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1 at is proteolytically processed to release a soluble form.
2 hances RANKL expression, particularly in its soluble form.
3 nly investigated the biologic effects of the soluble form.
4 me-enriched fraction but also was present in soluble form.
5 ssed in Escherichia coli and purified in the soluble form.
6 t a challenging target for design in a water-soluble form.
7 yme (TACE) to generate a biologically active soluble form.
8 d in NHBE cells and it remains active in its soluble form.
9 red to the cell wall and the other (prey) in soluble form.
10 H-L1(M)) in addition to the commonly studied soluble form.
11 phosphatidylinositol anchor or released as a soluble form.
12 thermal and operational stability than their soluble form.
13 n result in reactogenicity when delivered in soluble form.
14 IL-6 receptor and trans-signaling using its soluble form.
15 cytokine for release to neighboring cells in soluble form.
16 amine tracts and express these proteins in a soluble form.
17 X3CR1, signals both in membrane-anchored and soluble forms.
18 ive HtrABb occurs in both membrane-bound and soluble forms.
19 ble Abeta plaques and Abeta is likely in its soluble forms.
20 sis of carbon dioxide between gas- and water-soluble forms.
21 ity receptor for IgE, exists in membrane and soluble forms.
22 n, Env proteins are often made in truncated, soluble forms.
23 ll with an N-terminal protein S (PrS) tag in soluble forms.
24 tire ectodomain of PfEBA175 (PfEBA175 FL) in soluble form, allowing us to compare the biochemical and
25 ults demonstrate the existence of CL-12 in a soluble form and indicate a novel mechanism by which the
26 ly, a minority of D2R existed in a detergent-soluble form and interacted in a relatively unrestricted
27 sidues at the N terminus, can be purified in soluble form and is phosphorylated by cyclin-dependent k
28 e corresponding to X2IRBP was expressed in a soluble form and purified to homogeneity without its fus
31 orans alginate lyase known to be secreted in soluble form and to have a recognizable carbohydrate-bin
32 y, we investigated whether JAM-C is found in soluble form and whether soluble JAM-C (sJAM-C) mediates
33 tinctive structural properties which include soluble forms and the absence of typical SLAM signaling
36 of Escherichia coli CsgG in a non-lipidated, soluble form as well as in its native membrane-extracted
37 em likely encounters bacterial components in soluble form, as well as those associated with the intac
38 eptor subunits can exist in surface-bound or soluble forms, as well as in isolation or in partnership
39 Membrane-bound FasL can be processed into a soluble form by a metalloprotease similar to that which
42 t growth factor-23 (FGF23) and a circulating soluble form (cKL) created by endoproteolytic cleavage o
43 Ag expressed by intact bacteria versus Ag in soluble form, CL-sensitive cells appear to be necessary
44 ght to investigate whether uric acid, in the soluble form, could also activate the NLRP3 inflammasome
45 NA isoforms have been described, including a soluble form detected in human serum, which may have an
46 addition to its ability to maintain iron in soluble form, EDDS acts as a superoxide radical-promotin
47 EnvD was recovered from inclusion bodies in soluble form from an Escherichia coli expression vector
48 B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants an
49 lls, a full-length membrane-bound form and a soluble form generated by proteolytic cleavage that is s
51 s a result, STING agonists administered in a soluble form have elicited suboptimal immune responses.
57 g dual mitochondrial localization of Prx1: a soluble form in the intermembrane space and a form in th
59 on is an essential element for life, but its soluble form is scarce in the environment and is rarer i
61 s enzyme is regulated by its movement from a soluble form (largely in the nucleus) to a membrane-asso
62 urified recombinant membrane proteins in the soluble form most likely do not retain their native memb
63 tested in a panel of cancer cells, the water-soluble form of 3a, compound 8, displayed antiproliferat
64 his study, we tested the function of a novel soluble form of 4-1BB ligand (4-1BBL) costimulatory mole
65 therapeutic vaccines and, hence, generated a soluble form of 4-1BBL chimeric with streptavidin (SA-4-
67 inducing ligand (rhApo2L/TRAIL)-an optimized soluble form of an endogenous apoptosis-inducing ligand-
69 31 of whom underwent challenge with the only soluble form of aspirin, lysine aspirin (LAS), to confir
78 nto a construct that expresses a multitrimer soluble form of CD40L, leading to strongly protective CD
80 e severe pancreat CONCLUSIONS: : Activity of soluble form of CD73 at admission to hospital has progno
83 zyme-linked immunosorbent assay, activity of soluble form of CD73 using radioactive enzyme assays, an
84 g characteristic curve value for activity of soluble form of CD73 was 0.65 (95% CI, 0.51-0.80) among
85 ly, in the last-mentioned group, activity of soluble form of CD73 was better than C-reactive protein
89 d plasma enabled identification of a natural soluble form of CL-12 having an electrophoretic mobility
90 mined the three-dimensional structure of the soluble form of CPE in two crystal forms by X-ray crysta
91 nses of mice immunized with E1E2 and a novel soluble form of E1E2 (sE1E2) by a DNA prime and protein
98 proHB-EGF is known to be a precursor of the soluble form of HB-EGF (sHB-EGF), which promotes cell pr
101 of proprotein convertases, which releases a soluble form of HJV that suppresses BMP signaling and he
104 e previously shown that B7h triggering via a soluble form of ICOS (ICOS-Fc) inhibits the adhesion of
105 mIL-13Ralpha2 had no effect on levels of the soluble form of IL-13Ralpha2 in serum or BAL fluid and d
107 hat we developed, that a naturally occurring soluble form of IL-27Ralpha (sIL-27Ralpha) is produced b
108 It has been shown in several models that the soluble form of IL-6R (sIL-6R) is involved in the recrui
109 of the A allele increases expression of the soluble form of IL23R mRNA (which then functions as a de
110 adenovirus type 12 (HAdV12) complexed with a soluble form of integrin alphavbeta5 was determined by c
112 s fibroblast growth factor 23 (FGF23), but a soluble form of Klotho is also produced by alternative s
113 Indeed, we further demonstrate that the soluble form of LRP1 (sLRP1) inhibits alpha(M)beta(2)-me
114 farction led to significant elevation of the soluble form of MerTK (myeloid-epithelial-reproductive t
118 through attenuated iron incorporation by the soluble form of mutant ferritin and that the disordered
123 We engineered and heterologously expressed a soluble form of NUCB1 (sNUCB1) and characterized its bio
126 udy, we found that the expression of PTX3, a soluble form of pattern recognition receptor, was induce
130 (NTHI), those directed against a recombinant soluble form of PilA [the majority subunit of Type IV pi
131 mAb showed only marginal efficacy whereas a soluble form of platelet-derived growth factor receptor
133 gondii reveals that the parasite secretes a soluble form of PtdSer decarboxylase (TgPSD1), which pre
134 oxide compounds, a very concentrated and low-soluble form of Pu, which will serve as ongoing radioact
136 of integral membrane proteins that bind to a soluble form of silica, silicic acid, and transport it a
137 The median (interquartile range) value for soluble form of ST2 (33 [24.6-48.1] ng/mL) and galectin
139 ues less than the observed median (<33 ng/mL soluble form of ST2 and <17.8 ng/mL galectin 3) had redu
140 volume reduction varied by baseline level of soluble form of ST2 and galectin 3; patients with values
144 muscle or by systemic administration of the soluble form of the activin type IIB receptor (ACVR2B/Fc
145 l-length CERK1 receptor protein as well as a soluble form of the CERK1 ectodomain, whereas cerk1-4 pl
146 expression, purification, and refolding of a soluble form of the CGRP receptor comprising a heterodim
151 ast, treatment of Tie1-deficient mice with a soluble form of the extracellular domain of Tie2, which
153 ons, and MVvac2-Hsol, vectoring a truncated, soluble form of the H protein that is secreted into the
154 etic variants correlate with the levels of a soluble form of the IL-2 receptor in subjects with type
158 ulation so that cells are not exposed to the soluble form of the ligand that potentially has detrimen
160 f you, and found that it mediates release in soluble form of the mature, cholesterol- and palmitate-m
161 In contrast, intraventricular infusion of a soluble form of the Nogo receptor that blocks the action
163 a was subjected to extraction with the water-soluble form of the PAH receptor, ExBox.4Cl, resulting i
167 petitive inhibition of Pdpn functions with a soluble form of the protein, Pdpn-Fc, leads to reduced l
168 analysis revealed that the serum FcmuR is a soluble form of the receptor encoded by an alternatively
169 alveolar and plasma levels of cytokines and soluble form of the receptor for advanced glycation end-
170 ificant reduction over time in cytokines and soluble form of the receptor for advanced glycation end-
173 at the HPV1 E4 protein, in the presence of a soluble form of the replication-licensing factor (RLF) C
175 ly a single molecule of alphaSNAP binds to a soluble form of the SNARE complex, we find that three mo
176 mulated with GM-CSF secrete high levels of a soluble form of the VEGF receptor (sVEGFR-1), which neut
177 GM-CSF at low O(2) secrete high levels of a soluble form of the VEGF receptor 1 (sVEGFR-1), which ne
178 colony-stimulating factor (GM-CSF) produce a soluble form of the VEGF receptor-1 (sVEGFR-1), which ne
180 nit (classical IL-6R signaling) or through a soluble form of this cognate receptor (IL-6 trans signal
181 n, we expressed and purified a fully active, soluble form of this enzyme and used it to examine the p
183 study, we characterized a previously unknown soluble form of this molecule in human plasma termed sCD
191 iting recombinant fusion proteins in which a soluble form of TRAIL, FasL or CD40L is genetically fuse
194 gths as those involved in the binding of the soluble form of ZipA, lacking the transmembrane region,
195 mulating body of evidence has indicated that soluble forms of Abeta and tau work together, independen
196 pathological hallmark of AD, but oligomeric, soluble forms of Abeta have been implicated as the synap
197 t gene expression of Abca1 and ApoE, reduces soluble forms of Abeta, and abrogates release of pro-inf
198 ions to promote the proteolytic clearance of soluble forms of Abeta, and we found that the synthetic
201 ed monoclonal antibody, preferentially binds soluble forms of amyloid and in preclinical studies prom
203 neural circuits, or protective, sequestering soluble forms of amyloid-beta (Abeta) that initiate syna
204 lts demonstrate that the N-terminal secreted soluble forms of APP (in particular sAPPbeta) robustly d
206 ll differentiation by producing membrane and soluble forms of CD25, the IL-2 receptor alpha-chain, an
209 Furthermore, although fVIII bound avidly to soluble forms of clusters II and IV from LRP1, only solu
211 othesis that NIH3T3 fibroblasts that express soluble forms of Delta1 and Jagged1 accelerate tumorigen
213 n profile differs significantly from that of soluble forms of Env (gp120 or gp140) predominantly used
223 erall, our findings suggest a model in which soluble forms of mutant SOD1 initiate disease with large
227 cleaved with PreScission protease to release soluble forms of proteins that can be optionally biotiny
229 binding to macrophage cell line, as well as soluble forms of recombinant mouse CD36, SR-A, and LOX-1
231 ies are consistent with data generated using soluble forms of the chloroplast chaperone receptors, OE
232 and tightly bound soluble WT-hSOD1, whereas soluble forms of the Cu-V103Z and L126Z variants demonst
237 (IL-6) is coordinated by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes
241 phenotype and fail to respond efficiently to soluble forms of the optimized immunogen, unless it is h
242 yme-linked immunosorbent assay (ELISA) using soluble forms of the prefusion and postfusion forms of t
243 in gB, possibly due to the use of different soluble forms of the protein and different assays for an
244 ugh it is unclear whether aggregates or more soluble forms of the protein represent the pathogenic sp
245 refolding were not successful in generating soluble forms of the protein that contained well-ordered
246 ynthetic steps leading to membrane-bound and soluble forms of the protein, including both 50 and 40 k
250 n invested in the engineering of recombinant soluble forms of the virion-associated Env trimer as vac
252 t of diseases associated with the release of soluble forms of TREM proteins; and identification of th
253 odels of sepsis, exogenous administration of soluble forms of TREM-1 attenuates inflammation and mark
257 y, we demonstrated that filamentous, but not soluble, forms of wild-type tau inhibit anterograde, kin
258 sess functional roles of substrate-bound and soluble-forms of the protein during VM DA development.
259 ify extracellular Hsp70 and Hsp90, either in soluble form or secreted as part of exosomes from tumor
264 activates membrane-bound FasL and releases a soluble form reported to have both antagonist and agonis
265 yo-tomography and the x-ray structure of the soluble form reveals the detailed mechanisms by which th
266 rian cancer (EOC) cells and is released in a soluble form (sALCAM) by ADAM-17-mediated shedding.
272 eport that fibrils polymerized in vitro from soluble forms sequester toxic species that can be releas
274 Falpha, TGFalpha, and c-Met receptor (or its soluble form, sMet) were evaluated using ELISA and quant
275 Nix/Bnip3L (Nix) and its alternately spliced soluble form (sNix) in hearts, but relative sNix/Nix exp
278 increases in TREM-2 levels are found as the soluble form (sTREM-2) long after clearance of infection
280 leukocyte recruitment to the liver, and the soluble form (sVAP-1) accounts for most circulating mono
282 eins, WhiD has not so far been purified in a soluble form that contains a significant amount of clust
283 of the interleukin-1 receptor family with a soluble form that is markedly upregulated on application
285 press cell surface IL-13Ralpha2 but lack the soluble form that regulates IL-13 responses in mice.
286 ernative conformations in Escherichia coli-a soluble form that terminated transcription efficiently a
287 YC492, has been shown to exist in two forms: soluble forms that are believed to be toxic to the bacte
291 When this domain switches from its normal soluble form to an insoluble amyloid, the ensuing change
292 otein, called gp140, has also been made as a soluble form to mimic the native Env present on the viri
293 induces neuronal dysfunction and death in a soluble form; toxicity of the fragment is buffered by it
294 h convert transmembrane fractalkine into the soluble form, was significantly increased in these cases
296 cking BTN1A1 was released from the MFGM in a soluble form when the milk lipid droplets were disrupted
298 hly express SECTM1, including an N-terminal, soluble form, which can be detected in the sera of metas
299 mer and found to be an active ATPase both in soluble form with detergent and when reconstituted into
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