ライフサイエンスコーパス: sonic

1 We show that sonic activity allows a clear distinction between a diur

2 Advances in sonic and thermal diodes, optomechanical crystals, acous

3 relaxation boom in analogy to the classical sonic boom.

4 Sonic caterpillars are found in many distantly-related g

5 set of neural characters comprising a vocal-sonic central pattern generator (CPG) morphotype is prop

6 SRP was performed using a sonic device and hand instruments.

7 we show that some caterpillars also exhibit sonic displays.

8 The vibrational spectrum displays a sonic gap populated by topologically protected edge mode

9 harges on bathymetric highs characterized by sonic hard grounds, whereas glaciomarine and Holocene se

10 was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])-deficient FL showed increased

11 BCC is primarily driven by the Sonic Hedgehog (Hh) pathway.

12 he lysine-II&V/phenylalanine degradation and sonic hedgehog (Hh) pathways in reversible TMZ-effect ce

13 pression of genes encoding components of the Sonic Hedgehog (Hh) signaling pathway, a driver of mamma

14 Aberrant Sonic hedgehog (Shh) activation during adulthood leads t

15 modulate the activity of morphogens such as Sonic Hedgehog (SHH) and bone morphogenetic proteins (BM

16 ane, boosting cell sensitivity to the ligand Sonic Hedgehog (SHH) and consequently altering SHH-guide

17 Sonic hedgehog (SHH) and fibroblast growth factor (FGF)

18 sor cells, which express the secreted factor sonic hedgehog (Shh) and give rise to taste bud cells th

19 ed subgroup of medulloblastoma, is driven by Sonic hedgehog (Shh) and insulin-like growth factor (IGF

20 causes derepression of several genes, e.g., Sonic hedgehog (Shh) and Insulin-like growth factor-bind

21 The presence of Sonic Hedgehog (Shh) and its signaling components in the

22 However, the source of Hh ligand sonic hedgehog (SHH) and its target cells remains contro

23 (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of th

24 Sonic hedgehog (Shh) and retinoic acid (RA) signaling is

25 Sonic hedgehog (Shh) and Sca1, markers of aortic osteoge

26 d in the cerebellar stroma via tumor-derived Sonic hedgehog (Shh) and show that PlGF acts through Nrp

27 Signaling networks controlled by Sonic hedgehog (SHH) and the transcription factor Atoh1

28 Secreted signaling molecules, such as sonic hedgehog (Shh) and Wnts, are required for the init

29 Sonic hedgehog (Shh) attracts spinal cord commissural ax

30 The morphogen Sonic Hedgehog (Shh) controls the generation of oligoden

31 Epithelial-specific deletion of sonic hedgehog (Shh) during postnatal homeostasis in the

32 re able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 an

33 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic patter

34 Sonic hedgehog (Shh) expression in the limb bud organizi

35 xpression is upstream of p63, Ppargamma, and sonic hedgehog (Shh) expression in the ureteral epitheli

36 nitial presence in the cancer cell of origin Sonic hedgehog (Shh) expression is invariably lost durin

37 in conjunction with FoxA2, directly induces Sonic hedgehog (Shh) expression through binding to a Shh

38 of the chick limb bud times the duration of Sonic hedgehog (Shh) expression, which encodes the morph

39 he posterior HoxA/D genes maintain posterior Sonic Hedgehog (Shh) expression.

40 anisms, consisting of iterative signaling by Sonic hedgehog (SHH) followed by Bone morphogenetic prot

41 ), and that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal.

42 demonstrate a requirement for the Hh ligand Sonic Hedgehog (Shh) for the progression of SCLC.

43 Loss of expression of Sonic Hedgehog (Shh) from parietal cells results in hype

44 ling in axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh) guides axons via a noncanonical sig

45 Sonic hedgehog (Shh) has been suggested to promote the f

46 The morphogen Sonic hedgehog (Shh) holds great promise for repair or r

47 Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been

48 n Barrett's metaplasia and overexpression of Sonic hedgehog (SHH) in mouse esophageal squamous epithe

49 a perineural microenvironment, and deleting Sonic hedgehog (Shh) in neurons or Smoothened in the epi

50 llar architecture or a yet undefined role of Sonic hedgehog (Shh) in perinatal hippocampal developmen

51 Six2creFrs2alphaKO interstitium and ectopic sonic hedgehog (Shh) in subsets of non-dilated P7 mutant

52 e in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two s

53 The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical

54 Sonic hedgehog (Shh) is a mitogen for spinal cord progen

55 Sonic hedgehog (Shh) is a morphogenic protein that opera

56 Sonic hedgehog (Shh) is a secreted molecule made in the

57 Sonic hedgehog (Shh) is a secreted protein that controls

58 Sonic Hedgehog (Shh) is abnormally expressed in pancreat

59 Sonic hedgehog (SHH) is an essential morphogenetic signa

60 Yao and colleagues report that the morphogen sonic hedgehog (Shh) is driven by platelet-derived growt

61 Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patte

62 In the early limb bud, for instance, Sonic hedgehog (Shh) is expressed in the distal posterio

63 The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal meso

64 Sonic Hedgehog (Shh) is normally present in the axons of

65 Sonic hedgehog (Shh) is the primary mitogen that regulat

66 hypoxia strongly activates secretion of the sonic hedgehog (SHH) ligand by cancer cells, which in tu

67 e Gas1 gene, a crucial factor for binding of Sonic Hedgehog (Shh) ligand to its receptor PTCH1 and su

68 Sonic hedgehog (Shh) ligand was highly expressed in 89%

69 ion of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptc

70 n progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively.

71 Zeb1 expression is elevated in the Sonic Hedgehog (SHH) medulloblastoma subgroup originatin

72 ere treated with Smoothened Agonist (SAG), a Sonic Hedgehog (Shh) mimetic in order to fortify blood b

73 The CXCR4 chemokine and Sonic Hedgehog (SHH) morphogen pathways are well-validat

74 tiation, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants.

75 During embryogenesis, sonic hedgehog (SHH) negatively regulates taste bud patt

76 Stimulation with Sonic Hedgehog (Shh) of primary mammary mesenchymal cell

77 h ectopic expression of the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with

78 ry cilium to promote Smo phosphorylation and Sonic hedgehog (Shh) pathway activation.

79 Treatment with the Sonic hedgehog (Shh) pathway agonist purmorphamine or cy

80 ntified in genes involving regulation of the sonic hedgehog (Shh) pathway in 14/38 individuals (37%).

81 Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in a

82 udies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smooth

83 The Sonic Hedgehog (SHH) pathway is a key signaling pathway

84 We found that a noncanonical Sonic Hedgehog (Shh) pathway is rapidly activated in res

85 SCLC) often features the upregulation of the Sonic hedgehog (Shh) pathway leading to activation of Gl

86 two potent, small-molecule inhibitors of the Sonic Hedgehog (Shh) pathway, BRD50837 and BRD9526.

87 a wide spectrum of alterations involving the Sonic Hedgehog (Shh) pathway, consistent with a caretake

88 whose tumors are driven by mutations in the sonic hedgehog (SHH) pathway, SHH antagonists offer some

89 y, and IGF-1 expression was regulated by the Sonic Hedgehog (Shh) pathway.

90 is controlled by hormonal regulation of the Sonic hedgehog (Shh) pathway.

91 y cilia and are required for activity of the Sonic hedgehog (Shh) pathway.

92 s et al. implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb.

93 Using Sonic hedgehog (Shh) patterning of the ventral neural tu

94 Sonic hedgehog (SHH) plays a central role in patterning

95 thelial buds and suppress epithelial-derived sonic hedgehog (SHH) production.

96 Addition of Sonic hedgehog (Shh) protein up-regulated miR17-92 expre

97 egulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically

98 oding a transmembrane protein related to the Sonic hedgehog (Shh) receptor, Patched, and involved in

99 c hippocampal neurons in which activation of Sonic Hedgehog (Shh) receptors in dendrites stimulates a

100 Sonic Hedgehog (SHH) reduces ciliary cAMP levels, inhibi

101 We provide evidence here that sonic hedgehog (Shh) secreted from the gut epithelium pr

102 Sonic hedgehog (Shh) signal transduction was downregulat

103 Sonic hedgehog (Shh) signal, mediated by the Gli family

104 s and has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation.

105 m elongation, Smo ciliary translocation, and Sonic Hedgehog (Shh) signaling and ultimately impair emb

106 n the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion.

107 We found that constitutively active Sonic hedgehog (Shh) signaling expanded bRGs and IPCs an

108 atergic caudal thalamus (cTh) are induced by Sonic hedgehog (Shh) signaling from the zona limitans in

109 ingly endless capacity for regeneration, and sonic hedgehog (SHH) signaling has been implicated in th

110 ntly, stimulation of NOD2 failed to activate Sonic hedgehog (SHH) signaling in iNOS null macrophages,

111 helia and underlying stroma due to paracrine Sonic hedgehog (SHH) signaling in producing desmoplasia

112 possesses well-described roles in regulating sonic hedgehog (SHH) signaling in the skin and preventin

113 The primary cilium is required for Sonic hedgehog (Shh) signaling in vertebrates.

114 Normally, sonic hedgehog (Shh) signaling induces high levels of Pa

115 Sonic hedgehog (Shh) signaling is a developmental signal

116 interrogated large databases and found that sonic hedgehog (SHH) signaling is activated in PTEN-defi

117 Sonic Hedgehog (Shh) signaling is an important determina

118 l) mice were used to establish that impaired Sonic hedgehog (Shh) signaling is associated with loss o

119 Sonic hedgehog (Shh) signaling is critical in developmen

120 Sonic Hedgehog (Shh) signaling is crucial for growth, ce

121 t, in hippocampal neurons, activation of the Sonic hedgehog (Shh) signaling pathway affects multiple

122 groups where constitutive activation of the Sonic Hedgehog (SHH) signaling pathway is a hallmark of

123 of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway.

124 l cell types depend on the modulation of the sonic hedgehog (Shh) signaling pathway.

125 T and predicts the activation of the Wnt and Sonic hedgehog (SHH) signaling pathways during this proc

126 Sonic hedgehog (Shh) signaling patterns the vertebrate s

127 We report herein that sonic hedgehog (Shh) signaling plays a key role in catar

128 ant rescued mandibular morphogenesis through sonic hedgehog (SHH) signaling to the mesenchyme.

129 own of Stil gene expression or inhibition of Sonic hedgehog (Shh) signaling transduction decreases th

130 when maintained in a proliferative state by sonic hedgehog (Shh) signaling, and Aspm is expressed in

131 Patched 1 (PTCH1), an inhibitor of sonic hedgehog (SHH) signaling, harbored an enrichment o

132 stent with this, upon aberrant activation of Sonic hedgehog (Shh) signaling, NEPs exhibited more seve

133 ons causing EvC dwarfism do so by disrupting sonic hedgehog (Shh) signaling, our data implicate Shh s

134 ing progenitors at higher or lower levels of sonic hedgehog (Shh) signaling, respectively.

135 In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly ex

136 red ciliogenesis with concomitant defects in sonic hedgehog (SHH) signaling.

137 scue of the Sp8 mutant phenotype by reducing Sonic Hedgehog (SHH) signaling.

138 an expression profile consistent with active Sonic Hedgehog (SHH) signaling.

139 for Gli-mediated transcription activation in Sonic hedgehog (Shh) signaling.

140 calizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling.

141 al model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud sp

142 The Sonic hedgehog (Shh) signalling pathway plays important

143 In mice, sonic hedgehog (Shh) signals Gli to activate Brg1 in bul

144 clear genetically defined subclasses of the sonic hedgehog (SHH) subclass of medulloblastoma.

145 identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medulloblastomas (MBSHH) w

146 TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1.

147 anching area, along with a downregulation of sonic hedgehog (Shh) transcription, but not in the equal

148 pc(Min) mice were crossed with mice in which sonic hedgehog (SHH) was overexpressed specifically in t

149 Sponges loaded with lentivirus encoding for Sonic hedgehog (Shh) were investigated for acute (delive

150 Sonic hedgehog (SHH), a key regulator of embryonic neuro

151 he embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the act

152 We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial p

153 Sonic hedgehog (Shh), a soluble ligand overexpressed by

154 of a novel gene expression program involving sonic hedgehog (Shh), activated de novo in injured nerve

155 Sonic hedgehog (SHH), an activating ligand of smoothened

156 ly divergent progenitors commonly respond to Sonic hedgehog (Shh), and blockade of reception in TNC(Y

157 n that proliferation of GNPs is regulated by Sonic hedgehog (Shh), and that aberrant activation of th

158 Remarkably, p63 regulates the expression of Sonic Hedgehog (Shh), GLI family zinc finger 2 (Gli2), a

159 subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily

160 ubgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4.

161 ed of four subtypes of medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, and Group 4].

162 es (CRMs) associated with genes regulated by Sonic hedgehog (Shh), retinoids, or bone morphogenetic p

163 hanisms for how signalling proteins, such as sonic hedgehog (SHH), that possess membrane-bound covale

164 Here, we show that Sonic hedgehog (Shh), which encodes a secreted protein s

165 emethylation of H3K27 in many genes, such as Sonic hedgehog (Shh), which is silenced throughout Schwa

166 show that SOX2 is specifically expressed in Sonic hedgehog (SHH)-associated medulloblastoma with an

167 ded cyclic peptide was designed based on the sonic hedgehog (Shh)-binding loop of hedgehog-interactin

168 es in SLOS resemble those seen in congenital Sonic Hedgehog (SHH)-deficient conditions, leading to th

169 t low levels, defines a subset of aggressive Sonic hedgehog (SHH)-driven human medulloblastomas.

170 from patched (Ptch) mutant mice, a model of Sonic hedgehog (SHH)-driven MB.

171 loblastoma reveals MET kinase as a marker of sonic hedgehog (SHH)-driven medulloblastoma.

172 Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial ne

173 monstrate that RGS5 over-expression inhibits sonic hedgehog (Shh)-mediated signaling and osteogenesis

174 We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates

175 Transplantation of Sonic hedgehog (Shh)-soaked beads at the ventricular bas

176 C), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patie

177 with long-term survival as low as 50-60% for Sonic Hedgehog (Shh)-type medulloblastoma.

178 acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh).

179 ity emerges through the morphogen actions of Sonic hedgehog (Shh).

180 iferate after TACs form and begin expressing Sonic Hedgehog (SHH).

181 entate are controlled by distinct sources of Sonic Hedgehog (Shh).

182 CNS is controlled by the secreted morphogen sonic hedgehog (Shh).

183 centers that, among other molecules, secrete Sonic hedgehog (Shh).

184 mid1 expression, controlled by the morphogen Sonic hedgehog (Shh).

185 highly conserved long-range limb enhancer of Sonic hedgehog (Shh).

186 brain development via the secreted morphogen Sonic hedgehog (Shh).

187 nding sites in the limb-specific enhancer of Sonic hedgehog (SHH).

188 rating dermal adipogenesis through secreting Sonic Hedgehog (SHH).

189 ions are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medulloblastomas and are virtu

190 ent between molecular subgroups (WNT, n = 4; sonic hedgehog [SHH; n = 4]; group 4 [n = 41]; group 3 w

191 tility of Zwitch, we generated a conditional sonic hedgehog a (shha) allele.

192 This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian he

193 ecular subgroup of HCA with beta-catenin and sonic hedgehog activation associated with malignant tran

194 rease in intracellular RA concentration plus sonic hedgehog agonist treatment confer an LMC fate on d

195 tors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that

196 5H3 (unc5H3), doublecortin, cyclo-oxygenase, sonic hedgehog and Disrupted in schizophrenia-1 (DISC1),

197 ly committed sclerotome from somite requires sonic hedgehog and Nog.

198 m hair bulge explants, manipulating the WNT, sonic hedgehog and TGFbeta signalling pathways, and expo

199 totic cells that have been dorsalized by the sonic hedgehog antagonist cyclopamine, and that express,

200 GluN2B in the embryo brains, with changes in sonic hedgehog at 24h.

201 a short palmitoylated N-terminal fragment of Sonic Hedgehog binds Patched1 and, strikingly, is suffic

202 The rest of Sonic Hedgehog confers high-affinity Patched1 binding an

203 eous formation of new HFs and an increase in Sonic Hedgehog expression resembling wild-type mice at P

204 llbladder also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth mu

205 s this cascade by inducing the expression of Sonic hedgehog in cancer cells.

206 yos, which might be explained by the reduced Sonic hedgehog in embryos.

207 tebrates is its co-localisation with that of Sonic hedgehog in the floor plate of the neural tube.

208 Sonic hedgehog induces GLI1 binding to the IL-6 promoter

209 Palmitoylated sonic Hedgehog is found in the endoplasmic reticulum, th

210 validated model for timing under control of Sonic Hedgehog is revisited and generalized to an arbitr

211 Injection of zebrafish with recombinant Sonic Hedgehog led to biliary defects similar to those o

212 Overexpression of sonic hedgehog ligand (SHH) in infected WT mice accelera

213 ct, palmitate-dependent interaction with the Sonic Hedgehog ligand.

214 Using sonic hedgehog lineage tracing, we show that the third a

215 Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes a

216 with Patched1 is specifically impaired in a Sonic Hedgehog mutant causing human holoprosencephaly, t

217 y-acylated protein of interest, such as Wnt, Sonic Hedgehog or H-Ras.

218 minence progenitors by simple treatment with sonic hedgehog or its agonist purmorphamine over the nex

219 re was significantly lower mRNA abundance of sonic hedgehog pathway elements at P0 vs E12.5, while ab

220 nstream location of the SUFU gene within the sonic hedgehog pathway may explain why its loss is assoc

221 single treatment with SAG, an agonist of the Sonic hedgehog pathway, administered on the day of birth

222 n of Gli1, a transcriptional effector of the sonic hedgehog pathway.

223 f the INHBE and GLI1 genes and activation of sonic hedgehog pathway.

224 N identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord.

225 trated that the OLFM4 protein interacts with sonic hedgehog protein, as well as significantly inhibit

226 Notably, sonic hedgehog signaling activity influences clonal spat

227 in haired animals; however, the magnitude of sonic hedgehog signaling did not differ significantly.

228 Combined early activation of sonic hedgehog signaling followed by timed NOTCH inhibit

229 ally and examine these models in relation to Sonic Hedgehog signaling in the vertebrate central nervo

230 e mice at P0, thereby indicating that the HS/Sonic Hedgehog signaling pathway regulates HF formation

231 are spatially mixed following heterogeneous Sonic Hedgehog signaling responses.

232 ntify genes that functionally cooperate with sonic hedgehog signaling to initiate medulloblastoma (MB

233 s replicating alpha-cell exhibited activated Sonic hedgehog signaling, a pathway not previously known

234 e tumors were characterized by activation of sonic hedgehog signaling, due to focal deletions that fu

235 f purmorphamine, a small-molecule agonist of sonic hedgehog signaling, hPSCs were differentiated to d

236 mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly.

237 ligands for gp130, interleukin 6, cytokines, sonic hedgehog signaling, STAT3 phosphorylation (activat

238 ocalization for key signaling events such as sonic hedgehog signaling.

239 but in the absence of factors that activate sonic hedgehog signaling.

240 of the zebrafish neural tube in response to Sonic Hedgehog signaling.

241 Finally, in vivo inhibition of sonic hedgehog signalling in Eda null teeth enabled us t

242 lling functions, including growth factor and Sonic hedgehog signalling.

243 Our data demonstrate that Sonic Hedgehog signals via the palmitate-dependent arm o

244 t, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism t

245 mising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma.

246 medulloblastomas most closely resembled the sonic hedgehog subgroup of human medulloblastoma at the

247 essor gene Ptch1 and a recapitulation of the sonic hedgehog subgroup of human medulloblastomas.

248 ile having little effect on mouse MBs of the sonic hedgehog subgroup.

249 s, this was due to the overexpression of the sonic hedgehog transcription factor Gli1, which elevated

250 We observe that the sonic hedgehog transcription factor glioma-associated pr

251 urodevelopmental proteins, the expression of sonic hedgehog was increased, but DISC1 and dependence r

252 protein encoded by DYRK1B inhibits the SHH (sonic hedgehog) and Wnt signaling pathways and consequen

253 ecules (including Osterix, beta-catenin, and sonic hedgehog) that play a critical role in root format

254 SHH (Sonic Hedgehog)-GLI signaling plays an important role du

255 e influence of a common dorsoventral signal, sonic hedgehog, and distinct anterior-posterior (A-P) in

256 Signaling pathways (retinoic acid, sonic hedgehog, and Notch) that pattern the neural tube

257 development have been identified, including sonic hedgehog, bone morphogenetic protein 4 and multipl

258 on of multiple signaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast g

259 ta-catenin signaling in the cells and to add Sonic hedgehog, FGF10, and thymosin beta4.

260 by several transcriptional factors, such as sonic hedgehog, fibroblast growth factors, and wingless-

261 rmal integrin beta1 and include Wnt, but not sonic hedgehog, signaling.

262 ic palmitoylated proteins, as exemplified by sonic Hedgehog, tubulin, and Ras.

263 ess to platelet-derived growth factor-AA and sonic hedgehog, two cilium-associated stimuli.

264 a posttranslational mechanism, regulated by Sonic hedgehog, which is important to suppress Pax6 acti

265 Because of its production of Sonic hedgehog, ZLI acts as a morphogenetic signaling ce

266 unction experiments do not support a role in sonic hedgehog-dependent signaling, but reveal a disrupt

267 cyte progenitors can be a cell of origin for Sonic hedgehog-driven ERMS, showing that RMS can origina

268 ts demonstrate an unexpected role for ASC in Sonic hedgehog-driven medulloblastoma tumorigenesis, thu

269 to deletion of one allele of MyoD, two other Sonic hedgehog-driven mouse medulloblastoma models showe

270 ogenitors derived from hESCs and hiPSCs in a sonic hedgehog-independent manner.

271 s recently highlighted an important role for Sonic hedgehog-positive cells and retinoid signaling tha

272 histological architecture and expression of sonic hedgehog-regulated genes.

273 nsive discussion on how Wnt/beta-catenin and sonic hedgehog-Smoothened signaling mechanisms control t

274 er resting conditions but not in response to Sonic Hedgehog.

275 itions following disordered specification by Sonic hedgehog.

276 ng on a long-distance cis-acting enhancer of Sonic Hedgehog.

277 medulloblastoma subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) signaling.

278 , providing the most potent inhibitor of the sonic hedgehog/patched interaction reported to date.

279 In contrast, potent inhibitors of the sonic hedgehog/patched interaction, the most upstream ev

280 ressing versus -silenced PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two dif

281 ntles the primary cilium, known to transduce sonic-hedgehog signals, and is required for expression o

282 ibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB).

283 Sonic Hh (Shh) ligand-producing cells and Shh-responsive

284 We have determined crystal structures of Sonic Hh complexes with two GAGs, heparin and chondroiti

285 Of interest, expression of Sonic Hh increased in lung epithelial cells following th

286 bined with analytical ultracentrifugation of Sonic Hh-GAG complexes, suggests a potential mechanism f

287 nd protein expression in vehicle-treated and sonic Hh-treated CCA cells, confirming our previous micr

288 ed by spot number and intensity correlation (SONIC), is fully automated, robust to noise, and does no

289 The Sonic Kayak is a musical instrument used to investigate

290 A rich sonic palette is created by controlling the composition

291 Sonic properties of spider silks are measured independen

292 ory system about the occurrence of one's own sonic signal.

293 ent in a mechanism similar to thermospray or sonic spray ionization.

294 ctrospray ionization (DESI) and easy ambient sonic-spray ionization (EASI) with well-defined selectiv

295 lary was connected to a Venturi easy ambient sonic-spray ionization source, sampling the resulting an

296 rs for 21 days, followed by treatment with a sonic toothbrush for 21 days.

297 modulator Naive Patients in Crohn's Disease (SONIC trial).

298 ta from 172 patients who participated in the SONIC trial, were found to have endoscopic lesions at ba

299 ction caused by collapsing microbubbles when sonic waves propagate through a liquid medium.

300 and introduce energy via the dissipation of sonic waves.