving ledipasvir-sofosbuvir for 8 weeks (95% CI, 93%-98%), 97% receiving
113 in treatment-naive patients given ledipasvir/sofosbuvir for 8 weeks (P = .011), but not for 12 weeks.
114 efficacy and safety of 6 weeks of ledipasvir-sofosbuvir for acute genotype 1 or 4 HCV in HIV-1-coinfe
115 with a fixed-dose combination of ledipasvir-sofosbuvir for patients with acute genotype 1 or 4 HCV i
117 efficacy and safety of 4, 6, and 8 weeks of sofosbuvir, given in combination with the NS5A inhibitor
120 simeprevir (HCV NS3/4A protease inhibitor) + sofosbuvir (HCV nucleotide analogue NS5B polymerase inhi
121 aluate the efficacy and safety of ledipasvir-sofosbuvir in adolescents with chronic HCV genotype 1 in
122 aluate the safety and efficacy of ledipasvir/sofosbuvir in black patients using data from the three o
123 a small effect in patients given ledipasvir/sofosbuvir in combination with ribavirin for 12 weeks.
124 y and safety of 12 and 8 weeks of simeprevir+sofosbuvir in HCV GT1-infected treatment-naive and treat
125 icacy and safety of 12 weeks of simeprevir + sofosbuvir in HCV GT1-infected treatment-naive or treatm
126 feron- and ribavirin-free regimen ledipasvir-sofosbuvir in kidney transplant recipients with chronic
127 feron- and ribavirin-free regimen ledipasvir-sofosbuvir in kidney transplant recipients with chronic
129 ted three DAAs (simeprevir, daclatasvir, and sofosbuvir) in combination with anti-miR-122 treatment a
137 ed that adding a third DAA to ledipasvir and sofosbuvir (LDV/SOF) can result in high SVR rates in pat
140 tudy, black patients treated with ledipasvir/sofosbuvir (LDV/SOF) were significantly less likely to a
142 osure of Huh7.5 cells infected with DBN3a to sofosbuvir led to identification of an escape variant wi
144 ed after 6 weeks of anti-HCV treatment using sofosbuvir, ledipasvir and a non-nucleoside polymerase-i
145 fatigue (one [17%] of six patients receiving sofosbuvir, ledipasvir, and asunaprevir; one [17%] of si
147 er program to one of three treatment groups (sofosbuvir, ledipasvir, and asunaprevir; sofosbuvir, dac
148 e (tau) and maximum concentration values for sofosbuvir, ledipasvir, and GS-331007 were within the pr
149 okinetic evaluation of the concentrations of sofosbuvir, ledipasvir, and the sofosbuvir metabolite GS
150 investigated the real-world effectiveness of sofosbuvir, ledipasvir/sofosbuvir, and paritaprevir/rito
151 regimens containing sofosbuvir, simeprevir + sofosbuvir, ledipasvir/sofosbuvir, or paritaprevir/ombit
152 ients underwent antiviral therapy (AVT) with sofosbuvir/ledipasvir and chemotherapy (14 rituximab plu
155 mbitasvir, paritaprevir/ritonavir/dasabuvir; sofosbuvir/ledipasvir; and daclatasvir/sofosbuvir, respe
160 1-infected patients treated with ledipasvir/sofosbuvir monotherapy, black patients had significantly
161 tment with sofosbuvir (n = 2986), ledipasvir/sofosbuvir (n = 11,327), or PrOD (n = 3174), with or wit
162 35 with genotype 4) who began treatment with sofosbuvir (n = 2986), ledipasvir/sofosbuvir (n = 11,327
163 ION-4, and ALLY-2 that evaluated simeprevir; sofosbuvir; ombitasvir, paritaprevir/ritonavir/dasabuvir
166 (90 mg) and sofosbuvir (400 mg) (ledipasvir/sofosbuvir) once daily, with or without ribavirin twice
169 osbuvir, simeprevir + sofosbuvir, ledipasvir/sofosbuvir, or paritaprevir/ombitasvir/ritonavir/dasabuv
173 those who are treatment experienced, whereas sofosbuvir, pegylated interferon, and ribavirin for 12 w
174 s standard of care, sofosbuvir/simeprevir or sofosbuvir/pegylated interferon/ribavirin, was included
175 ribavirin for 24 weeks, 4 patients received sofosbuvir plus daclatasvir for 12 weeks, and 2 patients
177 l, interferon- and ribavirin-free regimen of sofosbuvir plus daclatasvir in patients with HCV-associa
178 pe 1 infections, sofosbuvir plus ledipasvir, sofosbuvir plus daclatasvir, or ombitasvir, paritaprevir
179 3-drug regimen consisting of ledipasvir and sofosbuvir plus GS-9451 for 4 weeks, and 25 received a 4
180 vir plus pegylated interferon and ribavirin, sofosbuvir plus ledipasvir, or sofosbuvir plus ribavirin
182 terferon plus ribavirin has been replaced by sofosbuvir plus pegylated interferon and ribavirin, and
184 erent duration) and 311 receiving ledipasvir-sofosbuvir plus ribavirin (212 for 12 weeks and 81 for 2
185 ron or pegylated interferon +/- ribavirin or sofosbuvir plus ribavirin +/- pegylated interferon thera
186 nd ribavirin, sofosbuvir plus ledipasvir, or sofosbuvir plus ribavirin for 12 weeks are all suitable.
187 sessed the efficacy and safety of ledipasvir/sofosbuvir plus ribavirin for 24 weeks in 9 human immuno
188 eated with DAA therapy (21 patients received sofosbuvir plus ribavirin for 24 weeks, 4 patients recei
189 d for the safety and efficacy of 12 weeks of sofosbuvir plus ribavirin for the treatment of acute HCV
190 tolerability, and efficacy of ledipasvir and sofosbuvir plus ribavirin in patients with genotype 3 HC
191 ted interferon with or without ribavirin, or sofosbuvir plus ribavirin with or without pegylated inte
192 plus ribavirin, and 70.6% of patients given sofosbuvir plus ribavirin), and 89.6% (95% CI 82.8%-93.9
193 nfection (77.9% in patients given ledipasvir/sofosbuvir plus ribavirin, 87.0% in patients given sofos
194 tasvir for 12 weeks, and 2 patients received sofosbuvir plus simeprevir for 12 weeks) in Paris, Franc
195 analogue nonstructural protein 5B inhibitor sofosbuvir plus the nonstructural protein 5A inhibitor v
198 with genotype 3 HCV, 12 weeks of ledipasvir-sofosbuvir provided a high level of SVR in those without
199 uvir; sofosbuvir/ledipasvir; and daclatasvir/sofosbuvir, respectively, to the Canadian Coinfection Co
200 with genotype 2/3, follow-up treatment with sofosbuvir + ribavirin for 12/16 weeks are performed on
201 , 24 weeks for treatment-naive patients; (2) sofosbuvir + ribavirin, 12 weeks for patients with genot
202 uated a fixed-dose combination of ledipasvir/sofosbuvir +/- ribavirin administered for 8, 12, or 24 w
210 tential for DDIs between all these drugs and sofosbuvir/ribavirin, ledipasvir/sofosbuvir, sofosbuvir/
211 antiviral treatment with regimens containing sofosbuvir, simeprevir + sofosbuvir, ledipasvir/sofosbuv
214 dipasvir/sofosbuvir, sofosbuvir/daclatasvir, sofosbuvir/simeprevir, ombitasvir/paritaprevir/ritonavir
217 ug interactions between ledipasvir (LDV) and sofosbuvir (SOF) against a genotype 1b replicon to deter
218 virus (HCV) genotypes (GTs) 2 and 3 contain sofosbuvir (SOF) and ribavirin (RBV) for 12 or 24 weeks.
219 oss 11 phase 3 clinical trials of ledipasvir-sofosbuvir (SOF) and SOF, only 12 of 3004 patients had d
221 efficacy and safety of ledipasvir (LDV) and sofosbuvir (SOF) for 12 weeks in HCV genotype-1 (GT-1) p
223 C virus (HCV)-infected patients treated with sofosbuvir (SOF) in combination with other direct acting
224 ety, and tolerability of regimens containing sofosbuvir (SOF) in the treatment of hepatitis C virus (
225 the safety and efficacy of ledipasvir (LDV)-sofosbuvir (SOF) in treating HCV genotype-4 infected pat
227 (BOC) or telaprevir (TEL) for 48 weeks, and sofosbuvir (SOF) plus daclastavir (DCV) or simeprevir (S
228 ustained virological response (SVR) rates on sofosbuvir (SOF)-containing regimens in clinical trials.
229 mens posttransplant, particularly the use of sofosbuvir (SOF)/ledipasvir (LDV) without RBV in this pa
230 and 8% GT1 no subtype) and were treated with sofosbuvir (SOF)/ledipasvir +/- ribavirin (85%) followed
231 A (NS5A) inhibitors should be retreated with sofosbuvir (SOF; NS5B inhibitor) combined with simeprevi
232 ypic nonstructural protein 5A inhibitor) and sofosbuvir (SOF; nucleotide nonstructural protein 5B inh
233 e drugs and sofosbuvir/ribavirin, ledipasvir/sofosbuvir, sofosbuvir/daclatasvir, sofosbuvir/simeprevi
235 exposure in adults treated in phase 2 and 3 sofosbuvir studies, the area under the curve and maximum
236 ation of the nucleotide polymerase inhibitor sofosbuvir, the NS5A inhibitor velpatasvir, and the NS3/
237 ation of the nucleotide polymerase inhibitor sofosbuvir, the NS5A inhibitor velpatasvir, and the NS3/
238 e either the nucleotide polymerase inhibitor sofosbuvir, the NS5A inhibitor velpatasvir, and the prot
239 nhibitors of NS5A and NS5B and resistance to sofosbuvir-the only nucleotide analog approved for treat
240 uired adjustment during and after ledipasvir-sofosbuvir therapy but antiretroviral regimens did not.
242 n 12 weeks of treatment with simeprevir plus sofosbuvir (treatment duration of up to 16 weeks); 169 o
244 t weeks of treatment with the combination of sofosbuvir, velpatasvir, and GS-9857 produced an SVR12 i
245 r-velpatasvir-voxilaprevir (163 patients) or sofosbuvir-velpatasvir (151 patients) for 12 weeks.
247 15, and September 1, 2015, patients received sofosbuvir-velpatasvir (400 mg/100 mg in a fixed-dose co
248 cy and safety of a fixed-dose combination of sofosbuvir-velpatasvir (400 mg/100 mg) plus weight-adjus
249 phase 3 study evaluating the combination of sofosbuvir-velpatasvir for 12 weeks in patients with gen
251 -voxilaprevir for 8 weeks was noninferior to sofosbuvir-velpatasvir for 12 weeks, but the 2 regimens
253 nts were reported in 15 patients (2%) in the sofosbuvir-velpatasvir group and none in the placebo gro
254 rate of sustained virologic response in the sofosbuvir-velpatasvir group was 99% (95% confidence int
256 In a phase 2 open-label trial, we found sofosbuvir-velpatasvir plus GS-9857 (8 weeks in treatmen
257 el trial, we found 8 weeks of treatment with sofosbuvir-velpatasvir plus GS-9857 to be safe and effec
258 direct-acting antiviral-based therapies with sofosbuvir-velpatasvir plus ribavirin for 24 weeks was w
259 nsated cirrhosis, 12 weeks of treatment with sofosbuvir-velpatasvir resulted in rates of sustained vi
260 uvir-velpatasvir-voxilaprevir to 12 weeks of sofosbuvir-velpatasvir using a noninferiority margin of
261 n to establish noninferiority to 12 weeks of sofosbuvir-velpatasvir, which produced an SVR in 98% of
262 randomly assigned in a 1:1 ratio to receive sofosbuvir-velpatasvir-voxilaprevir (163 patients) or so
263 confidence interval [CI], 86-100) receiving sofosbuvir-velpatasvir-voxilaprevir alone and 24 of 25 (
265 POLARIS-4, the rate of response was 98% with sofosbuvir-velpatasvir-voxilaprevir and 90% with sofosbu
266 agent were assigned randomly to groups given sofosbuvir-velpatasvir-voxilaprevir for 8 weeks or sofos
267 ith HCV infection, we did not establish that sofosbuvir-velpatasvir-voxilaprevir for 8 weeks was noni
270 alone were diarrhea and bronchitis; and with sofosbuvir-velpatasvir-voxilaprevir plus RBV were fatigu
273 ned to test the noninferiority of 8 weeks of sofosbuvir-velpatasvir-voxilaprevir to 12 weeks of sofos
275 ment with a fixed-dose combination tablet of sofosbuvir-velpatasvir-voxilaprevir with or without riba
277 of sustained virologic response was 96% with sofosbuvir-velpatasvir-voxilaprevir, as compared with 0%
279 3%-97%) of patients had an SVR to 8 weeks of sofosbuvir-velpatasvir-voxilaprevir; this did not meet t
281 ing the once-daily, pan-genotypic regimen of sofosbuvir/velpatasvir for hepatitis C virus infection,
282 Food and Drug Administration (FDA) approved sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) (Vosev
283 study, a 12-week regimen of simeprevir plus sofosbuvir was associated with high rates of SVR and inf
285 e interferon-free regimen of simeprevir plus sofosbuvir was recommended by professional guidelines fo
286 vir and NS5B nucleotide polymerase inhibitor sofosbuvir was shown to be safe and highly effective in
289 h7.5 cells with increasing concentrations of sofosbuvir was used to promote selection of HCV-resistan
291 has a high genetic barrier to resistance for sofosbuvir, whereas resistance to this DAA can be induce
292 Patients received treatment with ledipasvir-sofosbuvir, which was provided on site, according to U.S
293 gle patient receiving 12 weeks of ledipasvir-sofosbuvir who did not reach SVR12 did not complete trea
295 We examined the effectiveness of ledipasvir/sofosbuvir with or without ribavirin (LDV/SOF +/- RBV) a
296 fficacy of 8, 12, and 24 weeks of ledipasvir/sofosbuvir with or without ribavirin for the treatment o
297 type 3a variants with reduced sensitivity to sofosbuvir, with increased fitness and with cross-resist
298 esponse to the combination of ledipasvir and sofosbuvir, with or without ribavirin, in patients with
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