ライフサイエンスコーパス: somitogenesis

1 s they wait for the signal to begin entering somitogenesis.

2 during the course of gastrulation and early somitogenesis.

3 cad-3 and thereby to disruption of posterior somitogenesis.

4 grin-dependent migration and adhesion during somitogenesis.

5 control of early/anterior and late/posterior somitogenesis.

6 les rapidly, over a 4-hour window during mid-somitogenesis.

7 erm) results in random left-right asymmetric somitogenesis.

8 , and thus in ensuring bilaterally symmetric somitogenesis.

9 ells delaminate in blf morphants during late somitogenesis.

10 y have a gamma-secretase-independent role in somitogenesis.

11 with a critical role for N signaling during somitogenesis.

12 ilin in particular was analyzed during mouse somitogenesis.

13 Notch pathway mutants show severe defects in somitogenesis.

14 roles of this pathway in different steps of somitogenesis.

15 mitic mesoderm, tail bud, and somites during somitogenesis.

16 esomitic mesoderm and is required for normal somitogenesis.

17 cture of the axial skeleton is formed during somitogenesis.

18 ific tissues during posterior elongation and somitogenesis.

19 rbed motor axon outgrowth, neurogenesis, and somitogenesis.

20 d Shh, which may be functionally involved in somitogenesis.

21 tion, and unilateral expression during early somitogenesis.

22 that are thought to control segmentation and somitogenesis.

23 , beta-catenin and Lef1 are expressed during somitogenesis.

24 hogenetically plastic during early embryonic somitogenesis.

25 mechanism maintaining cell synchrony during somitogenesis.

26 tion and in the prechordal plate until early somitogenesis.

27 e signal transduction pathways that regulate somitogenesis.

28 e anterior neural tube, axial elongation and somitogenesis.

29 formation of a segmental prepattern prior to somitogenesis.

30 lineage and could play a role in regulating somitogenesis.

31 establishes a segmental prepattern prior to somitogenesis.

32 he period of tail bud development for caudal somitogenesis.

33 indbrain boundary region at the beginning of somitogenesis.

34 xis formation, neuroectoderm patterning, and somitogenesis.

35 on of miR-19 family members during zebrafish somitogenesis.

36 sential for proper segmentation during chick somitogenesis.

37 nd essential role for RARbeta2 in vertebrate somitogenesis.

38 tail elongation, mesodermal development and somitogenesis.

39 t1, NOTCH signaling is subtly reduced during somitogenesis.

40 respond to embryonic retinoid levels during somitogenesis.

41 axis elongation, cell fate specification and somitogenesis.

42 orter in the tailbud, PSM and somites during somitogenesis.

43 entation is initiated through the process of somitogenesis.

44 ed towards certain fates at the beginning of somitogenesis.

45 s that are essential for both myogenesis and somitogenesis.

46 ny one gene is insufficient to disrupt early somitogenesis.

47 ature of vertebrates and is patterned during somitogenesis.

48 xhibits a variable expression pattern during somitogenesis.

49 gene from early (8.5 dpc) to late (10.5 dpc) somitogenesis.

50 in Bmp4 activity that lasts throughout early somitogenesis.

51 ant to examine the role of the cell cycle in somitogenesis.

52 distinct ways in both midline formation and somitogenesis.

53 into skeleton, fast, and slow muscles during somitogenesis.

54 ression which is necessary for regulation of somitogenesis.

55 atterning during late gastrulation and early somitogenesis.

56 To dissect the roles played by Lfng during somitogenesis, a novel allele was established that lacks

57 gulatory factors (MRFs) are expressed during somitogenesis although cells with myogenic capacity are

58 tigated their potential requirement in mouse somitogenesis, an event with precise temporal periodicit

59 reiterating pattern that is coordinated with somitogenesis and also colocalizes with the Notch ligand

60 bit severe defects in neural tube formation, somitogenesis and cardiac development, have aberrant vas

61 mental periodicity represented by vertebrate somitogenesis and early Drosophila development.

62 se staining, was first detected during early somitogenesis and gradually expanded to other tissues of

63 developing trunk similar to how RA controls somitogenesis and heart development.

64 s uncover an unexpected relationship between somitogenesis and left-right patterning, and suggest tha

65 Classical models of somitogenesis and limb development implicated intrinsic

66 major sites of expression implicate Dll3 in somitogenesis and neurogenesis and in the production of

67 n Notch-Delta signaling result in defects in somitogenesis and neurogenesis.

68 e unsegmented mesenchymal PSM while blocking somitogenesis and notochord differentiation.

69 est that GCNF is required for maintenance of somitogenesis and posterior development and is essential

70 t mouse mutation that disrupts pigmentation, somitogenesis and retinal cell fate determination.

71 ignalling in the segmental plate to regulate somitogenesis and rostral-caudal patterning of somites s

72 We apply a CO model to vertebrate somitogenesis and show that we can reproduce the dynamic

73 development, with both apparent during early somitogenesis and subsequently down-regulated as develop

74 t led us to investigate the relation between somitogenesis and the left-right asymmetry machinery in

75 nscription factors, plays a critical role in somitogenesis and the pathogenesis of lumbar/sacral vert

76 broad and balanced cross-species overview of somitogenesis and to highlight the key molecular and cel

77 restricted to the posterior mesoderm during somitogenesis and to posterior mesoderm organs at pharyn

78 haly with small eye formation, disruption of somitogenesis, and curved body axis with bent tail.

79 rive Fgfr1 functions during gastrulation and somitogenesis, and drives normal MAPK responses to Fgf.

80 enesis during gastrulation, brain formation, somitogenesis, and heart development.

81 y within the neuroectodermal lineages during somitogenesis, and second, they show an altered brain mo

82 While somitogenesis appears to be a serially homologous, reite

83 tion and suggest that the earliest stages of somitogenesis are regulated by both Notch-dependent and

84 e targets of retinoic-acid signalling during somitogenesis are the node ectoderm and the posterior ne

85 e vertebrate body plan is established during somitogenesis as somite pairs sequentially form along th

86 duced within the myotome are correlated with somitogenesis as well as myocyte maturation.

87 ant from the 1-cell stage until the onset of somitogenesis, at which time it increased sharply.

88 e, Gax protein was expressed at the onset of somitogenesis before the expression of the myogenic basi

89 vel of RA generation was detected as soon as somitogenesis began.

90 During later somitogenesis, blf expression appears only in hematopoie

91 on, while during late gastrulation and early somitogenesis, blf expression becomes transiently restri

92 are all are known to be essential for normal somitogenesis but are expressed surprisingly early in th

93 , deltaC(tv2) cannot function effectively in somitogenesis but has an enhanced ability to signal duri

94 Thus, Wnt3a regulates somitogenesis by activating a network of interacting tar

95 ling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP rece

96 d severe defects in neural tube development, somitogenesis, cardiogenesis and vascular remodeling.

97 Throughout somitogenesis, Cdh2 promotes ECM assembly along tissue b

98 During somitogenesis, cells are recruited to the caudal presomi

99 spatial position of somite formation and the somitogenesis clock controls periodicity.

100 e is essential for normal functioning of the somitogenesis clock in zebrafish.

101 Previous mathematical models of the somitogenesis clock that invoke the mechanism of delayed

102 equirement for RPTPpsi in the control of the somitogenesis clock upstream of or in parallel with Delt

103 pluripotency is extinguished at the onset of somitogenesis, coincident with reduced expression and ch

104 Somitogenesis displays great autonomy, and it is general

105 We postulate that during somitogenesis Dll3 and Dll1 coordinate in establishing t

106 Somitogenesis during early stages in the chick and mouse

107 e segmentation of the body is established by somitogenesis, during which somites form sequentially in

108 ate mapping of mesodermal derivatives in mid-somitogenesis embryos suggests that EMPs are born direct

109 During somitogenesis, epithelial somites form from the pre-somi

110 Prior to somitogenesis expression of both Nanog and Oct4 is regio

111 During somitogenesis, Fak protein becomes concentrated at the b

112 ciliated KV cells are required during early somitogenesis for subsequent LR patterning in the brain,

113 thway plays multiple roles during vertebrate somitogenesis, functioning in the segmentation clock and

114 that the segmentation clock, which regulates somitogenesis, functions normally in the absence of cell

115 lysis of differential gene expression during somitogenesis has been problematic due to the limited am

116 ession, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and

117 is, are recessive monogenic traits affecting somitogenesis, however the etiologies of the majority of

118 r normal somite formation and that defective somitogenesis in b567 mutant embryos is due to deletion

119 onsistent with available data on the rate of somitogenesis in humans.

120 onent of the Notch signalling pathway during somitogenesis in mice.

121 nd of the presomitic mesoderm prior to overt somitogenesis in response to both Mesp2 and Notch signal

122 Ret1 mRNA first appears during early somitogenesis in the presumptive brain, spinal cord and

123 that the VER produces signals necessary for somitogenesis in the tail and that the cells that produc

124 This is particularly true for somitogenesis in the zebrafish.

125 s in the failure of convergent extension and somitogenesis in this tissue.

126 ons in neurogenic ectoderm of Drosophila and somitogenesis in vertebrate presomitic mesoderm.

127 during embryogenesis through the process of somitogenesis in which the paraxial mesoderm periodicall

128 py to analyze the mechanics underlying early somitogenesis in wild-type zebrafish and in the mutants

129 f actin regulatory proteins are required for somitogenesis in Xenopus.

130 ities in the genetic mechanisms underpinning somitogenesis in zebrafish and segmentation in the spide

131 We find that Bmp signaling continues during somitogenesis in zebrafish embryos, with high activity i

132 controlling somite number, we have compared somitogenesis in zebrafish, chicken, mouse and corn snak

133 and Zeeman's 'clock and wavefront' model of somitogenesis, in which a travelling wavefront determine

134 and-wavefront' mechanism operates to control somitogenesis; in all of them, somitogenesis is brought

135 ause multiple morphogenetic abnormalities in somitogenesis, including defects in intersomitic boundar

136 hown to regulate morphogenetic events during somitogenesis, including the transition of cells from me

137 lation and neurulation, both neurulation and somitogenesis initiate apparently normally in homozygous

138 Somitogenesis involves the segmentation of the paraxial

139 Somitogenesis is a highly controlled process that result

140 es to control somitogenesis; in all of them, somitogenesis is brought to an end through a process in

141 Somitogenesis is controlled in part by a segmentation cl

142 ng from the mid-gastrula stage through early somitogenesis is important for excluding blood and vascu

143 ells into the presomitic mesoderm throughout somitogenesis is not understood.

144 Somitogenesis is regulated by a molecular oscillator tha

145 Vertebrate somitogenesis is regulated by a segmentation clock.

146 d spatial control underlying this process of somitogenesis is regulated by the segmentation clock and

147 In Foxc1/2 double-mutant embryos, somitogenesis is severely affected, precluding analysis

148 retation of the clock and wavefront model of somitogenesis is that a posteriorly moving molecular gra

149 Somitogenesis is the process by which the segmented prec

150 Somitogenesis is thought to be controlled by a segmentat

151 quired suppression of wnt signaling in early somitogenesis; later, increased wnt activity altered end

152 ryos lacking RA results in a reversal of the somitogenesis laterality defect.

153 During somitogenesis, ndr2 is expressed asymmetrically in the l

154 s identifying the role of Dll3 in regulating somitogenesis, Nrarp emerges as a potentially important

155 d protein that plays specific roles in early somitogenesis of vertebrates.

156 er in gastrulation has no apparent effect on somitogenesis or elongation of the embryo.

157 er defects in hypochord formation but not in somitogenesis or hindbrain neurogenesis, indicating gene

158 n syndrome may arise through perturbation of somitogenesis or, alternatively, could result from defec

159 eriod, resembling that of the mouse or chick somitogenesis oscillator and governed by the delays in t

160 During somitogenesis, oscillatory expression of genes in the no

161 ts, indicating that the presomitogenesis and somitogenesis phases of MyoD expression can be uncoupled

162 Somitogenesis plays a key role in embryo morphogenesis a

163 he ventral cells throughout gastrulation and somitogenesis, previous studies in zebrafish have not ad

164 Prior to somitogenesis, RALDH-2-IR is present in the paraxial mes

165 is generally assumed in the literature that somitogenesis-related oscillations are cell-autonomous i

166 gations, but the role of Notch signalling in somitogenesis remains mysterious.

167 Somitogenesis requires a segmentation clock and Notch si

168 Somitogenesis requires bilateral rhythmic segmentation o

169 of activated Notch (NICD) and establish that somitogenesis requires less NICD than any other tissue i

170 e formation of VM, independent of defects of somitogenesis, resulting from aberrant bone deposition a

171 patterning defects at the earliest stages of somitogenesis, resulting in adult mice with severe verte

172 Ectopic activation of Bmp signaling during somitogenesis results in severe defects in the tailbud,

173 During vertebrate somitogenesis, retinoic acid is known to establish the p

174 During somitogenesis, segmental patterns of gene activity provi

175 We argue that this is because somitogenesis shows uncoupling or dissociation from the

176 Overexpression of Bmp during somitogenesis similarly results in bilateral livers and

177 uctors of left-right (LR) asymmetry in early somitogenesis stage embryos.

178 y in the caudal region of embryos during the somitogenesis stage.

179 Enforced Oct4 expression in somitogenesis-stage tissue provokes rapid reopening of O

180 and p1 domain markers are expressed at early somitogenesis stages in these mutants.

181 plate mesoderm (L LPM) during tailbud/early somitogenesis stages is associated in all vertebrates ex

182 from the completion of gastrulation to early somitogenesis stages to regulate BMP signaling.

183 es from a normalized cDNA library from early somitogenesis stages were picked randomly and tested by

184 following heat-shock, we found that at late somitogenesis stages Wnt8a, but not Bmp2b, overexpressio

185 However, from mid-gastrulation to the early somitogenesis stages, Bmp signaling is important for ven

186 wn of Etv2 in zebrafish embryos prior to mid-somitogenesis stages, but not later, caused severe vascu

187 During late somitogenesis stages, Gli3 is required as a repressor of

188 During somitogenesis stages, the anterior expression of mbx, wh

189 At early somitogenesis stages, when the zebrafish endoderm first

190 educed in size in mbx-MO-injected embryos by somitogenesis stages.

191 g specifically during gastrulation and early somitogenesis stages.

192 beta-Catenin involvement in somitogenesis suggests a role for Wnt-mediated signaling

193 The prevailing model of somitogenesis supposes that the presomitic mesoderm is s

194 Maintenance of somitogenesis symmetry requires retinoic acid (RA) and i

195 inoic acid (RA) regulates the maintenance of somitogenesis symmetry.

196 os to show that WIF-1 overexpression affects somitogenesis (the generation of trunk mesoderm segments

197 Furthermore, at the end of somitogenesis, the cell count of radial glia and trigemi

198 tween cell-cell and cell-ECM adhesion during somitogenesis, the formation of the segmented embryonic

199 During somitogenesis, the Nrarp gene is expressed in a pattern

200 Somitogenesis, the sequential formation of a periodic pa

201 During gastrulation and early somitogenesis, the ventral midline of the central nervou

202 rly expressed Bmp inhibitors function during somitogenesis to constrain Bmp signaling in the tailbud

203 late gastrulation and lasting through early somitogenesis to promote chordamesoderm proliferation.

204 tor, drive the formation of somites and link somitogenesis to the elongation of the anteroposterior a

205 1 die at midgestation with severe defects in somitogenesis, vasculogenesis, cardiogenesis, and neurog

206 ing Drosophila wing formation and vertebrate somitogenesis, we suggest that these boundaries constitu

207 The late stages of somitogenesis were rescued in Raldh2(-/-) mouse embryos

208 ell stage and allowed to develop until early somitogenesis when endogenous PLA(2) activity increases

209 dividual somites adopt distinct fates during somitogenesis, which is crucial for establishing the met

210 deployed for segmentation during vertebrate somitogenesis, which raises the possibility of a common

211 efects in trunk development, specifically in somitogenesis, which terminates by 8.75 dpc.

212 axis, reduced head structure, and perturbed somitogenesis, which were also found in embryos treated

213 mp signaling is continuously required during somitogenesis within the anterior lateral plate mesoderm