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1 ration and proliferation of the GH-producing somatotrope.
2 d in hypothalamic GHRH neurons and pituitary somatotropes.
3 of high-level hGH-N activation in pituitary somatotropes.
4 to support TRbeta2 promoter activity in GH3 somatotropes.
5 cluding the growth hormone gene expressed in somatotropes.
6 in chromatin isolated from a human pituitary somatotrope adenoma and in pituitaries of mice transgeni
7 uman growth hormone (hGH) gene is limited to somatotrope and lactosomatotrope cells of the anterior p
8 study we demonstrated that the LCR mediates somatotrope and lactosomatotrope restriction on an other
9 I), was found to be sufficient for mediating somatotrope and lactosomatotrope restriction, for approp
10 decrease in terminally differentiated dorsal somatotrope and lactotrope cell types and a marked incre
11 -autonomous factors required for thyrotrope, somatotrope and lactotrope ontogeny, but their relative
12 cluster, hGH-N, is expressed exclusively in somatotropes and lactosomatotropes of the anterior pitui
16 increased number of thyrotropes and loss of somatotrope cell types in the posterior pars distalis (P
18 It gives rise to gonadotrope, thyrotrope, somatotrope, corticotrope and lactotrope cells in the an
19 and alpha-T3 cells as well as those from GH3 somatotrope-derived cells interact with this region.
20 erminal seven amino acids) dimers in the rat somatotrope-derived GH(3) cell line in which both the re
21 the single subunit transfection model in rat somatotrope-derived GH3 cells with the use of immunofluo
22 one (MT-hGHRH) transgenic mice, that exhibit somatotrope hyperplasia before 9 months of age and subse
24 man growth hormone (hGH-N) gene in pituitary somatotropes is mediated by a locus control region (LCR)
25 ormone gene expression in one cell type, the somatotrope, it restricts its expression from a second c
26 enesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
27 n transcription factor Pit-1 is expressed in somatotropes, lactotropes, and thyrotropes of the anteri
28 uitary cell types-gonadotropes, thyrotropes, somatotropes, lactotropes, corticotropes, and melanotrop
29 N) locus is activated in the differentiating somatotrope midway through embryogenesis by a multicompo
30 iating factor in hGH locus activation during somatotrope ontogeny, acting through binding sites at HS
31 al GH axis, neuroDrd2KO mice displayed fewer somatotropes; reduced hypothalamic Ghrh expression, pitu
33 ed for high level, position-independent, and somatotrope-specific expression of a linked hGH-N transg
34 and HSII contains the predominant pituitary somatotrope-specific hGH-N activation function of the LC
35 noncoding Pol II transcription in pituitary somatotropes that includes the hGH LCR and adjacent CD79
36 emains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adu
37 in p27 expression is sufficient to sensitize somatotropes to the proliferative actions of excess GHRH
38 gene is predominantly expressed in pituitary somatotropes, whereas the remaining four genes, the chor
39 mice selectively expanded the population of somatotropes within the AL, where pituitaries of p27+/-,
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