ライフサイエンスコーパス: sonic hedgehog

1 er resting conditions but not in response to Sonic Hedgehog.

2 itions following disordered specification by Sonic hedgehog.

3 ng on a long-distance cis-acting enhancer of Sonic Hedgehog.

4 tility of Zwitch, we generated a conditional sonic hedgehog a (shha) allele.

5 This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian he

6 ecular subgroup of HCA with beta-catenin and sonic hedgehog activation associated with malignant tran

7 null allele of mouse Ttbk2 based on loss of Sonic hedgehog activity, a signaling pathway that requir

8 rease in intracellular RA concentration plus sonic hedgehog agonist treatment confer an LMC fate on d

9 tors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that

10 5H3 (unc5H3), doublecortin, cyclo-oxygenase, sonic hedgehog and Disrupted in schizophrenia-1 (DISC1),

11 ly committed sclerotome from somite requires sonic hedgehog and Nog.

12 m hair bulge explants, manipulating the WNT, sonic hedgehog and TGFbeta signalling pathways, and expo

13 protein encoded by DYRK1B inhibits the SHH (sonic hedgehog) and Wnt signaling pathways and consequen

14 e influence of a common dorsoventral signal, sonic hedgehog, and distinct anterior-posterior (A-P) in

15 Signaling pathways (retinoic acid, sonic hedgehog, and Notch) that pattern the neural tube

16 ignificantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups.

17 totic cells that have been dorsalized by the sonic hedgehog antagonist cyclopamine, and that express,

18 GluN2B in the embryo brains, with changes in sonic hedgehog at 24h.

19 a short palmitoylated N-terminal fragment of Sonic Hedgehog binds Patched1 and, strikingly, is suffic

20 development have been identified, including sonic hedgehog, bone morphogenetic protein 4 and multipl

21 on of multiple signaling pathways, including Sonic hedgehog, bone morphogenetic protein, fibroblast g

22 The rest of Sonic Hedgehog confers high-affinity Patched1 binding an

23 unction experiments do not support a role in sonic hedgehog-dependent signaling, but reveal a disrupt

24 scle progenitors can be a cell of origin for Sonic Hedgehog-driven embryonal rhabdomyosarcoma in an a

25 cyte progenitors can be a cell of origin for Sonic hedgehog-driven ERMS, showing that RMS can origina

26 ts demonstrate an unexpected role for ASC in Sonic hedgehog-driven medulloblastoma tumorigenesis, thu

27 to deletion of one allele of MyoD, two other Sonic hedgehog-driven mouse medulloblastoma models showe

28 ibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB).

29 eous formation of new HFs and an increase in Sonic Hedgehog expression resembling wild-type mice at P

30 llbladder also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth mu

31 ta-catenin signaling in the cells and to add Sonic hedgehog, FGF10, and thymosin beta4.

32 by several transcriptional factors, such as sonic hedgehog, fibroblast growth factors, and wingless-

33 SHH (Sonic Hedgehog)-GLI signaling plays an important role du

34 was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])-deficient FL showed increased

35 BCC is primarily driven by the Sonic Hedgehog (Hh) pathway.

36 he lysine-II&V/phenylalanine degradation and sonic hedgehog (Hh) pathways in reversible TMZ-effect ce

37 pression of genes encoding components of the Sonic Hedgehog (Hh) signaling pathway, a driver of mamma

38 s this cascade by inducing the expression of Sonic hedgehog in cancer cells.

39 yos, which might be explained by the reduced Sonic hedgehog in embryos.

40 tebrates is its co-localisation with that of Sonic hedgehog in the floor plate of the neural tube.

41 ogenitors derived from hESCs and hiPSCs in a sonic hedgehog-independent manner.

42 Sonic hedgehog induces GLI1 binding to the IL-6 promoter

43 Palmitoylated sonic Hedgehog is found in the endoplasmic reticulum, th

44 validated model for timing under control of Sonic Hedgehog is revisited and generalized to an arbitr

45 Patched (Ptc), the main receptor for Sonic Hedgehog, is a tumor suppressor.

46 Injection of zebrafish with recombinant Sonic Hedgehog led to biliary defects similar to those o

47 Overexpression of sonic hedgehog ligand (SHH) in infected WT mice accelera

48 ct, palmitate-dependent interaction with the Sonic Hedgehog ligand.

49 Using sonic hedgehog lineage tracing, we show that the third a

50 Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes a

51 with Patched1 is specifically impaired in a Sonic Hedgehog mutant causing human holoprosencephaly, t

52 y-acylated protein of interest, such as Wnt, Sonic Hedgehog or H-Ras.

53 minence progenitors by simple treatment with sonic hedgehog or its agonist purmorphamine over the nex

54 In this location, endothelial expression of sonic hedgehog parallels expression of notch-1 by pericy

55 medulloblastoma subtypes driven by aberrant Sonic Hedgehog/Patched (SHH/PTCH) signaling.

56 , providing the most potent inhibitor of the sonic hedgehog/patched interaction reported to date.

57 In contrast, potent inhibitors of the sonic hedgehog/patched interaction, the most upstream ev

58 re was significantly lower mRNA abundance of sonic hedgehog pathway elements at P0 vs E12.5, while ab

59 that Activin directly inhibits the mitogenic sonic hedgehog pathway in a Gli3-dependent manner while

60 nstream location of the SUFU gene within the sonic hedgehog pathway may explain why its loss is assoc

61 ociated fibroblasts with an inhibitor of the sonic hedgehog pathway reduces solid stress, decompresse

62 single treatment with SAG, an agonist of the Sonic hedgehog pathway, administered on the day of birth

63 n of Gli1, a transcriptional effector of the sonic hedgehog pathway.

64 f the INHBE and GLI1 genes and activation of sonic hedgehog pathway.

65 N identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord.

66 s recently highlighted an important role for Sonic hedgehog-positive cells and retinoid signaling tha

67 mature, cholesterol- and palmitate-modified Sonic hedgehog protein signal (ShhNp) when added to cult

68 trated that the OLFM4 protein interacts with sonic hedgehog protein, as well as significantly inhibit

69 histological architecture and expression of sonic hedgehog-regulated genes.

70 Aberrant Sonic hedgehog (Shh) activation during adulthood leads t

71 The secreted factor sonic hedgehog (SHH) acts through the conserved hedgehog

72 ze the effect that the extracellular ligands sonic hedgehog (Shh) and bone morphogenetic protein 4 (B

73 modulate the activity of morphogens such as Sonic Hedgehog (SHH) and bone morphogenetic proteins (BM

74 ane, boosting cell sensitivity to the ligand Sonic Hedgehog (SHH) and consequently altering SHH-guide

75 Sonic hedgehog (SHH) and fibroblast growth factor (FGF)

76 sor cells, which express the secreted factor sonic hedgehog (Shh) and give rise to taste bud cells th

77 ed subgroup of medulloblastoma, is driven by Sonic hedgehog (Shh) and insulin-like growth factor (IGF

78 causes derepression of several genes, e.g., Sonic hedgehog (Shh) and Insulin-like growth factor-bind

79 The presence of Sonic Hedgehog (Shh) and its signaling components in the

80 However, the source of Hh ligand sonic hedgehog (SHH) and its target cells remains contro

81 nt, like the axial skeleton, is dependent on Sonic hedgehog (Shh) and modulation of bone morphogeneti

82 (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) and retinoic acid (RA) is one of th

83 Sonic hedgehog (Shh) and retinoic acid (RA) signaling is

84 Sonic hedgehog (Shh) and Sca1, markers of aortic osteoge

85 d in the cerebellar stroma via tumor-derived Sonic hedgehog (Shh) and show that PlGF acts through Nrp

86 Signaling networks controlled by Sonic hedgehog (SHH) and the transcription factor Atoh1

87 Secreted signaling molecules, such as sonic hedgehog (Shh) and Wnts, are required for the init

88 Sonic hedgehog (Shh) attracts spinal cord commissural ax

89 The morphogen Sonic Hedgehog (Shh) controls the generation of oligoden

90 Epithelial-specific deletion of sonic hedgehog (Shh) during postnatal homeostasis in the

91 re able to repress transcription through the sonic hedgehog (Shh) endoderm-specific enhancer MACS1 an

92 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic patter

93 Sonic hedgehog (Shh) expression in the limb bud organizi

94 xpression is upstream of p63, Ppargamma, and sonic hedgehog (Shh) expression in the ureteral epitheli

95 nitial presence in the cancer cell of origin Sonic hedgehog (Shh) expression is invariably lost durin

96 in conjunction with FoxA2, directly induces Sonic hedgehog (Shh) expression through binding to a Shh

97 of the chick limb bud times the duration of Sonic hedgehog (Shh) expression, which encodes the morph

98 he posterior HoxA/D genes maintain posterior Sonic Hedgehog (Shh) expression.

99 n tumor cell growth and survival by aberrant sonic hedgehog (Shh) expression.

100 anisms, consisting of iterative signaling by Sonic hedgehog (SHH) followed by Bone morphogenetic prot

101 ), and that gustatory nerves are a source of sonic hedgehog (Shh) for taste bud renewal.

102 demonstrate a requirement for the Hh ligand Sonic Hedgehog (Shh) for the progression of SCLC.

103 Loss of expression of Sonic Hedgehog (Shh) from parietal cells results in hype

104 ling in axon guidance.SIGNIFICANCE STATEMENT Sonic hedgehog (Shh) guides axons via a noncanonical sig

105 Sonic hedgehog (Shh) has been suggested to promote the f

106 The morphogen Sonic hedgehog (Shh) holds great promise for repair or r

107 Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been

108 n Barrett's metaplasia and overexpression of Sonic hedgehog (SHH) in mouse esophageal squamous epithe

109 a perineural microenvironment, and deleting Sonic hedgehog (Shh) in neurons or Smoothened in the epi

110 llar architecture or a yet undefined role of Sonic hedgehog (Shh) in perinatal hippocampal developmen

111 Six2creFrs2alphaKO interstitium and ectopic sonic hedgehog (Shh) in subsets of non-dilated P7 mutant

112 e in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two s

113 demonstrate here that mouse embryos lacking Sonic hedgehog (Shh) in the prospective hypothalamus exh

114 The distribution of Sonic Hedgehog (Shh) is a highly regulated and critical

115 Sonic hedgehog (Shh) is a mitogen for spinal cord progen

116 Sonic hedgehog (Shh) is a morphogenic protein that opera

117 Sonic hedgehog (Shh) is a secreted molecule made in the

118 Sonic Hedgehog (Shh) is a secreted morphogen that regula

119 Sonic hedgehog (Shh) is a secreted protein that controls

120 Sonic Hedgehog (Shh) is abnormally expressed in pancreat

121 Sonic hedgehog (SHH) is an essential morphogenetic signa

122 Yao and colleagues report that the morphogen sonic hedgehog (Shh) is driven by platelet-derived growt

123 Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patte

124 In the early limb bud, for instance, Sonic hedgehog (Shh) is expressed in the distal posterio

125 The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal meso

126 Sonic Hedgehog (Shh) is normally present in the axons of

127 anule cell progenitors (GCPs) in response to Sonic hedgehog (SHH) is severely reduced.

128 We recently discovered that Sonic hedgehog (Shh) is solubilized by proteolytic proce

129 Sonic hedgehog (Shh) is the primary mitogen that regulat

130 hypoxia strongly activates secretion of the sonic hedgehog (SHH) ligand by cancer cells, which in tu

131 e Gas1 gene, a crucial factor for binding of Sonic Hedgehog (Shh) ligand to its receptor PTCH1 and su

132 Sonic hedgehog (Shh) ligand was highly expressed in 89%

133 ion of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptc

134 n progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively.

135 Zeb1 expression is elevated in the Sonic Hedgehog (SHH) medulloblastoma subgroup originatin

136 ere treated with Smoothened Agonist (SAG), a Sonic Hedgehog (Shh) mimetic in order to fortify blood b

137 The CXCR4 chemokine and Sonic Hedgehog (SHH) morphogen pathways are well-validat

138 tiation, causing limb defects that phenocopy Sonic Hedgehog (Shh) mutants.

139 During embryogenesis, sonic hedgehog (SHH) negatively regulates taste bud patt

140 Stimulation with Sonic Hedgehog (Shh) of primary mammary mesenchymal cell

141 h ectopic expression of the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with

142 ry cilium to promote Smo phosphorylation and Sonic hedgehog (Shh) pathway activation.

143 Treatment with the Sonic hedgehog (Shh) pathway agonist purmorphamine or cy

144 The Sonic Hedgehog (Shh) pathway drives a subset of medullob

145 ntified in genes involving regulation of the sonic hedgehog (Shh) pathway in 14/38 individuals (37%).

146 Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in a

147 udies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smooth

148 The Sonic Hedgehog (SHH) pathway is a key signaling pathway

149 We found that a noncanonical Sonic Hedgehog (Shh) pathway is rapidly activated in res

150 SCLC) often features the upregulation of the Sonic hedgehog (Shh) pathway leading to activation of Gl

151 two potent, small-molecule inhibitors of the Sonic Hedgehog (Shh) pathway, BRD50837 and BRD9526.

152 a wide spectrum of alterations involving the Sonic Hedgehog (Shh) pathway, consistent with a caretake

153 whose tumors are driven by mutations in the sonic hedgehog (SHH) pathway, SHH antagonists offer some

154 n addition, expression of the members of the sonic hedgehog (SHH) pathway, SHH, patched (PTCH-1), smo

155 y, and IGF-1 expression was regulated by the Sonic Hedgehog (Shh) pathway.

156 is controlled by hormonal regulation of the Sonic hedgehog (Shh) pathway.

157 y cilia and are required for activity of the Sonic hedgehog (Shh) pathway.

158 s et al. implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb.

159 Using Sonic hedgehog (Shh) patterning of the ventral neural tu

160 Sonic hedgehog (SHH) plays a central role in patterning

161 thelial buds and suppress epithelial-derived sonic hedgehog (SHH) production.

162 Addition of Sonic hedgehog (Shh) protein up-regulated miR17-92 expre

163 egulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically

164 oding a transmembrane protein related to the Sonic hedgehog (Shh) receptor, Patched, and involved in

165 c hippocampal neurons in which activation of Sonic Hedgehog (Shh) receptors in dendrites stimulates a

166 Sonic Hedgehog (SHH) reduces ciliary cAMP levels, inhibi

167 Sonic Hedgehog (Shh) regulates gastric epithelial differ

168 We provide evidence here that sonic hedgehog (Shh) secreted from the gut epithelium pr

169 Sonic hedgehog (Shh) signal transduction was downregulat

170 Sonic hedgehog (Shh) signal, mediated by the Gli family

171 s and has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation.

172 m elongation, Smo ciliary translocation, and Sonic Hedgehog (Shh) signaling and ultimately impair emb

173 n the present study, we uncovered a role for sonic hedgehog (SHH) signaling during lip fusion.

174 We found that constitutively active Sonic hedgehog (Shh) signaling expanded bRGs and IPCs an

175 atergic caudal thalamus (cTh) are induced by Sonic hedgehog (Shh) signaling from the zona limitans in

176 ingly endless capacity for regeneration, and sonic hedgehog (SHH) signaling has been implicated in th

177 ntly, stimulation of NOD2 failed to activate Sonic hedgehog (SHH) signaling in iNOS null macrophages,

178 helia and underlying stroma due to paracrine Sonic hedgehog (SHH) signaling in producing desmoplasia

179 Tmem107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and ac

180 possesses well-described roles in regulating sonic hedgehog (SHH) signaling in the skin and preventin

181 The primary cilium is required for Sonic hedgehog (Shh) signaling in vertebrates.

182 Normally, sonic hedgehog (Shh) signaling induces high levels of Pa

183 Sonic hedgehog (Shh) signaling is a developmental signal

184 interrogated large databases and found that sonic hedgehog (SHH) signaling is activated in PTEN-defi

185 Sonic Hedgehog (Shh) signaling is an important determina

186 l) mice were used to establish that impaired Sonic hedgehog (Shh) signaling is associated with loss o

187 Sonic hedgehog (Shh) signaling is critical in developmen

188 Sonic Hedgehog (Shh) signaling is crucial for growth, ce

189 t, in hippocampal neurons, activation of the Sonic hedgehog (Shh) signaling pathway affects multiple

190 groups where constitutive activation of the Sonic Hedgehog (SHH) signaling pathway is a hallmark of

191 of embryonic development, acting through the sonic hedgehog (SHH) signaling pathway.

192 l cell types depend on the modulation of the sonic hedgehog (Shh) signaling pathway.

193 T and predicts the activation of the Wnt and Sonic hedgehog (SHH) signaling pathways during this proc

194 Sonic hedgehog (Shh) signaling patterns the vertebrate s

195 We report herein that sonic hedgehog (Shh) signaling plays a key role in catar

196 ant rescued mandibular morphogenesis through sonic hedgehog (SHH) signaling to the mesenchyme.

197 own of Stil gene expression or inhibition of Sonic hedgehog (Shh) signaling transduction decreases th

198 when maintained in a proliferative state by sonic hedgehog (Shh) signaling, and Aspm is expressed in

199 Patched 1 (PTCH1), an inhibitor of sonic hedgehog (SHH) signaling, harbored an enrichment o

200 stent with this, upon aberrant activation of Sonic hedgehog (Shh) signaling, NEPs exhibited more seve

201 ons causing EvC dwarfism do so by disrupting sonic hedgehog (Shh) signaling, our data implicate Shh s

202 ing progenitors at higher or lower levels of sonic hedgehog (Shh) signaling, respectively.

203 In the ventral neural tube, sonic hedgehog (Shh) signaling, together with broadly ex

204 red ciliogenesis with concomitant defects in sonic hedgehog (SHH) signaling.

205 scue of the Sp8 mutant phenotype by reducing Sonic Hedgehog (SHH) signaling.

206 an expression profile consistent with active Sonic Hedgehog (SHH) signaling.

207 for Gli-mediated transcription activation in Sonic hedgehog (Shh) signaling.

208 calizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling.

209 al model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in the chick wing bud sp

210 The Sonic hedgehog (Shh) signalling pathway plays important

211 In mice, sonic hedgehog (Shh) signals Gli to activate Brg1 in bul

212 clear genetically defined subclasses of the sonic hedgehog (SHH) subclass of medulloblastoma.

213 identification of key tumorigenic events in Sonic Hedgehog (SHH) subgroup medulloblastomas (MBSHH) w

214 They express Yes-associated protein (YAP), a Sonic hedgehog (Shh) target markedly elevated in Shh-dri

215 TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1.

216 Here, we use the morphogen Sonic Hedgehog (Shh) to induce the in vitro organization

217 anching area, along with a downregulation of sonic hedgehog (Shh) transcription, but not in the equal

218 pc(Min) mice were crossed with mice in which sonic hedgehog (SHH) was overexpressed specifically in t

219 Sponges loaded with lentivirus encoding for Sonic hedgehog (Shh) were investigated for acute (delive

220 Sonic hedgehog (SHH), a key regulator of embryonic neuro

221 he embryonic vertebrate limb is dependent on Sonic hedgehog (Shh), a morphogen that regulates the act

222 We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial p

223 Sonic hedgehog (Shh), a soluble ligand overexpressed by

224 of a novel gene expression program involving sonic hedgehog (Shh), activated de novo in injured nerve

225 Sonic hedgehog (SHH), an activating ligand of smoothened

226 ly divergent progenitors commonly respond to Sonic hedgehog (Shh), and blockade of reception in TNC(Y

227 n that proliferation of GNPs is regulated by Sonic hedgehog (Shh), and that aberrant activation of th

228 Remarkably, p63 regulates the expression of Sonic Hedgehog (Shh), GLI family zinc finger 2 (Gli2), a

229 subgroups of medulloblastoma-wingless (WNT), sonic hedgehog (SHH), group 3, and group 4-in the daily

230 ubgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4.

231 ed of four subtypes of medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, and Group 4].

232 es (CRMs) associated with genes regulated by Sonic hedgehog (Shh), retinoids, or bone morphogenetic p

233 hanisms for how signalling proteins, such as sonic hedgehog (SHH), that possess membrane-bound covale

234 Here, we show that Sonic hedgehog (Shh), which encodes a secreted protein s

235 emethylation of H3K27 in many genes, such as Sonic hedgehog (Shh), which is silenced throughout Schwa

236 show that SOX2 is specifically expressed in Sonic hedgehog (SHH)-associated medulloblastoma with an

237 ded cyclic peptide was designed based on the sonic hedgehog (Shh)-binding loop of hedgehog-interactin

238 es in SLOS resemble those seen in congenital Sonic Hedgehog (SHH)-deficient conditions, leading to th

239 t low levels, defines a subset of aggressive Sonic hedgehog (SHH)-driven human medulloblastomas.

240 from patched (Ptch) mutant mice, a model of Sonic hedgehog (SHH)-driven MB.

241 loblastoma reveals MET kinase as a marker of sonic hedgehog (SHH)-driven medulloblastoma.

242 Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial ne

243 monstrate that RGS5 over-expression inhibits sonic hedgehog (Shh)-mediated signaling and osteogenesis

244 We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates

245 Transplantation of Sonic hedgehog (Shh)-soaked beads at the ventricular bas

246 C), and shows promise in clinical trials for SONIC HEDGEHOG (SHH)-subgroup medulloblastoma (MB) patie

247 with long-term survival as low as 50-60% for Sonic Hedgehog (Shh)-type medulloblastoma.

248 ity emerges through the morphogen actions of Sonic hedgehog (Shh).

249 iferate after TACs form and begin expressing Sonic Hedgehog (SHH).

250 entate are controlled by distinct sources of Sonic Hedgehog (Shh).

251 CNS is controlled by the secreted morphogen sonic hedgehog (Shh).

252 centers that, among other molecules, secrete Sonic hedgehog (Shh).

253 ressor antagonizes and posteriorly restricts Sonic hedgehog (Shh).

254 ity to midline cells without also turning on Sonic hedgehog (SHH).

255 mid1 expression, controlled by the morphogen Sonic hedgehog (Shh).

256 highly conserved long-range limb enhancer of Sonic hedgehog (Shh).

257 brain development via the secreted morphogen Sonic hedgehog (Shh).

258 nding sites in the limb-specific enhancer of Sonic hedgehog (SHH).

259 rating dermal adipogenesis through secreting Sonic Hedgehog (SHH).

260 acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh).

261 ions are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medulloblastomas and are virtu

262 ressing versus -silenced PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two dif

263 ent between molecular subgroups (WNT, n = 4; sonic hedgehog [SHH; n = 4]; group 4 [n = 41]; group 3 w

264 Notably, sonic hedgehog signaling activity influences clonal spat

265 ils to make cilia, and shows neural tube and Sonic hedgehog signaling defects.

266 in haired animals; however, the magnitude of sonic hedgehog signaling did not differ significantly.

267 Combined early activation of sonic hedgehog signaling followed by timed NOTCH inhibit

268 ally and examine these models in relation to Sonic Hedgehog signaling in the vertebrate central nervo

269 e mice at P0, thereby indicating that the HS/Sonic Hedgehog signaling pathway regulates HF formation

270 are spatially mixed following heterogeneous Sonic Hedgehog signaling responses.

271 ntify genes that functionally cooperate with sonic hedgehog signaling to initiate medulloblastoma (MB

272 s replicating alpha-cell exhibited activated Sonic hedgehog signaling, a pathway not previously known

273 e tumors were characterized by activation of sonic hedgehog signaling, due to focal deletions that fu

274 f purmorphamine, a small-molecule agonist of sonic hedgehog signaling, hPSCs were differentiated to d

275 mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly.

276 ligands for gp130, interleukin 6, cytokines, sonic hedgehog signaling, STAT3 phosphorylation (activat

277 ocalization for key signaling events such as sonic hedgehog signaling.

278 but in the absence of factors that activate sonic hedgehog signaling.

279 of the zebrafish neural tube in response to Sonic Hedgehog signaling.

280 al, and cerebellar defects, and misregulated Sonic hedgehog signaling.

281 rmal integrin beta1 and include Wnt, but not sonic hedgehog, signaling.

282 Finally, in vivo inhibition of sonic hedgehog signalling in Eda null teeth enabled us t

283 lling functions, including growth factor and Sonic hedgehog signalling.

284 Our data demonstrate that Sonic Hedgehog signals via the palmitate-dependent arm o

285 ntles the primary cilium, known to transduce sonic-hedgehog signals, and is required for expression o

286 nsive discussion on how Wnt/beta-catenin and sonic hedgehog-Smoothened signaling mechanisms control t

287 y concentration of Smoothened in response to Sonic hedgehog stimulation, and reduced Shh pathway tran

288 t, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism t

289 mising therapeutic paradigm for treatment of sonic hedgehog subgroup medulloblastoma.

290 medulloblastomas most closely resembled the sonic hedgehog subgroup of human medulloblastoma at the

291 essor gene Ptch1 and a recapitulation of the sonic hedgehog subgroup of human medulloblastomas.

292 ile having little effect on mouse MBs of the sonic hedgehog subgroup.

293 ecules (including Osterix, beta-catenin, and sonic hedgehog) that play a critical role in root format

294 s, this was due to the overexpression of the sonic hedgehog transcription factor Gli1, which elevated

295 We observe that the sonic hedgehog transcription factor glioma-associated pr

296 ic palmitoylated proteins, as exemplified by sonic Hedgehog, tubulin, and Ras.

297 ess to platelet-derived growth factor-AA and sonic hedgehog, two cilium-associated stimuli.

298 urodevelopmental proteins, the expression of sonic hedgehog was increased, but DISC1 and dependence r

299 a posttranslational mechanism, regulated by Sonic hedgehog, which is important to suppress Pax6 acti

300 Because of its production of Sonic hedgehog, ZLI acts as a morphogenetic signaling ce