ライフサイエンスコーパス: solubilizing

1 yrin arrays (triads, tetrad, pentad) bearing solubilizing 7-tridecyl (swallowtail) groups is presente

2 Heparin is capable of solubilizing a subset of collagen-tailed (A12) acetylcho

3 on can have a significant effect on both the solubilizing ability and the selectivity of ionic liquid

4 SMA copolymer is a highly efficient membrane-solubilizing agent and that lipid bilayer properties suc

5 Using GO as a solubilizing agent for SWCNTs establishes a new class of

6 , with beta-cyclodextrin being employed as a solubilizing agent for these drugs.

7 vior of zonal elution experiments in which a solubilizing agent is present in the mobile phase to aid

8 t of novel applications for this new type of solubilizing agent, and for optimization of the SMA tech

9 -6-fold in the presence of dodecane, a lipid-solubilizing agent, with 50% maximal activation achieved

10 T315I cells and avoiding the use of DMSO as solubilizing agent.

11 -type molecular containers (1a-1e) to act as solubilizing agents for 19 insoluble drugs including the

12 (benzene, naphthalene) sidewalls, to act as solubilizing agents for hydrocarbons in water is describ

13 Macromolecules can be convenient solubilizing agents for NTs and a structural element of

14 was increased upon addition of carbohydrate solubilizing agents, in particular, 2-hydroxypropyl-beta

15 stored in nonvolatile salt buffers and other solubilizing agents, such as organics or detergents, to

16 fluorinated surfactants over other types of solubilizing agents, with a specific emphasis on their p

17 , we describe a new class of general-purpose solubilizing agents-acyclic cucurbituril-type containers

18 ane-associated proteins and for use of other solubilizing agents.

19 rs, detergents, chaotropic agents, and other solubilizing agents.

20 rs, detergents, chaotropic agents, and other solubilizing agents.

21 actants/detergents, preservatives, and other solubilizing agents.

22 s the bioavailability of mineral-bound Pi by solubilizing Al(3+), Fe(3+), and Ca(2+) phosphates in th

23 drogen bonding to the oxygen of the adjacent solubilizing alkoxy substituent, provides a novel mechan

24 hese polymers are the incorporation of water solubilizing alkyl functional groups that are integrated

25 tions of the helicene inner rim and multiple solubilizing alkyl groups, is an attractive building blo

26 us niger and S. himantioides were capable of solubilizing all the insoluble oxides when incorporated

27 es of tetrahydroazepinoindoles with appended solubilizing amine functionalities were synthesized.

28 gioregular poly(3-hexylthiophene) core and a solubilizing, amorphous regiosymmetric poly(3-hexylthiop

29 ulation, we demonstrate a unique approach to solubilizing and administering membrane-bound proteins f

30 By repeatedly solubilizing and depositing a mixture that initially con

31 ene encapsulated by dendrons containing both solubilizing and electroactive moieties.

32 Difficulties in solubilizing and purifying active pMMO have led to confl

33 Solubilizing and purifying carbon nanotubes remains one

34 We present a method for solubilizing and purifying UDP-Glc:ceramide glucosyltran

35 ellular biofactory depends on technology for solubilizing and refolding proteins that are expressed a

36 After solubilizing and refolding these fusions from inclusion

37 By solubilizing and subfractionating individual connexons f

38 phosphorus (P) availability via a phosphate-solubilizing bacterium (PSB).

39 cationic lipid/DNA complexes were formed by solubilizing cationic liposomes with 1% octylglucoside a

40 alycins that play a well established role in solubilizing cellular fatty acids.

41 evealed that mutants deficient in binding or solubilizing cellulose also exhibit reduced expression o

42 t is represented by trisphenylamine, and the solubilizing chains by N-9-heptadecanyl-substituted pery

43 oribbon, possess phenyl groups with decyloxy solubilizing chains on each corner.

44 nctional groups) and the absence/presence of solubilizing chains.

45 Solubilizing concentrations of dodecyl maltoside left th

46 ctyl-beta-D-glucopyranoside) and under fully solubilizing conditions (rhodopsin in a micelle with cos

47 ated that the receptors are sensitive to the solubilizing conditions, which illustrates the potential

48 gp41 or the utilization of nonphysiological solubilizing conditions.

49 al (2S)-ethylhexanol for functionalizing and solubilizing conjugated polymers.

50 Triton X-100 is most effective at solubilizing COX, but it destabilizes COX dimers, even a

51 ecyl ether (C(12)E(8)) are less effective at solubilizing COX.

52 The approach mimics ChIP and requires solubilizing cross-linked complexes with sonication.

53 yl maltoside, or Triton X-100 is the primary solubilizing detergent or the enzyme is dispersed in pho

54 The structure of the solubilizing detergent, however, greatly alters detergen

55 sed to investigate the influence of membrane-solubilizing detergents on GLUT1/lipid/detergent micelle

56 For satisfactorily solubilizing detergents, at concentrations much greater

57 Because of their sensitivity to solubilizing detergents, membrane protein assemblies are

58 hat methods other than DMSO are employed for solubilizing drugs but, where no alternative exists, res

59 Resveratrol exhibits a clear amyloid-solubilizing effect in this assay, showing no toxicity t

60 The average solubilizing effect of 26% NO saturation was 0.045; much

61 e to inhibit polymerization by measuring the solubilizing effect of iron nitrosyl sickle hemoglobin (

62 lly folded states and early aggregates and a solubilizing effect on the native state.

63 does not benefit patients through any direct solubilizing effect.

64 ligated species do not provide a significant solubilizing effect.

65 UL12.5 protein were generated by selectively solubilizing either insoluble infected-cell proteins or

66 30% as active as human leukocyte elastase in solubilizing elastin.

67 bled delivery systems usually substitute one solubilizing excipient for another, bringing new issues

68 ally frozen drug micelles containing minimal solubilizing excipient.

69 ochlorine insecticide DDT in the presence of solubilizing factor sodium cholate.

70 stoylated ciliary proteins from the GDI-like solubilizing factor UNC119a/b.

71 that P. aeruginosa could be producing a PQS-solubilizing factor.

72 rd oral suspension formulation compared to a solubilizing formulation and were more active when admin

73 co-crystal structure of the lead 4, various solubilizing functional groups were introduced to optimi

74 ded in the design of compounds with tethered solubilizing functionalities designed to reach the solve

75 ility of these methods and the importance of solubilizing functionality, several large PAHs were synt

76 Phosphate solubilizing fungi (PSF) have huge potentials in enhanci

77 trogens attached to the pz periphery; R is a solubilizing group (either propyl (Pr) or 3,4,5-trimetho

78 We introduce a novel siloxane-terminated solubilizing group and demonstrate its effectiveness as

79 An attempt to install a water-solubilizing group at the para-position of the phenoxy g

80 ,3-triazol-4-yl unit, which incorporates the solubilizing group of 3, was accomplished by thermal rea

81 e carboxamide group of 1 with an added water solubilizing group.

82 easing molecular weight and (ii) appropriate solubilizing-group substitution.

83 2 nM), have been synthesized in which water-solubilizing groups [NHCO(CH(2))nNR(1)R(2), where n = 1

84 her substituted at the 1-position with water-solubilizing groups [NHCO(CH)(n)NR(1)R(2), where n = 1 o

85 rolyte, Pt-p, which features carboxylic acid solubilizing groups are reported.

86 ns popular strategies to attach polar ligand-solubilizing groups at the exposed terminus of substitue

87 Water-solubilizing groups could be installed conveniently at e

88 to explore the use of phenyls as alternative solubilizing groups for [n]phenacenes.

89 property refinement by the incorporation of solubilizing groups led to the identification of 3-((4-(

90 Changing the position of the solubilizing groups on an oligomer chain does not preclu

91 Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyr

92 s of the same length with and without ethoxy solubilizing groups reveals that both solubilized and un

93 by using taurine-derived carbamates as water solubilizing groups that are cleaved upon protein functi

94 glet fission and highlight the importance of solubilizing groups to optimize excited-state photophysi

95 and allows selective incorporation of water solubilizing groups to the primary amide in 2 without pr

96 ith different p-xylene straps and peripheral solubilizing groups were synthesized using a previously

97 Nile Red derivatives that incorporate water-solubilizing groups will tend to fluoresce with good qua

98 structs, interact additionally through their solubilizing groups with N-terminal lid residues that ar

99 ylenediimide dimers bearing long alkyl chain solubilizing groups, bis[1-ethynyl-N,N'-bis(1-hexylhepty

100 have been reported that include much-needed solubilizing groups.

101 depending on the size and shape of the alkyl solubilizing groups.

102 decorated with short PEG chains, serving as solubilizing groups.

103 position of the arylureido moiety with water solubilizing groups.

104 While this effect is lost by solubilizing guanylate cyclase, ATP binds the purified,

105 he osmolytes, with some protecting osmolytes solubilizing hydrophobic side chains as well as urea doe

106 rent surfactants or organic solvents used in solubilizing individual drugs.

107 veral years ago as an alternative method for solubilizing integral membrane proteins in stable, nativ

108 ulfobetaine (ASB)-16 all appeared capable of solubilizing IPC synthase.

109 tions of styrene were conducted with several solubilizing ligands for the copper(I) halides: 4,4'-di-

110 Isolating spacers introduced between solubilizing lysine regions and a polyalanine core permi

111 mbrane-bound metalloprotease responsible for solubilizing many pathologically significant membrane su

112 Interestingly solubilizing membrane expressing CFTR in detergents such

113 suggest that DHPC is a better detergent for solubilizing membrane proteins and may be useful in gene

114 Detergents are used most often for solubilizing membrane proteins, but they are associated

115 compatible with detergents commonly used for solubilizing membrane proteins, including dodecylphospho

116 ale lipid bilayers that offer a platform for solubilizing membrane proteins.

117 equestering metals in soils and sediments or solubilizing metals to aid in their extraction.

118 upper rim; and the introduction of the water-solubilizing methylimidazolium groups on the lower rim.

119 idogenic N terminus domain (N) and a charged solubilizing middle region (M).

120 Compounds such as 9m with water-solubilizing moieties at the para position of the B-ring

121 olecular topology, and also demonstrate that solubilizing moieties play a large role in disrupting th

122 Introduction of the charged solubilizing moieties suppresses cellular uptake or adso

123 trongly affected by length, structure of the solubilizing moieties, and pH of the solution.

124 ve trafficking of DeltaF508-CFTR, namely the solubilizing mutation F494N/Q637R and DeltaRI (deletion

125 ation in the presence of fewer and different solubilizing mutations.

126 inantly the result of oxalate complexing and solubilizing Ni.

127 ar transport, and the subsequent addition of solubilizing, nondissociating detergents generates highe

128 in-6-yl)methyldibenz[b,f]azepines with water-solubilizing O-carboxyalkyloxy or O-carboxybenzyloxy sid

129 chment sites for high loading capacities and solubilizing oligoether/alkyl groups.

130 isrupts sealed membrane compartments without solubilizing or denaturing the lipid bilayer to allow ma

131 s SUMO modification; and (c) introduction of solubilizing or revertant mutations to stabilize F508del

132 he data are consistent with lithium chloride solubilizing organozinc reagents from the surface of the

133 less linker for temporarily attaching highly solubilizing peptide sequences ("helping hands") onto in

134 tive proteolysis are effective in completely solubilizing PHF, while a variety of denaturants are ine

135 dendrimer growth as well as incorporation of solubilizing piperidine groups.

136 olesterol from the periphery to the liver by solubilizing plasma membrane phospholipid and cholestero

137 gyloxy side chains were used to attach water solubilizing poly(ethylene glycol) chains through a clic

138 s, while the other is used for attachment of solubilizing poly(ethylene oxide) chains.

139 All ionic liquids tested have excellent solubilizing properties and vacuum stability compared to

140 thermodynamic, transport, spectroscopic, and solubilizing properties.

141 Water is critical for solubilizing reaction components and ligates to Ag(I) un

142 tment of retinal cell membranes with several solubilizing reagents.

143 quence, and (iii) in-solution removal of the solubilizing sequence using mild aqueous hydrazine to cl

144 mine, (ii) Fmoc-SPPS elongation of a desired solubilizing sequence, and (iii) in-solution removal of

145 While varying the size and branching of solubilizing side chains in pi-conjugated polymers impac

146 ructure relates to the regiochemistry of the solubilizing side chains on the backbone.

147 by solid state diffusion into the layers of solubilizing side chains without disrupting the conjugat

148 molecular weight distribution, nature of the solubilizing side-chains appended to the backbones, and

149 However, the lack of a general means of solubilizing, stabilizing and structurally characterizin

150 .43 A pi-pi stacking distance with favorable solubilizing substituent orientations.

151 e monomer properties such as core planarity, solubilizing substituent tailorability, and appropriate

152 racterization has required the attachment of solubilizing substituents such as tert-butyl.

153 By attaching the appropriate solubilizing substituents, efficient molecular packing w

154 prionogenesis by fragmenting prions without solubilizing Sup35, whereas Hsp104 couples Sup35 prion f

155 unsymmetrical perylene diimides containing a solubilizing swallowtail alkyl group and a variety of su

156 the donor group to one imide nitrogen and a solubilizing swallowtail, normally a long (e.g., C(19))

157 studies of processed 45Ti were performed by solubilizing the 45Ti residue in 0.05N HCl, of which 1.2

158 7000-fold from crude cell extracts by first solubilizing the cell membranes with the zwitterionic de

159 rol (LPG), is a very effective detergent for solubilizing the CFTR expressed in both yeast and Sf9 in

160 uggest that this detergent may be useful for solubilizing the CFTR from other sources and for other d

161 on LBC agar suggesting that this molecule is solubilizing the cholesterol micelles in LBC agar.

162 (HFIP) was found to be the best solvent for solubilizing the crude peptides.

163 ate is independent of the detergent used for solubilizing the folded state.

164 he T-domain into the lipid vesicles, without solubilizing the latter.

165 e of a polar environment that was capable of solubilizing the methyl orange into the CO2-rich phase.

166 Furthermore, the potency of LPG in solubilizing the notoriously intractable underglycosylat

167 We describe a protocol for solubilizing the recombinant enzyme from inclusion bodie

168 uring the starch content of plant tissues by solubilizing the starch, converting it quantitatively to

169 organic solvent serves an essential role by solubilizing the transition metal catalyst.

170 eases and are generally believed to do so by solubilizing their substrates.

171 ges in their properties and is essential for solubilizing them in common solvents.

172 cids promote absorption of dietary lipids by solubilizing them in mixed micelles.

173 methyl group in the reduced ring and a water-solubilizing unit at the chlorin 10-position.

174 In one design (FbC1-PO3H2), the water-solubilizing unit is a 1,5-diphosphonopent-3-yl ("swallo

175 In the other design (FbC2-PO3H2), the water-solubilizing unit is a 2,6-bis(phosphonomethoxy)phenyl u

176 guous strings of alanines with no capping or solubilizing units present.

177 sts confirmed the efficacy of oxalic acid in solubilizing vanadinite and precipitating lead as oxalat

178 lvent in tandem with the highly fluorinated, solubilizing, weakly coordinating [Al(OR(f))4](-) anion