ライフサイエンスコーパス: soma

1 eolytically active lysosomes enriched in the soma.

2 ns in nuclear migration and anchorage in the soma.

3 on potentials and few sodium channels in the soma.

4 K channel expression at the pyramidal neuron soma.

5 ndfeet hundreds of micrometers away from the soma.

6 by decreased retrieval from the axon to the soma.

7 t delivers cargo from the distal axon to the soma.

8 solated after blocking GABAa receptor on the soma.

9 itic tips than for motion inwards toward the soma.

10 ntaining somatodendritic proteins toward the soma.

11 e on late endosomes for transport toward the soma.

12 distal axonal processes far removed from the soma.

13 e that maximises the current transfer to the soma.

14 ons and maximise the current transfer to the soma.

15 omical location of the retinal ganglion cell soma.

16 hereas most proteins are trafficked from the soma.

17 o X chromosomes is inactivated in the female soma.

18 sly by ions diffusing within the ER from the soma.

19 from its typical progression relative to the soma.

20 ity of synapses located more proximal to the soma.

21 ngthened and relocated proximally toward the soma.

22 equences, which are then eliminated from the soma.

23 egraded at the ONH than in the ganglion cell soma.

24 61, which accumulates alpha-synuclein in the soma.

25 requirement for retrograde transport to the soma.

26 these cells and thus convert them to actual soma.

27 mulation of unprocessed proforms in neuronal soma.

28 n germ cells when they are present in a male soma.

29 at apical dendrites, without inhibiting the soma.

30 uation and normalizing EPSP amplitude at the soma.

31 on, caused TH1-S31E accumulation in the cell soma.

32 orm amplitude of approximately 0.2 mV at the soma.

33 venation no matter how far they are from the soma.

34 d in the anterograde direction away from the soma.

35 he transport of signaling endosomes into the soma.

36 nuate excitatory signals passing to the cell soma.

37 nal Ca(2+) independently from actions at the soma.

38 an 26 mV) but are strongly attenuated at the soma (0.5-1 mV) and that the estimated neck resistance (

39 s 91 +/- 15 million, the volume of pyramidal soma 1,512 microm(3) , and the nuclear volume 348 microm

40 re-expressing p75NTR, the frequency of small soma 200-400 microm2 motor neurons increased, whereas th

41 shold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic bouto

42 to what extent the phenomena observed at the soma after induction of LTP/LTD reflects the actual (loc

43 leading to its significant reduction in the soma and abnormal retention within late endosomes in dis

44 We recorded the membrane potential from the soma and apical dendrite of layer 5 (L5) pyramidal neuro

45 cerebellum, basket cells (BCs) innervate the soma and axon initial segment (AIS) of Purkinje cells (P

46 itochondrial length in retinal ganglion cell soma and axon, but no degeneration.

47 ven the strong electrotonic coupling between soma and axon, the >25 mV depolarization associated with

48 PAD-induced spiking are arguably similar in soma and axon.

49 f soluble TNFalpha, effectively protects RGC soma and axons.

50 of DCVs after they bud from the Golgi in the soma and before they are trafficked to their release sit

51 nonical X dosage states that differ from the soma and between the sexes.

52 PTP1B inactivation prevents TrkA exit from soma and causes receptor degradation, suggesting a "gate

53 tic function are synthesized in the neuronal soma and conveyed via slow axonal transport.

54 network (TGN) and the plasma membrane of the soma and dendrites but not the axon.

55 ed ion channels in the AIS from those of the soma and dendrites have hampered understanding how AIS p

56 s were found to be unevenly clustered on the soma and dendrites of dopamine neurons within the substa

57 ntitative experimental measurements from the soma and dendrites of hippocampal pyramidal neurons.

58 iched MAP, was aberrantly distributed in the soma and dendrites of mutant Purkinje cells.

59 is, we performed patch-clamp recordings from soma and dendrites of rat hippocampal pyramidal neurons,

60 so develops substantially more slowly in the soma and dendrites than the development of the 1D MPS in

61 icroscopy recently revealed that, unlike the soma and dendrites, the axon membrane skeleton is struct

62 er distinct from that of HCN channels in the soma and dendrites.

63 cluster at inhibitory synapses mainly on the soma and dendritic shafts.

64 cytoskeletal protein present throughout the soma and dendritic tree of cerebellar Purkinje cells, to

65 rgoing IGF-1R knock-out reduced their apical soma and developed leaner dendrites, indicative of remar

66 ng reduction in astrocyte free Ca(2+) in the soma and endfeet.

67 of varying the AIS position relative to the soma and found that AIS distal relocation of both Nav an

68 and acts by controlling sex identity in both soma and germ line.

69 is achieved both at nerve terminals and the soma and is independent of membrane hyperpolarization an

70 hat augmenting viability of the motor neuron soma and maintaining functional neuromuscular junction c

71 ng sex chromosome dosage compensation in the soma and meiotic sex chromosome inactivation in the germ

72 We hypothesized that soma and neurite microcompartments exhibit distinct mech

73 nt, TH1-S31E, was distributed throughout the soma and neurites.

74 epigenome is distinguished from that of the soma and progenitor cells.

75 e synapses were localized exclusively on the soma and proximal dendrites, placing them in a good loca

76 thod and restricting channelrhodopsin to the soma and proximal dendrites, we are able to reliably evo

77 eled putative Renshaw cell synapses on their soma and proximal dendrites.

78 Axonal autophagosomes enter the soma and remain confined within the somatodendritic doma

79 h synaptic charge-transfer from dendrites to soma and spike propagation along the axon.

80 e data implicate different mechanisms in the soma and terminal in the transition to chronic pain.

81 all dye molecules diffused within ER between soma and terminal showing a single continuous ER compart

82 onal communication of Ca(2+) changes between soma and terminal.

83 ndependent, variation in contrast across the soma and the dendrite.

84 rase dUTP nick end labeling (TUNEL)-positive soma and the eventual loss of 5HT neurons in the DRif an

85 stance, denoting the path length between the soma and the start of the AIS, and to produce invariant

86 he trafficking of axonal retromer toward the soma and thus enhances protease transport to lysosomes,

87 eted siRNA led to striking protection of RGC somas and axons from hypertension-induced damage.

88 mulation and promoted robust survival of RGC somas and axons, supporting a critical role for tau alte

89 segment (AIS), controls retrograde (axon-to-soma) and anterograde (soma-to-axon) traffic of Tau.

90 channels are preferentially located near the soma, and control the frequency and pattern of spontaneo

91 l transcriptome in radial glia, far from the soma, and establish a tractable mammalian model for stud

92 s force for retrograde movements towards the soma, and kinesins move cargo in the opposite, anterogra

93 Ca(2+) channels decreased linearly from the soma, and leveled at the distal apical dendrite.

94 ts secreted from axons were processed in the soma, and many were dependent on somatic endocytosis for

95 nically isolate radial glia endfeet from the soma, and we use photoconvertible proteins to demonstrat

96 myelinated axons started more closely to the soma, ankyrin G, betaIV-spectrin, and the ion channel ex

97 hat the germ line is not segregated from the soma are characteristics of Hydra that may make nonsenes

98 ontrast, autophagosomes generated within the soma are less mobile and tend to cluster.

99 In Tetrahymena, the germline and soma are partitioned into two different nuclei within a

100 The soma area of motor neurons re-expressing p75NTR was alwa

101 Ganglion cells were classified based on soma area, dendritic field size, and branching of dendri

102 by increasing the number of neurites and the soma area.

103 cessful completion of migration and neuronal soma arrest occurs below the first stable branch point o

104 r; and (iii) using organelle motility inside somas as an intrinsic contrast agent.

105 Once in the soma, autophagosomes are confined to the somatodendritic

106 image was then used to locate recorded cell somas, axon initial segments, and axon trajectories, and

107 cal synapses develop in a soma-soma, but not soma-axon (removal of soma) configuration, indicating th

108 Neurons were cultured in a soma-soma or soma-axon configuration and synapses explored electrophy

109 (cholinergic) synapses between soma-soma and soma-axon pairs were indistinguishable, with both exhibi

110 Dual soma-axon patch-clamp recordings combined with axonal Na

111 dritic spikes that reliably propagate to the soma/axon.

112 Close to their soma, axons almost exclusively targeted inhibitory inter

113 ries substantial information that reveals GC somas, axons, and other retinal neurons and permits thei

114 L7 is part of a local feedback loop with the soma because it regulates cumulus cell replication.

115 Concomitantly, the soma becomes less mobile and the leading process acquire

116 cell types are always recorded first at the soma before backpropagating into the dendrites while und

117 er and size of proprioceptive sensory neuron soma between symptomatic SOD1(G93A) and control mice.

118 increase in SNAP25 cleavage detected in the soma chamber compared with nonstimulated neurons.

119 zed rule: for all nerve pathway origins, the soma cluster centroids in closest proximity are those wh

120 P amplitude increased with distance from the soma, compensating for dendritic attenuation and normali

121 n a soma-soma, but not soma-axon (removal of soma) configuration, indicating the requirement of gene

122 hypermethylation of 1 allele throughout the soma (constitutional epimutation) is an accepted mechani

123 s constructed and validated, confirming that SOMA construction is feasible.

124 We find that at steady state, the cell soma contains populations of autophagosomes derived from

125 This germ-soma demarcation has evolved independently in dozens of

126 llular matrix molecules that encapsulate the soma, dendrites, and axon segments of neurons in a latti

127 g to determine the signaling patterns in CA1 soma, dendrites, and axons associated with place field f

128 s stimulated by either Ca(2+) or 2-DG in the soma, dendrites, and axons of hippocampal neurons, with

129 reticulum (ER) that elaborate throughout the soma, dendrites, axon and presynaptic terminal.

130 el predictions and experimental results: net soma depolarizing currents increased choice hysteresis,

131 We placed the soma depolarizing electrode over medial frontal PFC.

132 Here we report that soma depth and dendritic path lengths within each cortic

133 Germline genes often become re-expressed in soma-derived human cancers as "cancer/testis antigens" (

134 t competing requirements of the germline and soma dictate organismal stress resistance as animals beg

135 mmed genome rearrangement during germline to soma differentiation.

136 % of the outer stratifying cells) have their soma displaced to the inner nuclear layer.

137 The origin of the germline-soma distinction is a fundamental unsolved question.

138 diated Ca(2+) signals >400 mum distal to the soma, due to unusually tight electrotonic coupling of th

139 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hyp

140 Inner stratifying cells have their soma exclusively in the ganglion cell layer and include

141 ation of specific mRNAs transported from the soma, exposing new mechanistic layers within stem cells

142 period, projections emerge from the cellular soma, extending toward a specific subpopulation of matur

143 Our SOMA faithfully represents the tissue-based molecular as

144 fluorescently tagged cholera toxin in their soma five days after injecting this retrograde tracer in

145 tracing via "backfilling" of the dye to the soma, followed by functional imaging in the labeled cell

146 A SOMA for a previously validated CCRCC-specific supervise

147 A SOMA for the CCRCC-specific SPC prognostic gene signatur

148 ls may be able to communicate changes in the soma from one generation to the next.

149 r that: axon-axon gap junctions close to the soma gave the best match to experimentally measured coup

150 vitro with endocrine cells and at the neuron soma, growth cones, neurites, axons, and dendrites but n

151 Dendritic tapering away from the soma has been suggested to both equalise contributions f

152 Interactions between the germ line and the soma help optimize reproductive success.

153 icrovesicular uptake as well as both soma-to-soma "horizontal" and bidirectional "vertical" synaptic

154 The soma, however, contains autophagosomes at different matu

155 tion zone (SIZ) that are often distal to the soma in invertebrate neurons.

156 otentials to antidromically propagate to the soma in retrograde signaling.

157 in injured and uninjured nerves in the skin, soma in trigeminal ganglion, and central terminals in th

158 ) and medium-field monostratified cells with somas in the ganglion cell layer (GCL).

159 M1-like cells typically had somas in the ganglion cell layer, with 23% displaced to

160 Calretinin-positive somas in the inner nuclear and the ganglion cell layer w

161 d and narrow-field monostratified cells with somas in the inner nuclear layer (INL) and medium-field

162 tochondrial degradation and mitophagy in RGC somas in vitro, it does not affect transport dynamics an

163 We perform morphometry on GC layer somas, including projection of GCs onto photoreceptors a

164 r how low sodium channel availability in the soma influenced the temporal precision of action potenti

165 mongst organisms, the importance of germline-soma interactions is a common theme.

166 ith neuronal cell bodies) to understand glia-soma interactions.

167 Segregation of the germ line from the soma is an essential event for transmission of genetic i

168 ch Nav1.6 nanoclusters are maintained in the soma is biologically different from axonal localization.

169 inhibitory input and that distance from the soma is compensated for by an increase in synaptic densi

170 annose-6-phosphate receptors (CI-MPR) in the soma is disrupted in mutant hAPP neurons, causing defect

171 Because the soma is interposed in the signal conduction pathway, the

172 i-dependent functions occur in the mammalian soma is unclear.

173 ctrophysiological properties recorded at the soma, it is not yet clear whether these differences are

174 In neuronal somas, KCC2b immunoreactivity was concentrated at the pl

175 arply in the dendrite with distance from the soma (length constant, 53.6 mum), but their attenuation

176 de synthesis suggesting that supply from the soma limits presynaptic neuropeptide accumulation.

177 kinin1 and Pet1 (Tac1-Pet1 neurons), mapping soma localization to the caudal medulla primarily and ax

178 1 shows all L4B neurons, regardless of their soma location in blob or interblob columns, as projectin

179 Irrespective of their soma location, the dendrites of secretagogin amacrine ce

180 ifying cells cover the retina independent of soma location.

181 Schwann cells had no impact on motor neuron soma loss from the spinal cord or ongoing systemic and p

182 nearly all found to express Kv3.1b in their soma membranes.

183 corresponding to neuronal structures (i.e., soma, neurite).

184 ns and co-localizes with lysosome markers in soma, neurites and synaptic boutons.

185 measure regional atrophy, neuronal loss, and soma neuronal atrophy in 3 components of the GP-the exte

186 ameiotic1 mutants (normal soma, no meiosis) accumulate both 21-nt and 24-nt phasiR

187 ts produce a 5- to 6-fold larger EPSP at the soma of CA2 compared with CA1 PNs, which is sufficient t

188 an unusually strong excitatory drive at the soma of CA2 pyramidal neurons, with EPSPs that are 5-6 t

189 in the soma of daf-2 worms compared with the soma of control worms.

190 actin-capping protein, in the dendrites and soma of cultured hippocampal neurons at different develo

191 py to analyze cell-surface Nav1.6 within the soma of cultured hippocampal neurons.

192 line transcripts are not up-regulated in the soma of daf-2 worms compared with the soma of control wo

193 the L-type calcium current is larger in the soma of dopamine neurons of the SNc, leading to a higher

194 d Tc-Ago3, are also expressed throughout the soma of early embryos.

195 the presynapse in mature neurons, and on the soma of immature neurons in the hippocampus.

196 dMiroT25N accumulated mitochondria in the soma of larval motor and sensory neurons, and prevented

197 Unlike in most vertebrate neurons, the soma of many arthropod and mollusc neurons is placed at

198 null mutant, TH1-S31A, was restricted to the soma of neuroblastoma cells, with decreased association

199 enance, was dynamically repositioning in the soma of newborn cells during this initial integration st

200 lar transcriptomes of neural projections and soma of primary mouse cortical neurons and two neuronal

201 ric alphaSyn were injected directly into the soma of pyramidal neurons in mouse neocortical brain sli

202 membrane trafficking defect was observed in soma of sensory neurons expressing mutant dSpt1, consist

203 much higher number of L-type channels in the soma of SNc DA neurons, as well as a smaller single-chan

204 Here we show that the individual somas of neurons within the retinal ganglion cell (RGC)

205 age compensation states between germline and soma offer unique perspectives on sex chromosome inferti

206 tive pretapetal cells), and msca1 (no normal soma or meiocytes)--lack 24-nt phasiRNAs.

207 showing a spatial specificity to either the soma or the axon.

208 Nav channels in the soma play a role in the transfer of axonal output inform

209 rve to innervate the labrum, indicating that soma position was independent of function and target are

210 morphology to individual neuron types, where soma position, dendritic architecture, and axonal projec

211 connections to cells at and below their own soma positions.

212 ns, which was confirmed after examination of somas post injection of a retrogradely transported antib

213 severe attenuation as they propagate to the soma, potentially reducing the influence of distal input

214 iating mutants that ultimately eradicate the soma-producing lineage.

215 ose instead that the absence of unicellular, soma-producing populations reflects their susceptibility

216 The absence of natural unicellular, soma-producing species previously prevented these hypoth

217 ations but are outcompeted by multicellular, soma-producing strains, suggesting that multicellularity

218 has dimensions similar to a pyramidal neuron soma, providing confined emission and electrophysiologic

219 ace and by simultaneously recording from the soma, proximal and distal dendrites of neocortical pyram

220 luorescence revealed the maintenance of cone soma, putative cone pedicles, and both rod and cone bipo

221 how abnormalities predominantly within their soma, rather than the apical dendrite.

222 ribution of mitochondria out of the neuronal soma regardless of the employed motor, likely by promoti

223 about gap junctions: locations close to the soma; relatively small numbers; many indirect connection

224 of irreversible conversion from germ line to soma, reproductive division of labor, and clonal multice

225 Transgenic cell labeling showed Tac1-Pet1 soma resident largely in the caudal medulla.

226 -zipper kinase (DLK) is critical for axon-to-soma retrograde signaling following nerve injury.

227 show evidence for cell differentiation, germ-soma separation, and programmed cell death.

228 uire activity at the site of injury, axon-to-soma signaling, and transcription.

229 Specific features, such as soma size and axon outgrowth, are graded along the spira

230 rites with increased autophagy, shrinkage of soma size and axonal pathology even in the pons region.

231 TOR in the VTA had no significant effects on soma size and dendritic morphology of VTA neurons but si

232 hese four GABAergic subtypes differ in their soma size and distribution among IC subdivisions.

233 we used cluster analyses based on changes in soma size and roundness to yield novel insights into the

234 A sex difference in neuronal soma size favoring males was also evident, but only on t

235 dent increases of dendritic arborization and soma size in both mouse and human cultures as measured 7

236 led significantly altered neurite length and soma size in CS patients.

237 neurons lacked detectable SP and had a mean soma size of 473 +/- 14 mum(2) (n = 5); 89% of the CGRP(

238 ess produced an enhanced reduction of neuron soma size within deprived dLGN layers.

239 ys produced a complete restoration of neuron soma size, and also reversed the significant loss of neu

240 We found that DACs density, soma size, and primary dendrite length are all significa

241 Their soma size, neurochemical profile, and peripheral and cen

242 nuclear PTEN alone is sufficient to regulate soma size.

243 rontal cortex, and decreases in VTA dopamine soma size.

244 ced DeltaFosB, and reduction of VTA dopamine soma size.

245 s have typically been limited to measures of soma size.

246 the nucleus partially restores regulation of soma size.

247 In addition, motor neuron counts and soma sizes were recorded.

248 that chemical (cholinergic) synapses between soma-soma and soma-axon pairs were indistinguishable, wi

249 Neurons were cultured in a soma-soma or soma-axon configuration and synapses explor

250 idence that electrical synapses develop in a soma-soma, but not soma-axon (removal of soma) configura

251 Not only are Golgi present in the neuronal soma (somal Golgi), they also exist in the dendrites as

252 olarizations from MNTB axon terminals to the soma, some hundreds of microns away.

253 is often accompanied by the misexpression of soma-specific proteins and the initiation of somatic dif

254 the lesion site in the axon back to the cell soma stimulates the increased growth capacity of injured

255 tion in promoting lysosome biogenesis in the soma, suggesting a potential approach for rescuing lysos

256 s to cell bodies, where they are inserted on soma surfaces and promote phosphorylation of resident na

257 We designed a high-efficacy soma-targeted opsin, finding that fusing the N-terminal

258 inputs as dendrite-targeting excitation and soma-targeting inhibition (the latter contributes non-di

259 xplain how dendrite-targeting excitation and soma-targeting inhibition generate these field potential

260 Most circuit models postulate that soma-targeting parvalbumin-positive GABAergic neurons ar

261 ulthood, with greater FMRP reductions in the soma than in the neurite, despite several-fold elevation

262 Conversely, far from the soma the targets were mostly other excitatory neurons, a

263 Kv 3.1b is restricted to the soma, the primary neurite and the axon branch.

264 molecules are studied on the surface of the soma: the voltage-gated potassium and sodium channels Kv

265 ess and despite their large magnitude at the soma they could be as distal as Na+ currents.

266 though axons often emanate directly from the soma, they may also originate more distally from a dendr

267 How commensals gain access to epithelial soma through densely packed microvilli rooted on the ter

268 BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta production.

269 te that the outward transport of dynein from soma to axon terminal is driven by direct interactions w

270 In particular, the efficiency of soma to dendrite voltage transfer is highly asymmetric i

271 unusually tight electrotonic coupling of the soma to distal dendrites.

272 municate synaptic Ca(2+) changes back to the soma to influence other critical cell processes.

273 ed primarily by increased transport from the soma to the axon but rather by decreased retrieval from

274 action potential to travel from the neuronal soma to the axon terminal, defining the temporal manner

275 e cells resembling action potential from the soma to the dendrites.

276 egulates the mobilization of lipids from the soma to the germline, which supports fecundity but at th

277 tertissue transport of fat reserves from the soma to the germline.

278 d nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathet

279 s retrograde (axon-to-soma) and anterograde (soma-to-axon) traffic of Tau.

280 omosome-regulatory functions contribute to a soma-to-germline model for cancer, in which activation o

281 tially microvesicular uptake as well as both soma-to-soma "horizontal" and bidirectional "vertical" s

282 st that, during maintained depolarization, a soma-to-terminal [Ca(2+)] gradient develops within the E

283 adient within the rod ER lumen that promotes soma-to-terminal diffusion of Ca(2+) to replenish intrat

284 ndrite is larger for motion outward from the soma toward the dendritic tips than for motion inwards t

285 ders; and unbiased stereology to compare the soma volume of layer V pyramidal and gigantopyramidal ne

286 treatment on the total number, density, and soma volume of septal cholinergic cells, which were visu

287 me decline, 60% neuron loss, and 34% reduced soma volume.

288 by 31%, with 48% neuron loss and 64% reduced soma volume.

289 The predictive power of the RRS SOMA was then prospectively validated in an independent

290 the distance of activated synapses from the soma, was dendritic in origin, and involved SK-dependent

291 From SIZ to soma, we observed and quantified selective morphological

292 addition, weakly labeled cells with a large soma were identified as parasol ganglion cells.

293 ge may occur in distal regions, far from the soma where most lysosomal degradation is thought to occu

294 antly in the retrograde direction toward the soma, where mature lysosomes are mainly located.

295 vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located.

296 n underwent retrograde transport to the cell soma, where they fused with lysosomes both in vitro and

297 or and the stress-stiffening response of the soma, whereas neurofilaments have a predominant contribu

298 ynamic clamp to mimic sodium channels in the soma, which yielded normal, overshooting action potentia

299 ess blocked the CUS-induced decreases in 5HT soma within the DRif and its projections to the mPFC.

300 the normalization of dendritic EPSPs at the soma would increase the importance of input timing versu