ライフサイエンスコーパス: somatic stem cell

1 e almost no data on protein synthesis in any somatic stem cell.

2 egulation of stemness and differentiation of somatic stem cells.

3 ifelong self-renewal is a unique property of somatic stem cells.

4 ransdifferentiation events between different somatic stem cells.

5 mall populations of observable germ-line and somatic stem cells.

6 rs responsible for pluripotency induction in somatic stem cells.

7 n neural stem cells that also apply to other somatic stem cells.

8 little is known about shelterin functions in somatic stem cells.

9 mesenchymal (MSCs) and hematopoietic (HSCs) somatic stem cells.

10 ce and for regulating the differentiation of somatic stem cells.

11 for maintenance of the resident germline and somatic stem cells.

12 ral solid cancers share characteristics with somatic stem cells.

13 ng been postulated to impair the function of somatic stem cells.

14 transplantation of both human embryonic and somatic stem cells.

15 (Gef26) results in loss of both germline and somatic stem cells.

16 g germline stem cells that are distinct from somatic stem cells.

17 signaling can promote self-renewal of adult somatic stem cells.

18 like previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intes

19 Even tissues endowed with somatic stem cells age while the germline appears immort

20 racing, we demonstrate the existence of such somatic stem cells and confirm that of germ-line stem ce

21 CIs express markers associated with germ and somatic stem cells and gene products that implicate CIs

22 ood circulation, there exists an exchange of somatic stem cells and germline stem cells, resulting in

23 GSCs, yet maintained a normal population of somatic stem cells and hub cells.

24 Planarian neoblasts are pluripotent, adult somatic stem cells and lineage-primed progenitors that a

25 rom a replicative decline in the function of somatic stem cells and other self-renewing cells.

26 rs can cause permanent epigenetic changes in somatic stem cells and that these accumulate over the li

27 dicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved proces

28 een implicated in both normal (embryonic and somatic) stem cells and CSCs.

29 is expressed at the cell surface of multiple somatic stem cells, and it is widely used as a cell surf

30 anscripts are enriched in ES cells and other somatic stem cells, and its ortholog is essential for he

31 l cord injuries with therapeutically plastic somatic stem cells, and suggest that neural stem/precurs

32 issue in stem cell biology is whether adult somatic stem cells are capable of accessing alternate ti

33 In the Drosophila testis, germline and somatic stem cells are housed together in a common niche

34 sing differentiation, whereas the dom mutant somatic stem cells are lost because of defective self-re

35 When unperturbed, somatic stem cells are poised to affect immediate tissue

36 , metastasis, and drug resistance, and, like somatic stem cells, are thought to be capable of unlimit

37 lained by the pervasive use of glycolysis by somatic stem cells as opposed to the predominance of mit

38 n requires the normal hedgehog signal of the somatic stem cells as well as proximity to the niche.

39 ing system, we found that both germ-line and somatic stem cells, as well as their progeny, adjust the

40 In Drosophila testes, germ line and somatic stem cells attach to a cluster of support cells

41 in has yet been functionally linked to adult/somatic stem cell behavior in vivo or to organ regenerat

42 repair plays a crucial role in embryonic and somatic stem cell biology and cell reprogramming.

43 In planarians, pluripotent somatic stem cells called neoblasts supply new cells for

44 ferating cells of M. lignano, represented by somatic stem cells, called neoblasts, and germline cells

45 th age, and how the regenerative capacity of somatic stem cells can be enhanced to promote healthy ag

46 Somatic stem cells contribute to tissue ontogenesis, hom

47 Somatic stem cells cycle slowly or remain quiescent unti

48 maintains both germline stem cells (GSC) and somatic stem cells (CySC).

49 onsible for corto suppression of the GSC and somatic stem cell defects of Yb mutants.

50 aging mechanisms that erode the function of somatic stem cells during aging, we have conducted a com

51 tosis congenita, a syndrome characterized by somatic stem cell dysfunction in multiple organs leading

52 uently, follicle cell progenitors, including somatic stem cells enter the niche, respond to Dpp, and

53 This work establishes function in somatic stem cells for another member of a putative impr

54 s of cellular physiology remain unstudied in somatic stem cells, for example, there are almost no dat

55 Because the regenerative potential of somatic stem cells generally weakens with increasing age

56 Somatic stem cells have been claimed to possess an unexp

57 ands" (CIs) as a niche for putative germ and somatic stem cells in Botryllus schlosseri, a colonial c

58 Resident pools of somatic stem cells in many organs are responsible for ti

59 nsidered one of the most valuable sources of somatic stem cells in regenerative medicine.

60 Here, we demonstrate that somatic stem cells in Schistosoma mansoni are biased tow

61 Understanding the biology of somatic stem cells in self renewing tissues represents a

62 lates the proliferation of both germline and somatic stem cells in the Drosophila melanogaster ovary

63 rdinating the proliferation of germ line and somatic stem cells in the Drosophila ovary.

64 Here we show that somatic stem cells in the Drosophila testis contribute t

65 Adult somatic stem cells in various organs maintain homeostati

66 hanisms that regulate the differentiation of somatic stem cells into specific cell types.

67 get chinmo prevents transformation of testis somatic stem cells into their ovarian counterparts.

68 ation; however, the role of these enzymes in somatic stem cells is largely unknown.

69 tent stem cell self-renewal, but its role in somatic stem cells is unknown.

70 cells, but contrary to its critical roles in somatic stem cells, it is dispensable for their prolifer

71 The somatic stem cells likely correspond to the ultrastructu

72 Conversely, the feminization of the testis somatic stem cell lineage caused by loss of chinmo is en

73 Somatic stem cells maintain tissue homeostasis by dynami

74 elial cadherin (DE-cadherin) is required for somatic stem cell maintenance and, consequently, the api

75 establish a strict link between dyskerin and somatic stem cell maintenance in a telomerase-lacking or

76 gate the specific role played by dyskerin in somatic stem cell maintenance.

77 Because somatic stem cells may respond to shifts in organismal p

78 hat Wolbachia reach the germline through the somatic stem cell niche in the D. melanogaster germarium

79 st that Wolbachia are highly abundant in the somatic stem cell niche of long-term infected hosts, imp

80 We sought to determine if somatic stem-cell niches more broadly are immune-privile

81 ern reflects maximum telomere restoration in somatic stem cells of early buds and suppression of telo

82 anism because of the presence of an abundant somatic stem cell population, the neoblasts.

83 the stem cell niche, which itself includes a somatic stem cell population.

84 Somatic stem cell populations participate in the develop

85 ifically eliminated oogenic stem cells while somatic stem cell populations were not affected.

86 re, in fact, derived from the nuclei of rare somatic stem cells present in adult tissues, rather than

87 esses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neig

88 Ovarian somatic stem cells produce follicle cells, which undergo

89 A dynamic pool of undifferentiated somatic stem cells proliferate and differentiate to repl

90 Precise control of somatic stem cell proliferation is crucial to ensure mai

91 anscription factor, nkx-2.2, is required for somatic stem cell proliferation, suggesting a niche-like

92 a new and tractable control point for adult, somatic stem cell regulation.

93 studies proposing such "plasticity" of adult somatic stem cells remain controversial, and in general,

94 Somatic stem cells require telomerase activity, as evide

95 ISWI and DOM control germline stem cell and somatic stem cell self-renewal in the Drosophila ovary,

96 somatic niche cells to control germ line and somatic stem cell self-renewal.

97 an embryonic stem cells and cells from other somatic stem cell sources.

98 promoting self-renewal and proliferation of somatic stem cells (SSCs) in the Drosophila ovary.

99 t pluripotency in germ stem cells (GSCs) and somatic stem cells (SSCs) may have had shared common evo

100 ated cell adhesion is required for anchoring somatic stem cells (SSCs) to their niches in the Drosoph

101 ision of both germline stem cells (GSCs) and somatic stem cells (SSCs), the two constituent stem cell

102 hog is the only known signal for maintaining somatic stem cells (SSCs).

103 ce of stem cells (germline stem cells, GSCs; somatic stem cells, SSCs) in the Drosophila ovary by spe

104 First, excess Hh signaling in somatic stem cells stimulates somatic cell over-prolifer

105 at the tip of the testis where germline and somatic stem cells surround the apical hub, a cluster of

106 outcomes that the lack of PRC2 can have in a somatic stem cell system.

107 As in other somatic stem cell systems, NSCs are proposed to be predo

108 hms in division frequencies of germ-line and somatic stem cells that act cooperatively to produce mal

109 In Drosophila, there must also be somatic stem cells that produce the cyst cells that acco

110 rectifying their gene expression, elevating somatic stem cell therapeutic potential beyond solely ce

111 ation, and to assess the plasticity of adult somatic stem cells to become male germ cells.

112 during recurrent epigenetic reprogramming of somatic stem cells to produce, recurrently and reversibl

113 The ability of somatic stem cells to self-renew and differentiate into

114 (HSCs) represent one of the first recognized somatic stem cell types.

115 precedented partnership between two distinct somatic stem-cell types and are indicative of a unique n

116 Inactivation of Rb in somatic stem cells typically leads to their overexpansio

117 stem cell competition, in which germline or somatic stem cells vie for residency in the niche.

118 ifferentiation has become a common claim for somatic stem cells, yet how such cells can be directed t