ライフサイエンスコーパス: sophisticated

1 at neutrophil functions are more complex and sophisticated.

2 techniques, both of which are expensive and sophisticated.

3 gies include prioritizing alerts, developing sophisticated alerts, customizing commercially available

4 high-resolution labeling data requires more sophisticated algorithms than typically employed: the co

5 analysis requires the application of highly sophisticated algorithms.

6 Yet, such sophisticated analyses are fraught with interpretive dif

7 is envisaged to have broad applicability to sophisticated analyses of pancreatic islet cells that re

8 adaption to personal and security needs, and sophisticated analyses that are independent of command-l

9 (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants wh

10 harper Bragg peaks, which in turn allow more sophisticated analysis of mechanochemical processes, ext

11 limitation and led to the generation of more sophisticated and accurate preclinical models of human c

12 are now thought of as one of the cell's most sophisticated and dynamic responsive sensing systems.

13 sembly of V2O5 nanofibres, features a highly sophisticated and elaborate architecture of equally spac

14 rchlorate in foods, nowadays only allowed by sophisticated and expensive equipment and laborious meth

15 ectric substrate without the requirement for sophisticated and expensive equipment.

16 nipulations provide unique opportunities for sophisticated and high-throughput biological assays such

17 Sophisticated and interactive visualizations are essenti

18 However, complex, sophisticated and multifunctional ER-PM junctions, capab

19 further evidence for the establishment of a sophisticated and specifically adapted nucleotide transp

20 at by the second year of life, children make sophisticated and subtle distinctions among a wide range

21 More sophisticated and targeted clinical trials utilizing suc

22 f RNA-based genetic circuitry that allow for sophisticated and temporal control of gene expression.

23 ether, cellular ubiquitination events form a sophisticated and versatile ubiquitin code.

24 rms range from the widely used ELISA to more sophisticated, and more expensive, approaches such as di

25 s of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular me

26 By 2450 BCE, the Egyptians had developed sophisticated apiculture, and, within two millennia, bee

27 lipid phase separations, which leads to more sophisticated applications in biosensors and as cell cul

28 xpected to spur the development of even more sophisticated applications of this technology for HIV th

29 The greater ambition and more sophisticated approach in combined intervention arms res

30 only to deal with land-cover change to more sophisticated approaches that allow also for the partial

31 These structures are the most sophisticated architectures made via programmable assemb

32 ons to integration of dynamic modulation and sophisticated architectures.

33 igence systems: the need to design effective sophisticated architectures.

34 For that purpose, sophisticated automated hematology analyzers, microscopy

35 her crustacean taxon, mantis shrimps display sophisticated behaviors relating to predation, spatial m

36 mit of detection of 10ng/mL, comparable to a sophisticated benchtop instrument.

37 d ncRNA classes with properties that suggest sophisticated biochemical functions and a multitude of p

38 d with other patient data and are mined with sophisticated bioinformatics tools to develop models tha

39 derstanding of how genetic networks regulate sophisticated biological phenotypes, to generate novel t

40 ural transformation, which is reminiscent of sophisticated biological systems such as allosteric enzy

41 g and engineering capabilities develop, more sophisticated biomedical materials can be synthesized th

42 by structured monochromatic light to perform sophisticated biomimetic motions.

43 nated in conjunction with the development of sophisticated biosafety level 4 laboratories at the US A

44 We have used sophisticated but accessible statistical methods to reve

45 y for novel therapeutic approaches requiring sophisticated carriers for intracellular delivery of act

46 These sophisticated catalysts are rarely employed by chemists,

47 is work will inspire the design of even more sophisticated catalysts, such that catalyst-controlled C

48 The emergence of such a sophisticated catalytic centre shows that there is nothi

49 In nature, proteins have evolved sophisticated cavities tailored for capturing target gue

50 e complex cell functions and for programming sophisticated cell behaviors.

51 ough microfluidic channels, and thus enables sophisticated cell manipulations in a passive manner.

52 As such, pathogenic bacteria have evolved sophisticated cell surface signaling and transport syste

53 BLADE enables execution of sophisticated cellular computation in mammalian cells, w

54 lavefaciens to recruit hemicellulases to the sophisticated cellulosomes acting in the gastrointestina

55 ills are already in place and do not require sophisticated cognition.

56 us glandarius), a bird species known for its sophisticated cognitive abilities.

57 iting is particularly common in behaviorally sophisticated coleoid cephalopods, with tens of thousand

58 urface chemistries enabling the formation of sophisticated colloidal molecules.

59 The sophisticated colors of medieval glasses arise from thei

60 a wide range of desirable tasks that require sophisticated computation and control.

61 vely parallel single-cell RNA sequencing and sophisticated computational methods are catalyzing a rev

62 benchmark data and the development of highly sophisticated computational methods is highlighted.

63 reconstruction, however, currently relies on sophisticated computational procedures, susceptible to r

64 ut single-cell data is a challenge requiring sophisticated computational tools.

65 tions of flying animals are isotropic, since sophisticated computer models are required to estimate t

66 Nature employs sophisticated control of a structure's properties at mul

67 The sophisticated control of surface wettability for target-

68 The more recent application of sophisticated cooling techniques to molecules, which has

69 nsive archaeological findings point to first sophisticated Cu metallurgy during the Moche culture 20

70 lytical window and have enabled increasingly sophisticated data processing strategies, indicating a b

71 etworks that enable living organisms to make sophisticated decisions.

72 A sophisticated demographic method of estimating Ne /N, wh

73 red also provide necessary information for a sophisticated design of relevant devices.

74 nisms routinely assemble such materials with sophisticated designs and advanced functional properties

75 on of beta-LG without using any labelling or sophisticated designs.

76 should enable flexibility in design of more sophisticated devices based on 2D materials.Strain engin

77 r architectures could serve as platforms for sophisticated devices that co-ordinate the activity of n

78 d versatile, enabling pinpoint deployment of sophisticated diagnostics to distributed field sites.

79 Sophisticated diagnostics, including molecular imaging a

80 atural genetic circuits enable cells to make sophisticated digital decisions.

81 nalogy, we subsume these essential and often sophisticated driven processes under the term machinery

82 cedented potentials for real-time, fast, and sophisticated electromagnetic wave manipulation such as

83 on in C4 plants is now needed to inform more sophisticated engineering attempts to alter leaf anatomy

84 rspecies discrepancies, nuisance inhibition, sophisticated enzyme assays, and limited structural info

85 annot be reprogrammed at will or rely on the sophisticated enzyme chemistry underlying the central do

86 as elimination of labeled antigen, need for sophisticated equipment and highly trained individuals.

87 rently in use are time-consuming and require sophisticated equipment or highly-trained personnel.

88 y does not use complicated nanostructures or sophisticated equipment, so it has potential application

89 sing conventional methods without the use of sophisticated equipments and its application as a potent

90 t yet extended at point-of-care (POC) due to sophisticated equipments, need of high expertize, compli

91 thought to be only useful in much larger and sophisticated eukaryotic cells.

92 t of effective vaccines to combat the highly sophisticated evasion mechanisms of pathogens.

93 inth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation o

94 However, current state of the art requires sophisticated ex vivo gene transfer in a dedicated Good

95 As sophisticated exercise equipment is unnecessary for this

96 However, such methods typically require sophisticated experimental apparatus or X-ray beams with

97 The development of sophisticated experimental means to control nanoscale sy

98 of dynamic heterogeneities typically require sophisticated experimental set-ups and are performed by

99 Sophisticated experiments under controlled conditions an

100 These methods have allowed for sophisticated explorations on the cellular and molecular

101 g a low cost, lack of external power sources/sophisticated external transducers, and the capacity to

102 This shows that sophisticated eyes already existed at the beginning of t

103 bivalve with well-developed adductor muscle, sophisticated eyes, and remarkable neurotoxin resistance

104 highlighted that the nervous system performs sophisticated feedback control over very short time scal

105 lant developmental biology into the dynamic, sophisticated field that it is today.

106 Glomeruli are highly sophisticated filters and glomerular disease is the lead

107 enables and drives the development of novel, sophisticated fluorescent dyes.

108 bility in reaction time were examined, and a sophisticated fMRI analytic approach was used to quantif

109 ering mechanisms of muscle weakness requires sophisticated force protocols, dissecting contributions

110 onstrate that the mollusc Lymnaea performs a sophisticated form of decision-making during food-search

111 d nucleoprotein motors may enable additional sophisticated functionalities.

112 State machines underlie the sophisticated functionality behind human-made and natura

113 es a generation of optical coatings in which sophisticated functionality is realized at the level of

114 iety of hierarchical structures that produce sophisticated functions.

115 evelopment using high-resolution imaging and sophisticated genetic and experimental manipulation.

116 Our findings indicate that sophisticated genetic mechanisms are involved in cyanoba

117 /Cas9 technology to demonstrate a variety of sophisticated genetic modifications via gene targeting i

118 od and annotated genome sequence will permit sophisticated genetic studies on stem cells and regenera

119 f the heteromers in situ in combination with sophisticated genetically modified animal models, togeth

120 ved, creating opportunities to engineer more sophisticated hierarchical materials.

121 id scientific basis, the development of more sophisticated hierarchies of evidence, the recognition o

122 In this review we describe the sophisticated homeostatic mechanisms by which fungi acqu

123 he virus to preserve its host, balanced with sophisticated host immune mechanisms that maintain viral

124 applications, metasurface stacks can perform sophisticated image corrections and can be directly inte

125 formation remains challenging, and relies on sophisticated image processing, in particular for templa

126 n, with improvements in and increased use of sophisticated imaging modalities, have led to early diag

127 n is well-recognized, but only recently have sophisticated imaging techniques begun to reveal their u

128 Despite various sophisticated imaging techniques, there are numerous pit

129 ould-be pathogens and pests, and thus have a sophisticated immune system to ward off these threats, w

130 Plants fine-tune their sophisticated immunity systems in response to pathogen i

131 While increasingly sophisticated immunotherapy targeting soluble and aggreg

132 age are now commonplace, but mitigating more sophisticated impacts associated with the ecological fun

133 are currently amenable typically through the sophisticated instrument based analyses confined mostly

134 detection of uric acid without involving any sophisticated instrument or trained personnel.

135 he time-consuming nature and/or the need for sophisticated instrumentation of those methods limit the

136 nuclear spin polarizations and the need for sophisticated instrumentation render conventional nuclea

137 n reaction (PCR) because they do not require sophisticated instruments needed for thermal cycling of

138 site detection of caffeine without involving sophisticated instruments or trained technicians.

139 More sophisticated, integrative methods have been described,

140 esearch in the last few years has revealed a sophisticated interaction network between multiple bone

141 These advances are illuminating sophisticated interactions between human-associated micr

142 These requirements lead to quite sophisticated interfacial design, often with molecular l

143 f the infected epithelial cell, suggesting a sophisticated interplay between host cell metabolism and

144 These intracellular pathogens have evolved a sophisticated invasion strategy that relies on delivery

145 eforms was developed with three increasingly sophisticated isolation methods.

146 mic partnership to train new candidates with sophisticated knowledge of contemporary drug design conc

147 storage, validation, and often the need for sophisticated laboratory and bioinformatics approaches.

148 istance genotyping, plasma analysis requires sophisticated laboratory equipment, personnel, space, an

149 Sophisticated laboratory grade tools such as ion selecti

150 ally time- and resource-consuming, requiring sophisticated lensing codes, several data preparation st

151 mpact geometries, with active components and sophisticated levels of functionality.

152 een focused on specific systems, and rely on sophisticated lithography and seeding techniques, making

153 Complex cognitive processes require sophisticated local processing but also interactions bet

154 ical locomotion, from which more complex and sophisticated locomotion modes involving outgrowths such

155 architectures, high-voltage operations, and sophisticated low-noise measurements.

156 We have now reconstituted this sophisticated machine with purified proteins, beginning

157 cumulate molecular data quickly and to apply sophisticated machine-learning algorithms, building gene

158 Salmonella have developed a sophisticated machinery to evade immune clearance and pr

159 acteriophages and large dsDNA viruses encode sophisticated machinery to translocate their DNA into a

160 h uses a counterselectable marker and allows sophisticated markerless gene editing in situ.

161 Typically, sophisticated mass spectrometry (MS)-based techniques ar

162 rids, where they have been associated with a sophisticated masticatory apparatus.

163 ible and will facilitate the construction of sophisticated materials and devices with sizes similar t

164 ary switching behavior provides a unique and sophisticated mechanism for optical anion sensing in com

165 control in human cells and sheds light on a sophisticated mechanism of nucleolar homeostasis surveil

166 epithelial stem cell dynamics constitutes a sophisticated mechanism that orchestrates epithelial reg

167 e mating type, highlights the existence of a sophisticated mechanism to increase chances of mate find

168 Plants have evolved sophisticated mechanisms to adapt to fluctuating environ

169 HIV-1 has evolved sophisticated mechanisms to avoid the exposure of Env AD

170 e organisms, terrestrial plants have evolved sophisticated mechanisms to coordinate the growth and de

171 Higher plants have developed sophisticated mechanisms to efficiently acquire and use

172 ts are often limiting, plants have developed sophisticated mechanisms to ensure adequate supply of nu

173 t it infects, indicating that it has evolved sophisticated mechanisms to evade host immunity.

174 Plants employ sophisticated mechanisms to interact with pathogenic as

175 Bacterial pathogens have evolved sophisticated mechanisms to sense and adapt to redox str

176 and co-condensation with tantalum vapor in a sophisticated metal-atom reactor.

177 ore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence

178 The most sophisticated method to date for identifying conserved c

179 samples using LC-MS techniques, even though sophisticated methodologies have been employed which sho

180 shape is a thorny evolutionary problem, and sophisticated methodology is needed to address it.

181 Although reliability estimates with highly sophisticated methodology were provided for 23 mental di

182 Sophisticated methods have been developed to distinguish

183 ing is compatible with a range of other more sophisticated methods to estimate the human contribution

184 More sophisticated methods, such as Artificial Neural Network

185 developed, obtaining several novel and more sophisticated methods, which are also included in the co

186 preparation of the antibody solutions nor a sophisticated microarray spotter is needed.

187 rophil biostabilization was explored using a sophisticated microfluidic assay to examine the effectiv

188 Several sophisticated microfluidic devices have recently been pr

189 nabled the realization of highly complex and sophisticated miniaturized platforms for several importa

190 Moreover, using a sophisticated model of cortical neurons, it is proposed

191 idence encouraging the development of a more sophisticated model that considers a network of individu

192 Increasingly sophisticated models based on these principles will help

193 accuracy comparable to the uncertainties of sophisticated models but about ten million times faster:

194 tudy shows how MaxEnt can be used to develop sophisticated models of past cultural processes, includi

195 inhibit functional RNAs, could have preceded sophisticated modern RNA regulatory mechanisms, such as

196 Our Drosophila model will enable a sophisticated molecular genetic dissection of cold nocic

197 k of general synthetic strategies leading to sophisticated molecular hosts.

198 are promising candidates for the creation of sophisticated molecular machines and smart soft material

199 t for understanding the emergent behavior of sophisticated molecular systems having multiple and para

200 The knockout mouse model in combination with sophisticated molecular techniques confirmed our physiol

201 Plants utilize sophisticated morphological and physiological mechanisms

202 encouraged the development of newer and more sophisticated mouse models for cancer research, but we b

203 ABTRACT: Cellulosomes are sophisticated multi-enzymatic nanomachines produced by a

204 The eukaryotic kinetochore is a sophisticated multi-protein machine that segregates chro

205 These changes are coordinated by a sophisticated network of protein-protein interactions an

206 A more sophisticated Nonlinear Coupled Constitutive Model (NCCM

207 ganization of eusocial Hymenoptera relies on sophisticated olfactory communication systems.

208 lest density functional LDA, and by the most sophisticated one, SCAN+rVV10.

209 ructures provide a feasible platform without sophisticated optical instrumentation to realize label-f

210 are reported as a toolbox for the design of sophisticated optical materials.

211 lts provide compelling evidence for a highly sophisticated organization of the sympathetic nervous sy

212 t that development of the ability to perform sophisticated other-regarding social inference is associ

213 trategies to induce spatially and temporally sophisticated perturbation of network microcircuits.

214 iRNAs remains challenging and often requires sophisticated platforms.

215 into the structure-property relationships of sophisticated polymeric materials.

216 linical validation of such emerging targets, sophisticated preclinical model systems, and the molecul

217 This sophisticated process is intrinsically linked to the act

218 rance by ER-associated degradation (ERAD), a sophisticated process that mediates the ubiquitin-depend

219 Converting the algorithm into a sophisticated product that works consistently in broad,

220 naturally transformable species, has evolved sophisticated protein machinery for the binding and upta

221 by simple alkyl groups and evolved into the sophisticated ProTide system as known today.

222 their development and modification guided by sophisticated psychometric methods.

223 Li bond chemistry in Li-S batteries through sophisticated quantum chemical calculations, in combinat

224 ys-from simple text and sequence searches to sophisticated queries that apply 3D structural constrain

225 ponses should be carefully monitored by both sophisticated radiologic and pathologic evaluations.

226 adaptations present in infancy that support sophisticated reasoning about perceptual properties of f

227 In A. cerana, sophisticated recruitment communication that encodes foo

228 sets from raw reads by highlighting several sophisticated reference-based methods representing the c

229 ering to the design and construction of more sophisticated regulatory networks.

230 nd Decision Tree, were employed to study the sophisticated relationship between influential factors a

231 echniques can bring many benefits, including sophisticated reliability measures, improved construct v

232 design motifs, self-assembled from a single, sophisticated resist.

233 new knowledge, better family data, and more sophisticated risk prediction models, allowing for more

234 ng cell types and differentiation fates, and sophisticated robustness assessments, as in the case of

235 ggests that dopaminergic neurons play a more sophisticated role in predicting rewards than previously

236 ased systems to function in broader and more sophisticated roles beyond cargo transport and imaging.

237 ingly acknowledged as having fundamental and sophisticated roles in brain function and dysfunction.

238 The flagellar motor is a sophisticated rotary machine facilitating locomotion and

239 s on-chip detection simplifies GP imaging as sophisticated s-SNOM detection schemes can be avoided.

240 tional fluorescence microscopy, requiring no sophisticated sample preparation protocols.

241 Although several sophisticated SAXS/SANS programs have been developed rec

242 ing properties of GS reveal this enzyme as a sophisticated sensor of the nitrogen and energy state of

243 ased on the reality of "clutter" and lack of sophisticated separation/discrimination mechanisms in a

244 academic and industrial groups comprise more sophisticated sequences.

245 bel-free kinetic assays; however, costly and sophisticated setups are required, decreasing its access

246 Yeasts have sophisticated signaling pathways for sensing glucose, th

247 er for ADCs to deliver their full potential, sophisticated site-specific conjugation technologies to

248 l brain', a set of brain regions involved in sophisticated social inference.

249 ely sensitive sound detection by the ear and sophisticated sound analysis by the brain.

250 tions that require microscale actuation with sophisticated spatiotemporal coordination for advanced m

251 While sophisticated static experiments have probed hydrogen's

252 nd cheaper computing power, and increasingly sophisticated statistical models combine to enable machi

253 analysis in corn syrups was developed using sophisticated statistical tools by the first time.

254 Sophisticated stimuli, inspired by those used in clinica

255 ol will permit the rapid development of more sophisticated strategies for radiotherapy.

256 In prominent gut Bacteroides strains, sophisticated strategies have been evolved to achieve th

257 nfected individuals.IMPORTANCE HIV-1 evolved sophisticated strategies to conceal Env epitopes from AD

258 The results demonstrate a sophisticated structural plasticity of a human tRNA synt

259 As these sophisticated structures are often difficult to access t

260 then reacted with thiol derivatives to yield sophisticated structures comprising photo- and/or electr

261 Larger, more sophisticated studies are needed in order to determine t

262 rior genomic resources, enables increasingly sophisticated studies of the genomic basis of evolution,

263 e use of carefully designed ligands and more sophisticated synthesis protocols.

264 e function and networks, but also to perform sophisticated synthetic biology to develop innovative en

265 s (NPs) and their assemblies and expanded to sophisticated synthetic protocols involving nanostructur

266 Here, we show that flies have a sophisticated systemic RNAi-based immunity mediated by m

267 Bacterial cells have developed sophisticated systems to deal with the toxicity of metal

268 within a narrow concentration range requires sophisticated systems to sense, regulate, and transport

269 The sophisticated tail structures of DNA bacteriophages play

270 C/D and H/ACA box snoRNAs; developing a more sophisticated technique in the SVM training phase with r

271 ur work suggests that animals might use more sophisticated techniques for attacking and disrupting ri

272 In parallel, more sophisticated techniques for genetic manipulation are fa

273 ew diagnostics for UTI and the need for more sophisticated techniques in terms of selectivity and sen

274 We used a sophisticated text-mining pipeline to extract 1.15 milli

275 avy treatments (such as nanoscale tailoring, sophisticated textures, or coating) to obtain long cycle

276 ion understanding in early childhood is more sophisticated than previously believed, extending well b

277 s in quantum systems, and the development of sophisticated theoretical methods for the interpretation

278 As a result, a sophisticated time-consuming numerical approach was used

279 t are prone to toxicity in chronic settings, sophisticated time-lapse microscopy, or bulky/expensive

280 e, web-based tool that gives users access to sophisticated tools for analysis of RNA-Seq and other da

281 cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for

282 s a task that is highly complex and requires sophisticated tools to describe processes, inputs, and m

283 ncing and analyses will provide increasingly sophisticated tools to interrogate human-associated micr

284 A new study by Fairn and colleagues uses sophisticated tools to perturb specific lipids in living

285 the 2000s, as increasing resources and more sophisticated tools were devoted to understanding the mi

286 aling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrat

287 Sophisticated tricyclic and tetracyclic tetralin analogu

288 There it forms a sophisticated tubular network at the cell periphery, as

289 Despite our increasingly sophisticated understanding of mechanisms ensuring effic

290 A sophisticated understanding of sediment elevation dynami

291 xibility of the 140s loop and illustrate the sophisticated variety of biochemical mechanisms employed

292 Sophisticated video games that integrate engaging cognit

293 Microbial pathogens employ sophisticated virulence strategies to cause infections i

294 ovided strong selection for the evolution of sophisticated virus-encoded anti-CRISPR mechanisms.

295 Birdsong is a prime example of acoustically sophisticated vocal behaviour, but its complexity has ev

296 ion about hydrodynamic events and enable the sophisticated wake-tracking abilities of these animals.

297 The influence of a sophisticated water distribution system on urban develop

298 and pathogen have coevolved, each acquiring sophisticated ways of inducing or protecting from diseas

299 black surfaces have evolved and become more sophisticated with time, carbon still remains one of the

300 integration of disparate software tools into sophisticated workflows, challenging its adoption by non