ライフサイエンスコーパス: somatomedin

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1 The NH(2)-terminal somatomedin B (SMB) domain (residues 1-44) of human vitr

2 The N-terminal cysteine-rich somatomedin B (SMB) domain (residues 1-44) of the human

3 ocalized to the NH(2)-terminal cysteine-rich somatomedin B (SMB) domain (residues 1-44).

4 The primary sequence of the N-terminal somatomedin B (SMB) domain of native vitronectin contain

5 n activator inhibitor 1 (PAI-1) binds to the somatomedin B (SMB) domain of vitronectin (VN), a domain

6 uPAR only bound to fragments containing the somatomedin B (SMB) domain, and monoclonal antibodies (m

7 ino acids from human plasma vitronectin, the somatomedin B (SMB) domain, has been determined by two-d

8 lasma glycoprotein vitronectin, known as the somatomedin B (SMB) domain, mediates the interaction bet

9 been attributed primarily to binding of the somatomedin B (SMB) domain, which comprises the N-termin

10 f vitronectin with respect to the N-terminal somatomedin B (SMB) domain.

11 within residues 12-30 in the amino-terminal somatomedin B (SMB) domain.

12 In contrast to the PAI-1-somatomedin B binding, the second interaction had almost

13 ndary site, a vitronectin mutant lacking the somatomedin B domain (rDeltasBVN) was engineered.

14 The somatomedin B domain of vitronectin (SMBD) did not affec

15 e for PAI-1 is located within the N-terminal somatomedin B domain of vitronectin; however, several st

16 he same site in VN (i.e., the amino-terminal somatomedin B domain; SMB), and that PAI-1 competes with

17 ately 100-fold higher than that of the PAI-1-somatomedin B interaction.

18 ein', contains domains that have homology to somatomedin B, heparin-binding proteins, mucins and haem

19 The opposite face of the somatomedin B-like domain interacts with the catalytic p

20 ent-exposed surface of the N-terminal tandem somatomedin B-like domains in binding to platelet integr

21 the ENPP1 enzyme that is mediated by its two somatomedin-B-like domains.

22 Somatomedin C/insulin-like growth factor-I (IGF-I) is re

23 Thus the original somatomedin hypothesis has undergone further modificatio

24 The somatomedin hypothesis proposed that insulin-like growth

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