ライフサイエンスコーパス: sooty mangabey

1 ommon evolutionary ancestor with SIVsm (from sooty mangabeys).

2 macaques, pig-tailed macaques, baboons, and sooty mangabeys).

3 r dataset, and a preliminary assembly of the Sooty mangabey.

4 macaques, cynomolgus macaques, baboons, and sooty mangabeys.

5 ulation, on monocytes, and on neutrophils of sooty mangabeys.

6 first report of SIV-specific CTL epitopes in sooty mangabeys.

7 -specific CTL activity in naturally infected sooty mangabeys.

8 n control or persistence of SIV infection in sooty mangabeys.

9 ter than that reported in naturally infected sooty mangabeys.

10 as significantly lower in naturally infected sooty mangabeys.

11 urally infected and three SIVmac239-infected sooty mangabeys.

12 ce in SIVsm-infected feral and household pet sooty mangabeys.

13 CCR5 entry pathways, as has been observed in sooty mangabeys.

14 were no longer detected in the lymph node of sooty mangabeys.

15 nfection of African green monkeys (AGMs) and sooty mangabeys.

16 f CD4 and CD8 T cells in rhesus macaques and sooty mangabeys.

17 lorectal mucosa of chronically infected SIV+ sooty mangabeys.

18 cted humans, and SIV-infected and uninfected sooty mangabeys.

19 ive nature of nonpathogenic SIV infection in sooty mangabeys.

20 s was not observed in naturally SIV-infected sooty mangabeys.

21 macaques and nonpathogenic SIV infection of sooty mangabeys.

22 an immunodeficiency virus (SIV) infection of sooty mangabeys.

23 naturally SIV-infected and five SIV-negative sooty mangabeys.

24 for the first time, we treated SIV-infected sooty mangabeys, a natural host for the infection, with

25 Natural SIV hosts (for example, sooty mangabeys, African green monkeys and mandrills) sh

26 in 5 different species of natural SIV hosts (sooty mangabeys, African green monkeys, mandrills, sun-t

27 ocytes identified in the peripheral blood of sooty mangabeys also did not show evidence of increased

28 ng primary SIV infection of the natural host sooty mangabey and the non-natural host pig-tailed macaq

29 CD4(+) T lymphocytes in viremic SIV-infected sooty mangabeys and protect against progression to AIDS.

30 be associated with the divergent outcome in sooty mangabeys and rhesus macaques.

31 enic SIV infection in sooty mangabeys, three sooty mangabeys and three rhesus macaques were inoculate

32 an immunodeficiency virus of rhesus macaque, sooty mangabey, and HIV-2 (SIVsmm/SIVmac/HIV-2) lineage

33 s macaques, 5 of 11 pigtail macaques, 2 of 4 sooty mangabeys, and 0 of 1 chimpanzee.

34 -specific CTL activity in SIVmac239-infected sooty mangabeys, and high viral loads with generally wea

35 nction with studies of SIVsmm, which infects sooty mangabeys, and SIVagmVer, which infects vervet mon

36 Sooty mangabeys are a natural host of simian immunodefic

37 Host immune responses to SIV infection in sooty mangabeys are likely to be an important determinan

38 uses, SIVcpz from chimpanzees and SIVsm from sooty mangabeys, are the cause of acquired immunodeficie

39 ontributes to the lack of immunopathology in sooty mangabeys as opposed to species with pathogenic le

40 s showed that while the viruses of all eight sooty mangabeys belonged to the SIVsm/HIV-2 family, each

41 Sooty mangabeys bred to homozygosity for the deletion al

42 tation in CD4 domain 1, present in human and sooty mangabey CD4 orthologs, largely restored rhCD4-Ig

43 e we found that, after in vitro stimulation, sooty mangabey CD4(+) T cells fail to upregulate CCR5 an

44 ese data suggest that low CCR5 expression on sooty mangabey CD4(+) T cells favors the preservation of

45 Sooty mangabey CD4(+) T(CM) cells that express low amoun

46 of HIV-2 has been clearly identified as the sooty mangabey (Cercocebus atys), the origin of HIV-1 re

47 n of natural hosts of SIV infection, such as sooty mangabeys (Cercocebus atys), which typically do no

48 iruses (SIVs) that are natural infections of sooty mangabeys (Cercocebus torquatus atys).

49 raction of CD4(+)CCR5(+) T cells is lower in sooty mangabeys compared to humans and macaques.

50 The sooty mangabey-derived simian immunodeficiency virus (SI

51 nd simian T-cell lymphotropic virus-infected sooty mangabey (designated FGb) to rhesus and pig-tailed

52 In two SIVs from sooty mangabeys discovered about 100 miles (ca. 161 Km)

53 These studies indicate that SIV-infected sooty mangabeys do not appear to rely entirely on CD4(+)

54 simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to AIDS despite high-lev

55 st, natural reservoir hosts for SIV, such as sooty mangabeys, do not progress to AIDS and show a lack

56 cute, SIV-induced CD4(+) T cell depletion in sooty mangabeys does not result in immune dysfunction an

57 Moreover, all CD4-low sooty mangabeys elicited a de novo immune response follo

58 Rhesus macaques and sooty mangabeys express orthologues of HLA-A, -B, and -E

59 Nonetheless, all sooty mangabeys generated SIV-specific antibody and T ce

60 rural Sierra Leone, where both feral and pet sooty mangabeys harbor divergent members of the human im

61 Some sooty mangabeys harbored near-identical viruses (<2% int

62 Here we show that sooty mangabeys have substantially reduced levels of inn

63 To understand how natural sooty mangabey hosts avoid AIDS despite high levels of s

64 ion and immunopathology is absent in natural sooty mangabey hosts.

65 hogenic and macrophages can be infected, and sooty mangabeys, i.e., natural SIV hosts in which the in

66 with SIV through cross-species transfer from sooty mangabeys in captivity.

67 community of approximately 120 free-ranging sooty mangabeys in the Tai Forest, Cote d'Ivoire.

68 similarly uncoupled from CCR5 expression in sooty mangabeys in vivo during acute SIV infection and t

69 in contrast to apathogenic SIV infection in sooty mangabeys in which levels of immune activation, TG

70 To test this hypothesis, SIVs from eight sooty mangabeys, including six new viruses from West Afr

71 he absence of AIDS in naturally SIV-infected sooty mangabeys is independent of a strong cellular immu

72 wo patterns of asymptomatic SIV infection in sooty mangabeys: low viral loads with vigorous SIV-speci

73 Here we show that in sooty mangabey lymphocytes, infection is mediated by the

74 HIV-infected patients; and (6) SIV-infected sooty mangabeys maintain healthy frequencies of Th17 cel

75 These natural hosts of SIV, like sooty mangabeys, maintain high levels of SIV replication

76 rthermore, in nonpathogenic SIV infection of sooty mangabeys, microbial translocation did not seem to

77 pines, as well as from wild armadillos and a sooty mangabey monkey.

78 f CCR5, with an allele frequency of 0.04, in sooty mangabey monkeys (Cercocebus torquatus atys), a na

79 phages by simian immunodeficiency virus from sooty mangabey monkeys (SIV(SM)).

80 nd SIVmac, which both originated from SIV of sooty mangabey monkeys (SIVsmm), suggesting that the A3G

81 Many strains of SIV from sooty mangabey monkeys are susceptible to resistance by

82 In contrast, sooty mangabey monkeys that represent natural hosts for

83 of simian immunodeficiency virus (SIV) from sooty mangabey monkeys to humans.

84 The SIV(+) sooty mangabey natural hosts, which do not proceed to cl

85 Sooty mangabeys naturally infected with simian immunodef

86 Sooty mangabeys naturally infected with simian immunodef

87 ven SIV CTL epitopes were identified in five sooty mangabeys: one in Gag and three each in Nef and En

88 an immunodeficiency virus (SIV) infection in sooty mangabeys or chimpanzees does not exhibit these ha

89 solates used in the macaque model evolved in sooty mangabeys over millennia.

90 ing acute and chronic SIV infection and that sooty mangabey plasmacytoid dendritic cells (pDCs) produ

91 human infections in the eastern part of the sooty mangabey range.

92 mmunodeficiency viruses from chimpanzees and sooty mangabeys, respectively, and Vifs from these virus

93 SIVmac239 infection of sooty mangabeys resulted in 2- to 4-log-lower viral load

94 IV infection of natural host species such as sooty mangabeys results in high viral replication withou

95 revealed its similarity to SIV isolates from sooty mangabeys, significant amino acid differences in E

96 human immunodeficiency virus type 2 (HIV-2)-sooty mangabey simian immunodeficiency virus (SIVsm) fam

97 aged and uncultured human (HIV-1 and HIV-2), sooty mangabey (simian immunodeficiency virus SIV(SM)),

98 om five SIV isolates from rhesus macaques or sooty mangabeys (SIVmac/sm) and four HIV-2 isolates.

99 n immunodeficiency virus (SIV) isolated from sooty mangabey (SIVsm [n = 6]), stumptail (SIVstm [n = 1

100 tion with simian immunodeficiency virus from sooty mangabey (SIVsm) to evaluate the effect of TRIM5al

101 uses of the simian immunodeficiency virus of sooty mangabey (SIVsm)-HIV-2 lineage, SAMHD1 is countera

102 related simian immunodeficiency viruses from sooty mangabeys (SIVsm) and macaques (SIVmac) comprise a

103 orted that the TRIM5alpha-sensitive SIV from sooty mangabeys (SIVsm) clone SIVsmE543-3 acquired amino

104 Comparison with Vpx from SIV that infects sooty mangabeys (SIVsmm) complexed with SAMHD1-DCAF1 ide

105 Simian immunodeficiency virus of sooty mangabeys (SIVsmm) is recognized as the progenitor

106 imited set of related viruses originating in sooty mangabeys (SIVsmm).

107 The sooty mangabey (SM) (Cercocebus atys) is the natural hos

108 demiology was performed on samples from four sooty mangabey (SM) colonies in the United States to cha

109 Despite high viral loads, T cells from sooty mangabey (SM) monkeys that are naturally infected

110 (SIV) infection in disease-resistant African sooty mangabeys (SM) and disease-susceptible Asian rhesu

111 V-infected African natural hosts such as the sooty mangabeys (SM) are resistant to disease.

112 African green monkeys (AGM) and sooty mangabeys (SM) are well-studied natural hosts of s

113 ency virus (SIV) infection of African-origin sooty mangabeys (SM) generally does not result in simian

114 Natural-host sooty mangabeys (SM) infected with simian immunodeficien

115 Natural host sooty mangabeys (SM) infected with simian immunodeficien

116 In contrast, naturally SIV-infected sooty mangabeys (SM) remain asymptomatic and retain immu

117 genic SIV infection in natural hosts such as sooty mangabeys (SM) remains to be defined.

118 rimentally infected rhesus macaques (RM) and sooty mangabeys (SM) with controlled or uncontrolled SIV

119 ally infected with SIV, such as chimpanzees, sooty mangabeys (SM), and African green monkeys (AGM).

120 sts, such as African green monkeys (AGM) and sooty mangabeys (SM), are protected against SIV-induced

121 le RM but not SIV-infected disease-resistant sooty mangabeys (SM), denoting an association of downreg

122 In certain nonhuman primate species, such as sooty mangabeys (SM), SIV infection does not lead to AID

123 sts, such as African green monkeys (AGM) and sooty mangabeys (SM).

124 ques (RM) and nonpathogenic SIV infection of sooty mangabeys (SM).

125 ssue that had been serially passaged in four sooty mangabeys (SMs) (Cercocebus atys).

126 eviously shown that chronic SIV infection in sooty mangabeys (SMs) and African green monkeys (AGMs) i

127 iency virus (SIV) SIV(smm) naturally infects sooty mangabeys (SMs) and is the source virus of pathoge

128 Simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) do not develop AIDS despite high l

129 fferentiating nonpathogenic SIV infection of sooty mangabeys (SMs) from pathogenic HIV/SIV infections

130 Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic

131 Sooty mangabeys (SMs) naturally infected with simian imm

132 Naturally SIV-infected sooty mangabeys (SMs) remain asymptomatic despite high v

133 simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despi

134 an immunodeficiency virus (SIV) infection of sooty mangabeys (SMs) that typically is nonpathogenic de

135 an immunodeficiency virus (SIV) infection in sooty mangabeys (SMs) typically does not result in AIDS,

136 HIV-infected humans, naturally SIV-infected sooty mangabeys (SMs) very rarely progress to AIDS.

137 The Delta24 frequency was 4.1% in 34 sooty mangabeys (SMs), a geographically isolated subspec

138 n of rhesus macaques (RMs), SIV infection of sooty mangabeys (SMs), a natural host African monkey spe

139 CD4(+) TCM cells of sooty mangabeys (SMs), a natural host for SIV in which i

140 we show that nonpathogenic SIV infection of sooty mangabeys (SMs), a natural host species for SIV, i

141 SIV infection of sooty mangabeys (SMs), a natural host species, does not

142 derlying the absence of AIDS in SIV-infected sooty mangabeys (SMs), a natural host species, we perfor

143 humans and rhesus macaques (RMs) but not in sooty mangabeys (SMs), a natural host, remains unclear.

144 Sooty mangabeys (SMs), a reservoir host for SIV, do not

145 zed by progression to AIDS, and natural host sooty mangabeys (SMs), a species which remains AIDS free

146 cribed in studies conducted predominantly in sooty mangabeys (SMs), African green monkeys (AGMs), and

147 cribed in studies conducted predominantly in sooty mangabeys (SMs), African green monkeys (AGMs), and

148 ) infection of natural-host species, such as sooty mangabeys (SMs), is characterized by a high level

149 trast, during nonpathogenic SIV infection of sooty mangabeys (SMs), neither spontaneous nor experimen

150 s), HIV-infected humans, and SIVsmm-infected sooty mangabeys (SMs).

151 n primate species, rhesus macaques (RMs) and sooty mangabeys (SMs).

152 rous studies have reported that SIV-infected sooty mangabeys (SMs; Cercocebus atys) remain disease fr

153 iciency viruses (SIVs) that naturally infect sooty mangabeys (SMs; Cercocebus atys).

154 al Primate Research Center (TNPRC) colony of sooty mangabeys (SMs; Cercocebus atys).

155 (rhesus macaques [RMs]) and nonprogressive (sooty mangabeys [SMs]) SIV infection.

156 lular immune responses in naturally infected sooty mangabeys suggests that immune attenuation is neit

157 evolution of CCR5-null alleles in humans and sooty mangabeys suggests that similar negative selection

158 Natural hosts of SIV, such as sooty mangabeys, sustain high viral loads but do not dev

159 l T- and B-lymphocyte counts in SIV-infected sooty mangabeys than in SIV-negative mangabeys, the turn

160 However, sooty mangabeys that are genetically deficient in CCR5 d

161 Further, studies in sooty mangabeys that do not progress to simian AIDS and

162 m peripheral blood samples from patients and sooty mangabeys that exhibited either a CD4-healthy (>20

163 d humans but not in chronically SIV-infected sooty mangabeys that show low levels of immune activatio

164 Sooty mangabeys, the natural host of simian immunodefici

165 te the basis of apathogenic SIV infection in sooty mangabeys, three sooty mangabeys and three rhesus

166 ion, the turnover of CD4(+) T lymphocytes in sooty mangabeys was significantly higher (P < 0.01) than

167 Sooty mangabeys were observed to have higher percentages

168 ing of why SIV infection is nonpathogenic in sooty mangabeys while it is pathogenic in macaques, and

169 Passaging plasma from an SIV-infected sooty mangabey with very few CD4(+) T cells to SIV-negat

170 HIV-infected humans but not in SIV-infected sooty mangabeys with high viremia, suggesting a direct r

171 also contains free-living and household pet sooty mangabeys with highly divergent variants of SIVsm.

172 esponses were investigated in a cohort of 25 sooty mangabeys with natural SIV infection.