ライフサイエンスコーパス: sorting signal

1 llest essential component of its basolateral sorting signal.

2 ting their recognition of the ubiquitin (Ub) sorting signal.

3 threonine and the glycine of its NPKTG motif sorting signal.

4 is hexapeptide acts as a sterol-regulated ER sorting signal.

5 it a nascent helix encompasses the lysosomal sorting signal.

6 effects of blocking the rhodopsin C-terminal sorting signal.

7 ct to binding of cargo with a tyrosine-based sorting signal.

8 strates that possess an LPXTG-type cell wall sorting signal.

9 immunoglobulin binding protein with an LPXTG sorting signal.

10 Sed5 molecules, as well as to the DxE cargo-sorting signal.

11 rd intracellular loop contains a basolateral sorting signal.

12 reorganization of the binding pocket for the sorting signal.

13 eraction motif and a putative tyrosine-based sorting signal.

14 xyl-terminal sequence, which encodes a novel sorting signal.

15 aid to N-linked glycosylation as a potential sorting signal.

16 howed that this sequence acts as a recycling sorting signal.

17 wn function 1542) and a C-terminal cell wall sorting signal.

18 pace by proteolytic removal of a hydrophobic sorting signal.

19 nchors proteins bearing a noncanonical LPNTA sorting signal.

20 ossesses a new distinct C-terminal cell wall sorting signal.

21 h carries an in-frame fusion of Ub as an MVB sorting signal.

22 signal peptide and a C-terminal LPXTG motif sorting signal.

23 in discrete tER sites depends upon positive sorting signals.

24 ously unrecognized diversity among dileucine sorting signals.

25 afficking mechanisms of D/EXXXL[LI]-mediated sorting signals.

26 ernalization mediated by the dileucine-based sorting signals.

27 f most surface proteins containing cell wall sorting signals.

28 e proteins with different types of cell wall sorting signals.

29 s putative transmembrane regions and protein-sorting signals.

30 ng of AP-3 to Arf but not to dileucine-based sorting signals.

31 motes cargo sorting by recognizing recycling sorting signals.

32 s, ESMI(623)LL and QVVA(635)LL, as candidate sorting signals.

33 ng N-terminal signal peptides and C-terminal sorting signals.

34 at allow for recognition of a diverse set of sorting signals.

35 cells typically requires cytoplasmic domain sorting signals.

36 sensus sequences for kinases, and post-Golgi sorting signals.

37 ses of specifically defined membrane protein sorting signals.

38 n signals might also function as basolateral sorting signals.

39 d cytoplasmic tails with tyrosine-containing sorting signals.

40 protein that is known to interact with such sorting signals.

41 tivated PAR1 and recognize discrete receptor sorting signals.

42 ided in part by a tyrosine-based basolateral sorting signal, (318)YNQV(321).

43 oxyl-terminal fragment contains a di-leucine sorting signal ((495)DDISLL(500)) and a ubiquitination s

44 Two sorting signals, a PXXP motif and a 658LL659 motif, are

45 physically engaging peptide-based endocytic sorting signals, a subset of clathrin-dependent transmem

46 A pathway by at least two different types of sorting signals: acidic cluster-dileucine motifs and cov

47 cagon is directed into granules by intrinsic sorting signals after initial processing to glicentin an

48 Sequences containing the M(3) sorting signal also conferred basolateral targeting to M

49 e NMR structure of (Ba)SrtA bound to a LPXTG sorting signal analog.

50 within peroxisomal APX as an overlapping pER sorting signal and a membrane peroxisome targeting signa

51 T) and the glycine (G) residues of its LPXTG sorting signal and catalyzes formation of an amide bond

52 rom the ER through direct interaction with a sorting signal and COPII.

53 f an amide bond between threonine (T) of the sorting signal and lysine (K) in the YPKN motif of anoth

54 19-amino acid peptide representing the M(3) sorting signal and surrounding sequence was analyzed via

55 ) glycoprotein contained an intrinsic apical sorting signal and that N- and O-linked glycans can act

56 The nature of the specific sorting signal and the mechanism through which it is int

57 quence (50 amino acid residues), a cell wall sorting signal and two repeat regions.

58 sortase A is involved in the binding of both sorting signals and calcium.

59 me signals are referred to as tyrosine-based sorting signals and conform to the NPXY or YXXO consensu

60 sortase enzymes cleave precursor proteins at sorting signals and involve the side chain amino groups

61 sortase enzymes cleave precursor proteins at sorting signals and involve the side-chain amino groups

62 oroplast targeting sequence or other obvious sorting signals and is not imported into isolated chloro

63 shed new light on the hierarchy of polarized sorting signals and on the mechanisms by which newly syn

64 ortases A and B recognize unique features of sorting signals and peptidoglycan substrates to deposit

65 encode sortase and pilin subunit genes with sorting signals and pilin motifs.

66 encode sortase and pilin subunit genes with sorting signals and pilin motifs.

67 ized by SrtC proteins through a pentapeptide sorting signal, and while previous studies have sought t

68 nforming to well-characterized leucine-based sorting signals, and a second containing a polyproline c

69 (Arf-1)-guanosine triphosphate (GTP), cargo sorting signals, and phosphoinositides.

70 ant for cellular function, including lateral sorting, signaling, and trafficking.

71 Nevertheless, sorting signals are located in the cytoplasmic domain si

72 e generally cytoplasmically disposed, apical sorting signals are not typically accessible to the cyto

73 paA pilin precursor, the pilin motif and the sorting signal, are together sufficient to promote the p

74 and Val(281) comprise a novel dihydrophobic sorting signal as mutations of either residue singly or

75 dase appears to have at least three distinct sorting signals as follows: the light chain (L-BEK) dire

76 m requiring surface proteins with C-terminal sorting signals as well as sortase enzymes.

77 ndoplasmic reticulum to the vacuole requires sorting signals as well as specific transport mechanisms

78 ite cysteine of sortase C and an LPNTA motif sorting signal at the C-terminal end of the BasI precurs

79 ion is necessary for it to bind a prohormone sorting signal at the trans-Golgi network (TGN) to facil

80 cell wall of Gram-positive bacteria, cleaves sorting signals at the LPXTG motif.

81 aining the LPKTGGS and LPKTGGRS sequences as sorting signals at the peptide C-terminus were effective

82 ace depends on the presence of a basolateral sorting signal (BaSS) in their cytoplasmic domain.

83 f the presence or absence of the basolateral sorting signal, because apical delivery was also inhibit

84 eaved peptides encompassing LPXTG motif-type sorting signals between the threonine (T) and the glycin

85 in precursors bearing C-terminal LPXTG motif sorting signals between the threonine and glycine residu

86 This specificity is tuned by the sorting signal binding conformation in which the first t

87 ably, a SpaB mutant that lacks the cell wall sorting signal but contains a critical lysine residue is

88 ow that SrtA adaptively recognizes the LPXTG sorting signal by closing and immobilizing an active sit

89 nd the glycine of its C-terminal LPXTG motif sorting signal by the pilin-specific sortase D.

90 in glucagon and GLP-1, but not GLP-2, act as sorting signals by efficiently directing a heterologous

91 me coat polymerization to the recognition of sorting signals by the BBSome.

92 Recognition of Ub as a sorting signal can occur at the trans-Golgi network and

93 g reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved betwe

94 These results identify a novel sorting signal controlling the endocytic trafficking iti

95 To investigate whether this sorting signal could be involved in presentation of mela

96 N, mediated by tyrosine- and dileucine-based sorting signals, could be a mechanism for functional seg

97 due K139 or truncation of the SpaB cell wall-sorting signal (CWSS) abolished assembly of the SpaBC he

98 All basolateral sorting signals described to date reside in the cytoplas

99 Specific sorting signals direct transmembrane proteins to the com

100 yeast Ggas also function by binding peptide-sorting signals directly.

101 on microscopy, cell fractionation, cell wall sorting signal domain swapping, and Western blotting, we

102 ncompasses the YPK pilin motif and the LPXTG sorting signal, each of which is absolutely required for

103 , we discovered a highly conserved dileucine sorting signal encoded within the cytoplasmic tail that

104 escription of tyrosine-dependent cytoplasmic sorting signal for a type III membrane protein, have sug

105 led that BapA1 possesses a typical cell wall-sorting signal for cell surface-anchored proteins from G

106 accumulation: phosphorylation of p75NTR is a sorting signal for delayed sequestering of p75NTR-bound

107 iquitination of cargo proteins serves as the sorting signal for downstream trafficking and relies on

108 1 subunit at multiple sites is the lysosomal sorting signal for GABAB receptors.

109 ests the possibility that it may represent a sorting signal for glycosylated Gag.

110 of AQP-1, implying that ubiquitination is a sorting signal for its release.

111 tachment to membrane proteins can serve as a sorting signal for lysosomal delivery.

112 n intrinsically disordered linker encode the sorting signal for recruiting the transport factors for

113 Sorting signals for apically destined proteins are highl

114 ns and clathrin for endocytosis and serve as sorting signals for internalized cargo.

115 Thus, this receptor subunit may use distinct sorting signals for its constitutive regulation and liga

116 So far, no sorting signals for membrane trafficking have been ident

117 Acidic clusters act as sorting signals for packaging cargo into clathrin-coated

118 elopment of the cell, obviating the need for sorting signals for proper packaging of their constituen

119 e inner envelope protein CemA indicates that sorting signals for the thylakoid and envelope membranes

120 ith each other, with membranes, and with the sorting signals found on cargo molecules.

121 distinct subsets of tyrosine-based (YXXphi) sorting signals found within the cytoplasmic domains of

122 eceptor, provide the first example of such a sorting signal functioning in a proximal portion of the

123 While plant vacuolar sorting signals have been well described for two decades

124 dentification of an adaptor protein-specific sorting signal in a t-SNARE protein, and suggest that AP

125 the cellular protein sorting machinery, the sorting signal in HIV-1 Nef has not been identified.

126 mutant form of HA (C560Y) with a basolateral sorting signal in its cytoplasmic domain.

127 ebrate evolution, was shown to act also as a sorting signal in mouse gp75, confirming that its sortin

128 These data indicate that a dileucine-based sorting signal in Nef is utilized to address the cellula

129 the GPI modification serves as a primary Pd sorting signal in plant cells.

130 ce protein ubiquitination is the predominant sorting signal in receptor endocytosis, we investigated

131 suggest a model in which the tyrosine-based sorting signal in RID plays a role in RID's ability to d

132 These results identify an LV-based sorting signal in the ALP cytoplasmic domain that direct

133 basolateral surface by a tyrosine-dependent sorting signal in the APP cytoplasmic tail.

134 Mutagenesis studies identified a YYXXF sorting signal in the C-terminal cytosolic domain of Van

135 e normal interactions between the di-leucine sorting signal in the CD4 cytoplasmic domain and AP-2, b

136 Mutation of a methionine-based sorting signal in the cytoplasmic domain of either Sncp

137 ning a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein, increasing

138 three critical features that comprise an ART sorting signal in the Mup1 N-terminal cytosolic tail: 1)

139 ed mutagenesis of the acidic dileucine-based sorting signal in the pigment cell-specific protein OCA2

140 We have identified a sorting signal in the yeast cell fusion protein Fus1p th

141 To identify the lipoprotein-sorting signals in Borrelia burgdorferi, we generated ch

142 Here, we aimed to determine the sorting signals in HIV-1 Nef that were responsible for i

143 both of which are well-described trafficking/sorting signals in the cellular secretory pathway.

144 in targeting native molecules bearing these sorting signals in the context of HLA-DM and the invaria

145 -receptor complex can occur without specific sorting signals in the cytoplasmic region of ObR.

146 n of furin to the TGN is largely mediated by sorting signals in the cytosolic tail of the protein, we

147 t to occur at the TGN through recognition of sorting signals in the cytosolic tails of the cargos by

148 in an Arf-dependent fashion and to recognize sorting signals in the cytosolic tails of the transmembr

149 suggest the existence of a diverse array of sorting signals in the GPCR superfamily that mediate sub

150 eral sorting motifs, which are homologous to sorting signals in the low density lipoprotein receptor,

151 ted to lysosomes by virtue of tyrosine-based sorting signals in their cytosolic tails.

152 apical surface of the cell, guided by apical sorting signals in their transmembrane or cytoplasmic do

153 recycling and bind conserved Asn-Pro-Xaa-Tyr-sorting signals in transmembrane cargos via an atypical

154 suggest a new role for peptide precursors as sorting signals in vesicular transport.

155 hin the prohormone sequence does not act as "sorting signal" in late secretion; instead, it seems to

156 Cleavable vacuolar sorting signals include the NH(2)-terminal propeptide (N

157 the absence of this cytoplasmic basolateral sorting signal, information within the extracellular lig

158 pigmentosa alleles that affect the rhodopsin sorting signal interfere with interactions between ARF4

159 ubstitution of sequences containing the M(3) sorting signal into the homologous regions of M(2) was s

160 The PY and YXXphi motifs are canonical sorting signals involved in trafficking.

161 ations reveal a novel mode of recognition of sorting signals involving the gamma/delta and sigma subu

162 We show that a functionally similar ART sorting signal is also required for the endocytosis of a

163 ic domain, a motif that resembles a cellular sorting signal is critical for activity.

164 e results indicate that the M(3) basolateral sorting signal is dominant over apical signals in M(2) a

165 on, the cytoplasmic tail where the endosomal sorting signal is located, and a small portion of the lu

166 d active site His-Cys-Arg triad that joins a sorting signal located at the C terminus of their protei

167 plex to the endocytic pathway, directed by a sorting signal located in the cytoplasmic tail.

168 rted example of a sequence-specific vacuolar sorting signal located within an internal propeptide.

169 Although the identity of certain sorting signals located in Ii's cytoplasmic tail is know

170 han (658)LL(659) at overriding strong apical sorting signals located in the same molecule.

171 gon fragment, leading to the hypothesis that sorting signals may be present in multiple domains.

172 identified, there are few examples of linear sorting signals mediating directed export of membrane pr

173 ng of COPII-coated proteins to a hexapeptide sorting signal (MELADL) in Scap, the SREBP-escort protei

174 hese mutations did not share a single common sorting signal, nor were proteins sharing a putative cla

175 here that sortase C (SrtC) cleaves the LPNTA sorting signal of BasH and BasI, thereby targeting both

176 ires sortase A, which also cleaves the LPXTG sorting signal of BcpA between its threonine and glycine

177 sortases A and D require only the C-terminal sorting signal of BcpA for substrate cleavage.

178 Here, we show that the IPNTG sorting signal of BcpB, the minor pilin, is cleaved by s

179 sorting signal of H2M or the dileucine-based sorting signal of CD3gamma, confirming a role for clathr

180 C2 requires the VPPTG motif in the cell wall-sorting signal of Cpa.

181 Inactivation of the cell wall sorting signal of fap1 also eliminated long fimbrial for

182 his process involves the pilin motif and the sorting signal of FimA as well as corynebacterial sortas

183 lecules containing either the tyrosine-based sorting signal of H2M or the dileucine-based sorting sig

184 ic route, and that cleavage of the lysosomal sorting signal of Ii by CatS can occur there in mature D

185 The sorting signal of IsdC is cleaved between threonine and

186 n N-terminal signal sequence with a putative sorting signal of L(P/T/S)X(T/N/D)G and two unique signa

187 s pattern of distribution requires the LPXTG sorting signal of protein A as well as sortase A, the tr

188 evere form mutations occur in the C-terminal sorting signal of rhodopsin, VXPX-COOH.

189 requires the pilin motif and the C-terminal sorting signal of SpaA, and is proposed to occur by a me

190 1) protein, carrying the endosomal/lysosomal sorting signal of the LAMP-1, are capable of stimulating

191 of Pseudomonas aeruginosa exotoxin A, or the sorting signal of the lysosome-associated membrane prote

192 heat shock protein 70, calreticulin, or the sorting signal of the lysosome-associated membrane prote

193 After cleavage of the LPXTG sorting signal of the major pilin, BcpA, sortase D forms

194 her show that the sequence-specific vacuolar sorting signals of both proricin and pro2SA bind in vitr

195 ur interest in understanding the basolateral sorting signals of CD147 in prototypic Madin-Darby canin

196 ar cargo receptor AtELP to interact with the sorting signals of heterologous and endogenous plant vac

197 All identified basolateral sorting signals of integral membrane proteins are cytopl

198 Thus, unique attributes of the sorting signals of minor pilins provide Gram-positive ba

199 ics simulations of each SrtC enzyme with the sorting signals of RrgA, RrgB, and RrgC to determine the

200 us assembly upon alteration of the cell wall sorting signals of the accessory subunit proteins.

201 We identified three canonical tyrosine-based sorting signals of the type "YXXPhi" in the Cx43 C-termi

202 ddition of the mannose 6-phosphate lysosomal sorting signal on acid hydrolases, exhibited extensive v

203 Endocytic protein trafficking is directed by sorting signals on cargo molecules that are recognized b

204 Sorting signals on cargo proteins are recognized by coat

205 ange is associated with increased binding to sorting signals on the cytoplasmic tails of cargo molecu

206 rm and in three liganded forms (bound with a sorting signal or calcium or both).

207 eins does not appear to involve N-glycans as sorting signals, or lectin sorters.

208 dered to ordered transition upon binding the sorting signal, potentially facilitating recognition of

209 Similarly, both the kinase activity and the sorting signal present in PI4KIIalpha are necessary to r

210 elial cells is dependent on yet unidentified sorting signals present in the luminal domains of these

211 The molecular basis of transpeptidation and sorting signal recognition are not well understood, beca

212 This study shows that coatomer couples sorting signal recognition to the GTP hydrolysis reactio

213 at the plasma membrane is distinct from the sorting signal recognized by basolateral sorting machine

214 dense granule proteins, we demonstrate that sorting signals recognized by adaptor protein-3 are nece

215 These mGluR sorting signals represent novel plasma membrane axon/den

216 The M(3) sorting signal represents a novel basolateral targeting

217 e caused by mutations in nef, this Tyr-based sorting signal represents a novel target for future mode

218 LAT palmitoylation functions primarily as a sorting signal required for its PM transport.

219 For HA+8, the basolateral sorting signal required the same tyrosine as the interna

220 -leucine sequence that is closely related to sorting signals required for AP-3 adaptor-dependent tran

221 dependent on a novel bipartite juxtamembrane sorting signal residing between Gln-692 and Thr-701.

222 cargo receptor complex and that the primary sorting signals residing in the B domain direct the bind

223 rminates upon sortase A cleavage of the BcpA sorting signal, resulting in a covalent bond between Bcp

224 To identify the sorting signal(s) that direct trafficking of NKCCs, we g

225 ytoplasmic domain replaced by a constitutive sorting signal (Sec22b SNARE) retains stress-responsive

226 It is inferred that, in vivo, sorting signal selection is under kinetic control, with

227 proteins to the lysosomes using a conserved sorting signal similar to that used by yeast and mammali

228 imary sequence conservation suggest that the sorting signal-stabilized oxyanion hole is a universal f

229 conserved threonine residue within the bound sorting signal substrate facilitates construction of the

230 covalent complex with an analog of its NPQTN sorting signal substrate, revealing the structural basis

231 Ahp1p contains a peroxisomal sorting signal, suggesting a peroxisomal localization.

232 e capable of interacting with tyrosine-based sorting signals, suggesting that they are functionally e

233 blocked the ability of Ub to serve as an MVB sorting signal, supporting the idea that both the Vps27-

234 Distinct cytoplasmic sorting signals target integral membrane proteins to lat

235 This Leucine-Valine (LV)-based sorting signal targeted chimeric proteins and native ALP

236 results suggest a model in which this novel sorting signal targets A(F-->A)-ALP into clathrin/AP-1 v

237 duces Env expression on infected cells and a sorting signal that directs Env expression to the basola

238 In many cases, ubiquitin functions as a sorting signal that facilitates trafficking of mammalian

239 These data define a novel sorting signal that is both necessary and sufficient for

240 We suggest that IXTPK comprises a novel sorting signal that is recognized and bound by exomer le

241 main functions as a transplantable endocytic sorting signal that is sufficient to re-route endocytose

242 equence of YRSL conforms to a tyrosine-based sorting signal that mediates clathrin-dependent endocyto

243 f Tac-furin trafficking, acting as an active sorting signal that mediates the selective sorting of Ta

244 athways is regulated by a latent basolateral sorting signal that restores EGF receptor polarity in cy

245 Ubiquitin (Ub) is a sorting signal that targets integral membrane proteins t

246 The concept of competing sets of sorting signals that act positively and negatively durin

247 fferent cellular compartments is mediated by sorting signals that are recognized by coat proteins inv

248 e polarized protein distributions depends on sorting signals that designate the trafficking route and

249 The sorting signals that direct proteins to the apical surfa

250 VGLUT1 thus contains multiple sorting signals that engage distinct trafficking mechani

251 irus (CaMV) MP contains three tyrosine-based sorting signals that interact with an Arabidopsis (Arabi

252 To identify potential sorting signals that mediate mAChR targeting, we examine

253 using an artificial reporter lacking natural sorting signals that recapitulates the energy dependence

254 leucine motif, one of two well-characterized sorting signals that target membrane proteins to clathri

255 ) have two chaplin domains and a C-terminal "sorting signal" that targets them for covalent attachmen

256 in the YCK3 gene identify the Yck3p vacuolar sorting signal-the tetrapeptide YDSI, a perfect fit to t

257 study suggest that SrtA recognizes the LPXTG sorting signal through a lock-in-key mechanism in contra

258 The similarity of the ALP sorting signal to mammalian dileucine sorting motifs, an

259 tidases join proteins bearing an appropriate sorting signal to strategically positioned amino groups

260 f a sequence containing the M(3) basolateral sorting signal to the cytoplasmic tail of the interleuki

261 tes with binding via cytoplasmically exposed sorting signals to either heterotetrameric adaptor AP-1

262 mic domain of TfR that function as recycling sorting signals to promote its transport from the recycl

263 The fusion of cell wall sorting signals to reporter proteins bearing N-terminal

264 anchors surface proteins bearing LPXTG motif sorting signals to the cell wall envelope of vegetative

265 IsdC precursor with a C-terminal NPQTN motif sorting signal, to the cell wall envelope.

266 We demonstrate interaction of the protein sorting signal Ubiquitin with the Vps9-CUE, a Ubiquitin

267 a known EGF receptor leucine-based lysosomal sorting signal used during ligand-induced trafficking, w

268 udy, an essential 14-amino acid (aa 335-348) sorting signal was defined on the cytoplasmic tail of As

269 the accuracy of predicting membrane protein sorting signals, we developed a general methodology for

270 To identify additional MVB sorting signals, we examined the previously described ub

271 s between dileucine-based and tyrosine-based sorting signals, we have categorized the motif through w

272 Multiple new prokaryotic C-terminal protein-sorting signals were found that reprise the tripartite a

273 Two distant topological sorting signals were required for efficient nuclear impo

274 complexes reveal the molecular basis of the sorting signal which depends on the residues at the -1 a

275 cytoplasmic tail domain contains a vacuolar sorting signal which is responsible for the active recog

276 proteins (or "cargoes") generally acts as a sorting signal, which is recognized, captured, and deliv

277 s in a previously described 679-LL lysosomal sorting signal, which restrict ligand-dependent receptor

278 nown to contain a sequence-specific vacuolar sorting signal whose functionality depends on the presen

279 This unusual basolateral sorting signal will be useful in unraveling the speciali

280 eptidation mechanism, requiring a C-terminal sorting signal with a conserved LPXTG motif.

281 all by a mechanism requiring a COOH-terminal sorting signal with a conserved LPXTG motif.

282 all by a mechanism requiring a COOH-terminal sorting signal with a conserved LPXTG motif.

283 all by a mechanism requiring a COOH-terminal sorting signal with a conserved LPXTG motif.

284 glycan by a mechanism requiring a C-terminal sorting signal with a LPXTG motif.

285 velope by a mechanism requiring a C-terminal sorting signal with an LPXTG motif.

286 velope by a mechanism requiring a C-terminal sorting signal with an LPXTG motif.

287 glycan by a mechanism requiring a C-terminal sorting signal with an LPXTG motif.

288 inantly vesicular carriers by interaction of sorting signals with adaptor proteins, but proteins in t

289 envelope by a mechanism requiring C-terminal sorting signals with an LPXTG motif.

290 ifferent, functionally redundant basolateral sorting signals with distinct amino acid requirements: o

291 of a phaseolin variant lacking its vacuolar sorting signal, with the aim to target the protein for s

292 Finally, we characterized the sorting signal within the context of a reconstructed Stv

293 reaction that joins a highly conserved LPXTG sorting signal within their polypeptide substrate to the

294 ough membranes, MIPS genes were analyzed for sorting signals within primary structures and upstream o

295 This is because redundant sorting signals within the cytosolic domain of the Droso

296 nction non-redundantly by recognizing unique sorting signals within their protein substrates.

297 ssed at an unexpected site downstream of the sorting signal yet still associates with the bacterial s

298 pable of interacting with the tyrosine-based sorting signal YQRL from TGN38.

299 uronal form of L1 carries the tyrosine-based sorting signal YRSLE, which is critical for sorting L1 t

300 osine residue forms part of a tyrosine-based sorting signal (Yxxphi).