ライフサイエンスコーパス: solute carrier

1 the respiratory supercomplex (RSC) and other solute carriers.

2 structurally and functionally related human solute carriers.

3 glutamate transporter subtypes belong to the solute carrier 1 (SLC1) family and a second family, SLC6

4 ysteine transporter 2 (ASCT2) belongs to the solute carrier 1 (SLC1) family of solute transporters an

5 y the neutral amino acid transporters of the solute carrier 1 [SLC1, alanine serine cysteine transpor

6 conserved properties predicted for the Nramp/Solute carrier 11 (Slc11) family, such as 12-transmembra

7 etal transporter/divalent cation transporter/solute carrier 11 group A member 2 or 3 (DMT1/DCT1/SLC11

8 Solute carrier 11A1 (SLC11A1) is a divalent ion transpor

9 -, alanine-rich kinase directly regulate the solute carrier 12 family of cation-chloride cotransporte

10 icarboxylate cotransporters (NaDC1) from the solute carrier 13 (SLC13) family.

11 gens (DDX3Y; ribosomal protein S4, Y linked; solute carrier 1A5; and signal sequence receptor 1) were

12 ation transporters (OCTs) are members of the solute carrier 22 family of transporter proteins that ar

13 r-3), a polyspecific drug transporter in the solute carrier 22 family.

14 endent Na(+)/Ca(2+) exchangers belong to the solute carrier 24 (SLC24A1-5) gene family of membrane tr

15 Solute carriers--solute carrier 25A23 (SLC25A23), SLC25A24, and SLC25A25-

16 Here we identify a solute carrier 26 (Slc26) family protein as an essential

17 The solute carrier 26 (SLC26) transporters are anion transpo

18 Mutations in SLC26A3 (solute carrier 26 family member 3), which functions as a

19 lyspecific organic cation transporter in the solute carrier 29 (SLC29) family.

20 and 3; SLC4A1) is the founding member of the solute carrier 4 (SLC4) family of bicarbonate transporte

21 y associated with homozygous mutation of the solute carrier 4 family gene SLC4A4.

22 The choline transporter-like protein 1/solute carrier 44A1 (CTL1/SLC44A1) and mRNA expression w

23 The folding trajectory of solute carrier 6 (SLC6) family members is of interest be

24 Many solute carrier 6 (SLC6) family transporters require anci

25 The solute carrier 6 (SLC6) is a family of ion-dependent tra

26 Here, we report the identification of the solute carrier 6 (SLC6) transporter protein SNF-10 as a

27 This analysis was extended to other SLC6 (solute carrier 6) transporter family members: siRNA-depe

28 Trh), serotonin receptor 2a (5HT2a), and the solute carrier 7-family amino acid transporter, JhI-21,

29 r expression [notably a leucine transporter, solute carrier 7A5 (SLC7A5)] is required to initiate AA-

30 Membrane solute carriers are key proteins involved in drug transp

31 Another solute carrier (Cl(-)/HCO3- exchanger) gene, Ae3, is in

32 f a newly discovered memory suppressor gene, Solute Carrier DmSLC22A, a member of the organic cation

33 n of a multigene transport system, involving solute carriers (encoded by Slc26a4, Slc4a8, and Slc4a9)

34 cassette (ABC) transporters and the organic solute carrier family (SLC) proteins.

35 organic cation and anion transporters of the solute carrier family (SLC22), which are implicated in c

36 is a member of the vertebrate mitochondrial solute carrier family (SLC25) that we call mitoferrin (m

37 ne, and cysteine transporters) belong to the solute carrier family 1 (SLC1), which also includes the

38 id transporter 3 [EAAT3; also termed Slc1a1 (solute carrier family 1 member 1)] to support de novo gl

39 -364, of human glutamate transporter SLC1A2 (solute carrier family 1 member 2), also known as glutama

40 A/glutamate receptor subunit 2C, calmodulin, solute carrier family 1 member 2, and glutamine syntheta

41 s away from the SLC1A5 gene, a member of the solute carrier family 1, had a genome-wide significant a

42 The glutamate transporter gene solute carrier family 1, member 1 (SLC1A1) is a promisin

43 In contrast, the expression of solute carrier family 10 member 1 (Slc10a1) and solute c

44 screening and subsequent analysis identified solute carrier family 11 member 1 (SLC11A1; formerly NRA

45 Solute carrier family 11, member 2 (SLC11A2) is the only

46 his gene SLC12A8, coding for a member of the solute carrier family 12 proteins.

47 The solute carrier family 13 member 5 (SLC13A5) is a sodium-

48 The solute carrier family 13 member 5 (SLC13A5), a sodium-co

49 A new study reports that loss of solute carrier family 13 member 5, which transports citr

50 The signal localizes to the solute carrier family 14 member 1 gene, SLC14A1, a urea

51 at impairs the peptide/histidine transporter solute carrier family 15, member 4 (SLC15A4).

52 NC93B1 and the endosomal proton transporter, solute carrier family 15, member 4.

53 als a loss-of-function mutation in slc16a6a (solute carrier family 16a, member 6a), a gene that we sh

54 present evidence that the gene SLC19A2 (for solute carrier family 19 (thiamine transporter), member

55 regulation of metallothioneine-2A (MT2A) and solute carrier family 19 member 2 (SLC19A2), two GR targ

56 cysteine transporters (ASCTs) belong to the solute carrier family 1A (SLC1A), which also includes th

57 etin), SLC2A1 (also known as GLUT1, encoding solute carrier family 2 (facilitated glucose transporter

58 Several SNPs of SLC2A1 (solute carrier family 2 [facilitated glucose transporter

59 sms in genes involved in fructose transport (solute carrier family 2 facilitated glucose transporter,

60 d glucose transporter, member 2 (SLC2A2) and solute carrier family 2 facilitated glucose/fructose tra

61 ansporter member 14 (GLUT14), encoded by the solute carrier family 2 member 14 (SLC2A14) gene, is a p

62 We demonstrate that solute carrier family 2, member 2 (also known as GLUT2),

63 have consistently identified associations of solute carrier family 2, member 9 (SLC2A9), polymorphism

64 that extracellular phosphate uptake through solute carrier family 20 (phosphate transporter), member

65 C, we studied LCN2 and its specific receptor solute carrier family 22 member 17 (SLC22A17) in human p

66 sing a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23A1) gene (rs3397

67 reated mice deficient in the mouse ortholog (solute carrier family 23 member 1 or Slc23a1) of a rat a

68 Solute carrier family 24, member 4 (SLC24A4), is a Na(+)

69 The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitoch

70 The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitoch

71 mitochondrial pyruvate carrier 1 (Mpc1), and solute carrier family 25 member 19 (Slc25a19)] involved

72 ic stress or coinjection of oocytes with the solute carrier family 26 (anion exchanger)-member 9 (SLC

73 ansmembrane conductance regulator (CFTR) and solute carrier family 26 (SLC26) Cl(-)/HCO3(-) exchanger

74 We detected biallelic mutations in SLC26A1 (solute carrier family 26 member 1) in two unrelated indi

75 ory bowel diseases has reduced expression of solute carrier family 26 member 3 (SLC26A3, also called

76 ductance regulator (CFTR) anion channels and solute carrier family 26 member A6 (SLC26A6) anion excha

77 (NBC1) and apical Cl(-) /HCO3(-) exchanger (solute carrier family 26 member A6; SLC26A6), increasing

78 Prestin, a member of the solute carrier family 26, is expressed in the basolatera

79 mice with disruptions in genes encoding the solute carrier family 26, member 6 (Slc26a6(-/-) mice) a

80 Cl(-)/HCO(3)(-) exchange mediated by luminal solute carrier family 26, member 6 (Slc26a6) and CFTR.

81 To determine the role of the solute carrier family 26, member 9 (SLC26A9) Cl- channel

82 eceptor-gamma-DBD-interacting protein 1; and solute carrier family 27 (fatty acid transporter), membe

83 Here we show that zebrafish solute carrier family 3 member 2 (Slc3a2) is expressed s

84 Solute carrier family 30 (SLC30A) proteins maintain cyto

85 nymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight

86 studies demonstrated that common variants of solute carrier family 30 member 8 gene (SLC30A8) increas

87 We showed that SLC30A9 (solute carrier family 30 member 9; also known as ZnT-9)

88 n-American populations, risk variants at the solute carrier family 30, member 8 (SLC30A8) locus were

89 s well as in sodium-dependent Pi transporter solute carrier family 34, member 1 (NaPi2a)-knockout (Na

90 ygous and homozygous (comp/hom) mutations in solute carrier family 34, member 3 (SLC34A3), the gene e

91 yrosylprotein sulfotransferase 2 (TPST2) and solute carrier family 35 member B2 (SLC35B2) function in

92 = 1.33 x 10-9 for the meta-analysis) in the solute carrier family 35 member G1 gene (SLC35G1); and r

93 gf2 (insulin-like growth factor 2), Slc38a4 (solute carrier family 38 member 4), and Peg1 (paternally

94 4 (LPPR4) (OR, 2.30; P = 4.82 x 10(-6)) and solute carrier family 38 member 8 (SLC38A8) (OR, 3.14; P

95 Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus a

96 nine at position 391 in the zinc transporter solute carrier family 39, member 8 protein (SLC39A8 alan

97 that osteoclast-targeted deletion in mice of solute carrier family 4 anion exchanger member 2 (Slc4a2

98 CO(3)(-) cotransport mediated by basolateral solute carrier family 4 member 4 (NBCe1-B) and by Cl(-)/

99 ort that the bicarbonate/chloride exchanger, solute carrier family 4, anion exchanger, member 2 (SLC4

100 osis gene (Hfe)] and ferroportin [encoded by solute carrier family 40 (iron-regulated transporter), m

101 ene fusions and identified the SLC45A3-BRAF (solute carrier family 45, member 3-v-raf murine sarcoma

102 ed that riboflavin absorption occurs through solute carrier family 52 members (SLC52) A1, A2 and A3.

103 lymorphism of the serotonin transporter gene solute carrier family 6 (neurotransmitter transporter, s

104 rs 1 and 2 (GlyT1 and GlyT2)--members of the solute carrier family 6 (SLC6).

105 n receptor 1a) gene and STin2 in the SLC6A4 (solute carrier family 6 [neurotransmitter transporter, s

106 an SNP in the 3'-untranslated region of the solute carrier family 6 member 14 (SLC6A14) gene (P = 0.

107 As encoding tryptophan 2,3-dioxygenase-2 and solute carrier family 6 member 19 (also called B0AT1) we

108 at mediate clearance of NE via expression of solute carrier family 6 member 2 (SLC6A2), an NE transpo

109 f the human norepinephrine transporter gene [solute carrier family 6, member 2 (SLC6A2)].

110 nes (plasmacytoma expressed transcript 1 and solute carrier family 6, member 4) in the zebrafish.

111 Variations in solute carrier family 6A, member 3 (SLC6A3/DAT1), the hu

112 The glutamate/cystine antiporter solute carrier family 7 member 11 (SLC7A11, also called

113 We asked if SLC7A14 (solute carrier family 7 member A14), an orphan protein a

114 Solute carrier family 7, member 11 (Slc7a11) is a plasma

115 Three single nucleotide polymorphisms in solute carrier family 8, member 1 (SLC8A1), a sodium/cal

116 found increased expression of proximal colon solute carrier family 9 (sodium/hydrogen exchanger), mem

117 Mutations in solute carrier family 9 isoform 6 on chromosome Xq26.3 e

118 ntain the psoriasis candidate genes SLC9A3R (solute carrier family 9, isoform 3 regulatory factor), N

119 fied an in-frame 9 base pair deletion in the solute carrier family 9, isoform A6 (SLC9A6 gene), which

120 tathione S-transferase, Indian hedgehog, and solute carrier family genes.

121 oferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inn

122 SLC3A2, a member of the solute carrier family, was identified by proteomics meth

123 are homologous members of the mitochondrial solute carrier family.

124 iled-coil-domain-containing 57 (CCDC57), and solute-carrier family 16, member 3 (SLC16A3).

125 The solute carrier gene family 26 (SLC26) encodes membrane p

126 SLC39A8 is a member of the solute carrier gene family known to import Mn, Zn, and o

127 cima-1 encodes a solute carrier in the SLC17 family of transporters that

128 Two solute carrier (Na(+)/H(+) exchanger) genes, Nhe2 and Nh

129 ute carrier family 10 member 1 (Slc10a1) and solute carrier organic anion transporter family member (

130 cgammaRIIIA, ferritin light chain (FTL), and solute carrier organic anion transporter family member 2

131 The A. stephensi solute carriers prestinA and NDAE1 were up-regulated in

132 s inducible nitric oxide synthase (iNOS) and solute carrier protein 11A1 (SLC11A1).

133 o a distinct anion transporter family called solute carrier protein 26A, or SLC26A.

134 c properties acquired the ability to use the solute carrier protein family 35 member F2 (SLC35F2) as

135 ne bound molecular motors, identified as the solute carrier protein SLC26a5, that drive somatic motil

136 is a member of a very interesting family of solute carrier proteins (SLCs), some of which have been

137 Increased expression of additional solute carrier proteins, including Slc5a12 (>10-fold) we

138 tokines, and several proteasome subunits and solute carrier proteins, whereas it downregulated antiap

139 In general, SLC26 solute carriers serve to transport a variety of anions a

140 ate efflux transporter Bor1, a member of the solute carrier (SLC) 4 transporter family with homology

141 disease, and transport studies suggest that solute carrier (SLC) and ATP binding cassette (ABC) mult

142 ingly, prestin is a member of a gene family, solute carrier (SLC) family 26, that encodes anion trans

143 Solute carrier (Slc) family 26A encodes different anion

144 cy, <5%) and by variants in the proximity of solute carrier (SLC) genes.

145 Solute carrier (SLC) membrane transport proteins control

146 A number of solute carrier (SLC) proteins are subject to changes in

147 showed that hOAT2 (SLC22A7), a member of the solute carrier (SLC) superfamily, was a facilitative tra

148 Two proteins from the solute carrier SLC19A gene family have been identified a

149 ous studies identified several isoforms of a solute carrier Slc26a6 to be highly expressed in cardiom

150 stolic BP and the previously uncharacterized solute carrier SLC35F3.

151 proton-coupled amino acid transporter 1), or solute carrier SLC36A1, represents the imino acid carrie

152 High affinity transporters in the solute carrier SLC6A family function in removing monoami

153 periments were designed to determine whether solute carrier SLC6A14 is the molecular correlate of the

154 ction variants associating with SCr in three solute carriers (SLC6A19, SLC25A45 and SLC47A1) and two

155 owing association with SNP rs13120371 in the solute carrier SLC7A11, previously implicated in chemore

156 ATP-binding cassette (ABC) transporters and solute carriers (SLCs), have been identified in platelet

157 Solute carriers--solute carrier 25A23 (SLC25A23), SLC25A

158 The SLC26/SulP (solute carrier/sulphate transporter) proteins are a ubiq

159 10 human integral membrane proteins from the solute carrier superfamily.

160 is the Slc39a8 gene encoding a member of the solute-carrier superfamily.

161 By structural homology to other solute carriers, TMD2 may form part of the PCFT substrat

162 The solute carrier transmembrane protein prestin (SLC26A5) d

163 ke function has not been demonstrated by any solute carrier transport system identified at the molecu

164 Here, we show that the solute carrier transporter 7a5 (SLC7A5), a large neutral

165 tive nucleoside transporters, members of the solute carrier transporter superfamily SLC28, use an ion

166 elected one candidate transporter, the SLC7 (Solute Carrier) transporter family member JhI-21 (Juveni

167 nism by the human SLC13 family and other key solute carrier transporters.

168 ated associations of the amine compound SLC (solute-carrier) transporters gene set with the learning

169 s: cell adhesion molecules, ion channels and solute carriers/transporters, ATP-binding proteins, syna

170 the evolutionarily conserved exchangers and solute carriers, which are also involved in ion transpor