ライフサイエンスコーパス: solve @2 structure

1 new multidimensional chemical approaches to solve RNA structures.

2 to guide quantum mechanical calculations to solve the TS structure.

3 based on separate modeling using previously solved crystal structures.

4 from the same organism, of which we recently solved a crystal structure.

5 h motion may therefore affect the process of solving crystal structures.

6 f sufficiently high resolution with which to solve the crystal structure.

7 ing to prepare fully disialylated IgG Fc and solved its crystal structure.

8 raction with the checkpoint kinase Rad53 and solved its crystal structure.

9 ll molecules are often used as additives for solving the protein structures.

10 onstruct three-dimensional (3D) lattices for solving macromolecular structures.

11 nsp12-RdRp structure and superimposed it on solved picornaviral RdRp structures.

12 a benchmark of large protein complexes with solved three-dimensional structures.

13 re domain of RVFV NSs (residues 83-248), and solved its crystal structure, a novel all-helical fold o

14 Use of recently solved K(2P) structures allows us to explore the molecul

15 lity of the classical electron tomography to solve 3D structures and the chemical selectivity of the

16 prediction both on epitope data derived from solved 3D structures, and on a large collection of linea

17 x with the A:dTTP base pair is available, no solved non-cognate structures are available.

18 eltaE-LULL1 interaction, which enabled us to solve its structure at 1.4 A also.

19 strate preference of the Sicarius enzyme, we solved its crystal structure at 2.1 A resolution.

20 (with a self-complemented donor strand) and solved its crystal structure at 2.6 A resolution.

21 ignals by other members of the mu family, we solved the crystal structure at 1.85 A resolution of the

22 llular loop with apocytochrome b(562)RIL and solved the structure at 1.8 angstrom resolution.

23 very similar in structure to the previously solved Nipah-N structure, but with a difference in the a

24 express Lily in Schneider 2 insect cells and solve its structure by X-ray crystallography at 3.5 A re

25 lection method that uses a single crystal to solve X-ray structures by native SAD (single-wavelength

26 the role of these two zinc fingers, we have solved their structure by NMR.

27 gement of the C-terminal CA domains and have solved their structure by using hybrid cryo-EM and tomog

28 Subsequently solved crystal structures confirmed binding modes predic

29 esence of manganese instead of magnesium and solved the structure de novo using the anomalous signal

30 hese proteins (i.e. ~75,000 or < 0.07%) have solved tertiary structures determined by experimental te

31 Additionally, we solved a crystal structure for the apo form of AgmNAT wi

32 Using the recently solved cryo-EM structure for the Eag-family channel as a

33 and ligand docking studies based on recently solved muscarinic receptor structures, further support t

34 ling nanoparticles with atomic precision and solving their total structures have long been major drea

35 on between these findings and the previously solved PglD crystal structures illustrates a dichotomy a

36 r ligase VanG from Enterococcus faecalis and solved its crystal structure in complex with ADP.

37 mic of the beta-hairpin from EC869 toxin and solved its structure in complex with cognate immunity pr

38 We have solved its structure in complex with the C-terminal pept

39 To aid drug discovery efforts, here we solve a structure of CCR2 in a ternary complex with an o

40 Here, we solve a structure of Saccharomyces cerevisiae Pol I-CF-D

41 rbation data and experimental restraints, we solve a structure of the Sgt2_NT/Get5_UBL complex, valid

42 Here we solve the crystal structure of a ternary complex compris

43 Here we solve the crystal structure of an intein trapped in the

44 We identify oligomerization mutants and solve the crystal structure of E4-ORF3.

45 We solve the crystal structure of the LZ:CM2 complex, revea

46 Furthermore, we solve the crystal structures of E. coli PBP1b bound to m

47 Here we solve the crystal structures of the N-terminal domains o

48 Here we solve the crystal structures of the: (1) PF4 tetramer/fo

49 nvene to form a F(-)-selective pore, here we solve the crystal structures of two bacterial Fluc homol

50 Here we solve the dimer structures of wild-type APPTM (AAPTM WT)

51 We solve the NMR structure of its transmembrane domain in m

52 lasso peptides, astexin-2 and astexin-3, and solve the solution structure of astexin-3.

53 Here we solve the solution structure of the RNF126 zinc finger d

54 ning light and heavy elements, and use it to solve the structure of a beam-sensitive carbon nanostruc

55 We further solve the structure of a related enzyme, hydroxyethylpho

56 Here, we use NMR experimental constraints to solve the structure of a type-2 diabetes related human i

57 cryo-EM single-particle 3D reconstruction to solve the structure of CMG in complex with a DNA fork.

58 Here, we solve the structure of hRpn13 with a segment of hRpn2 th

59 Here we unambiguously solve the structure of molybdenum disulfide monolayers u

60 ics of SCD function, here we crystallize and solve the structure of mouse SCD1 bound to stearoyl-CoA

61 We solve the structure of one of these conformers by cryo e

62 We also solve the structure of the Drosophila Sas-6 N-terminal d

63 This structure was used to solve the structure of the enzyme in complex with 3-deaz

64 high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD compl

65 Using NMR, we solve the structure of the inactive state of the ribozym

66 We have used NMR spectroscopy to solve the structure of the NOXO1beta PX domain and surfa

67 by phage display was used to crystallize and solve the structure of the Rev oligomerization domain.

68 We also solve the structure of this complex by negative stain el

69 Here we use cryo-electron microscopy to solve the structures of AMPA receptor-auxiliary subunit

70 ay free electron laser, which can be used to solve the structures of complex proteins via serial femt

71 we use cryo-EM reconstruction techniques to solve the structures of the HPV16 capsid complexes using

72 golipid deficient, enabling us to purify and solve the structures of three alkaline-stable lipids pre

73 To analyze the interaction details, we solved a crystal structure of an sAC.bithionol complex.

74 Recently we solved a crystal structure of the C-type lectin-like dom

75 We solved co-crystal structures of both VRK1 and VRK2 bound

76 Recently solved cocrystal structures of the MV attachment protein

77 ding mode of LDI as compared with previously solved complex structures of related cereal type family

78 ur IWF structure agrees well with a recently solved cryo-EM structure of a CFTR IWF state.

79 We used the recently solved crystal structure of a highly conserved region of

80 Moreover, the recently solved crystal structure of AMPK has shed light both int

81 Subsequently, the solved crystal structure of Drosophila Orai (dOrai) subs

82 Recently, the solved crystal structure of Escherichia coli topoisomera

83 ely 30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin

84 Starting from the recently solved crystal structure of Hv1, we used structural mode

85 g cation-pi interactions, as revealed by the solved crystal structure of its complex with human BChE.

86 The solved crystal structure of PhiCpeT at 1.8-A resolution

87 The solved crystal structure of ToxT revealed an unstructure

88 dem (Xyn10C-XBD), which represents the first solved crystal structure of two contiguous CBM22 modules

89 We have solved crystal structures of a human Brf2-TBP complex bo

90 We solved crystal structures of free CRM1 from the thermoph

91 We solved crystal structures of murine IRE1alpha in complex

92 s into substrate binding and specificity, we solved crystal structures of MurU of Pseudomonas putida

93 To provide structural insight, we solved crystal structures of SART3 in the apo-form and i

94 We have solved crystal structures of seven AT-less type I PKS KS

95 The previously solved crystal structures of the AvrPto-Pto and AvrPtoB-

96 We solved crystal structures of the human p63 tetramerizati

97 Here, we solved crystal structures of the human RECQ1 helicase in

98 I-binding domain of RavA, and the previously solved crystal structures of the individual components,

99 n of LMAN1 binding to glycoprotein cargo, we solved crystal structures of the LMAN1-CRD bound to Man-

100 We solved crystal structures of the OLF domain of myocilin

101 o involved in dimer formation as seen in the solved crystal structures of the VosA homodimer and the

102 We also solved crystal structures of tubulin in complex with bot

103 We solved crystal structures of two active-site conformatio

104 nsible for autoinhibition of DNA binding and solved crystal structures of uninhibited, autoinhibited,

105 n conformations of virion-associated Env, we solved EM structures of an Env/CD4/CD4-induced antibody/

106 Interestingly, solved forkhead structures of members from the P subfami

107 n insight into this promutagenic process, we solved four ternary structures of polbeta with an incomi

108 We solved multiple crystal structures of this mutant A1 and

109 ase AtxE2 from Asticcacaulis excentricus, we solved NMR structures of its substrates astexin-2 and as

110 Many of solved tertiary structures of unknown functions do not h

111 Using cryo-electron microscopy, we solved the atomic structure of an apex bnAb, PGT145, in

112 ystallization so we instead crystallized and solved the atomic structure of its close homolog from Tr

113 Here, we solved the atomic structure of the CTD of gingipain B (R

114 n insight into inhibition of MPO by SPIN, we solved the cocrystal structure of SPIN bound to a recomb

115 We have solved the crystal structure of a dimeric Mdv1-Fis1 comp

116 Using this construct, we solved the crystal structure of a mini-hSIRT1-STAC compl

117 We solved the crystal structure of a similar but higher aff

118 Finally, we solved the crystal structure of a single EGF repeat cova

119 We have solved the crystal structure of a truncated form of UbiI

120 Herein, we solved the crystal structure of a typical 2-Cys peroxire

121 We solved the crystal structure of A49 from VACV Western Re

122 anism of AdPLA and LRAT-related proteins, we solved the crystal structure of AdPLA.

123 Here, we have solved the crystal structure of an EBNA1 hexameric ring

124 Recently, we solved the crystal structure of DnaK in complex with ATP

125 We solved the crystal structure of four hits, determined th

126 We also solved the crystal structure of full-length KGA and pres

127 We solved the crystal structure of GCGR ECD containing a na

128 We solved the crystal structure of GpsB and the interaction

129 ing how COQ9 can perform these functions, we solved the crystal structure of Homo sapiens COQ9 at 2.4

130 We solved the crystal structure of human monoclonal antibod

131 We have solved the crystal structure of human TIPRL at 2.15 A re

132 o understand the physical basis for this, we solved the crystal structure of JFH-1 NS3, revealing a n

133 We solved the crystal structure of M. tuberculosis PKS11 an

134 We have solved the crystal structure of MEDI4893 Fab bound to mo

135 We solved the crystal structure of monoFc, which explains h

136 nd the mechanism of pre-transfer editing, we solved the crystal structure of MST1 complexed with an a

137 Furthermore, we purified zebrafish MTH1 and solved the crystal structure of MTH1 bound to its inhibi

138 We have solved the crystal structure of OmoMYC and show that it

139 We solved the crystal structure of OrfX at 1.7 A and found

140 We have solved the crystal structure of oxidized and reduced P45

141 We have solved the crystal structure of paddle chimera, a Kv cha

142 e the interface between PexRD54 and ATG8, we solved the crystal structure of potato ATG8CL in complex

143 We solved the crystal structure of PRORP2 (3.2A) revealing

144 To define that interaction, we solved the crystal structure of RBBP4 in complex with an

145 We have solved the crystal structure of T. solenopsae Kt-23 RNA

146 We have solved the crystal structure of TarM at 2.4 A resolution

147 We solved the crystal structure of the 6-HB formed by MT-WQ

148 nism of action of this isolated antibody, we solved the crystal structure of the alpha-hemolysin:anti

149 -subunits influence Nav channel function, we solved the crystal structure of the beta2 extracellular

150 Spo0J from Helicobacter pylori (HpSpo0J) and solved the crystal structure of the C-terminal domain tr

151 We solved the crystal structure of the catalytic domain of

152 and the enzymatic mechanism of cleavage, we solved the crystal structure of the catalytic domain of

153 We have solved the crystal structure of the catalytic module of

154 We solved the crystal structure of the CCHFV strain Baghdad

155 We solved the crystal structure of the complex between an o

156 More particularly, we solved the crystal structure of the complex between huma

157 We solved the crystal structure of the complex of Gal3p-Gal

158 We also solved the crystal structure of the covalent inhibitor i

159 Here, we solved the crystal structure of the cytosolic domain of

160 We solved the crystal structure of the E2 for the small ubi

161 To explore these observations further, we solved the crystal structure of the extracellular beta4

162 To delineate the binding mechanism, we have solved the crystal structure of the GluN1 ligand-binding

163 We solved the crystal structure of the human Dicer-TRBP int

164 nd both Rap1 and HEG1 simultaneously, and we solved the crystal structure of the KRIT1-Rap1-HEG1 tern

165 asis for this functional differentiation, we solved the crystal structure of the Na(+)-driven membran

166 We solved the crystal structure of the PDZ domain of PTPN4

167 Recently, we have solved the crystal structure of the phosphatase domain o

168 We solved the crystal structure of the previously reported

169 We solved the crystal structure of the SLX4BTB dimer, ident

170 Here, we solved the crystal structure of the tubulin-pironetin co

171 We solved the crystal structure of the tumor overexpressed

172 To understand this specificity, we solved the crystal structure of the VCC beta-prism domai

173 We solved the crystal structure of this IRES bound to a bac

174 We solved the crystal structure of this peptide in complex

175 We solved the crystal structure of UbV.7.2 and rationalized

176 We have now solved the crystal structure of VP90(71-415) (amino acid

177 We have solved the crystal structure of VP90(71-415) of human as

178 We solved the crystal structure of YfcM and performed funct

179 We solved the crystal structures of a Yersinia pestis outer

180 We solved the crystal structures of cis-divalent streptavid

181 s of this protease-substrate coevolution, we solved the crystal structures of drug resistant I50V/A71

182 We solved the crystal structures of EXLX1 complexed with ce

183 gin of fluorescence in these phytofluors, we solved the crystal structures of IFP1.4 and a comparison

184 tand this ERK1/2 signalling complex, we have solved the crystal structures of PEA-15 bound to three d

185 We solved the crystal structures of tau55-HPD and its close

186 We solved the crystal structures of the AIPL1-FKBP domain a

187 We have solved the crystal structures of the apo and L-arabinose

188 for dCTP incorporation opposite dG(1,8), we solved the crystal structures of the complexes of Dpo4 a

189 We recently solved the crystal structures of the V1 moiety of Entero

190 We then solved the crystal structures of the wild-type mIDH2 and

191 We solved the crystal structures of these compounds in the

192 n adopted by ELIC under these conditions, we solved the crystal structures of two of these mutants in

193 We also solved the crystal structures of two purine NRHs, PpNRH1

194 he liganded-gating equilibrium constant, and solved the crystal structures of two such mutants (T25'A

195 We have solved the crystal structures of wild-type AdiC in the p

196 inhibitor, we used X-ray crystallography and solved the first structure of a Nedd4-1 family ligase bo

197 Here we have solved the first structure of a T3SS-associated PG-lytic

198 We previously solved the first structure of an IP(5) 2-K, which shed l

199 We have solved the first structure of one of these enzymes, that

200 Recently, we solved the functional structure of AID and demonstrated

201 o address this gap in our knowledge, we have solved the NMR structure of the 10th complement type rep

202 We solved the NMR structure of the DNA-binding Myb domain o

203 First, we solved the solution structure of OspE by NMR, revealing

204 ar basis of the high-affinity HM binding, we solved the solution structure of the apo form and the cr

205 We solved the solution structures of the RRM in complex wit

206 We have solved the structure of a potent TRIM21-dependent neutra

207 We purified and solved the structure of a thiopeptide antibiotic, lactoc

208 and the basis for BRCC36 regulation, we have solved the structure of an active BRCC36-KIAA0157 hetero

209 uide the design of improved therapeutics, we solved the structure of CCR5 in complex with chemokine a

210 le-particle electron cryomicroscopy, we have solved the structure of CrPV-IRES bound to the ribosome

211 In the current study, we solved the structure of DbpA from B. burgdorferi strain

212 We also solved the structure of FIPV M(pro) complexed with two i

213 ns in Munc18-2 give rise to disease, we have solved the structure of human Munc18-2 at 2.6 A resoluti

214 To elucidate its mechanism of action, we solved the structure of LJM716 bound to HER3, finding th

215 We have solved the structure of one of the constitutive mutants,

216 To overcome heterogeneity, we solved the structure of P405M-HlyIIC, a mutant that excl

217 We have solved the structure of Pseudomonas aeruginosa FabA with

218 We solved the structure of PSI(PsaJF) and a monomeric PSI,

219 We solved the structure of SIRT1 in complex with resveratro

220 We solved the structure of SpaI, a LanI protein from the su

221 We have solved the structure of the 14.1Fab fragment in complex

222 We also solved the structure of the [4Fe-4S] cluster-bound, engi

223 ron microscopy and helical reconstruction we solved the structure of the crenactin filament to 3.8 A

224 We solved the structure of the erythrocyte-binding DBL doma

225 ptides can bind to the Hat2p WD40 domain and solved the structure of the Hat1p/Hat2p/CoA/H4/H3 peptid

226 Here we have solved the structure of the holo-SubAB toxin that, in co

227 We have solved the structure of the HR1 domain of TOCA1, providi

228 Additionally, we solved the structure of the human LRH-1 DNA-binding doma

229 engineering with a novel fusion chimaera, we solved the structure of the human OX2R bound to suvorexa

230 Using x-ray crystallography, we solved the structure of the human SUMO E1 ubiquitin fold

231 We solved the structure of the MPE8 antibody bound to RSV F

232 Here, we solved the structure of the N2N3 domains containing the

233 o investigate this unusual behavior, we have solved the structure of the Nbp2p SH3-Ste20 peptide comp

234 We solved the structure of the phorbol-binding domain (C1B)

235 hyR-mediated partner-switching mechanism, we solved the structure of the PhyR(SL)-NepR complex using

236 ively dysregulate parasite PKA signaling, we solved the structure of the PKA regulatory subunit in co

237 f electron cryo-microscopy (cryoEM), we have solved the structure of the Pyrococcus furiosus archaell

238 We solved the structure of the Thermus thermophilus ribosom

239 Accordingly, we solved the structure of the unligated HA1.7 TCR and comp

240 We have solved the structure of the yeast mitoribosomal large su

241 the HEG1 C terminus (K(d) = 1.2 microM) and solved the structure of this assembly.

242 Here, we solved the structure of this crucial bulge by nuclear ma

243 We also solved the structure of trans-divalent streptavidin boun

244 We solved the structure of zinc-loaded Zur bound to the P(z

245 We solved the structures of 11 real-life examples, includin

246 ions of the MBD2-NuRD complex, we previously solved the structures of MBD2 bound to methylated DNA an

247 We have solved the structures of the Thermus thermophilus 70S ri

248 We also solved the structures of three bisamidines binding to DN

249 In this study, we solved the structures of three different FabI homologues

250 We solved the structures of three noncleavable mutants of t

251 We solved the structures of two 15-mer epitopes in complex

252 The recently solved three-dimensional structure of the protein lpg221

253 We solved two crystal structures of the Nostoc sp. PCC 7120

254 We solved two new structures of the domain crystallized und

255 d transport of Na(+) and bile acids, here we solved two structures of an ASBT homologue from Yersinia

256 In this study, we used solved x-ray structures of inhibitor-bound PDEdelta targ

257 e of the periplasmic domain of FtsQ has been solved, the structure of the FtsQBL complex is unknown,

258 de rationalization of the mode of binding by solving co-crystal structures of selected inhibitors in

259 By solving crystal structures of maltose binding protein (M

260 By solving crystal structures of TTL in complex with tubuli

261 By solving solution NMR structures of selected macrocycles

262 utralization mechanisms were demonstrated by solving the atomic structure of a NAb-RBD complex, throu

263 studied the conformational change in GlpG by solving the cocrystal structure of the protease with a m

264 Solving the crystal structure of Cbl(TKB) in complex wit

265 By solving the crystal structure of human AlaRS and compari

266 Unexpectedly, solving the crystal structure of Tda2 revealed it belong

267 In solving the crystal structure of the B. anthracis sidero

268 d the molecular basis for this inhibition by solving the crystal structure of the complex and simulat

269 By solving the crystal structure of the complex of the trim

270 Solving the crystal structure of the DEKK Fc region at a

271 activator, Intersectin, biochemically and by solving the crystal structure of the engineered complex.

272 By solving the crystal structure of the Hook domain and usi

273 By solving the crystal structure of the IL-1alpha/aptamer,

274 By solving the crystal structure of the paromomycin-ribosom

275 By solving the crystal structures of Btk inhibitors bound t

276 trate-binding pocket is also demonstrated by solving the crystal structures of inhibitor-bound NMT1 a

277 lecular dynamics simulations is validated by solving the crystal structures of three members of this

278 We confirmed this by solving the structure of Bsg25A complexed to the Insv si

279 acid residues, and suggests an approach for solving the structure of more complex, highly sulfated h

280 Solving the structure of proteins is pivotal to achievin

281 e acylbenzene derivative 10 was validated by solving the structure of the complex with the CREBBP bro

282 By solving the structure of the human SRSF1 pseudo-RRM boun

283 By solving the structure of the protease domain bound to a

284 ion and provide reagents for stabilizing and solving the structure of viral surface proteins.

285 Furthermore, a general technical approach to solving the structures of small molecules is demonstrate

286 -Sham scheme of density functional theory to solve electronic structure problems in a wide variety of

287 Solving its crystal structure revealed almost perfect al

288 We solved crystal structures showing that region III and TS

289 s demonstrate that DNCs have the capacity to solve complex, structured tasks that are inaccessible to

290 Along with the previously solved NgTet1-5mC structure, the two complexes offer a d

291 rosophila Ana2 CCCD forms a tetramer, and we solve its structure to 0.8 A, revealing that it adopts a

292 c binding, we crystallized VRN1(208-341) and solved its crystal structure to 1.6 A resolution using s

293 ed FlhE from the periplasm of Salmonella and solved its structure to 1.5A resolution.

294 We crystallized BR_A215T from bicelles and solved its structure to 3.0 A resolution to enable an at

295 from Chlamydomonas reinhardtii (CrISA1) and solved the crystal structure to 2.3 A and in complex wit

296 e latter technique offers the possibility to solve high-resolution structures using submicron crystal

297 Because of the insufficient number of solved peptoid structures, we have calculated the relati

298 In addition to solving the crystal structure, we found that apart from

299 mode method for systematically exploring and solving such structures which will be widely applicable

300 bitor, we developed a more potent analog and solved a cocrystal structure, which is the first crystal