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1 recurrent negative feedback collaterals onto somatodendritic 5-HT(1A) and 5-HT(1D) autoreceptors thus
4 minopeptidase-like protein subunits comprise somatodendritic A-type channels in mammalian neurons.
5 the unitary conductance (gamma) of neuronal somatodendritic A-type K(+) channels composed of Kv4 por
6 hat Kv4.2 subunits are major constituents of somatodendritic A-type K(+) channels in these four types
7 nisms of inactivation gating of the neuronal somatodendritic A-type K(+) current and the cardiac I(to
11 equired excitation of DA neurons mediated by somatodendritic alpha4beta2 nAChRs, as well as enhanceme
12 to KYNA (>/=100 nm) inhibited activation of somatodendritic alpha7 nAChRs; the IC(50) for KYNA was a
13 rthermore, the MT network was reduced in the somatodendritic and AIS compartments, and both the heavy
15 ll as in membrane protein trafficking in the somatodendritic and axonal compartments of differentiate
22 d Kv3.1b, are differentially targeted to the somatodendritic and axonal membrane, respectively, the l
24 aneous transmission was due to activation of somatodendritic and axonal receptors while the depressio
25 ed to soma and dendrites and postulated that somatodendritic and axonal/presynaptic isoforms of N-typ
29 of elevated extracellular DA levels, altered somatodendritic and presynaptic D2 DA receptor (D2R) fun
30 erway to examine the sensitivity of both the somatodendritic and terminal 5-HT autoreceptors in malno
32 e like calcium channels localize to both the somatodendritic and the axonal compartment of larval cra
33 stic frequency in the theta range across the somatodendritic arbor and specific STA measurements were
37 and in the sensory cortex, and are found at somatodendritic as well as nerve terminal sites in the r
38 PAT-labeled 5-HT(1a) binding in pre-synaptic somatodendritic autoreceptors on dorsal raphe nucleus re
40 to a reconfiguration of inhibition along the somatodendritic axis of pyramidal cells, and enhances th
41 ion of T-type Ca2+ channels along the entire somatodendritic axis of sensory thalamocortical (TC) neu
42 e quantitative changes in boosting along the somatodendritic axis suggest that inputs from different
43 angential current flow (perpendicular to the somatodendritic axis) modulates synaptic efficacy acutel
44 (2) Radial current flow (parallel to the somatodendritic axis) modulates synaptic efficacy consis
46 nterneurons, this plasticity was observed at somatodendritic basket cell synapses, but not at distal
49 2-LO regulates LTP by enhancing postsynaptic somatodendritic Ca(2+) influx through L-type channels du
50 y combined in situ patch clamp recordings of somatodendritic calcium currents in an identified adult
51 a(v)2 homolog, Dmca1A, underlies HVA and LVA somatodendritic calcium currents in the same neuron.
54 s, the AIS location is finely tuned with the somatodendritic capacitive load, serving as a homeostati
57 d Kv2.2 heteromultimers did not aggregate in somatodendritic clusters observed with expression of Kv2
58 ly phosphorylated, localized in high-density somatodendritic clusters, and has a relatively depolariz
59 umption that mislocalization of tau into the somatodendritic compartment (6) and accumulation of fibr
60 rs that immunocytochemically highlight their somatodendritic compartment and brush, respectively.
62 n growth) became selectively targeted to the somatodendritic compartment and excluded from axons by p
63 nsistent with an adaptation occurring in the somatodendritic compartment and independent of a circuit
64 neurons, PMCA2b was abundant throughout the somatodendritic compartment and often extended into the
65 trast, CaV3.1 channels were localized to the somatodendritic compartment and proximal axon, but were
67 of both sexes is distributed throughout the somatodendritic compartment but is particularly enriched
68 client, was rerouted from the axonal to the somatodendritic compartment by dominant-negative SEC24D.
69 n together, our results demonstrate that the somatodendritic compartment directly inhibits myelinatio
70 tion of mouse tau, its redistribution to the somatodendritic compartment in cortical and hippocampal
71 py revealed abundant ErbB4 expression in the somatodendritic compartment in which it accumulates at,
75 at MAP1B light chain (LC) accumulates in the somatodendritic compartment of hippocampal neurons, wher
76 geted Channelrhodopsin-2 specifically to the somatodendritic compartment of neurons in mice in vivo.
78 xons of L4-L2/3 synapses, rather than on the somatodendritic compartment of presynaptic L4 neurons.
79 emonstrate the mislocalization of tau in the somatodendritic compartment of RGCs subjected to high in
81 be activated by glutamate released from the somatodendritic compartment of the postsynaptic pyramida
82 icroscopic analyses, which revealed that the somatodendritic compartment was the principal target of
83 tial segment (AIS) electrically connects the somatodendritic compartment with the axon and converts t
84 , axons and dendrites (or more properly, the somatodendritic compartment) are radically different.
85 ly, misfolded Tau can be internalized at the somatodendritic compartment, or the axon terminals and i
93 subcellular distribution for ZNF804A within somatodendritic compartments and a nanoscopic organizati
94 n occur in the absence of pyramidal neuronal somatodendritic compartments and are temporally correlat
96 as restricted to C1 neurons and filled their somatodendritic compartments and efferent axons 7-28 day
97 by formation in axons by days 4-7, spread to somatodendritic compartments by days 7-10 and neuron dea
98 he co-existence of MOR and CB1r-ir in common somatodendritic compartments of catecholaminergic neuron
99 ors located on the presynaptic terminals and somatodendritic compartments of cortical GABAergic inter
101 an exacerbated NMDAR-DeltaCa(2+) response in somatodendritic compartments of MNCs of RVH rats, and (2
103 might differentially influence inhibition in somatodendritic compartments of pyramidal neurons and af
104 tentials propagated reliably into axonal and somatodendritic compartments with conduction velocities
105 , with alpha7 targeted preferentially to the somatodendritic compartments, whereas alpha4beta2 was lo
112 elated neural rhythms, but the importance of somatodendritic conductances in rhythm generation is sti
114 hannel KCNB1 (Kv2.1), which conducts a major somatodendritic current in cortex and hippocampus, is kn
115 ed the magnitude of D2R-dependent inhibitory somatodendritic currents and blunted the impact of D2R a
116 neurons display prominent, non-desensitizing somatodendritic D2-autoreceptor responses that show pron
117 anism was suggested by the observations that somatodendritic D2R activation produces hyperpolarizatio
119 ), suggesting a mechanism for maintenance of somatodendritic DA release with limited Ca(2+) entry.
120 which couple to IP(3) production), increased somatodendritic DA release, whereas CPCCOEt, an mGluR1 a
122 ocalization and function of Kv2.1, the major somatodendritic delayed rectifier voltage-dependent K+ c
123 t glutamate triggers GABA release only after somatodendritic depolarization and action potential gene
127 This likely relates to the differential somatodendritic distribution of mGluRs and mAChRs and ma
129 fen protein displays a microtubule-dependent somatodendritic distribution pattern that overlaps with
130 R appeared as punctate structures within the somatodendritic domain and by electron microscopy was sh
131 of EAAT3 in neurons, its restriction to the somatodendritic domain and its clustering near postsynap
133 initial segment (AIS) along with the entire somatodendritic domain of adult male mouse dopaminergic
134 solateral domain of epithelial cells and the somatodendritic domain of neurons is mediated by recogni
135 brane of polarized epithelial cells, and the somatodendritic domain of neurons through interactions w
136 ter ATP7B and the vesicle-SNARE VAMP4 to the somatodendritic domain of rat hippocampal neurons is med
137 istribution in pyramidal neurons, across the somatodendritic domain, depends on ongoing cyclic adenos
138 the soma, autophagosomes are confined to the somatodendritic domain, facilitating cargo degradation a
139 of the AIS, but not its position within the somatodendritic domain, is the major causal determinant
140 logs FXR1P and FXR2P are well studied in the somatodendritic domain, recent evidence suggests that th
142 rity is established, how distinct axonal and somatodendritic domains are maintained, and how integral
144 teractions is supported by colocalization in somatodendritic domains of cortical neurons in culture a
145 rs formed alpha1/beta-containing clusters on somatodendritic domains of MNTB principal neurons, coloc
147 thesized in, and released from, postsynaptic somatodendritic domains that are readily accessible to w
148 d proteins, which are normally restricted to somatodendritic domains, redistribute into the former ax
149 ctrin is found in neurons in both axonal and somatodendritic domains, using proteomics, biochemistry,
154 his study examined the mechanisms underlying somatodendritic dopamine and noradrenaline transmission
155 re the time course and calcium dependence of somatodendritic dopamine release in the ventral tegmenta
156 he mechanisms and functional consequences of somatodendritic dopamine transmission in the VTA vary am
157 ratios and decreased extracellular levels of somatodendritic dopamine, consistent with a decrease in
158 us implicating endosomal trafficking through somatodendritic early endosomes in L1-mediated axon grow
161 lation of L1/NgCAM occurs via nondegradative somatodendritic endosomes and subsequent anterograde axo
162 Early Endosomal Protein 21 kDa) localizes to somatodendritic endosomes, and downregulation of NEEP21
165 -rectifier Kv2.1 potassium channels regulate somatodendritic excitability during periods of repetitiv
166 but how these circuits interact to shape the somatodendritic excitability of Purkinje cells during mo
171 omous activity, while synaptic activation of somatodendritic GABA(A) receptors regulates the axonal i
172 -G (480-kDa ankyrin-G) promotes stability of somatodendritic GABAergic synapses in vitro and in vivo.
175 with a similar morphology but reversed I(h) somatodendritic gradient to that previously observed in
176 cede the appearance of SWDs and that altered somatodendritic HVA currents are not required for abnorm
179 ortical inhibition is recruited by classical somatodendritic integration rather than direct activatio
183 and computational modeling showed that while somatodendritic K(v)7 channels are strongly activated by
185 n Alzheimer's disease (AD), we asked whether somatodendritic levels of human BC200 RNA are deregulate
186 On the basis of these findings plus the somatodendritic localization of RACK1, we hypothesize th
187 f SNc neurons, suggesting that activation of somatodendritic M5 increases the intrinsic excitability
189 ique to provide qualitative and quantitative somatodendritic measures of gigantopyramidal neurons acr
190 density innervation of 5-HT terminals on the somatodendritic membrane and a complete absence on the A
191 the function of alpha7 nAChRs located on the somatodendritic membrane of hippocampal interneurons.
192 cipal contributors to A-type channels in the somatodendritic membrane of mammalian brain neurons.
193 cells of SCA1 mice and indicate that altered somatodendritic membrane trafficking and loss of protein
195 plasmic vacuoles contained proteins from the somatodendritic membrane, including mGluR1, GluRDelta1/D
197 g the ICAMs, because it is only expressed in somatodendritic membranes of telencephalic neurons.
198 ude that in addition to previously described somatodendritic MOR-li, a substantial amount of MOR-li i
201 ouse cortex undergoes significant changes in somatodendritic morphology during the critical period fo
202 nomic groups could be discriminated based on somatodendritic morphology for both superficial and giga
203 esent study characterized and quantified the somatodendritic morphology of neocortical neurons in pre
204 e evaluated potassium channel expression and somatodendritic morphology of projection neurons and the
205 we studied the developmental changes of the somatodendritic morphology of subplate neurons with spec
206 it robust projection-specific differences in somatodendritic morphology, cellular excitability, and l
209 dhesion molecule 2 (JAM2) as an inhibitor of somatodendritic myelination in spinal cord neurons, ther
210 stribution of membrane proteins to axonal or somatodendritic neuronal compartments is fundamental to
213 s respond with transient Ca(2+) increase and somatodendritic oxytocin release following neuropeptide
214 CNQ2 and KCNQ3 proteins are colocalized in a somatodendritic pattern on pyramidal and polymorphic neu
215 M interneuron models that incorporated I(M), somatodendritic placement of Kv7 channels best reproduce
217 d a uniform distribution of receptors in the somatodendritic plasma membrane when imaged over a 1 min
222 ic micron-scale domains within extrasynaptic somatodendritic plasma membranes of pyramidal neurons.
224 ab5 in rat hippocampal neurons abrogates the somatodendritic polarity of the transferrin receptor and
226 beling during P5-P10 was mainly localized in somatodendritic profiles but also was readily seen in ax
227 localized to endomembranes in DAT-containing somatodendritic profiles but showed a more prominent, si
228 mmunogold labeling was predominately seen in somatodendritic profiles throughout the PPT/LTD complex.
230 densities of NK3Rs in PVN AVP- or OC-labeled somatodendritic profiles were measured by quantitative i
232 the CB1r-immunoreactive structures, 66% were somatodendritic profiles, 22% were axon terminals, and t
234 HT1A immunoreactivity was mainly observed in somatodendritic profiles, but it was also present in sma
236 s population, striatal MSNs have dichotomous somatodendritic properties that mirror differences in th
237 n, functions in the neuronal soma to exclude somatodendritic proteins from axonal transport carriers.
239 rom the brain and colocalizes with Cav1.2 in somatodendritic puncta of cortical neurons in culture.
241 shy cells of the cochlear nucleus, expressed somatodendritic receptors (alpha1/beta heteromers) and s
243 e that small endosomal carriers derived from somatodendritic recycling endosomes can serve to redistr
244 phin, which is known to be secreted from the somatodendritic region and has been shown previously to
245 xon guidance; localization of Kalirin to the somatodendritic region of adult neurons provides the bas
246 nterneurons and GluR6-containing KARs in the somatodendritic region of both interneurons and pyramida
247 Shh signal transduction originates from the somatodendritic region of the neurons and occurs in neur
250 related to calmodulin (CaM) and localized in somatodendritic regions of principal neurons throughout
251 targeted mitochondria are accumulated in the somatodendritic regions where mature lysosomes are predo
252 th approaches demonstrated that, in midbrain somatodendritic regions, HA-DAT was present in the plasm
254 in translocation predominantly occurs in the somatodendritic regions; such distribution is associated
259 mediated synaptic current that resulted from somatodendritic release of dopamine in brain slices take
261 vesicles that mediate the activity-dependent somatodendritic release of multiple retrograde signals i
263 entricular (i.c.v.) NPS evoked a significant somatodendritic release of OXT within the PVN as assesse
264 Here, we provide the first evidence for somatodendritic release of the satiety peptide cholecyst
266 ) and oxytocin (OT) undergo Ca(2+)-dependent somatodendritic release within the supraoptic and parave
268 hers ATP7A at the trans-Golgi network in the somatodendritic segments of motor neurons and that alter
269 up the Kv4.2 potassium channels (involved in somatodendritic signal integration and attenuation of de
271 uggest that the M3 subtype is present on the somatodendritic site of glycinergic neurones and is main
272 -HT(1A) receptor; Rh-CT(5-HT1A) localizes to somatodendritic sites and is efficiently trafficked to d
274 the primary recognition event that underlies somatodendritic sorting and contribute to the evolving v
277 keleton, exclusion of both axon-specific and somatodendritic-specific cell surface proteins, and accu
278 that these properties underpin a whole-cell somatodendritic spike generation mechanism that makes th
280 s of the voltage-gated K+ channel underlying somatodendritic subthreshold A-type currents (I(SA)) in
281 Kv4.2 is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current (I
284 VGSCs in hippocampal neurons to limit their somatodendritic surface expression, although exerting li
285 MPA-type glutamate receptors (AMPARs) to the somatodendritic surface of rat hippocampal pyramidal neu
286 phas (alpha) 1, 2, 3 subunits was located on somatodendritic surfaces of neurochemically distinct mye
288 fects occurred without altering AIS Na(+) or somatodendritic T-type channel activity and could be med
292 levels in the brain and a greater extent of somatodendritic tau redistribution by three months of ag
293 RN) were examined with whole-cell recording, somatodendritic three-dimensional reconstructions and mo
294 v) channel alpha subunit responsible for the somatodendritic transient or A-type current I(SA) that a
298 t that there is a decrease in the content of somatodendritic vesicular dopamine in the Lep(ob/ob) mic
300 ining pattern for PICK1-immunoreactivity was somatodendritic with scattered puncta in neuropil and so
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