ライフサイエンスコーパス: somatically

1 , in which homologous chromosomes are paired somatically.

2 codes a single transcript which is expressed somatically.

3 these cases, competency stages are inherited somatically.

4 bridge cycles generate dicentric chromosomes somatically.

5 xcept for most cancer mutations, which arise somatically.

6 and other hypoproliferative anemias may have somatically acquired 5q deletions with RPS14 haploinsuff

7 Germline and somatically acquired ALK aberrations induce increased au

8 tle imbalances were detected that are likely somatically acquired alterations and include genes invol

9 Somatically acquired alterations at chromosome arms 3p a

10 omplexity of transcript regulation caused by somatically acquired alterations.

11 hey also represent the first human report of somatically acquired altered stromal TGF-beta signaling

12 dissected tissues, we show that TGFBR1*6A is somatically acquired by stromal and epithelial cells adj

13 congenital or perinatal lethal disorders to somatically acquired cancers.

14 easurement and single-molecule sequencing of somatically acquired carcinogenic translocations at extr

15 roximately 220 kb in length and represents a somatically acquired change in the primary breast cancer

16 Cancers arise as the result of somatically acquired changes in the DNA of cancer cells.

17 Nonrandom and somatically acquired chromosomal translocations can be i

18 lymphoma, and leukemia are characterized by somatically acquired chromosome translocations that resu

19 An average of 1.14 somatically acquired CNAs per patient were observed.

20 Human neuroblastomas are characterized by somatically acquired copy number changes, including loss

21 of myelodysplastic syndrome, is caused by a somatically acquired deletion of chromosome 5q, which le

22 Somatically acquired epigenetic changes are present in m

23 ated a system whereby PML-RARA expression is somatically acquired from the mouse Pml locus in the con

24 ic loss of 18q markers and in one of these a somatically acquired G-->T missense mutation was found i

25 Somatically acquired genetic abnormalities lead to the s

26 lastic syndromes (MDS) is driven by diverse, somatically acquired genetic abnormalities.

27 biology of neuroblastoma is characterized by somatically acquired genetic events that lead to gene ov

28 All identified somatically acquired genetic lesions were backtracked to

29 And some somatically acquired genetic variants direct the choice

30 Human cancers often carry many somatically acquired genomic rearrangements, some of whi

31 We have previously shown that TGFBR1*6A is somatically acquired in head and neck and colon cancer (

32 Further study of one insertion, somatically acquired in primary leukaemia tumour genomes

33 Somatically acquired missense mutations were observed in

34 espite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion

35 lorectal cancer, and the firstmouse model of somatically acquired MMR-deficient colorectal cancer.

36 Yet the genomic landscape of somatically acquired molecular alterations in airway epi

37 ical malignancies frequently associated with somatically acquired mutation of the JAK2 gene.

38 aternally inherited diseases; maternally and somatically acquired mutations also accumulate over time

39 cent cancer sequencing studies also revealed somatically acquired mutations and deletions in ribosoma

40 e largest public resource for information on somatically acquired mutations in human cancer and is av

41 performed whole-exome sequencing to identify somatically acquired mutations in six patients who had p

42 n 194 high-risk neuroblastoma samples showed somatically acquired mutations in the tyrosine kinase do

43 we report that ASC tumors frequently harbor somatically acquired mutations in the UPF1 gene, which e

44 Parental tumour and MFD-1 carried four somatically acquired mutations in three recurrent mutate

45 other cancers, is characterized by multiple somatically acquired mutations that affect genes of diff

46 is that older plants may not pass along more somatically acquired mutations to their offspring.

47 at the SPEN locus and that 3% to 4% harbored somatically acquired mutations.

48 Cancer is driven by somatically acquired point mutations and chromosomal rea

49 sequencing data from 660 cancer samples for somatically acquired pseudogenes.

50 Somatically acquired structure variations (SVs) and copy

51 Somatically acquired SV may regulate the expression of t

52 Somatically acquired translocations play a major role in

53 The somatically acquired V600E mutation of the BRAF gene has

54 Somatically acquired, activating mutations of GNAS, the

55 uch studies lies in correctly distinguishing somatically acquired, cancer-specific lesions from patie

56 a remodeled replication origin, inherited or somatically acquired, provides a survival advantage and

57 s, and that activating mutations can also be somatically acquired.

58 C to T transition mutation was proven to be somatically acquired.

59 Copy number abnormalities (CNAs) such as somatically-acquired chromosomal deletions and duplicati

60 ganization of c-Myc but many had one or more somatically-acquired MuLV proviral integrations that wer

61 Somatically-acquired translocations may serve as importa

62 Here we used a somatically activatable mutant Kras-driven model of mous

63 Targeting somatically activated oncogenes has revolutionized the t

64 by an array of diverse pathogens but lack a somatically adaptive immune system.

65 odulated excitatory and inhibitory inputs to somatically aligned, morphologically realistic pyramidal

66 ve identified many genes that are frequently somatically altered across multiple tumour types, sugges

67 tumor suppressor gene is the most frequently somatically altered gene in human cancers.

68 ing approaches to exploring the functions of somatically altered genes in cancer.

69 The most prevalent genes somatically altered in metastatic cancer included TP53,

70 ddition, the PTPRJ gene has been shown to be somatically altered in several human cancer types such a

71 confer better survival for tumor cells when somatically amplified.

72 F-V600E kinase-activating mutation, which is somatically and clonally present in almost all patients

73 The repeats expand both somatically and on intergenerational transmission and in

74 lease of several key factors, which act both somatically as hormones and within the brain as neuromod

75 ; and instead of V(D)J recombination VLR are somatically assembled by a gene conversion process.

76 Highly diverse VLR genes are somatically assembled by the insertion of variable LRR s

77 We found that a somatically biased gradient of K(v)1 channels underlies

78 ors are encoded in the germline or generated somatically by gene rearrangement.

79 repeats and that the duplication is mediated somatically by homologous recombination between the flan

80 that the Ph1 locus acts both meiotically and somatically by reducing non-homologous centromere associ

81 DNA (RAPD) markers, conclusively showed that somatically compatible isolates are not necessarily gene

82 carry this germline compound deletion, with somatically decreased tumour USF3 expression.

83 e studies demonstrate that it is feasible to somatically delete a large chromosomal segment implicate

84 eted validation studies further confirm that somatically deleted genes function both in adult (meioti

85 Furthermore, when Wnt7b is somatically deleted in macrophages, repair of injury is

86 Therefore, such a somatically derived chimeric chromosome can also be heri

87 uclear protein present in the germ cells and somatically derived follicle cells throughout oogenesis

88 t prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion t

89 cificity for dsDNA is generated but also how somatically derived structures generated during V-D-J re

90 (SE), primitive zygotic (EC), embryonal-like somatically differentiated (TE), and extra-embryonally d

91 of jawed vertebrates, that clonally express somatically diversified antigen receptors termed variabl

92 invertebrate defense molecules because it is somatically diversified by gene conversion and point mut

93 ly of V structures resembling those that are somatically diversified in adaptive immunological respon

94 ess adaptive immune systems based on a vast, somatically diversified repertoire of lymphocyte-bound a

95 they are proliferating and the Ig genes are somatically diversified.

96 ut 1-2 mo of age nearly all Ig VDJ genes are somatically diversified.

97 examined the extent to which VDJ genes were somatically diversified.

98 Ig VDJ genes in rabbit somatically diversify by both hyperpointmutation and gen

99 adaptive immune system in which lymphocytes somatically diversify their variable lymphocyte receptor

100 bit establishes its primary Ab repertoire by somatically diversifying an initial repertoire that is l

101 ased adaptive immune system that is based on somatically diversifying leucine-rich repeat (LRR)-based

102 that intestinal microflora are required for somatically diversifying the Ab repertoire.

103 Asexual animals maintain telomere length somatically during reproduction by fission or when regen

104 , we explored the extent to which they occur somatically during tumorigenesis.

105 We show that Lar acts somatically early in oogenesis, during follicle formatio

106 oviruses with different insertion sites that somatically emerged during malignant transformation or p

107 y and infectivity of a novel retrovirus that somatically emerged during melanoma formation.

108 The mechanisms by which B cells somatically engineer their genomes to generate the vast

109 Pairing the test input with somatically evoked action potentials mimicked this form

110 o eliminated striatal mutant huntingtin with somatically expanded glutamine tracts and caused an appr

111 Dnmt1o is a variant form of the somatically expressed Dnmt1 cytosine methyltransferase t

112 We isolated the D. virilis orthologs of the somatically expressed gene, alpha4_dm, and the testes-sp

113 eport, we demonstrate that the function of a somatically expressed gene, cut, is critical for maintai

114 their ability to transduce the activity of a somatically expressed TGF-beta ligand, the BMP5/8 orthol

115 The model allowed us to somatically extinguish or induce dystrophin gene transcr

116 the ability of granule cell axons to convey somatically generated action potentials to distant synap

117 Somatically generated APs actively backpropagated into t

118 Here, we demonstrate that the somatically generated CDR3 loops can markedly alter evol

119 ut that this reactivity is fine-tuned by the somatically generated CDR3 loops.

120 e prenegative selection TCR repertoire, many somatically generated complementary-determining region (

121 inidomains generated through combinations of somatically generated disulfides.

122 ncluding the genes for lymphoid Ag receptors somatically generated from germline minigenes.

123 s are not germline encoded; rather, they are somatically generated in each developing lymphocyte by a

124 ved RFs, we previously demonstrated that the somatically generated light chain complementarity-determ

125 neural cells throughout the neuraxis showing somatically generated mosaic aneuploidy indicates that t

126 residues as well as the enhanced presence of somatically generated proline residues that preclude hyd

127 In principle, either germline-encoded or somatically generated sequences could function as target

128 of the CDR3 loop in the axolotl consisted of somatically generated sequences, compared with 44% in ta

129 y points to the critical contribution of the somatically generated VJ junction to RF autoantibody spe

130 eural cell survival, providing evidence that somatically generated, cell-autonomous genomic alteratio

131 ocessed pseudogenes, but whether this occurs somatically has not been evaluated.

132 Although they are somatically heritable, modifications of DNA and histones

133 lity of their nontransformed counterparts to somatically hypermutate Ig V genes by nucleotide substit

134 that both Pms2- and Mlh1-deficient mice can somatically hypermutate the Ig test gene at approximatel

135 -cell receptor repertoire is oligoclonal and somatically hypermutated and shares similar clonal group

136 ity, neutralizing antibodies by selection of somatically hypermutated B cell antigen receptors (BCR)

137 lts from the selection of B cells expressing somatically hypermutated B cell receptors (BCRs) with in

138 ines was introduced based on the analysis of somatically hypermutated donor-derived repertoires.

139 pecific MBCs consisted of three populations: somatically hypermutated immunoglobulin M(+) (IgM(+)) an

140 m of GC-derived B cells than any other known somatically hypermutated non-Ig gene.

141 nge experiments revealed that high affinity, somatically hypermutated Plasmodium-specific IgM(+) MBCs

142 Somatically hypermutated VHDJH rearrangements were signi

143 These cells are clearly somatically hypermutated, albeit modestly.

144 ction is essential for the generation of the somatically hypermutated, high-affinity antibodies that

145 (L597V)BRAF mutations are acquired somatically in human cancer samples and are frequently c

146 me FGFR3 mutations have also been identified somatically in human cancers, including multiple myeloma

147 me FGFR3 mutations have also been identified somatically in human cancers, including multiple myeloma

148 tic and developmental disorders and to arise somatically in many cancers.

149 Mutations in the c-KIT receptor occur somatically in many sporadic Gastrointestinal Stromal Tu

150 n most likely arose either during meiosis or somatically in small sectors of the plant.

151 dispose to cancer, and they are also mutated somatically in sporadic forms of the disease.

152 The element appears to be very mobile somatically in the inbred line V26, with 38% of plants f

153 nstitutionally in the general population and somatically in the majority of cancers.

154 two X-linked tumor suppressor genes that are somatically inactivated by single genetic hits.

155 OPCML is frequently somatically inactivated in EOC by allele loss and by CpG

156 NF1 was the only gene that was recurrently somatically inactivated in multiple tumors.

157 first showed that KLF6 is a tumor suppressor somatically inactivated in prostate cancer and since the

158 By somatically inactivating Lkb1 with K-Ras activation (+/-

159 rthermore, using tetracycline regulation, we somatically induced human GAA in the knockout mice, and

160 Both germline and somatically induced p63 deficiency activates widespread

161 Somatically inducible Cre lines are used extensively to

162 rent conditions that might occur in vivo, we somatically injected aperiodic current waveforms into co

163 Furthermore, mutant genes are introduced somatically into animals, as occurs in the majority of n

164 e, encompasses a CTCF insulator, and spreads somatically into the H19 gene.

165 +) B cells and found that 24 (6.5 %) contain somatically introduced insertions or deletions.

166 LEOPARD syndrome frequently carry a second, somatically introduced subset of missense mutations in S

167 orebrain neurones under voltage clamp from a somatically located patch-clamp pipette.

168 f the two genomic loci encoding miR-101 were somatically lost in 37.5% of clinically localized prosta

169 at autosomal testis-biased miRNAs tend to be somatically male-biased, whereas autosomal ovary-biased

170 IgG2) and IgA antibodies arose from the same somatically matured B cell.

171 ng regions (CDRs) 1 and 3, both germline and somatically matured V regions displayed significant stru

172 structurally characterized the germline and somatically matured versions of a type II variable (V) r

173 eurofibromatosis type 1 (NF1) patient who is somatically mosaic for a large maternally derived deleti

174 d sources of microDNA in the adult brain are somatically mosaic for microdeletions that appear to ari

175 Such somatically mosaic parents might also have germline mosa

176 etogenesis result in a greater proportion of somatically mosaic transmitting mothers who are thus at

177 at B cells of the putative fetal lineage can somatically mutate and diversify an initially limited re

178 c PAHA created a B cell population primed to somatically mutate and Ig class switch when subjected to

179 tem that lethally mutate viral pathogens and somatically mutate immunoglobulins, and contribute to th

180 Antibodies somatically mutate to attain high affinity in germinal c

181 u) sequences were identified and found to be somatically mutated (range, 1.4% to 6.5%), with a low le

182 The donors had all mounted somatically mutated Abs toward PC using a broad variety

183 from CD138(+) cells in MS CeSF has revealed somatically mutated and expanded IgG clonotypes consiste

184 Notably, bNAbs are highly somatically mutated and generated by a fraction of HIV-1

185 and IgG3 antibodies in the mice were highly somatically mutated and used distinct repertoires of VH

186 tent with the x-ray crystal structure of the somatically mutated anti-Ars Ab 36-71, while Sulf bindin

187 knock-in mouse that expresses V regions of a somatically mutated anti-Id mAb with intermediate affini

188 Panels of somatically mutated antibodies encoded by a common VH ge

189 y a tyrosine in the heavy chain along with a somatically mutated arginine residue.

190 , we identified 68 genes that appeared to be somatically mutated at elevated frequency, many of which

191 Although somatically mutated autoantibodies are characteristic of

192 on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helpe

193 We have recently demonstrated that a novel somatically mutated B220(-) memory B cell subset rapidly

194 These nonsecreting somatically mutated B220(-) memory responders rapidly do

195 ing (bn) Abs and that identification of less somatically mutated bn Abs may help in the design of eff

196 on between IgH and Igbeta, both of which are somatically mutated by AID.

197 p between the genes involved in OGID and 260 somatically mutated cancer driver genes (p = 1.75 x 10(-

198 Discovery of somatically mutated cells in human tissues has been less

199 rodegenerative diseases may often begin from somatically mutated cells.

200 in heavy and light chains in 6 patients with somatically mutated CLL-cell immunoglobulin genes and id

201 We identified CSDE1 as a somatically mutated driver gene, complementing four know

202 This analysis links four somatically mutated genes associated with diverse oncolo

203 ns in this autoimmune disease are encoded by somatically mutated genes in the patients' incipient can

204 Among all somatically mutated genes, CREBBP mutations were most si

205 tides were recovered from non-immunoglobulin somatically mutated genes.

206 tantial contribution to total diversity from somatically mutated germline encoded CDRs 1 and 2.

207 ration of B cells and plasma cells producing somatically mutated gut antigen-specific IgA antibodies

208 ia (PNH) lack GPI proteins on the surface of somatically mutated hematopoietic stem cell and its prog

209 entarity-determining region 2 (HCDR2) of the somatically mutated high-affinity anti-p-azophenylarsona

210 Somatically mutated high-affinity autoantibodies are a h

211 This population of somatically mutated HSC, which initiates and sustains MP

212 hogens as functional ligands for a subset of somatically mutated human B cell lymphomas.

213 ells, considered to be memory cells based on somatically mutated Ig genes, we found that the reductio

214 that have frequently acquired rearranged and somatically mutated Ig genes.1,2 Despite their B-cell or

215 tion to the marginal zone, the expression of somatically mutated Ig V region genes, and the preferent

216 cells have been shown in some cases to have somatically mutated Ig variable region genes, indicating

217 ice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function as fi

218 (PB) IgM(+)IgD(+)CD27(+) B lymphocytes with somatically mutated IgV genes are controversially discus

219 We found somatically mutated IgV(H) genes in 24 (73%) of 33 sampl

220 ization to mucosal epithelium, expression of somatically mutated immunoglobulin (Ig) variable (V) reg

221 indicated that a fraction of B-CLL displays somatically mutated immunoglobulin variable heavy chain

222 istinguished as carrying either unmutated or somatically mutated immunoglobulins (Igs), which are ass

223 We found that PIK3R1 was somatically mutated in 43% of EECs and 12% of NEECs.

224 ylation during embryogenesis and is commonly somatically mutated in acute myeloid leukemia.

225 ies that broadly neutralize HIV-1 are highly somatically mutated in antibody clonal lineages that per

226 PIGA is somatically mutated in blood cells from patients with pa

227 arbor germline mutations; the same genes are somatically mutated in CMM, or their encoded proteins ar

228 may aid the identification of genes that are somatically mutated in essential thrombocytosis.

229 are germ-line variants at FLT3 (a gene often somatically mutated in leukemia) associated with monocyt

230 APC(AS9) and the wild-type APC alleles were somatically mutated in most colorectal tumors from these

231 The p53 gene is somatically mutated in over half of all human cancers.

232 osophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene

233 One of these genes was found to be somatically mutated in two of eighteen colorectal cancer

234 (FUSE) binding protein] on chromosome 1p was somatically mutated in two tumors.

235 ived beta-gal+ B cells exclusively contained somatically mutated lambda1 V regions and were capable o

236 The somatically mutated memory hybridoma, M3C65, possesses h

237 Normally, kappa genes are somatically mutated only in the VJ region, but not in th

238 In addition, many of these genes are somatically mutated or deleted in various cancers.

239 pha exposure creates an environment in which somatically mutated preleukemic stem cell clones are sel

240 cans were recognized by germline-encoded and somatically mutated residues on the Ab heavy chain.

241 ant cooperativity was found between pairs of somatically mutated residues.

242 In those CLLs defined by somatically mutated V(H) genes, 4 of 9 cases predictivel

243 ertion and four deletion events in otherwise somatically mutated VH gene cDNA molecules.

244 All cases were somatically mutated with an intraclonal variation.

245 V(H) genes were somatically mutated with no evidence of intraclonal vari

246 nd VH1 (1 of 5) families and were all highly somatically mutated with strong evidence for antigen sel

247 ch was efficiently recognized by the mature (somatically mutated) antibodies.

248 The lupus-associated, somatically mutated, and class-switched pathogenic autoa

249 i-Dsg response is restricted in V(H) use, is somatically mutated, and is Ag selected.

250 ined in overrepresented populations and were somatically mutated, consistent with an antigen-targeted

251 The cloned anti-talin-H IgGs were highly somatically mutated, indicative of an antigen-driven, af

252 Multiple myeloma (MM), a malignant tumor of somatically mutated, isotype-switched plasma cells (PC),

253 These antibodies were highly somatically mutated, which was indicative of an affinity

254 All were somatically mutated, with a mean deviation from germline

255 ce analysis revealed that the Abs are highly somatically mutated, with high replacement to silent rat

256 The genes were all isotype-switched and somatically mutated.

257 lele, designated 51p1, 163 of which were not somatically mutated.

258 m line counterparts indicated that they were somatically mutated.

259 cells may be either germ-line in sequence or somatically mutated.

260 ave undergone rearrangement and are commonly somatically mutated.

261 ll as 1,586 non-germline DNMs arising either somatically or in the cell lines from which the DNA was

262 nation ensures genomic integrity while cells somatically rearrange their antigen receptor genes [in a

263 either germ line-encoded (CDR1 and CDR2) or somatically rearranged (CDR3).

264 btypes encoding their antigen receptors from somatically rearranged genes.

265 , is a more recent development that utilizes somatically recombined antigen receptor genes to recogni

266 Rs, and antibodies are the three lineages of somatically recombined antigen receptors.

267 t T22 recognition correlates strongly with a somatically recombined TCRdelta complementarity-determin

268 One contains two variable domains: a somatically recombined V and a prejoined V.

269 (TCRmu) that has V, D, and J that are either somatically recombined, as in conventional TCRs, or are

270 though we observed minimal alteration of the somatically recorded action potential waveform, action p

271 Surprisingly, somatically recorded action potentials also dramatically

272 Somatically recorded AOB synaptic inputs had slower kine

273 g spontaneous slow oscillatory activity that somatically recorded delta (1-4 Hz) and slow (<1 Hz) osc

274 KChIP proteins supports the hypothesis that somatically recorded native Kv4 channels in neurons incl

275 The kinetic properties of the somatically recorded postsynaptic current are correlated

276 variable electrotonic distances that distort somatically recorded synaptic currents, it is not known

277 to ~20-fold in the remaining phytochromes in somatically regenerated PHYA1 RNAi cotton plants.

278 Two somatically related human antibodies, PG9 and PG16, howe

279 Twelve somatically related neutralizing antibodies (CAP256-VRC2

280 tal and neonatal B cell repertoires, and are somatically selected.

281 Ten somatically sequenced patients had deleterious alteratio

282 These results indicate that somatically synthesized BDNF promotes spine formation, w

283 We use the rodent malaria P. yoelii, and somatically transinfected An. stephensi as a model syste

284 d any significant [Ca2+] increase depends on somatically triggered Na+ action potentials.

285 The HD CAG repeat is somatically unstable, undergoing progressive length incr

286 A second mutation arises somatically, yielding a greatly elevated mutation rate d