ライフサイエンスコーパス: sparing

1 of vaccines has been shown to result in dose sparing.

2 ripetal GA spread in eyes with GA and foveal sparing.

3 as associated with marked spinal cord tissue sparing.

4 es, which can be avoided with effective land sparing.

5 and sharing is increasingly inferior to land sparing.

6 -treated mice resulted in increased neuronal sparing.

7 id not translate to significant in vivo dose sparing.

8 typical, limbic-predominant, or hippocampal-sparing.

9 g/h and results in a large intravenous fluid sparing.

10 to those of penetrating keratoplasty, while sparing a healthy endothelial graft.

11 tor blockade to sites of inflammation, while sparing a multitude of desired IL-1-related activities,

12 Instead, it may have insulin-sparing action, which seems to reduce the need for insul

13 ulators that maintain activity on S1P1 while sparing activity on other S1P receptors could offer equi

14 solone, suggesting the potential for steroid sparing activity.

15 and safety of adalimumab as a glucocorticoid-sparing agent for the treatment of noninfectious uveitis

16 has shown effectiveness as a corticosteroid-sparing agent or in case of relapse.

17 atment with prednisone and/or glucocorticoid-sparing agents.

18 gh risk of toxicity from steroids or steroid-sparing agents.

19 GA lesion enlargement due to possible foveal sparing, alternative assessments are being explored to c

20 as to outline important components of opioid-sparing analgesic regimens.

21 lack of TLR4 signaling impairs white matter sparing and functional recovery after SCI.

22 Areas of foveal sparing and GA were measured by 2 independent readers us

23 arch into the contrasting strategies of land sparing and land sharing has suggested that land sparing

24 garding target coverage, organ-at-risk (OAR) sparing and monitor units (MUs).

25 mice exhibited increased myelin and neuronal sparing and protection against locomotor deficits, inclu

26 conditions intensify and then resolve, often sparing and recovering some of the injured tissue.

27 g after SCI is important for OL lineage cell sparing and replacement, as well as in regulating cytoki

28 tensive surgery by assuring both parenchymal sparing and suitable oncologic resection.

29 right eye showed inferior arch with fixation sparing and supero-temporal central scotoma.

30 unity-level phylogenetic diversity than land sparing and that with increasing distance from forest (f

31 Hippocampal-sparing and the no atrophy group showed less aggressive

32 on-memory cognitive functions in hippocampal-sparing and the no atrophy group.

33 ity of improved vaccine immunogenicity, dose sparing and thermostability.

34 clude therapies that are oral, anthracycline sparing, and deliverable in resource-limited settings.

35 se to VLP immunization, provided VLP antigen sparing, and protected mice from a lethal challenge with

36 acrophages enhances NG2 cell responses, axon sparing, and sprouting of serotonergic axons.

37 development of highly effective, interferon-sparing anti-hepatitis C virus (HCV) drugs, the global b

38 le antinociceptive effects, and offer opioid-sparing antinociceptive effects in myriad preclinical in

39 nipulation to eliminate alloreactivity while sparing antiviral and antitumor T cells, we infused 12 h

40 dialysis initiation may serve as a "catheter-sparing" approach and allow delay of permanent access pl

41 COND-LINE randomised trial showed that NtRTI-sparing ART with ritonavir-boosted lopinavir and raltegr

42 more diffuse lesions with only periarterial sparing at the most severe end of the spectrum.

43 th conditions for the native organism, while sparing ATP consumption under conditions of cold-shock.

44 Although aortic valve-sparing (AVS) operations are established alternatives to

45 es is to inhibit detrimental signaling while sparing beneficial pathways.

46 bearing large-animal model while selectively sparing blood vessels and collagen.

47 tivation of ML impaired face detection while sparing body and object detection.

48 st considerable benefit in terms of toxicity sparing, but this has only recently been confirmed by su

49 of fatty acid utilization to the more oxygen-sparing carbohydrate metabolism.

50 b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced

51 fecting mainly CD4(+) T effector cells while sparing CD4(+)Foxp3(+) Treg cells have still to be fully

52 rons in the RMTg significantly while largely sparing cells in neighboring regions.

53 se ( IBD inflammatory bowel disease ), while sparing children and adolescents from potential risks of

54 inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues

55 ing and land sharing has suggested that land sparing-combining high-yield agriculture with the protec

56 CCF642, a bone marrow-sparing compound, exhibited a submicromolar IC50 in 10 o

57 eration and resistance to apoptosis in vitro sparing control cells.

58 ut there was no difference in corticosteroid-sparing control of inflammation (P = .99).

59 Primary outcome was corticosteroid-sparing control of inflammation at 5 and 6 months.

60 steroids were able to achieve corticosteroid-sparing control of inflammation by 6 months.

61 The odds of achieving corticosteroid-sparing control of inflammation with methotrexate were 2

62 ne resolved, and 88% achieved corticosteroid-sparing control of inflammation.

63 selectively blunts CD28 costimulation while sparing CTLA-4 and PD-L1 coinhibitory signals.

64 antagonists blunt T cell costimulation while sparing CTLA-4 and PD-L1-dependent coinhibitory signals.

65 vided an impetus for the search for cortisol-sparing CYP11B2 inhibitors.

66 eath driven by chronic TCR stimulation while sparing cytotoxic activity.

67 virologic response (SVR12) during interferon-sparing direct-acting antiviral therapies.

68 ther addition or substitution of a potassium-sparing diuretic, amiloride, to treatment with a thiazid

69 ulopathy, are usually treated with potassium-sparing diuretics or nonsteroidal anti-inflammatory drug

70 nduced a robust antibody response at antigen-sparing doses in healthy adults.

71 adjuvant enhanced immune response at antigen-sparing doses.

72 letion in the spinal cord, we used the brain-sparing driver Hoxb8::Cre.

73 Here we report the development of a brain-sparing DT, termed BRAINSPAReDT, for tissue-specific gen

74 we know that major components of fetal brain sparing during acute hypoxia are triggered exclusively b

75 intradermal delivery of IPV may lead to dose-sparing effect and reduction of the vaccination cost.

76 PC nanogel as a vaccine adjuvant had a dose-sparing effect and significantly enhanced the long-lasti

77 The safety profile and steroid-sparing effect favoured the combination of prednisone pl

78 -3 activation, which may explain its steroid-sparing effect in pediatric liver and intestine recipien

79 iol treatment, we hypothesized that the bone-sparing effect of estrogen in females is WNT16-dependent

80 6 mice and WT mice, suggesting that the bone-sparing effect of estrogen is WNT16-independent.

81 The role of WNT16 for the bone-sparing effect of estrogen was also evaluated in Wnt16(-

82 ade of interleukin-5 has significant steroid-sparing effects and attenuates blood and sputum eosinoph

83 at the endocannabinoid system promote opioid-sparing effects in the treatment of pain reflects an imp

84 In conclusion, the bone-sparing effects of estrogen and WNT16 are independent of

85 and thromboxane A2 receptor (TP) (11) while sparing EP2, EP3, and prostaglandin I2 receptors (IPs);

86 restrial-origin carbohydrates for energy and sparing essential fatty acids and amino acids for somati

87 us-free remission year per patient--actually sparing euro3 million on just 94 patients at the cost of

88 irs perisomatic hippocampal inhibition while sparing excitation provide additional support for synapt

89 The benefits of land sparing for both biodiversity and carbon storage suggest

90 vaccine supply, prompting WHO to adopt dose sparing for its vaccination campaign in Kinshasa, Democr

91 of which was identified as potentially land-sparing for solar energy development.

92 geographic atrophy (GA) and residual foveal sparing (FS), and to identify the minimum FS and maximum

93 Of the 5 eyes exhibiting foveal-sparing GA, OCTA showed CC flow within the region of fov

94 ater in the standard group than in the NtRTI-sparing group (mean percentage change -2.49% vs -1.00%,

95 k 48 in the standard group than in the NtRTI-sparing group (mean percentage change -3.30% vs -0.73%;

96 occurred during the trial (two in the NtRTI-sparing group and five in the standard group).

97 % of cochlear nerve afferent synapses, while sparing hair cells, in adult mice virtually eliminated t

98 nic B-lymphocytic leukemia tumor cells while sparing healthy B cells.

99 necessary to eradicate the malignancy while sparing healthy cells.

100 eukemia cell lines and patient samples while sparing healthy cells.

101 ic target for eradicating cancer cells while sparing healthy cells.

102 and preferential DNA delivery to HCC cells, sparing healthy hepatocytes.

103 therapeutic activity at the site of disease, sparing healthy tissues.

104 chemotherapeutics at the tumour site, while sparing healthy tissues.

105 Nonanatomical tissue-sparing hepatectomies are associated with worse DFS in p

106 fluidic workflow, we have developed a sample-sparing, high-throughput, solution-phase alternative for

107 ols in drug discovery, by providing resource sparing higher quality data acquisition means to replace

108 ency 4.7+/-1.6 mm; mean+/-SD) and epicardial sparing (HIU 2.9+/-2.1 mm versus radiofrequency 0.1+/-0.

109 to pathogens even at first encounter, while sparing host cells in the process.

110 hologically defined AD subtypes (hippocampal sparing [HpSp]; typical and limbic) and further examine

111 y more than 90% and 60%, respectively, while sparing immune and cardiac functions.

112 us uveitis requiring systemic corticosteroid-sparing immunosuppressive therapy.

113 nt inflammation necessitating corticosteroid-sparing immunosuppressive therapy.

114 CNV location was foveal-sparing in 12 eyes.

115 A showed CC flow within the region of foveal sparing in 4 of the eyes.

116 r and larger lesions with greater epicardial sparing in a dose-dependent manner.

117 ne, a functional group that is conspicuously sparing in the sequences of mussel proteins, exhibit rev

118 abitats within farmland landscapes, and land sparing intensifies farming to allow the offset of natur

119 hole-brain irradiation (WBRT) or hippocampal sparing irradiation (HSI).

120 dominal and hamstring muscles with iliopsoas sparing is common in facioscapulohumeral muscular dystro

121 p53-deficient cells with camptothecin while sparing isogenic p53-positive cells.

122 SCC for reduced radiation dose as a means of sparing late sequelae.

123 ted controls and those with selective, fiber-sparing lesions of either the OFC or VLPFC.

124 To test this premise, the effects of axon-sparing lesions of the RMTg were assessed on LHb-induced

125 Here, we show that axon-sparing lesions of the rostromedial tegmentum attenuate

126 e receptor 4 (TLR4) supports OL lineage cell sparing, long-term OL and OL progenitor replacement, and

127 which is most likely to be achieved via land-sparing measures.

128 A well-studied copper-sparing mechanism that operates in microalgae faced with

129 that use inorganic cofactors, but elemental sparing mechanisms can reduce this quota.

130 e media analysis provides an effective, skin-sparing method for preclinical assessment of novel drug

131 There is little evidence that CNI-sparing/minimization strategies, steroid minimization or

132 limbic-predominant (n = 33), or hippocampal-sparing (n = 35) by using the Scheltens' scale for media

133 ting that the ADO pathway may be involved in sparing natural hosts of SIVs from developing SIV-relate

134 es the rapidity, universality, and substance sparing nature of physical analysis, with the accuracy t

135 thesia blocks consciousness and memory while sparing non-conscious brain activities.

136 py-resistant Ewing sarcoma stem cells, while sparing non-malignant cells.

137 n of pathogenic Th17 cells while potentially sparing non-pathogenic tissue-protective ones.

138 Effects were selective, sparing nontaste papillae.

139 e and time-dependent apoptosis in CLL cells, sparing normal B lymphocytes.

140 ely infect and destroy cancerous cells while sparing normal cells and tissues.

141 totoxic drugs to prostate cancer cells while sparing normal cells that lack PSMA, thus improving pote

142 ells and/or virally infected cells, although sparing normal cells, and has been implicated in the pat

143 apoptosis of various cancer cell lines while sparing normal cells.

144 s a challenge to eradicate tumor cells while sparing normal cells.

145 at RT53 selectively kills cancer cells while sparing normal cells.

146 ectively trigger cancer cell apoptosis while sparing normal cells.

147 xtensive apoptosis in carcinoma cells, while sparing normal epithelial cells.

148 lls remaining after surgical resection while sparing normal healthy brain cells.

149 leukemia stem/progenitor cells while largely sparing normal hematopoietic stem/progenitor cells.

150 of transplantable human LSCs in mice, while sparing normal HSCs.

151 ng as a target for anti-cancer therapy while sparing normal organs.

152 nd selectively targeted leukemia cells while sparing normal progenitor cells.

153 rs that can enable complete resections while sparing normal surrounding tissues.

154 DR)-mediated apoptosis in cancer cells while sparing normal tissue.

155 Cancer-specific targeting sparing normal tissues would significantly enhance cance

156 potential for treating micrometastases while sparing normal tissues.

157 AIL) induces apoptosis in cancer cells while sparing normal tissues.

158 sible to target tumors more accurately while sparing normal tissues.

159 suitable for treating micrometastases while sparing normal tissues.

160 ed that the IS-RA significantly improves the sparing of BS/SC without compromising dosimetric require

161 better target dose distribution and similar sparing of critical structures.

162 Based on the relative sparing of frontal grey matter, we propose to redefine t

163 ticipants of the FAM study exhibiting foveal sparing of GA.

164 ration of alpha MNs (alpha-MNs) and complete sparing of gamma MNs (gamma-MNs), which selectively inne

165 delivery of tumoricidal radiation doses with sparing of nearby organs at risk.

166 g of other OARs except for slightly improved sparing of optic structures.

167 -RA demonstrated similar target coverage and sparing of other OARs except for slightly improved spari

168 etabolism on (18)F-FDG PET, whereas relative sparing of posterior cingulate metabolism compared with

169 a 'reversed' temporal gradient with relative sparing of recent memories.

170 white matter in normal aging, with relative sparing of sensorimotor fibers.

171 Importantly, CCR2 antagonism resulted in a sparing of TBI-induced hippocampal-dependent cognitive d

172 th fat deposition in most thigh muscles, but sparing of the adductors and semitendinosus.

173 ical progression across time and a selective sparing of the cerebellum.

174 Relative sparing of the efferent auditory and vestibular neurons

175 unusual patterns of subpial tau deposition, sparing of the hippocampus and co-localization with moss

176 d with predefined variant profiles (relative sparing of the hippocampus and/or occipital lobe).

177 e U fibers, corpus callosum involvement with sparing of the outer blades, and involvement of corticos

178 ng of the U fibers, the corpus callosum with sparing of the outer blades, the basis pontis, middle ce

179 r PAMM illustrating a fern-like pattern with sparing of the periarteriolar area in all cases.

180 and upper extremities' muscles, with marked sparing of the quadriceps.

181 hinning and autofluorescence showed relative sparing of the temporal sector.

182 hemispheric white matter abnormalities with sparing of the U fibers, corpus callosum involvement wit

183 f the cerebral hemispheric white matter with sparing of the U fibers, the corpus callosum with sparin

184 5 mg/kg) treatment resulted in a significant sparing of tyrosine hydroxylase-immunoreactive (THir) ne

185 The development of aortic valve-sparing operations (reimplantation of the aortic valve a

186 In many cardiac units, aortic valve-sparing operations have become the preferred surgical pr

187 Aortic valve-sparing operations in patients with Marfan syndrome were

188 mined the long-term outcomes of aortic valve-sparing operations in patients with Marfan syndrome.

189 tients with Marfan syndrome had aortic valve-sparing operations.

190 The mPEG carrier alone did not have bone-sparing or anti-inflammatory properties.

191 r with diplopia, ptosis, 6th nerve and pupil-sparing partial 3rd nerve palsies as well as progressive

192 in 11 operations (41%) performed with caval sparing (piggyback) surgical technique.

193 e, reduced RST atrophy, and/or increased RST sparing/plasticity in the GM.

194 rats showed enhanced rubrospinal tract (RST) sparing/plasticity in the gray matter (GM) rostral to in

195 Here, we evaluate the land sparing potential of solar energy development across fou

196 ponse into an anti-inflammatory and neuronal sparing profile.

197 d cognitive function in rats, and its energy-sparing properties suggest that it may help to treat a r

198 tional anatomy approach, starting with nerve-sparing prostatectomy, assumes that quality-of-life outc

199 eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for

200 leotide exchange factor (GEF) activity while sparing protein expression also impaired TH17 cell diffe

201 outcomes, and outline the capacity of vessel-sparing radiotherapy to preserve sexual function in 90%

202 ring iron availability and facilitating iron-sparing rather than only long-term iron storage.

203 ts to the substudy, 70 assigned to the NtRTI-sparing regimen and 76 to the standard regimen.

204 A potent rifamycin-sparing regimen could revolutionize the treatment of adu

205 her raltegravir (400 mg twice per day; NtRTI-sparing regimen) or tenofovir (245 mg once per day) and

206 on of treatment, participants receiving dose-sparing regimen.

207 Nine of these patients received a dose-sparing regimen.

208 tide reverse transcriptase inhibitor (NtRTI)-sparing regimen.

209 rculosis, including the use of antimicrobial-sparing regimens, leading to improved outcomes.

210 ial antituberculosis drugs in new rifampicin-sparing regimens.

211 stigation of the dynamics of the fetal brain sparing response for the first time.

212 The fetal brain sparing response matures as the fetus approaches term, i

213 te intense interest into how the fetal brain sparing response may be affected by adverse intrauterine

214 rd, as iron levels decline further, an "iron-sparing" response (fsrA, fbpAB, and fbpC) is induced to

215 m a pool of 322 patients who underwent nerve-sparing robot-assisted radical prostatectomy without mul

216 ynamic contrast-material enhanced) and nerve-sparing robot-assisted radical prostatectomy, during whi

217 ese data identify therapeutic and antibiotic sparing roles for vaginal immunomodulatory agents that s

218 dentification of a second generation of S1P3-sparing S1P1 agonists.

219 eous features at baseline, efficacy, steroid-sparing, safety, and relapses were recorded.

220 w precise therapeutic discrimination in vivo-sparing single antigen "bystander" tumors while efficien

221 nical potential (TWh year(-1)) of these land sparing sites and test the degree to which projected ele

222 agreement for measurements of GA and foveal-sparing size were 0.995 and 0.946, respectively.

223 nique assessment challenges because of their sparing solubility in water and difficulties in empirica

224 The energy-sparing spring theory of the foot's arch has become cent

225 OCS-sparing strategies are extremely important to improve pa

226 Effective SCS-sparing strategies might reduce the burden associated wi

227 placed with follow-up or less invasive organ-sparing strategies.

228 ramuscular route and offers a potential dose-sparing strategy to stretch the limited global IPV suppl

229 e to deliver deep lesions through fat, while sparing superficial structures.

230 ed our institutional experience with nephron sparing surgery (NSS) in patients with synchronous bilat

231 from 69.0% to 42.5%), and the use of nephron-sparing surgery (partial nephrectomy and ablation) incre

232 y of life than those who underwent sphincter-sparing surgery (SSS).

233 The use of nephron-sparing surgery exceeds radical nephrectomy in patients

234 e, the addition of radiotherapy (RT) to limb-sparing surgery may result in higher local control rates

235 ho received surgical treatment, only nephron-sparing surgery was associated with a benefit in cancer-

236 views all these aspects, in addition to limb-sparing surgery.

237 A parenchyma-sparing surgical strategy seems appropriate in patients

238 Tissue-sparing surgical techniques and carbon dioxide laser tre

239 s enable selective treatment of tumors while sparing surrounding healthy tissue, but optimal clinical

240 Scaling was selective, sparing synapses that were large and lacked recycling en

241 event thrombotic complications of HIT, while sparing systemic hemostatic pathways.

242 ive optimization of hemoglobin levels, blood-sparing techniques, and standardization of transfusion p

243 T results in clinically meaningful cognitive sparing that significantly exceeds that of modern XRT pr

244 pattern of calcifications: small, symmetric, sparing the basal ganglia, and a stepping stone appearan

245 the convexities of the cerebral hemispheres, sparing the brainstem, cerebellum and spinal cord.

246 of the immunoproteasome beta5i subunit while sparing the constitutive beta5c subunit.

247 sacrifice (confidence in reasonable utility, sparing the donor, ensuring reciprocal donor benefit), a

248 ar first in the perifoveal macula, initially sparing the foveal center, and over time often expand an

249 rolling GVHD in an Ag-dependent manner while sparing the GVL effect.

250 ible mechanism for attacking the virus while sparing the host cell.

251 suppression of all specialized genes, while sparing the housekeeping ones, and, thus, attenuated pat

252 involvement of subjacent muscles and usually sparing the internal organs.

253 OFC damage, 18 patients with frontal damage sparing the lateral OFC, and 53 matched healthy particip

254 s lateral oscillations of the anterior body, sparing the need for 'action selection'.

255 tosis in inv(16)(+) AML CD34(+) cells, while sparing the normal hematopoietic stem cells.

256 of-principle that clodronate is effective at sparing the number of donor BM cells required to achieve

257 in other TORCH infections, while relatively sparing the other organ systems.

258 Selective truncation of XistAR, while sparing the overlapping Xist RNA, leads to a deficiency

259 can be performed using ultrasound guidance, sparing the patient transport to a fluoroscopy suite.

260 site by at least one prediction tool, while sparing the residues previously shown to be phosphorylat

261 ons have been observed in infarcts initially sparing the thalamus but interrupting thalamo-cortical o

262 ssue, 172 patients with an infarct initially sparing the thalamus were prospectively evaluated clinic

263 Controls and subjects with prefrontal damage sparing the VMF showed normal reward priming, but VMF-da

264 subjects and patients with prefrontal damage sparing the VMF.

265 o selectively suppress the mutant gene while sparing the wild-type counterparts.

266 nd enhance targeting of CML stem cells while sparing their normal counterparts.

267 odies are not only possible novel GVL effect-sparing therapeutics for the treatment of GVHD but might

268 a mechanism for assessing potential infarct-sparing therapies with a level of rigor analogous to mul

269 was also effective as an oral glucocorticoid-sparing therapy in patients relying on oral glucocortico

270 to the regions and 21% (21/100) of patients sparing these regions.

271 upted grid and HD cell characteristics while sparing theta rhythmicity in these regions.

272 ssion of T lymphocytes that drive GVHD while sparing those that mediate graft-versus-malignancy (GVM)

273 ing multiple proinflammatory receptors while sparing those with anti-inflammatory activity.

274 onse-based treatment adaptation and toxicity sparing through the reduction or elimination of RT and t

275 s various treatment options, including organ-sparing TMT.

276 T provided the optimal dose distribution and sparing to heart.

277 aT supplements as a complementary or steroid-sparing treatment for asthma.

278 hould be considered as a first-line, steroid-sparing treatment of patients needing chronic therapy.

279 n with chemotherapy and P/D forms a new lung-sparing treatment paradigm for patients with locally adv

280 cation (P/D) as part of a multimodality lung-sparing treatment.

281 ent duration and the need to compare steroid-sparing treatments to pericardiectomy.

282 r cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethr

283 scle-invasive tumours can be offered bladder-sparing trimodality treatment consisting of transurethra

284 rugs to cancerous tissues shows potential in sparing unaffected tissues.

285 it through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia

286 ibits cytotoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to

287 f ROP stage 4A, 4B, and 5 who underwent lens-sparing vitrectomy (LSV) between 1992 and 2013.

288 and factors related to, glaucoma after lens-sparing vitrectomy (LSV) surgery in advanced retinopathy

289 ad a higher incidence of glaucoma after lens-sparing vitrectomy.

290 Granulomatous skin lesions sparing warm regions (eg, flexural surfaces and skinfold

291 Antigen sparing was achieved through combination with AS03 adjuv

292 No steroid sparing was observed in group 2.

293 Steroid sparing was significant.

294 inimum urine output target is safe and fluid sparing when compared with the standard target.

295 lower vaccination costs through antigen dose-sparing, which is especially relevant in underserved cou

296 ely to enable both antigen and adjuvant dose sparing while retaining efficacy.

297 cent clinical RTOG 0933 study of hippocampal sparing whole-brain irradiation.

298 novo and upon resistance acquisition, while sparing wild-type (WT) EGFR.

299 egy would selectively lower mutant HTT while sparing wild-type.

300 interdependent land uses, we found that land sparing would allow larger estimated populations of most