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1 at neutrophil functions are more complex and sophisticated.
2 techniques, both of which are expensive and sophisticated.
3 gies include prioritizing alerts, developing sophisticated alerts, customizing commercially available
4 high-resolution labeling data requires more sophisticated algorithms than typically employed: the co
7 is envisaged to have broad applicability to sophisticated analyses of pancreatic islet cells that re
8 adaption to personal and security needs, and sophisticated analyses that are independent of command-l
9 (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants wh
10 harper Bragg peaks, which in turn allow more sophisticated analysis of mechanochemical processes, ext
11 limitation and led to the generation of more sophisticated and accurate preclinical models of human c
12 are now thought of as one of the cell's most sophisticated and dynamic responsive sensing systems.
13 sembly of V2O5 nanofibres, features a highly sophisticated and elaborate architecture of equally spac
14 rchlorate in foods, nowadays only allowed by sophisticated and expensive equipment and laborious meth
16 nipulations provide unique opportunities for sophisticated and high-throughput biological assays such
19 further evidence for the establishment of a sophisticated and specifically adapted nucleotide transp
20 at by the second year of life, children make sophisticated and subtle distinctions among a wide range
22 f RNA-based genetic circuitry that allow for sophisticated and temporal control of gene expression.
24 rms range from the widely used ELISA to more sophisticated, and more expensive, approaches such as di
25 s of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular me
26 By 2450 BCE, the Egyptians had developed sophisticated apiculture, and, within two millennia, bee
27 lipid phase separations, which leads to more sophisticated applications in biosensors and as cell cul
28 xpected to spur the development of even more sophisticated applications of this technology for HIV th
30 only to deal with land-cover change to more sophisticated approaches that allow also for the partial
36 her crustacean taxon, mantis shrimps display sophisticated behaviors relating to predation, spatial m
38 d ncRNA classes with properties that suggest sophisticated biochemical functions and a multitude of p
39 d with other patient data and are mined with sophisticated bioinformatics tools to develop models tha
40 derstanding of how genetic networks regulate sophisticated biological phenotypes, to generate novel t
41 ural transformation, which is reminiscent of sophisticated biological systems such as allosteric enzy
42 g and engineering capabilities develop, more sophisticated biomedical materials can be synthesized th
44 nated in conjunction with the development of sophisticated biosafety level 4 laboratories at the US A
46 y for novel therapeutic approaches requiring sophisticated carriers for intracellular delivery of act
48 is work will inspire the design of even more sophisticated catalysts, such that catalyst-controlled C
52 ough microfluidic channels, and thus enables sophisticated cell manipulations in a passive manner.
53 As such, pathogenic bacteria have evolved sophisticated cell surface signaling and transport syste
55 lavefaciens to recruit hemicellulases to the sophisticated cellulosomes acting in the gastrointestina
58 iting is particularly common in behaviorally sophisticated coleoid cephalopods, with tens of thousand
62 vely parallel single-cell RNA sequencing and sophisticated computational methods are catalyzing a rev
64 reconstruction, however, currently relies on sophisticated computational procedures, susceptible to r
66 tions of flying animals are isotropic, since sophisticated computer models are required to estimate t
70 nsive archaeological findings point to first sophisticated Cu metallurgy during the Moche culture 20
71 lytical window and have enabled increasingly sophisticated data processing strategies, indicating a b
75 nisms routinely assemble such materials with sophisticated designs and advanced functional properties
77 should enable flexibility in design of more sophisticated devices based on 2D materials.Strain engin
78 r architectures could serve as platforms for sophisticated devices that co-ordinate the activity of n
79 d versatile, enabling pinpoint deployment of sophisticated diagnostics to distributed field sites.
82 nalogy, we subsume these essential and often sophisticated driven processes under the term machinery
83 cedented potentials for real-time, fast, and sophisticated electromagnetic wave manipulation such as
84 on in C4 plants is now needed to inform more sophisticated engineering attempts to alter leaf anatomy
85 rspecies discrepancies, nuisance inhibition, sophisticated enzyme assays, and limited structural info
86 annot be reprogrammed at will or rely on the sophisticated enzyme chemistry underlying the central do
87 as elimination of labeled antigen, need for sophisticated equipment and highly trained individuals.
88 rently in use are time-consuming and require sophisticated equipment or highly-trained personnel.
89 y does not use complicated nanostructures or sophisticated equipment, so it has potential application
90 sing conventional methods without the use of sophisticated equipments and its application as a potent
91 t yet extended at point-of-care (POC) due to sophisticated equipments, need of high expertize, compli
94 inth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation o
95 However, current state of the art requires sophisticated ex vivo gene transfer in a dedicated Good
99 of dynamic heterogeneities typically require sophisticated experimental set-ups and are performed by
102 g a low cost, lack of external power sources/sophisticated external transducers, and the capacity to
104 bivalve with well-developed adductor muscle, sophisticated eyes, and remarkable neurotoxin resistance
105 highlighted that the nervous system performs sophisticated feedback control over very short time scal
109 bility in reaction time were examined, and a sophisticated fMRI analytic approach was used to quantif
110 ering mechanisms of muscle weakness requires sophisticated force protocols, dissecting contributions
111 onstrate that the mollusc Lymnaea performs a sophisticated form of decision-making during food-search
114 es a generation of optical coatings in which sophisticated functionality is realized at the level of
115 evelopment using high-resolution imaging and sophisticated genetic and experimental manipulation.
117 /Cas9 technology to demonstrate a variety of sophisticated genetic modifications via gene targeting i
118 od and annotated genome sequence will permit sophisticated genetic studies on stem cells and regenera
119 f the heteromers in situ in combination with sophisticated genetically modified animal models, togeth
121 id scientific basis, the development of more sophisticated hierarchies of evidence, the recognition o
123 he virus to preserve its host, balanced with sophisticated host immune mechanisms that maintain viral
124 applications, metasurface stacks can perform sophisticated image corrections and can be directly inte
125 formation remains challenging, and relies on sophisticated image processing, in particular for templa
126 n, with improvements in and increased use of sophisticated imaging modalities, have led to early diag
127 n is well-recognized, but only recently have sophisticated imaging techniques begun to reveal their u
129 ould-be pathogens and pests, and thus have a sophisticated immune system to ward off these threats, w
132 age are now commonplace, but mitigating more sophisticated impacts associated with the ecological fun
133 are currently amenable typically through the sophisticated instrument based analyses confined mostly
135 he time-consuming nature and/or the need for sophisticated instrumentation of those methods limit the
136 nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclea
137 n reaction (PCR) because they do not require sophisticated instruments needed for thermal cycling of
140 esearch in the last few years has revealed a sophisticated interaction network between multiple bone
143 f the infected epithelial cell, suggesting a sophisticated interplay between host cell metabolism and
144 These intracellular pathogens have evolved a sophisticated invasion strategy that relies on delivery
146 mic partnership to train new candidates with sophisticated knowledge of contemporary drug design conc
147 storage, validation, and often the need for sophisticated laboratory and bioinformatics approaches.
148 istance genotyping, plasma analysis requires sophisticated laboratory equipment, personnel, space, an
150 ally time- and resource-consuming, requiring sophisticated lensing codes, several data preparation st
152 een focused on specific systems, and rely on sophisticated lithography and seeding techniques, making
154 ical locomotion, from which more complex and sophisticated locomotion modes involving outgrowths such
157 cumulate molecular data quickly and to apply sophisticated machine-learning algorithms, building gene
159 acteriophages and large dsDNA viruses encode sophisticated machinery to translocate their DNA into a
163 ible and will facilitate the construction of sophisticated materials and devices with sizes similar t
164 ary switching behavior provides a unique and sophisticated mechanism for optical anion sensing in com
165 control in human cells and sheds light on a sophisticated mechanism of nucleolar homeostasis surveil
166 epithelial stem cell dynamics constitutes a sophisticated mechanism that orchestrates epithelial reg
167 e mating type, highlights the existence of a sophisticated mechanism to increase chances of mate find
170 e organisms, terrestrial plants have evolved sophisticated mechanisms to coordinate the growth and de
172 ts are often limiting, plants have developed sophisticated mechanisms to ensure adequate supply of nu
177 ore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence
179 samples using LC-MS techniques, even though sophisticated methodologies have been employed which sho
181 Although reliability estimates with highly sophisticated methodology were provided for 23 mental di
183 ing is compatible with a range of other more sophisticated methods to estimate the human contribution
185 developed, obtaining several novel and more sophisticated methods, which are also included in the co
187 rophil biostabilization was explored using a sophisticated microfluidic assay to examine the effectiv
189 nabled the realization of highly complex and sophisticated miniaturized platforms for several importa
191 idence encouraging the development of a more sophisticated model that considers a network of individu
193 accuracy comparable to the uncertainties of sophisticated models but about ten million times faster:
194 tudy shows how MaxEnt can be used to develop sophisticated models of past cultural processes, includi
195 inhibit functional RNAs, could have preceded sophisticated modern RNA regulatory mechanisms, such as
198 are promising candidates for the creation of sophisticated molecular machines and smart soft material
199 t for understanding the emergent behavior of sophisticated molecular systems having multiple and para
200 The knockout mouse model in combination with sophisticated molecular techniques confirmed our physiol
202 encouraged the development of newer and more sophisticated mouse models for cancer research, but we b
209 ructures provide a feasible platform without sophisticated optical instrumentation to realize label-f
211 lts provide compelling evidence for a highly sophisticated organization of the sympathetic nervous sy
212 t that development of the ability to perform sophisticated other-regarding social inference is associ
213 trategies to induce spatially and temporally sophisticated perturbation of network microcircuits.
216 linical validation of such emerging targets, sophisticated preclinical model systems, and the molecul
218 rance by ER-associated degradation (ERAD), a sophisticated process that mediates the ubiquitin-depend
220 naturally transformable species, has evolved sophisticated protein machinery for the binding and upta
223 Li bond chemistry in Li-S batteries through sophisticated quantum chemical calculations, in combinat
224 ys-from simple text and sequence searches to sophisticated queries that apply 3D structural constrain
225 ponses should be carefully monitored by both sophisticated radiologic and pathologic evaluations.
226 adaptations present in infancy that support sophisticated reasoning about perceptual properties of f
228 sets from raw reads by highlighting several sophisticated reference-based methods representing the c
230 nd Decision Tree, were employed to study the sophisticated relationship between influential factors a
231 echniques can bring many benefits, including sophisticated reliability measures, improved construct v
233 new knowledge, better family data, and more sophisticated risk prediction models, allowing for more
234 ng cell types and differentiation fates, and sophisticated robustness assessments, as in the case of
235 ggests that dopaminergic neurons play a more sophisticated role in predicting rewards than previously
236 ased systems to function in broader and more sophisticated roles beyond cargo transport and imaging.
237 ingly acknowledged as having fundamental and sophisticated roles in brain function and dysfunction.
239 s on-chip detection simplifies GP imaging as sophisticated s-SNOM detection schemes can be avoided.
242 ing properties of GS reveal this enzyme as a sophisticated sensor of the nitrogen and energy state of
243 ased on the reality of "clutter" and lack of sophisticated separation/discrimination mechanisms in a
245 bel-free kinetic assays; however, costly and sophisticated setups are required, decreasing its access
247 er for ADCs to deliver their full potential, sophisticated site-specific conjugation technologies to
250 tions that require microscale actuation with sophisticated spatiotemporal coordination for advanced m
252 nd cheaper computing power, and increasingly sophisticated statistical models combine to enable machi
257 nfected individuals.IMPORTANCE HIV-1 evolved sophisticated strategies to conceal Env epitopes from AD
260 then reacted with thiol derivatives to yield sophisticated structures comprising photo- and/or electr
262 rior genomic resources, enables increasingly sophisticated studies of the genomic basis of evolution,
264 e function and networks, but also to perform sophisticated synthetic biology to develop innovative en
265 s (NPs) and their assemblies and expanded to sophisticated synthetic protocols involving nanostructur
268 within a narrow concentration range requires sophisticated systems to sense, regulate, and transport
270 C/D and H/ACA box snoRNAs; developing a more sophisticated technique in the SVM training phase with r
271 ur work suggests that animals might use more sophisticated techniques for attacking and disrupting ri
273 ew diagnostics for UTI and the need for more sophisticated techniques in terms of selectivity and sen
275 avy treatments (such as nanoscale tailoring, sophisticated textures, or coating) to obtain long cycle
276 ion understanding in early childhood is more sophisticated than previously believed, extending well b
277 s in quantum systems, and the development of sophisticated theoretical methods for the interpretation
279 t are prone to toxicity in chronic settings, sophisticated time-lapse microscopy, or bulky/expensive
280 e, web-based tool that gives users access to sophisticated tools for analysis of RNA-Seq and other da
281 cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for
282 s a task that is highly complex and requires sophisticated tools to describe processes, inputs, and m
283 ncing and analyses will provide increasingly sophisticated tools to interrogate human-associated micr
284 A new study by Fairn and colleagues uses sophisticated tools to perturb specific lipids in living
285 the 2000s, as increasing resources and more sophisticated tools were devoted to understanding the mi
286 aling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrat
291 xibility of the 140s loop and illustrate the sophisticated variety of biochemical mechanisms employed
294 ovided strong selection for the evolution of sophisticated virus-encoded anti-CRISPR mechanisms.
295 Birdsong is a prime example of acoustically sophisticated vocal behaviour, but its complexity has ev
296 ion about hydrodynamic events and enable the sophisticated wake-tracking abilities of these animals.
298 and pathogen have coevolved, each acquiring sophisticated ways of inducing or protecting from diseas
299 black surfaces have evolved and become more sophisticated with time, carbon still remains one of the
300 integration of disparate software tools into sophisticated workflows, challenging its adoption by non
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