ライフサイエンスコーパス: solvent-exposed

1 the binding to the collagen triple-helix are solvent exposed.

2 C-terminal 40 residues remain disordered and solvent exposed.

3 ion buffer where the peptides are completely solvent exposed.

4 th the N- and C-termini are unstructured and solvent exposed.

5 sic amino acid residues, and predicted to be solvent exposed.

6 the core in both SIV and HIV Nef were highly solvent exposed.

7 change data reveal that the center of TM3 is solvent exposed.

8 bserved for Fd, where the [Fe4S4] cluster is solvent exposed.

9 g conformations in which the nucleotides are solvent exposed.

10 polyglutamine (polyQ) segment disordered and solvent-exposed.

11 ent, while the hydrocarbon tail is partially solvent-exposed.

12 UNAG, and has the Cys115-terreic acid adduct solvent-exposed.

13 from the N terminus appear unstructured and solvent-exposed.

14 erminal portion of the fusion peptide can be solvent-exposed.

15 the subunit interface, moves from buried to solvent-exposed.

16 becomes disordered and the heme ring becomes solvent-exposed.

17 tacts with the enzyme, and the hydroxyls are solvent-exposed.

18 rophobic pocket while the helix and loop are solvent-exposed.

19 (residues 141-149) become substantially less solvent-exposed.

20 he hydrophobic core while, in ReAz108W it is solvent-exposed.

21 ally, the adenine ring is substantially more solvent-exposed, a result that could be explained by the

22 iking feature of the structure is an unusual solvent exposed acidic pocket formed between the peptide

23 A mutation in the solvent-exposed acidic domain of DSS1 compromises the ef

24 Glu69-containing molecule, revealed a unique solvent-exposed acidic pocket that includes betaGlu69 an

25 ly polymerase, which has a more spacious and solvent-exposed active site than replicative and repair

26 is HisG has been solved and reveals a large, solvent-exposed active site with subsites for ATP and PR

27 ve NADP(H) and (hydroxy)ornithine bound in a solvent-exposed active site, providing structural eviden

28 er loop region in Mtb DsbF results in a more solvent-exposed active site.

29 rier (20.0 vs 15.0 kcal/mol) due to the more solvent-exposed active site.

30 r copper monooxygenases that function with a solvent-exposed active site.

31 The presence of a solvent-exposed alanine residue stabilizes a helix by 0.

32 tates of the spin-label were resolved at the solvent-exposed alpha-helical site, at residue 28; these

33 -sheet content but also retain an element of solvent-exposed alpha-helix.

34 differential exchange rate constant for each solvent-exposed amide proton that is not hydrogen bonded

35 ange of peptide acidities observed for these solvent-exposed amides.

36 sence of a native-like N() with a disordered solvent-exposed amino-terminal beta-strand.

37 Conversely, the THA group in fact remains solvent exposed and does not disrupt base stacking in RA

38 segment in alpha-synuclein, NAC(8-18), in a solvent exposed and extended conformation that can form

39 in the GRK2 large lobe whose side chains are solvent exposed and facing the membrane were targeted fo

40 shown to be critical for K1's function, are solvent exposed and located on a convex surface, opposit

41 The aryl ring of benzimidazole is partially solvent exposed and only participates in van der Waals i

42 motif, whereas the C-terminal SUMO target is solvent exposed and situated in a typical consensus moti

43 the facially amphiphilic biaryl dendrons are solvent-exposed and accessible for recognition.

44 , or an open conformation, with Gly-734 more solvent-exposed and accessible to the PFL-AE active site

45 ore, the structurally defined N-NO moiety is solvent-exposed and available to transfer NO to a partne

46 , the phosphoinositide head groups are fully solvent-exposed and complete the LBD fold by organizing

47 orylation, resulting in a more comprehensive solvent-exposed and conformationally dynamic enzyme.

48 The terminal ZL portion of the inhibitor is solvent-exposed and highly flexible, and is thus not inv

49 genetic cluster, on the other hand, occupies solvent-exposed and highly mobile regions.

50 The altered residues in the polymerase are solvent-exposed and lie in regions that are adjacent to

51 at in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core is highly structure

52 A short helix, nHelix C, was fully solvent-exposed and nearly perpendicular to the bundle.

53 g the hypothesis that the thiol residues are solvent-exposed and not involved in disulfide bonds that

54 is domain, thereby leaving the cleavage site solvent-exposed and ready for cleavage.

55 e it includes a poorly conserved sequence, a solvent-exposed and somewhat unstable helix and a mobile

56 he receptor, whereas its glutamate moiety is solvent-exposed and sticks out of the pocket entrance, a

57 Mutations that were solvent-exposed and therefore accessible to T-cell antig

58 ggesting that individual domains of hA3G are solvent-exposed and therefore may interact with other ma

59 EGCG, the Abeta(1-40) oligomers become less solvent exposed, and the beta-regions, which are involve

60 l group and first eight residues of Frq1 are solvent-exposed, and Ca2+ binds the second, third, and f

61 ever, the active site of PPIases is shallow, solvent-exposed, and well conserved between family membe

62 We previously identified a highly solvent-exposed apoA-I loop domain (Leu(159)-Leu(170)) i

63 Hydrophilic moieties, addressing the solvent-exposed area adjacent to hydrophilic region II,

64 luster of positively charged residues in the solvent-exposed area outside of the adenine pocket adjac

65 d footprinting strategy was adopted to probe solvent-exposed aspartic and glutamic acid residues on t

66 vent-exposed surfaces of the FMO by labeling solvent-exposed aspartic and glutamic acid residues.

67 igand-binding sites is bonded to a different solvent-exposed Au atom, suggesting an associative mecha

68 module nor mutations altering access to the solvent-exposed axial copper coordination site significa

69 A solvent-exposed backbone on a beta-strand is thought of

70 interactions between the sidechains of these solvent-exposed basic residues and the graphene surface

71 The solvent-exposed beta- and gamma-phosphates of ATP are lo

72 we uncovered a point mutation (Y456T) on the solvent-exposed beta-sheet surface that allowed this dom

73 termining region 3 (CDR3H) that folds into a solvent-exposed beta-strand "stalk" fused to a disulfide

74 In contrast to deep, solvent-exposed binding pockets observed in other peptid

75 ending on whether the phenolic side chain is solvent-exposed, buried, or hydrogen-bonded.

76 e stronger ( approximately 4 Hz) than in the solvent exposed C-terminal AR ( approximately 2 Hz).

77 d in an intertau interface, from that of the solvent-exposed C terminus.

78 The more solvent exposed calcium can be easily displaced by mono-

79 tructural model, including the presence of a solvent-exposed cavity within its transmembrane region.

80 ER server that suggests that MurJ contains a solvent-exposed cavity within the plane of the membrane.

81 ica juncea) HMGCS binds hymeglusin in a more solvent-exposed cavity.

82 with the displacement of iron atoms from the solvent-exposed cluster, suggesting that Cu(I) damages t

83 secondary structures, and to the presence of solvent-exposed clusters of negatively charged side-chai

84 ed that Rpe employs a ferrous iron atom as a solvent-exposed cofactor and that H(2)O(2) rapidly oxidi

85 , the FAD of T. thermophilus PRODH is highly solvent-exposed compared with PutA due to a 4-A shift of

86 ally possible for Tyr106 to isomerize from a solvent exposed configuration to a buried rotameric stat

87 emplating base, the B[a]P moiety is in a non-solvent exposed conformation stacked within the DNA heli

88 xide (DMSO), the adduct is able to move to a solvent-exposed conformation, which enables error-prone

89 ase fold with the active site in the "open", solvent-exposed conformation.

90 nects the buried ligand-binding pocket and a solvent-exposed coregulator interaction surface.

91 The solvent-exposed Cys causes virtually complete retention

92 ein as EDTA-metal complexes by introducing a solvent-exposed cysteine residue using site-directed mut

93 human protein also contains three additional solvent-exposed cysteine residues (C95, C173, C188) that

94 , the nanocapsid surface was modified with a solvent-exposed cysteine to conjugate monolayer protecte

95 d has a comparable pK(a) for the active-site solvent-exposed cysteine.

96 in shape and electrostatics features of the solvent-exposed cytosolic receptor domains involved in t

97 ost of which are located in proximity to the solvent-exposed edge of the FMN cofactor along with othe

98 residues of recoverin at the N terminus are solvent-exposed, enabling the N-terminal myristoyl group

99 Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the

100 ix 3, helix 4, and helix 11 that move from a solvent-exposed environment to one that interacts extens

101 tion in center layers and GT conformation in solvent-exposed exocyclic groups.

102 ydrophobic cavity upon ligand binding to the solvent exposed exterior of the LTP, facilitating proteo

103 on were overrepresented within the predicted solvent-exposed face of the LRR domain, although several

104 The solvent-exposed face of the third helix was found to con

105 oil with conserved residues clustered on the solvent-exposed face.

106 O,Ph), 1HHy(CO,Ph)), leading to an elongated solvent-exposed Fe-Fe bond.

107 nd a CE meander with a cis-Pro followed by a solvent-exposed, flexible four-residue region.

108 -terminus of the peptide into both bound and solvent-exposed fractions.

109 water-network relaxation around the shallow, solvent-exposed function site.

110 lulose III(I), which increased the number of solvent-exposed glucan chain hydrogen bonds with water b

111 n of Z (but not OG) is strongly preferred at solvent-exposed guanine nucleobases at duplex ends.

112 mutant (GB1) with various amino acids at the solvent exposed guest position 53 in the internal strand

113 two distinct ring binding modes, buried and solvent-exposed, have been observed by X-ray structure a

114 ozyme, each containing a single p-AcPhe at a solvent-exposed helix site; the mutants were expressed i

115 in unphosphorylated Noxa, consistent with a solvent-exposed helix/loop, but strongly constrained in

116 In particular, the solvent-exposed heme is axially liganded by His75 and is

117 HigA does not cover the solvent-exposed HigB active site, suggesting that, in ge

118 Although solvent-exposed His and Tyr residues are more reactive w

119 The determination of pKa values for the solvent-exposed histidine residues shows that the surfac

120 this interaction, 13-HODE was docked to the solvent exposed histidines of a 15-hLO-2 homology model

121 where a beta-strand distortion results in a solvent-exposed hydrophobic amino acid at residue 5.

122 ate) phases], including the involvement of a solvent-exposed hydrophobic cluster and another delocali

123 protein reveals an SH3-like topology with a solvent-exposed hydrophobic ligand binding site.

124 Furthermore, an extended solvent-exposed hydrophobic loop, located between the Sy

125 A prominent solvent-exposed hydrophobic patch formed by residues Phe

126 eptide substrates is necessary to complete a solvent-exposed hydrophobic pocket to form the catalytic

127 The solvent-exposed hydrophobic residues (V619 and L623) the

128 One beta-turn and two loops containing solvent-exposed hydrophobic residues extend from the C2

129 dj3, as was the ability of ERdj3 to mask the solvent-exposed hydrophobic residues of CTA1.

130 ture of helix alpha1 is characterized by two solvent-exposed hydrophobic residues, F46 and L50, sugge

131 of factors V and VIII, some or all of these solvent-exposed hydrophobic residues, Trp26, Leu28, Phe3

132 hormone-bound GR interact with two distinct, solvent-exposed hydrophobic sites in the Hsp90 C-termina

133 Ca(2+)-bound CaBP7 NTD has a solvent-exposed hydrophobic surface that is more expansi

134 ges of Abeta40 and Abeta42 contain different solvent-exposed hydrophobic surfaces that are located at

135 l change, which was featured by an increased solvent-exposed hydrophobicity, while MsESAT-6 showed li

136 all non-DeltaF508 structures but completely solvent exposed in all DeltaF508 structures.

137 side chain of this residue remains partially solvent exposed in both the lit and dark states.

138 side chain, which is glycosylated in E2 and solvent exposed in other complexes, is slightly buried u

139 uctures show that Y272 is significantly more solvent exposed in the W290G variant but that W290F limi

140 myristoyl group attached to FCaBP is indeed solvent-exposed in both the Ca(2+)-free and Ca(2+)-bound

141 This PH domain surface is not solvent-exposed in crystal structures of PLC-beta, neces

142 the phenylazido side chain was predominantly solvent-exposed in the bound conformation.

143 These include several residues that are solvent-exposed in the CPR crystal structure, indicating

144 as Asn-415 is buried by HCV1 and AP33, it is solvent-exposed in the HC33.1-E2(412-423) complex, such

145 d hydrophobic BP pyrenyl residue is entirely solvent-exposed in the major groove of the DNA.

146 in Abeta (residues 16-22 and 30-42) are more solvent-exposed in the more toxic Abeta oligomer.

147 inaccessible in the native state but become solvent-exposed in unfolded state, thus enabling GroEL t

148 hed myristoyl group at the N terminus may be solvent-exposed, in contrast to the highly sequestered m

149 f all xylose residues in the active site are solvent exposed, indicating that arabinose substituents

150 residues, only Trp-105, containing the most solvent-exposed indole moiety in MEDI-493 and residing i

151 These singularities, called dehydrons, are solvent-exposed intramolecular hydrogen bonds that may b

152 rge portion of the backbone amide groups are solvent-exposed leading to fast hydrogen exchange and ca

153 is closed, a region of the binding pocket is solvent-exposed, leading to the hypothesis that it may a

154 the enzyme active site but rather in a more solvent-exposed location.

155 With the exception of the aqueous solvent exposed loop containing residues 20 and 21, the

156 ured N-terminus, a helical C-terminus, and a solvent-exposed loop containing Trp28 and Phe29.

157 ons in sequence at just three positions in a solvent-exposed loop greatly alter the extent of IB form

158 cid was extrapolated and incorporated into a solvent-exposed loop of a protein domain; the protein ex

159 ed that amino acids 121 to 124, located on a solvent-exposed loop of the protein, are important for M

160 anine mutagenesis of structurally determined solvent-exposed loop residues of the IGF-II-binding site

161 domains have the ferredoxin-like fold and a solvent-exposed loop with a MXCXXC motif that can bind C

162 X(11)C(12)X(13)X(14)C(15) motif located in a solvent-exposed loop.

163 Two small solvent-exposed loops (loops A and B) located within TBD

164 ay library of Fn3 was created in which three solvent-exposed loops were diversified in terms of amino

165 t peptide with four disulfide bonds and four solvent-exposed loops, as a scaffold for engineering pep

166 We illustrate this new strategy by labeling solvent-exposed lysine residues with commercially availa

167 rough nonspecific modification of the mAb at solvent-exposed lysine residues.

168 benzoquinone (NAC-BQ) preferentially bind to solvent-exposed lysine-rich regions within cytochrome c.

169 Individual mutation of three solvent-exposed lysines in the villin headpiece subdomai

170 rmer, the carcinogenic moiety resides in the solvent-exposed major groove throughout the replication/

171 n peroxide-treated sample, in contrast, four solvent-exposed Met residues in the Fc portion were comp

172 The rate constants and activation energy of solvent exposed methionines in protein and peptide were

173 tion was observed for the oxidation rates of solvent-exposed methionines with any thermodynamic param

174 dule forming a foothold on the virus and the solvent-exposed module able to adapt to bind to a variet

175 ding module containing domains 1 and 4 and a solvent-exposed module containing domains 2 and 3.

176 eading to locally enhanced chain dynamics of solvent-exposed monomers.

177 , where X1,2 not equal proline) in flexible, solvent-exposed motifs; however, several native glycopro

178 The solvent-exposed MPER tryptophan residue (Trp-680) was im

179 p predicted a mechanical intermediate with a solvent-exposed N terminus spanning the A and B beta-str

180 ic Abeta1-42 oligomers had more flexible and solvent-exposed N-termini than Abeta1-40 oligomers.

181 a3-40/42 had significantly more flexible and solvent-exposed N-termini than Abeta1-40/42 conformation

182 exhibit folded configurations with different solvent-exposed native-state surface morphologies.

183 lass A beta-lactamases and is located in the solvent-exposed Omega-loop of KPC-2.

184 ns suggest that the thiol groups present are solvent-exposed on a single protein surface and are too

185 tures include elongated beta-sheets that are solvent-exposed on both faces and the lack of a canonica

186 residues are more accurately described than solvent-exposed ones.

187 ntacts also place the NAC(8-18) segment in a solvent exposed orientation, a finding in contrast to th

188 , AlkD captures the extrahelical lesion in a solvent-exposed orientation, providing an illustration f

189 The flavin cofactor of PhzS is in the solvent exposed out orientation typically seen in unliga

190 esponding to the dimer interface became more solvent exposed over time at 3 degrees C; unexpectedly,

191 These residues form a solvent-exposed patch on the surface of the chaperone-bo

192 s and that fibrillization is promoted by two solvent-exposed patches, which are also involved in reco

193 AFUDG contains a large solvent-exposed peptide region containing an alpha helix

194 ains pack within a shallow depression at the solvent-exposed periphery of the interface.

195 a novel peptide-binding motif centered on a solvent-exposed phosphate anchor.

196 morphinan ligand binds deeply within a large solvent-exposed pocket.

197 bonds that can form in the membrane and the solvent-exposed polar surface area correlate more poorly

198 Here, 20 variants at the completely solvent-exposed position 76 of ribonuclease (RNase) Sa a

199 eeply buried position in the dark state to a solvent-exposed position in the light excited state.

200 ups that are gradually pulled from a distal, solvent-exposed position into the flat, bowl-shaped S2'

201 te and involved Ala and Gly substitutions of solvent exposed positions in the RT loop.

202 result in semiconservative substitutions at solvent-exposed positions in the folded conformation and

203 esigned with randomized amino acids at seven solvent-exposed positions was developed from 1.6 x 10(9)

204 examined alpha --> beta substitution at four solvent-exposed positions, Asn19, Trp23, Gln26 and Lys30

205 2 of the V(H) exhibited frequent mutation in solvent-exposed positions, but conservation of common st

206 burial to flat beta-sheet stability even at solvent-exposed positions.

207 In lead optimization, open, solvent-exposed protein pockets are often disregarded as

208 S-sulphenylation is favored at solvent-exposed protein surfaces and is associated with

209 DXMS identifies solvent-exposed protein surfaces; docking is used to cre

210 Molecular dynamics simulations show that solvent-exposed proteins (S15 and S17) tend to adopt mor

211 the glucosyltransferase, appears as a large solvent-exposed protrusion.

212 an incompletely formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and prov

213 en the coupling constants for the buried and solvent-exposed radical are primarily caused by variatio

214 e compared to those of a previously studied, solvent-exposed radical at position 108 to identify sign

215 ed by approximately 7 cm(-1) relative to the solvent-exposed radical, and large changes in intensity

216 tch, near the Chi recognition domain, on the solvent-exposed RecC surface.

217 the structure also reveals the presence of a solvent-exposed redox-sensitive disulphide bridge, uniqu

218 to engineer structural modifications in the solvent-exposed region of the ATP-binding site that sign

219 sters, we explored the chemical space in the solvent-exposed region of the enzyme catalytic binding p

220 he apopeptide, and that C133 is located in a solvent-exposed region with no definite secondary struct

221 s: while sequons were positively selected in solvent exposed regions, they were almost completely eli

222 eptide and PPACK, generating an enzyme whose solvent-exposed regions are even further stabilized from

223 located within or near to the interdomain or solvent-exposed regions in the antibody structure.

224 The interaction specifically involved solvent-exposed regions in the hsp90beta M domain that a

225 proteins tend to be clustered in buried and solvent-exposed regions, respectively.

226 n compared with C3b, revealing more dynamic, solvent-exposed regions.

227 ow that while the majority of Nef was highly solvent exposed, regions outside the core may have struc

228 Intriguingly, substitution of a single solvent-exposed residue enabled the parallel coiled-coil

229 Phenylalanine-427 (F427), a solvent-exposed residue in the lumen of the pore, was id

230 Moreover, solvent exposed residues have amide I bands with >20 cm(

231 inetic effect of mutating both interface and solvent exposed residues in pKID.

232 8 mutants of the SARS-CoV nsp1, targeting 62 solvent exposed residues out of the 180 amino acid prote

233 xtensive hydrogen-bonding network with three solvent exposed residues, linking the catalytic Fe(II) t

234 Solvent-exposed residues along the alpha-helices of the

235 quantify the number of lipid-correlated and solvent-exposed residues by amino acid type, which furth

236 Indeed, the CBD helix and the solvent-exposed residues in the dimeric CREB bZip coiled

237 Val-131, Leu-132, and Leu-135) interact with solvent-exposed residues in the Frq1 C-terminal pocket (

238 -160, Val-161, Met-165, and Met-167) contact solvent-exposed residues in the Frq1 N-terminal pocket (

239 ine GRK1 as a guide, we generated mutants of solvent-exposed residues in the GRK1 kinase domain that

240 osine-glutamine-phenylalanine (YQF) triad of solvent-exposed residues that are displayed on the beta-

241 26 mutants wherein clusters of 1-5 putative solvent-exposed residues were changed to alanine, ultima

242 InsA14-20 shares two solvent-exposed residues with previously identified AI4

243 rface, featuring key charged and hydrophobic solvent-exposed residues, at the membrane-distal tip of

244 integrated alleles that target conserved and solvent-exposed residues, we identified surfaces on p35/

245 structural distortions occur: distortions in solvent-exposed seed and 3'-end regions are less likely

246 reased sequence coverage and localization of solvent-exposed segments for mass-analyzed solution-phas

247 tify multiple structural features within the solvent-exposed SF region of apoA-I of nascent HDL essen

248 5 unit, respectively, than commonly seen for solvent-exposed side chains in water-soluble proteins, i

249 4 side chains move to interact with the more solvent-exposed side chains of D88 and E100'.

250 Localization of the oxidative label to solvent-exposed side chains was determined by high-resol

251 highly water soluble and monomeric, and with solvent-exposed side chains.

252 strand, shows the presence of three distinct solvent-exposed side-chain rotamers.

253 hill is also unusual, consisting of a highly solvent-exposed single-layer beta-sheet.

254 Glycans were introduced at seven solvent exposed sites within the Im7 sequence and the ki

255 latter two phenotypes lie in two overlapping solvent-exposed sites adjacent to the sugar-binding clef

256 redicted by existing methods, even when only solvent-exposed sites are targeted.

257 and are generally considered as prototypical solvent-exposed sites on the surfaces of alpha-helices.

258 n bonding interactions with the enzyme and a solvent exposed six-membered ring, consistent with its p

259 lar-pseudolamellar organization, and (3) the solvent-exposed Solar Flare loops, proposed sites of int

260 th in silico docking calculations identified solvent-exposed STAS residues involved in nucleotide bin

261 onment in closed buried hydrophobic and open solvent-exposed states.

262 The more solvent exposed structure of intermediate oligomers in t

263 e compounds can be modulated by variation of solvent-exposed substituents.

264 trained TCR docking mode, an optimal peptide solvent exposed surface leading to an optimal complement

265 mino acid substitutions introduced along the solvent exposed surface of the inhibitory helix.

266 f nine individual sites, each located on the solvent exposed surface of the protein where structural

267 The plot of free energy against the apparent solvent-exposed surface area is given for linear alkanes

268 to each other, differing primarily in their solvent-exposed surface areas in a manner accounting for

269 Modeling of solvent-exposed surface electrostatic potentials showed

270 of hydroxyl radicals to covalently label the solvent-exposed surface of proteins has been shown to be

271 transformation, we designed mutations on the solvent-exposed surface of TAg.

272 dues ( approximately 75%) are located on the solvent-exposed surface of the complex, a number of buri

273 residues (81%) are located on the oxygenated solvent-exposed surface of the complex, several residues

274 ns have been introduced incrementally on the solvent-exposed surface of the main alpha-helix (residue

275 tal structure of ATX suggests a role for the solvent-exposed surface of the N-terminal tandem somatom

276 by the presence of the olefinic chain on the solvent-exposed surface of the peptide.

277 syndrome missense mutations map to a common solvent-exposed surface that is not expected to alter en

278 sidues were predicted to cluster on a common solvent-exposed surface, suggesting a model in which the

279 ense negative external and positive internal solvent exposed surfaces.

280 distributions of hydrophobic residues on the solvent-exposed surfaces of native proteins.

281 ionizable amino acid residues present on the solvent-exposed surfaces of proteins, the protein charge

282 a mass spectrometry-based method that probes solvent-exposed surfaces of the FMO by labeling solvent-

283 the chemical equivalence of the protons of a solvent-exposed tert-butyl group from Tby, the singlet r

284 irst, the central region of (CAG)(8) is more solvent-exposed than single-stranded DNA, which suggests

285 ince this strategy leaves the alkylated base solvent exposed, the means to achieve enzymatic cleavage

286 When the cyanylated cysteine side chain is solvent-exposed throughout the structural transition, it

287 shifted compared to native PNP, suggesting a solvent-exposed Trp residue.

288 ctivity of hSOD1 causes oxidation of its own solvent-exposed Trp(32) residue.

289 action strongly depends on the presence of a solvent-exposed tryptophan residue (Trp-164).

290 d changes in its tertiary structure and more solvent-exposed tryptophan residues.

291 in docking of the short helix III remaining solvent-exposed until after the rate-limiting transition

292 s show that the ClpP N-terminus becomes more solvent-exposed upon interaction with ClpA.

293 mably because the hydrophobic inner sheet is solvent-exposed upon tetramer disassembly.

294 nd is anchored at both of its ends, with the solvent-exposed Watson-Crick edges of stacked bases 2 to

295 no ligands, and the active site is open and solvent-exposed when compared to structures of similar e

296 riments showed that the 2F5 epitope was more solvent exposed, whereas the 4E10 epitope was immersed i

297 s reveal that the distal NPXY motif is fully solvent-exposed, whereas the proximal one is not.

298 vicinity of the loop, the bases become more solvent exposed, which suggests that the instability ass

299 (AppA1-126) reveals that Trp104 is partially solvent exposed while a BLUF domain containing a slightl

300 Mutation of the solvent-exposed Y127, positioned on the beta-platform su