ライフサイエンスコーパス: sorting nexin

1 Sorting nexin 1 (SNX1) and SNX2 are the mammalian homolo

2 Sorting nexin 1 (SNX1) and SNX2, homologues of the yeast

3 Sorting nexin 1 (SNX1) is a protein that binds to the ep

4 dopamine D5 receptor (D(5)R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor r

5 Here, we report that Hrs interacts with sorting nexin 1 (SNX1), a recently identified mammalian

6 on of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), as well as decreased mannose 6 p

7 we investigated whether PAR1 interacted with sorting nexin 1 (SNX1).

8 rotrophin receptors with retromer-associated sorting nexin 1.

9 Sorting nexins 1 (Snx1) and 2 (Snx2) are homologues of t

10 t the putative mammalian retromer components sorting nexins 1 and 2 (Snx1 and Snx2) result in embryon

11 A protein, sorting nexin-1 (SNX1), was identified in a human cell l

12 significant sequence homology with mammalian sorting nexin-1.

13 n c.212 + 1 G > T in the SNX10 gene encoding sorting nexin 10.

14 microtubule-dependent shuttle that requires sorting nexin 11 (Snx11).

15 RGS-PX1 (also known as sorting nexin 13) is a member of both the regulator of G

16 rt the identification of causal mutations in Sorting Nexin 14 (SNX14) found in seven affected individ

17 -associated splice donor site variant in the sorting nexin 14 gene (SNX14) as a strong causative cand

18 Nwk acts through a physical interaction with sorting nexin 16 (SNX16).

19 g endosomal signaling compartment containing Sorting Nexin 16 and a reduction in late endosomes conta

20 Here we show that sorting nexin 17 (Snx 17) is part of the cellular sortin

21 Sorting nexin 17 (SNX17) is a member of the family of cy

22 ified a novel intracellular adaptor protein, sorting nexin 17 (SNX17), that binds specifically to the

23 ein potentially involved in TCR transport is sorting nexin 17 (SNX17).

24 ies have demonstrated an interaction between sorting nexin 17 and the L2 capsid proteins from a varie

25 FERM-domain-containing proteins kindlin and sorting nexin 17 plays pivotal roles in integrin recycli

26 cycling pathway, in part by association with sorting nexin 17, to ensure that virus DNA bound to L2 i

27 In this study, we identify sorting nexin 18 as a novel FIP5-interacting protein and

28 Sorting Nexin 2 (SNX2), which is involved in trafficking

29 Sorting nexin 27 (SNX27) contains a PDZ domain that is p

30 Here we show that sorting nexin 27 (SNX27) functions as an adaptor that co

31 Mass spectrometry identified sorting nexin 27 (SNX27) in isolated endosomes as a PTHR

32 Sorting nexin 27 (SNX27) is a 62-kDa protein localized t

33 Sorting nexin 27 (SNX27) is a PDZ-containing protein kno

34 Here, we show that sorting nexin 27 (SNX27) is required for efficient PDZ-d

35 s regulated by the psychostimulant-sensitive sorting nexin 27 (SNX27) protein through a class I (-X-S

36 Sorting nexin 27 (SNX27), a brain-enriched PDZ domain pr

37 fies one member of the sorting nexin family, Sorting Nexin 27 (SNX27), as a critical component in thi

38 oteins and the related PX-FERM family member sorting nexin 27 (SNX27), which is mediated in part by a

39 ified a unique rodent intracellular protein, sorting nexin 27 (SNX27), which regulates the traffickin

40 The sorting nexin 27 (SNX27)-retromer complex is a major reg

41 th protein kinase C alpha 1, syntenin-1, and sorting nexin 27.

42 isoforms of the retromer-associated protein sorting nexin 3 (SNX3), including a novel isoform that b

43 ed to endosomes by the small GTPase Rab7 and sorting nexin 3.

44 and have identified essential roles for the sorting nexin 4 (SNX4)-mediated, signal-independent path

45 e discovery of a dynamic interaction between sorting nexin 5 (SNX5), a component of the mammalian ret

46 In this pathway, PIPKIgammai5 interacts with sorting nexin 5 (SNX5), a protein that binds PtdIns4,5P(

47 d regulation of intracellular traffic (e.g., sorting nexin 5 [SNX5], SNX6, and SNX9).

48 e retromer components identified in mammals, sorting nexin 5 and 1 (SNX5; SNX1) have recently been fo

49 reported that IncE binds specifically to the Sorting Nexin 5 Phox domain (SNX5-PX) and disrupts retro

50 CHC22 binds to sorting nexin 5 through a coiled-coil domain present in

51 inity purification (TAP), we herein identify sorting nexin 6 (SNX6) as a BACE1-associated protein.

52 We demonstrate that GIT1 interacts with sorting nexin 6 (SNX6), a member of the SNX family that

53 ein signaling complex composed of eukaryotic sorting nexin 9 (SNX9) and neuronal Wiskott-Aldrich synd

54 Here, we identify sorting nexin 9 (SNX9) as a new regulator of breast canc

55 Under these conditions, sorting nexin 9 (Snx9) can be implicated as a specific a

56 Sorting nexin 9 (SNX9) functions in a complex with the G

57 chemical, and immunofluorescence approaches, sorting nexin 9 (SNX9) is identified as being required f

58 inflammatory conditions, we discovered that sorting nexin 9 (SNX9), a protein that participates in e

59 hat is fused to an aminoterminal sequence of sorting nexin 9 (SNX9), which was previously shown to bi

60 several host proteins, including N-WASP and sorting nexin 9 (SNX9).

61 is, namely the sorting nexin protein SH3PX1 (sorting nexin 9).

62 Sorting nexin 9, an abundant dynamin partner, transientl

63 e temporal ordering of three proteins-actin, sorting nexin 9, and clathrin-in the endocytic pathway.

64 identified protein partner of dynamin, SNX9, sorting nexin 9.

65 g an initial proteomic screen, we identified sorting nexin-9 (SNX9) and dynamins, key components of c

66 Unlike many sorting nexins, a SNX15 ortholog has not been identified

67 17) is a member of the family of cytoplasmic sorting nexin adaptor proteins that regulate endosomal t

68 an that observed for the knockdown of either sorting nexin alone.

69 These sorting nexins also associated with the long isoform of

70 In mammals, it is composed of a dimer of sorting nexins and of the core retromer consisting of va

71 Sorting nexins are a family of phox homology domain cont

72 Despite their hydrophilic nature, the sorting nexins are found partially associated with cellu

73 of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs).

74 esses in collaboration with the retromer and sorting nexins, but its in vivo function has not been ex

75 ains are in many protein families, including sorting nexins, centaurins, and oligophrenins.

76 eracting retromer complex, consisting of the sorting nexin dimer (SNX-BAR) and the trimeric cargo sel

77 lishing a precedent for a mechanism by which sorting nexins expand the repertoire of retromer-depende

78 ive, this study identifies one member of the sorting nexin family, Sorting Nexin 27 (SNX27), as a cri

79 present the first mutations in the mammalian sorting nexin gene family and indicate that sorting nexi

80 af-6 mutants, we identified an allele of the sorting nexin gene snx-1.

81 sability, due to truncating mutations in the sorting nexin gene SNX14, encoding a ubiquitously expres

82 an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer compl

83 As with Golgi proteins, this requires the sorting nexin Grd19p and components of the retromer coat

84 and differential functions of two groups of sorting nexins in phagosome maturation and reveal a sign

85 ur findings suggest a general role for yeast sorting nexins in protein retrieval, rather than degrada

86 ytosis and SH3PX1 has sequence similarity to sorting nexins in yeast, we propose that endophilin I an

87 rols the retrograde transport of CI-M6PR via sorting nexins, including the PI4P effector SNX6.

88 ed, although the tissue distribution of each sorting nexin mRNA varies.

89 The FERM-like domain-containing sorting nexins of the SNX17/SNX27/SNX31 family have been

90 At the same time, retromer associated sorting nexin one (SNX-1) and its binding partner, J-dom

91 han degradation, and indicate that different sorting nexins operate in different classes of endosomes

92 sorting nexin gene family and indicate that sorting nexins perform essential functions in mammals.

93 y been implicated in endocytosis, namely the sorting nexin protein SH3PX1 (sorting nexin 9).

94 infection but that double knockdown of both sorting nexins results in a striking reduction in infect

95 -dependent recycling tubules marked by actin/sorting nexin/retromer tubular (ASRT) microdomains.

96 The regulation of endosomal trafficking via sorting nexins reveals a previously unknown mechanism fo

97 Sorting nexin (SNX) 1 and SNX2 are mammalian orthologs o

98 hox-homology (PX) domain-containing proteins sorting nexin (SNX) 17, SNX27, and SNX31 have emerged re

99 Vps17 is a sorting nexin (SNX) and a component of the retromer, a p

100 that participates in cargo recognition and a sorting nexin (SNX) dimer that binds to endosomal membra

101 Mammalian retromer is composed of a sorting nexin (SNX) dimer that binds to phosphatidylinos

102 Two other sorting nexin (SNX) family members, namely SNX27 and SNX

103 The sorting nexin (SNX) family of proteins is characterized

104 There are 17 human members of the sorting nexin (SNX) family of proteins that contain Phox

105 e regulator of G protein signaling (RGS) and sorting nexin (SNX) protein families.

106 responses, we identified the members of the SORTING NEXIN (SNX) protein family.

107 Sorting nexin (SNX) proteins that normally function in e

108 s a Phox (PX) domain that resembles those in sorting nexin (SNX) proteins.

109 sorting pathway in conjunction with various sorting nexin (SNX) proteins.

110 nsport, the targeting of the retromer-linked sorting nexin (SNX)-Bin, Amphiphysin, and Rvs (BAR) prot

111 5 trimer and a membrane-deforming subunit of sorting nexin (SNX)-Bin, Amphyphysin, and Rvs (BAR; SNX-

112 Sorting nexins (SNX) comprise a family of proteins with

113 Sorting nexins (SNX) orchestrate membrane trafficking an

114 mplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6.

115 We identify five (clathrin, dynamin1, AP2, sorting nexins [SNX] SNX27, and SNX1) that increase and

116 When expressed in COS7 cells, epitope-tagged sorting nexins SNX1, SNX1A, SNX2, and SNX4 coimmunopreci

117 ins, named Vps26, Vps29, and Vps35, plus the sorting nexin, SNX1.

118 ve identified a novel 342-amino acid residue sorting nexin, SNX15, and a 252-amino acid splice varian

119 omologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4).

120 vidence, however, as to whether a homologous sorting nexin, SNX2, is truly a component of the retrome

121 rize the interaction between L2 and a second sorting nexin, SNX27, which is also part of the retromer

122 Like most sorting nexins, SNX27 possesses a functional PX domain t

123 We further showed that the cargo-selective sorting nexin Snx3 is required for Neo1 trafficking and

124 he VPS26 and VPS35 subunits of retromer, the sorting nexin SNX3, and a recycling signal from the diva

125 s identified a requirement for the conserved sorting nexin Snx4 in the autophagic turnover of proteas

126 via two independent pathways mediated by the sorting nexins Snx4/41/42 and the retromer complex, resp

127 We demonstrate that Snx4 cooperates with sorting nexins Snx41 and Snx42 to mediate proteasome tur

128 Snc1p from post-Golgi endosomes requires the sorting nexin Snx4p, to which Snc1p can be cross-linked.

129 The sorting nexin, SNX9, localizes to clathrin-coated pits w

130 IncE binds to sorting nexins (SNXs) 5/6, components of the retromer, w

131 Sorting nexins (Snxs) are a recently discovered family o

132 Sorting nexins (SNXs) are regulators of endosomal sortin

133 Sorting nexins (SNXs) or phox homology (PX) domain conta

134 ing family of proteins known collectively as sorting nexins, some of which have been shown to be invo

135 The retromer complex, composed of sorting nexin subunits and a Vps26/Vps29/Vps35 trimer, m

136 GTP and requires the Vps5 and Vps17 retromer sorting nexin subunits.

137 demonstration of a large conserved family of sorting nexins that interact with a variety of receptor

138 NX-1, and SNX-6, three BAR domain-containing sorting nexins, that act in two parallel pathways to dri

139 sphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, a

140 SNX27, however, is the only sorting nexin to contain a PDZ domain.

141 The ability of sorting nexins to bind specific phospholipids as well as

142 ed by PtdIns(3)P, and executed through these sorting nexins to degrade apoptotic cells.

143 The yeast sorting nexins Vps5p and Vps17p form a dimer and are als

144 ly define the different domains of the yeast sorting nexins Vps5p and Vps17p, we have generated vario

145 sting findings with yeast orthologs of other sorting nexins, we propose that overexpression of SNX15