ライフサイエンスコーパス: spare

1 But CF mice are spared.

2 r neurocognitive declines whereas others are spared.

3 rolateral and right ventricular were usually spared.

4 g in autologous HCT recipients generally was spared.

5 otein synthesis, certain oncogenic mRNAs are spared.

6 ability (learning) and impulse control were spared.

7 the visual system, whereas macrophages were spared.

8 dial cerebellar structures were functionally spared.

9 id not translate to significant in vivo dose sparing.

10 typical, limbic-predominant, or hippocampal-sparing.

11 g/h and results in a large intravenous fluid sparing.

12 doscopy algorithm was similar and would have spared 19 unnecessary esophagectomies and 16 explorative

13 xpanded-Baveno VI criteria would potentially spare 367 (40%) endoscopies (21% with Baveno VI criteria

14 ividuals without CAC or carotid plaque could spare a significant proportion of elderly people from ta

15 s was missed and 31/73 (42%) men potentially spared a re-biopsy (NPV of 0.97, sensitivity 0.95).

16 to those of penetrating keratoplasty, while sparing a healthy endothelial graft.

17 Instead, it may have insulin-sparing action, which seems to reduce the need for insul

18 ulators that maintain activity on S1P1 while sparing activity on other S1P receptors could offer equi

19 solone, suggesting the potential for steroid sparing activity.

20 ies significantly mediated the age effect on SPARE-AD explaining 32.8% of the variance.

21 apturing age-related brain atrophy), and the SPARE-AD index (previously developed to capture patterns

22 The direct age effect explained 66.0% of the SPARE-AD variance.

23 and safety of adalimumab as a glucocorticoid-sparing agent for the treatment of noninfectious uveitis

24 atment with prednisone and/or glucocorticoid-sparing agents.

25 me applies to therapeutic stimulation of the spared allele by artificial transactivators.

26 e mechanism by which monocytic (M)-MDSCs are spared, allowing them to polarize towards M1 macrophages

27 GA lesion enlargement due to possible foveal sparing, alternative assessments are being explored to c

28 as to outline important components of opioid-sparing analgesic regimens.

29 lack of TLR4 signaling impairs white matter sparing and functional recovery after SCI.

30 arch into the contrasting strategies of land sparing and land sharing has suggested that land sparing

31 garding target coverage, organ-at-risk (OAR) sparing and monitor units (MUs).

32 mice exhibited increased myelin and neuronal sparing and protection against locomotor deficits, inclu

33 tensive surgery by assuring both parenchymal sparing and suitable oncologic resection.

34 Hippocampal-sparing and the no atrophy group showed less aggressive

35 on-memory cognitive functions in hippocampal-sparing and the no atrophy group.

36 ity of improved vaccine immunogenicity, dose sparing and thermostability.

37 clude therapies that are oral, anthracycline sparing, and deliverable in resource-limited settings.

38 acrophages enhances NG2 cell responses, axon sparing, and sprouting of serotonergic axons.

39 le antinociceptive effects, and offer opioid-sparing antinociceptive effects in myriad preclinical in

40 nd have a CNS relapse risk < 5%; they may be spared any diagnostic and therapeutic intervention.

41 pproximately 96% of corticospinal fibers but spared approximately 3% of CST fibers that project via t

42 Crucially, these activations spared areas related to language and to general-knowledg

43 nhance experience-dependent modifications in spared areas.

44 If gonadal tissue is spared-as in somatic genomic mosaicism-the mutation and

45 more diffuse lesions with only periarterial sparing at the most severe end of the spectrum.

46 arning methods resulting in two indices: the SPARE-BA index (capturing age-related brain atrophy), an

47 The direct age effect explained 70.2% of the SPARE-BA variance.

48 tion modelling showed that the age effect on SPARE-BA was mediated by white matter hyperintensities a

49 and white matter hyperintensities burden on SPARE-BA, revealing a statistically significant (P < 0.0

50 impaired and 0.39% (0.15) for seizures with spared behavioral responses (mean difference 0.14%, 95%

51 compared with 3.8 s (3.0) for seizures with spared behaviour (mean difference 4.1 s, 95% CI 3.0-5.3;

52 impaired and 0.34% (0.14) for seizures with spared behavioural responses (mean difference 0.07%, 95%

53 with impaired, 24.6 (8.6) for seizures with spared behavioural responses (mean difference 17.0, 95%

54 with impaired, 13.3 (3.4) for seizures with spared behavioural responses (mean difference 22.1, 95%

55 th impaired and 24.8 (6.5) for seizures with spared behavioural responses (mean difference 25.6, 95%

56 amplitudes in seizures with impaired versus spared behavioural responses analysed by t test.

57 bearing large-animal model while selectively sparing blood vessels and collagen.

58 tivation of ML impaired face detection while sparing body and object detection.

59 P completely avoided neutropenia and anemia, spared bone marrow and thymic niches, enabling rapid rec

60 ) astrocyte scar border, and (c) surrounding spared but reactive neural tissue.

61 st considerable benefit in terms of toxicity sparing, but this has only recently been confirmed by su

62 strains, and deletions truncating IR1 always spare BWRF1.

63 a suggested that CD19(+)CD20(-) plasma cells spared by anti-CD20 therapy likely contribute to residua

64 The heart was spared by IMRT compared to TOMO in terms of mean heart d

65 the minor dorsolateral corticospinal pathway spared by our injury.

66 the connections between gray-matter regions spared by the lesion.

67 influenced by disruption of areas seemingly spared by the stroke due to loss of white matter connect

68 of fatty acid utilization to the more oxygen-sparing carbohydrate metabolism.

69 b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced

70 10" N-terminal domain of p35, absent in p25, spares Cdk5/p35 because p10 binds to macromolecules (e.g

71 rons in the RMTg significantly while largely sparing cells in neighboring regions.

72 inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues

73 ing and land sharing has suggested that land sparing-combining high-yield agriculture with the protec

74 CCF642, a bone marrow-sparing compound, exhibited a submicromolar IC50 in 10 o

75 eration and resistance to apoptosis in vitro sparing control cells.

76 ut there was no difference in corticosteroid-sparing control of inflammation (P = .99).

77 Primary outcome was corticosteroid-sparing control of inflammation at 5 and 6 months.

78 steroids were able to achieve corticosteroid-sparing control of inflammation by 6 months.

79 ne resolved, and 88% achieved corticosteroid-sparing control of inflammation.

80 us recovery after SCI and support a focus on spared corticospinal neurons as a target for therapy.

81 Sprouting of spared corticospinal tract axons in the contralesional s

82 ies target bulk tumor cells while tending to spare CSC.

83 selectively blunts CD28 costimulation while sparing CTLA-4 and PD-L1 coinhibitory signals.

84 eath driven by chronic TCR stimulation while sparing cytotoxic activity.

85 ated in sensory neurons from the rat in vivo spared dermatome model of collateral sprouting identifie

86 s, by attenuating the lipolysis pathway, but spared differentiated cells.

87 ther addition or substitution of a potassium-sparing diuretic, amiloride, to treatment with a thiazid

88 ibutions of injured dorsal projecting versus spared dorsolateral projecting corticospinal neurons, we

89 a transient silencing approach to inactivate spared dorsolaterally projecting corticospinal neurons s

90 nduced a robust antibody response at antigen-sparing doses in healthy adults.

91 adjuvant enhanced immune response at antigen-sparing doses.

92 Here we report the development of a brain-sparing DT, termed BRAINSPAReDT, for tissue-specific gen

93 we know that major components of fetal brain sparing during acute hypoxia are triggered exclusively b

94 PC nanogel as a vaccine adjuvant had a dose-sparing effect and significantly enhanced the long-lasti

95 The safety profile and steroid-sparing effect favoured the combination of prednisone pl

96 ade of interleukin-5 has significant steroid-sparing effects and attenuates blood and sputum eosinoph

97 at the endocannabinoid system promote opioid-sparing effects in the treatment of pain reflects an imp

98 antly lower than that of WT, indicating less spare energy generating capacity.

99 and thromboxane A2 receptor (TP) (11) while sparing EP2, EP3, and prostaglandin I2 receptors (IPs);

100 restrial-origin carbohydrates for energy and sparing essential fatty acids and amino acids for somati

101 ups, while lower leg muscles were relatively spared even in advanced disease.

102 nerve motor nuclei but not in the relatively spared extraocular nuclei.

103 proteins in the early secretory pathway yet spares folding intermediates from being destroyed.

104 have difficulty humming melodies but can be spared for singing familiar songs with familiar lyrics [

105 The benefits of land sparing for both biodiversity and carbon storage suggest

106 vaccine supply, prompting WHO to adopt dose sparing for its vaccination campaign in Kinshasa, Democr

107 of which was identified as potentially land-sparing for solar energy development.

108 f the quiescent CNV seemed to cover the area spared from atrophy.

109 dium through proliferation of cardiomyocytes spared from damage.

110 with no evidence that elderly population was spared from excess mortality.

111 cally, LLC tumor-bearing TLR4(-/-) mice were spared from muscle wasting due to a blockade in muscle c

112 geographic atrophy (GA) and residual foveal sparing (FS), and to identify the minimum FS and maximum

113 ablates alpha1beta glycinergic synapses but spares GABAergic synapses.

114 etric analyses revealed that RNS60 increased spare glycolytic capacity (SGC) under normal culture con

115 % of cochlear nerve afferent synapses, while sparing hair cells, in adult mice virtually eliminated t

116 Thus, mapping of LM using HRCM-RV can help spare healthy tissue by reducing the number of biopsies

117 nic B-lymphocytic leukemia tumor cells while sparing healthy B cells.

118 ic target for eradicating cancer cells while sparing healthy cells.

119 eukemia cell lines and patient samples while sparing healthy cells.

120 and preferential DNA delivery to HCC cells, sparing healthy hepatocytes.

121 therapeutic activity at the site of disease, sparing healthy tissues.

122 Nonanatomical tissue-sparing hepatectomies are associated with worse DFS in p

123 fluidic workflow, we have developed a sample-sparing, high-throughput, solution-phase alternative for

124 y more than 90% and 60%, respectively, while sparing immune and cardiac functions.

125 nt inflammation necessitating corticosteroid-sparing immunosuppressive therapy.

126 Given that this brain region is often spared in aphasic stroke, we propose that it is a sensib

127 gue muscle neuromuscular junctions were also spared in both animal models.

128 In contrast, familiarity was spared in each task.

129 wildtype (WT) mice whereas OHCs were largely spared in prestin knockout (KO) mice in the basal region

130 sic processing, music perception seems to be spared in this population.

131 CNV location was foveal-sparing in 12 eyes.

132 ne, a functional group that is conspicuously sparing in the sequences of mussel proteins, exhibit rev

133 dominal and hamstring muscles with iliopsoas sparing is common in facioscapulohumeral muscular dystro

134 p53-deficient cells with camptothecin while sparing isogenic p53-positive cells.

135 Although this strategy can potentially spare land from conversion to agriculture(3), it relies

136 SCC for reduced radiation dose as a means of sparing late sequelae.

137 ted controls and those with selective, fiber-sparing lesions of either the OFC or VLPFC.

138 To test this premise, the effects of axon-sparing lesions of the RMTg were assessed on LHb-induced

139 Here, we show that axon-sparing lesions of the rostromedial tegmentum attenuate

140 e receptor 4 (TLR4) supports OL lineage cell sparing, long-term OL and OL progenitor replacement, and

141 Although Patricia fortuitously spared major cities, it reminded us of the threat tropic

142 leaves the majority of the mRNAs in vivo but spares many essential mRNAs (e.g., secY mRNA) and, surpr

143 e media analysis provides an effective, skin-sparing method for preclinical assessment of novel drug

144 There is little evidence that CNI-sparing/minimization strategies, steroid minimization or

145 The new Expanded-Baveno VI criteria spare more endoscopies than the original criteria with a

146 ontaining mouse cardiomyocytes, representing spared myocardium after injury, and cardiomyocytes gener

147 ted at the junction between newly formed and spared myocytes.

148 limbic-predominant (n = 33), or hippocampal-sparing (n = 35) by using the Scheltens' scale for media

149 ns and to define their gene profiling in rat spared nerve injury (SNI) model of neuropathic pain.

150 e mechanisms of mPFC deactivation in the rat spared nerve injury (SNI) model of neuropathic pain.

151 in-related hypersensitivity generated by the spared nerve injury model of neuropathic pain was revers

152 (complete Freund's adjuvant) or neuropathic (spared nerve injury) model of persistent pain, we observ

153 which reversed tactile allodynia in a mouse spared-nerve injury (SNI) model.

154 cord injury is to strengthen transmission in spared neural networks.

155 thesia blocks consciousness and memory while sparing non-conscious brain activities.

156 py-resistant Ewing sarcoma stem cells, while sparing non-malignant cells.

157 Effects were selective, sparing nontaste papillae.

158 nd could reveal therapeutic targets that may spare normal cells with intact p53.

159 ML cells compared to FLT3/ITD(neg) cells and spared normal umbilical cord blood cells.

160 e and time-dependent apoptosis in CLL cells, sparing normal B lymphocytes.

161 ells and/or virally infected cells, although sparing normal cells, and has been implicated in the pat

162 apoptosis of various cancer cell lines while sparing normal cells.

163 ectively trigger cancer cell apoptosis while sparing normal cells.

164 xtensive apoptosis in carcinoma cells, while sparing normal epithelial cells.

165 of transplantable human LSCs in mice, while sparing normal HSCs.

166 nd selectively targeted leukemia cells while sparing normal progenitor cells.

167 Cancer-specific targeting sparing normal tissues would significantly enhance cance

168 potential for treating micrometastases while sparing normal tissues.

169 ed that the IS-RA significantly improves the sparing of BS/SC without compromising dosimetric require

170 better target dose distribution and similar sparing of critical structures.

171 ration of alpha MNs (alpha-MNs) and complete sparing of gamma MNs (gamma-MNs), which selectively inne

172 delivery of tumoricidal radiation doses with sparing of nearby organs at risk.

173 g of other OARs except for slightly improved sparing of optic structures.

174 -RA demonstrated similar target coverage and sparing of other OARs except for slightly improved spari

175 etabolism on (18)F-FDG PET, whereas relative sparing of posterior cingulate metabolism compared with

176 a 'reversed' temporal gradient with relative sparing of recent memories.

177 white matter in normal aging, with relative sparing of sensorimotor fibers.

178 ical progression across time and a selective sparing of the cerebellum.

179 unusual patterns of subpial tau deposition, sparing of the hippocampus and co-localization with moss

180 d with predefined variant profiles (relative sparing of the hippocampus and/or occipital lobe).

181 e U fibers, corpus callosum involvement with sparing of the outer blades, and involvement of corticos

182 ng of the U fibers, the corpus callosum with sparing of the outer blades, the basis pontis, middle ce

183 r PAMM illustrating a fern-like pattern with sparing of the periarteriolar area in all cases.

184 hinning and autofluorescence showed relative sparing of the temporal sector.

185 hemispheric white matter abnormalities with sparing of the U fibers, corpus callosum involvement wit

186 f the cerebral hemispheric white matter with sparing of the U fibers, the corpus callosum with sparin

187 The development of aortic valve-sparing operations (reimplantation of the aortic valve a

188 The mPEG carrier alone did not have bone-sparing or anti-inflammatory properties.

189 on factor for treatment of disc disease must spare osmoprotective, prosurvival, and matrix homeostati

190 directly modulate BACE processing of APP but spare other BACE substrates and achieve therapeutic conc

191 ion, leads to complete loss of fibrosis, but spares other macrophage functions such as wound healing,

192 s due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that exp

193 c: We are more willing to sacrifice gains to spare others from harm than to spare ourselves from harm

194 m (i.e., the willingness to forego reward to spare others from harm), we observed strongly egoistic t

195 fice gains to spare others from harm than to spare ourselves from harm.

196 relate with acute orofacial dysfunction with spared pathways contributing to orofacial motor recovery

197 y, with metabolic imaging and endoscopy, may spare patients' operative intervention.

198 de an accessory TfR1 endocytosis signal that spares patients from severe anemia.

199 ents are proposed as treatments for PDR that spare peripheral vision.

200 receptive fields and rescale sensitivity to spared peripheral inputs following sensory nerve damage.

201 sphorylated ERK expression were increased in spared phrenic motor neurons (p < 0.05), consistent with

202 Here, we evaluate the land sparing potential of solar energy development across fou

203 eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for

204 outcomes, and outline the capacity of vessel-sparing radiotherapy to preserve sexual function in 90%

205 on of treatment, participants receiving dose-sparing regimen.

206 Nine of these patients received a dose-sparing regimen.

207 ial antituberculosis drugs in new rifampicin-sparing regimens.

208 rlook structural disconnections to seemingly spared regions and may fail to adjudicate between region

209 ires remnant insulin action originating from spared residual beta-cells: these mice indeed became hyp

210 Mechanistically, cisplatin decreased spare respirator capacity of brain synaptosomes and caus

211 und that human EM CD4(+) T cells had greater spare respiratory capacity (SRC) than did naive counterp

212 on oxidative phosphorylation and increasing spare respiratory capacity are essential for the differe

213 a recessive NDUFS2 mutation, respiration and spare respiratory capacity are increased by prodrug admi

214 h mitochondrial respiratory gene expression, spare respiratory capacity, and ATP levels.

215 with decreased citrate synthase activity and spare respiratory capacity.

216 stigation of the dynamics of the fetal brain sparing response for the first time.

217 The fetal brain sparing response matures as the fetus approaches term, i

218 te intense interest into how the fetal brain sparing response may be affected by adverse intrauterine

219 rd, as iron levels decline further, an "iron-sparing" response (fsrA, fbpAB, and fbpC) is induced to

220 ioural responses compared with seizures with spared responses.

221 ese data identify therapeutic and antibiotic sparing roles for vaginal immunomodulatory agents that s

222 dentification of a second generation of S1P3-sparing S1P1 agonists.

223 eous features at baseline, efficacy, steroid-sparing, safety, and relapses were recorded.

224 eformed regulators on autologous surfaces to spare self-cells from the undirected nature of AP activa

225 s, acting in a divisive manner, but entirely spares sensory-driven firing.

226 w precise therapeutic discrimination in vivo-sparing single antigen "bystander" tumors while efficien

227 nical potential (TWh year(-1)) of these land sparing sites and test the degree to which projected ele

228 th large choroidal melanoma, and may help to spare some vision.

229 ntified mechanism provides a simple means to spare specific substrates from an adaptor-dependent prot

230 OCS-sparing strategies are extremely important to improve pa

231 placed with follow-up or less invasive organ-sparing strategies.

232 ramuscular route and offers a potential dose-sparing strategy to stretch the limited global IPV suppl

233 reas vulnerable in AD, as well as relatively spared structures, such as the cerebellum.

234 Even when the left hemisphere was relatively spared, subjects with disorganized community structure h

235 This approach has the potential to spare substantial numbers of women the morbidity of ALND

236 most, yet other lymphocyte populations were spared, suggesting a targeted effect of sirolimus.

237 e, the addition of radiotherapy (RT) to limb-sparing surgery may result in higher local control rates

238 views all these aspects, in addition to limb-sparing surgery.

239 Tissue-sparing surgical techniques and carbon dioxide laser tre

240 The selective delivery spares surrounding normal liver, reducing the risk of li

241 s enable selective treatment of tumors while sparing surrounding healthy tissue, but optimal clinical

242 Scaling was selective, sparing synapses that were large and lacked recycling en

243 primary progressive aphasia with relatively spared syntax, but they were modulated to a lesser exten

244 event thrombotic complications of HIT, while sparing systemic hemostatic pathways.

245 ive optimization of hemoglobin levels, blood-sparing techniques, and standardization of transfusion p

246 i that otherwise produce strong pleasure and spares that of less-pleasant stimuli.

247 T results in clinically meaningful cognitive sparing that significantly exceeds that of modern XRT pr

248 e to develop antiinflammatory therapies that spare the constitutive expression necessary for normal h

249 ally target rapidly dividing Lgr5+ cells but spare the Mex3a-high/Lgr5+ population, helping to promot

250 the PCS; lesions to dorsolateral dlPFC that spare the PCS have no effect on WM.

251 ia therapy would selectively block NaPIC and spare the transient Na(+) current.

252 Thus, a substantial number of patients are spared the adverse effects of systemic chemotherapy.

253 B203580-inhibited transcription factors, but spared the anti-inflammatory MSK1/2 pathway.

254 intracellular ATPase-driven chaperoning, but spared the extracellular fragment-5-supported pro-motili

255 activated and killed the hypoxic cells, but spared the normoxic cells.

256 , or R848/TLR7/8 activation, but selectively spared the polyinosinic-polycytidylic acid/TLR3 pathway.

257 However, C1-INH spares the alternative pathway and the membrane attack c

258 of glucagon, and glucagon-mediated delivery spares the cardiovascular system from adverse T3 action.

259 Cs in non-lymphoid and lymphoid tissues, but spares the main cross-presenting CD103(+) DC subset.

260 refore recognizes kappa-restricted cells and spares the normal B cells expressing the nontargeted lam

261 e fratricide conferred by SLAMF7-CAR T cells spares the SLAMF7(-/low) fraction in each cell subset an

262 ets selected drug-resistant EGFR mutants but spares the wild-type receptor.

263 pattern of calcifications: small, symmetric, sparing the basal ganglia, and a stepping stone appearan

264 of the immunoproteasome beta5i subunit while sparing the constitutive beta5c subunit.

265 sacrifice (confidence in reasonable utility, sparing the donor, ensuring reciprocal donor benefit), a

266 ar first in the perifoveal macula, initially sparing the foveal center, and over time often expand an

267 ible mechanism for attacking the virus while sparing the host cell.

268 s lateral oscillations of the anterior body, sparing the need for 'action selection'.

269 of-principle that clodronate is effective at sparing the number of donor BM cells required to achieve

270 in other TORCH infections, while relatively sparing the other organ systems.

271 site by at least one prediction tool, while sparing the residues previously shown to be phosphorylat

272 ons have been observed in infarcts initially sparing the thalamus but interrupting thalamo-cortical o

273 ssue, 172 patients with an infarct initially sparing the thalamus were prospectively evaluated clinic

274 o selectively suppress the mutant gene while sparing the wild-type counterparts.

275 In the Spare-the-Nephron (STN) Study, kidney transplant recipie

276 nd enhance targeting of CML stem cells while sparing their normal counterparts.

277 was also effective as an oral glucocorticoid-sparing therapy in patients relying on oral glucocortico

278 to the regions and 21% (21/100) of patients sparing these regions.

279 s various treatment options, including organ-sparing TMT.

280 T provided the optimal dose distribution and sparing to heart.

281 aT supplements as a complementary or steroid-sparing treatment for asthma.

282 hould be considered as a first-line, steroid-sparing treatment of patients needing chronic therapy.

283 n with chemotherapy and P/D forms a new lung-sparing treatment paradigm for patients with locally adv

284 cation (P/D) as part of a multimodality lung-sparing treatment.

285 ent duration and the need to compare steroid-sparing treatments to pericardiectomy.

286 r cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethr

287 scle-invasive tumours can be offered bladder-sparing trimodality treatment consisting of transurethra

288 it through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia

289 patient selection could improve outcomes and spare unnecessary toxicity.

290 man societies greatly depend on tools, which spare us considerable time and effort.

291 and factors related to, glaucoma after lens-sparing vitrectomy (LSV) surgery in advanced retinopathy

292 ad a higher incidence of glaucoma after lens-sparing vitrectomy.

293 No steroid sparing was observed in group 2.

294 Steroid sparing was significant.

295 inimum urine output target is safe and fluid sparing when compared with the standard target.

296 lower vaccination costs through antigen dose-sparing, which is especially relevant in underserved cou

297 ely to enable both antigen and adjuvant dose sparing while retaining efficacy.

298 novo and upon resistance acquisition, while sparing wild-type (WT) EGFR.

299 egy would selectively lower mutant HTT while sparing wild-type.

300 interdependent land uses, we found that land sparing would allow larger estimated populations of most