ライフサイエンスコーパス: spatial regulation

1 lar structures requires precise temporal and spatial regulation.

2 s multiple enzymes under strict temporal and spatial regulation.

3 yl-1,4-naphthoquinone, or Compound 5, on the spatial regulation and activation kinetics of tyrosine p

4 Both transcripts also display spatial regulation and are found in the dorsal mesoderm

5 ting exhibits sexually dimorphic patterns of spatial regulation and can be modified by abiotic enviro

6 effect (itself of interest), in other cases, spatial regulation and control can profoundly affect the

7 ties, mechanisms underlying its temporal and spatial regulation and functional plasticity still remai

8 y cellular activity in adherent cells, their spatial regulation and the corresponding change in membr

9 of light to mediate these reactions permits spatial regulation and the generation of unique, multifu

10 ty, but little is known in mammals about its spatial regulation and the relevance of spatial Cdc42 po

11 uding synergistic activation, long-range and spatial regulation, and gene expression memory.

12 le severing and the mechanisms governing its spatial regulation are not well understood.

13 proteins show almost identical temporal and spatial regulation at the cell cortex.

14 The phas promoter displays stringent spatial regulation, being very highly expressed during e

15 of the assembly of these polymers and their spatial regulation by accessory factors, framing them in

16 The exocyst complex seems to achieve this spatial regulation by determining the sites at the membr

17 We independently confirmed insulin-dependent spatial regulation by using static spatial statistics me

18 mplex subcellular localization, yet how MCAK spatial regulation contributes to spindle assembly is no

19 Thus, in addition to temporal and spatial regulation, dosage-dependent threshold requireme

20 ression of sigmaH is subject to temporal and spatial regulation during colony development, that this

21 ep tissues, however ov1aS shows temporal and spatial regulation during fetal lung development, being

22 the poised enhancer state may be a mark for spatial regulation during tissue patterning.

23 Temporal and spatial regulation have emerged as the central themes, w

24 se in cardiomyocytes is most consistent with spatial regulation in microdomains of the plasma membran

25 ing technology to gain new information about spatial regulation in signaling events.

26 to be learned about cellular engineering and spatial regulation in these 'simple' cell wall-less bact

27 vertebrate neural tube closure, however, its spatial regulation is largely unknown.

28 but the molecular mechanism underlying this spatial regulation is not understood.

29 rs and membrane signaling proteins, but this spatial regulation is not well defined.

30 essive architecture, which confers stringent spatial regulation, is disrupted upon transcriptional ac

31 dhesion cascade, and its strict temporal and spatial regulation make it an ideal target for imaging a

32 thway via both S127 phosphorylation-mediated spatial regulation (nuclear-cytoplasmic shuttling) and t

33 e that produces the ventral signal, but that spatial regulation occurring downstream of Nudel proteas

34 of this study was to further investigate the spatial regulation of [Ca(2+)](i) clearance in parotid a

35 or this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response

36 aling components in lipid rafts provides key spatial regulation of AC activity.

37 te how microtubules contribute to the proper spatial regulation of actin assembly and polarized cell

38 pecific roles of different actin isoforms in spatial regulation of actin dynamics and stability in ax

39 be novel mechanisms of cofilin severing and spatial regulation of actin filament turnover in cells.

40 We describe an approach for analyzing spatial regulation of actin polymerization and depolymer

41 Microtubules (MTs) participate in the spatial regulation of actin-based processes such as cyto

42 s indicate that both GAPs collaborate in the spatial regulation of active Cdc42.

43 These results show that tight spatial regulation of actomyosin contractility is requir

44 a demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex

45 Together, we show that spatial regulation of ADF/cofilin activity controls the

46 ta suggest a molecular model of temporal and spatial regulation of alphaB, alphaA and gamma-crystalli

47 neural precursor formation suggests that the spatial regulation of an AS-C gene was modified during L

48 ffects of absent blood flow include abnormal spatial regulation of angiogenesis and elevated VEGF sig

49 ngly bind ankB in the distal axon because of spatial regulation of ankyrin affinity by phosphorylatio

50 king pathways, but little is known about the spatial regulation of ARF activation.

51 B, but the mechanism and significance of the spatial regulation of Aurora B activity remain unclear.

52 provide a mechanistic theoretical model for spatial regulation of Aurora B phosphorylation.

53 Our data provide a novel model for the spatial regulation of axon branching by Netrin-1, in whi

54 est that to achieve the precise temporal and spatial regulation of BB/centriole assembly, the initiat

55 Temporal and spatial regulation of beta A3/A1 expression in the lens

56 our findings indicate that Ca(2+)-dependent spatial regulation of beta-actin synthesis through Src c

57 ions to invadopodia through the temporal and spatial regulation of c-Src activity.

58 Such tight spatial regulation of Ca(2+) efflux is likely important

59 However, the precise temporal and spatial regulation of CaMKII activity in living cells ha

60 muialpha can be used to observe temporal and spatial regulation of CaMKII activity in living neurons.

61 diomyocytes and elicit differential temporal/spatial regulation of cAMP signaling.

62 ic pattern along the root's axis, suggesting spatial regulation of carotenoid synthesis.

63 hese data are consistent with a temporal and spatial regulation of Cdc24p-dependent activation of Cdc

64 cam1 controls neuronal morphogenesis through spatial regulation of Cdc42 signaling and, subsequently,

65 l eukaryotic cells [1], and the temporal and spatial regulation of Cdc42p depends on the activity and

66 se findings indicate that in eye development spatial regulation of cell death and survival is integra

67 Temporal and spatial regulation of cell division assures that each da

68 Spatial regulation of cell division in Escherichia coli

69 Temporal and spatial regulation of cell division is critical for prop

70 component of the Min system involved in the spatial regulation of cell division.

71 In multicellular organisms, temporal and spatial regulation of cell proliferation is central for

72 tural filamentous proteins necessary for the spatial regulation of cell shape, cell division, and chr

73 s PG splitting process requires temporal and spatial regulation of cell wall hydrolases.

74 ch as length or curvature, arise through the spatial regulation of cell wall synthesis by cytoskeleta

75 In particular, the spatial regulation of cellular processes can be examined

76 rs, are critical for the proper temporal and spatial regulation of cellular proliferation.

77 ce elements responsible for the temporal and spatial regulation of CFTR expression.

78 aising the possibility that the temporal and spatial regulation of chitin synthesis is mediated by th

79 The temporal and spatial regulation of chitin synthesis was investigated

80 Thus, spatial regulation of classical cadherin adhesive functi

81 ith the coagulation system, the temporal and spatial regulation of coagulation activity in neuroinfla

82 To better understand the spatial regulation of cohesin association, we mapped bud

83 gration driven by Endo180 as a model for the spatial regulation of contractility and adhesion dynamic

84 e Escherichia coli Min system contributes to spatial regulation of cytokinesis by preventing assembly

85 chia coli, the Min system contributes to the spatial regulation of cytokinesis by preventing the asse

86 d1) and discordia2 (dcd2), which disrupt the spatial regulation of cytokinesis during asymmetric cell

87 cal to the oscillatory mechanism involved in spatial regulation of division.

88 act as a dynamic and sensitive mechanism for spatial regulation of DNA transactions in vivo by select

89 gs for understanding the transcriptional and spatial regulation of dysfunctional T cells and for the

90 Together, these data indicate that spatial regulation of EGFR signaling may be an important

91 tion of ILVs within the MVB and thus for the spatial regulation of EGFR signaling.

92 Loss of the normal spatial regulation of eph/ephrin expression in val mutan

93 ture-dependent assembly pathway provides the spatial regulation of ESCRT-III to fuse juxtaposed bilay

94 0 component of the exocyst is a key event in spatial regulation of exocytosis by Rho GTPases.

95 Temporal and spatial regulation of expression of introduced genes, or

96 d proteins and/or via changes in temporal or spatial regulation of expression.

97 anscription machinery to accomplish rigorous spatial regulation of expression.

98 se prosaposin displayed similar temporal and spatial regulation of expression.

99 These observations suggest that the precise spatial regulation of FORSE-1 binding in the embryonic f

100 MinCDE system indeed is sufficient to cause spatial regulation of FtsZ, required for Z-ring position

101 This is likely due to the temporal and spatial regulation of GA biosynthesis, perception, and s

102 We present evidence that the spatial regulation of GAL1 and CLN3 transcripts is what

103 scores the need for the precise temporal and spatial regulation of gcm transcription.

104 Developmental changes in the temporal and spatial regulation of gene expression drive the emergenc

105 Precise temporal and spatial regulation of gene expression during Drosophila

106 The temporal and spatial regulation of gene expression in mammalian devel

107 Selective spatial regulation of gene expression lies at the core o

108 Spatial regulation of gene expression time delays is a n

109 an extensive analysis of transcriptional and spatial regulation of gene expression.

110 ks of transcription factors to ensure robust spatial regulation of gene expression.

111 and tissue-specific transcription factors to spatial regulation of gene expression.

112 r shape is correlated with both temporal and spatial regulation of gene expression.

113 the skeleton relies on precise temporal and spatial regulation of genes expressed in cartilage and b

114 at Cdc42 regulates cell polarity through the spatial regulation of GSK-3beta and Apc.

115 r its functions in vivo and propose that the spatial regulation of Gwl at mitotic entry contributes t

116 thus suggesting a role for autoprocessing in spatial regulation of hh signaling.

117 RNA hybridization analysis, the temporal and spatial regulation of HMG1, one of the genes encoding HM

118 e that is indispensable for the temporal and spatial regulation of host response and, together with i

119 system represents a useful tool for studying spatial regulation of IL-1beta production in skin.

120 signaling proteins and provide temporal and spatial regulation of intracellular Ca(2+) in different

121 ontext, Rab5a plays an important role in the spatial regulation of intracellular transport and signal

122 Further, temporal and spatial regulation of irreversible post-translational mo

123 ulates RNR activity through the temporal and spatial regulation of its subunits.

124 ever, little is known about the temporal and spatial regulation of its synthesis.

125 nes in the CNS, we examined the temporal and spatial regulation of key signal transducers and activat

126 stasis, and establish the importance of fine spatial regulation of lipid biosynthesis for cellular fu

127 Spatial regulation of maternal RNA translation, which ha

128 A, and we propose that it contributes to the spatial regulation of MCAK activity within inner centrom

129 t microdomains, and provide insight into the spatial regulation of membrane invagination.

130 Spatial regulation of microtubule (MT) dynamics contribu

131 We show that the spatial regulation of microtubule catastrophe parameters

132 eveal that A. nidulans exhibits a remarkable spatial regulation of microtubule disassembly within hyp

133 a unique and quantitative approach to study spatial regulation of microtubule dynamics in cells.

134 ery controls membrane ruffling, and that the spatial regulation of MLC phosphorylation plays critical

135 st that ROCK and MLCK play distinct roles in spatial regulation of MLC phosphorylation.

136 These mechanisms of functional and spatial regulation of MMP-2 may also be applicable to di

137 also enhanced catalytic activity due to the spatial regulation of MNPs as close as possible to the M

138 A potential mechanism for spatial regulation of motor proteins is provided by post

139 engaged for local protein production and how spatial regulation of mRNA-protein interactions mediates

140 Thus, spatial regulation of myosin motor function is in part c

141 Our study reveals a critical step in the spatial regulation of myosin V-dependent organelle trans

142 Spatial regulation of nanos is achieved by a combination

143 temporally distinct activities contribute to spatial regulation of nanos translation.

144 x development, emphasizing the importance of spatial regulation of nos mRNA [3, 5].

145 olated vulval precursor cell behavior and in spatial regulation of Notch activity.

146 sis of Fn1 in cardiovascular development and spatial regulation of Notch signaling.

147 sion of NTPDases in the vasculature suggests spatial regulation of nucleotide-mediated signaling.

148 The tight spatial regulation of opponent splice variants helps ens

149 at similar mechanisms may be involved in the spatial regulation of other genes in early embryonic dev

150 rod-shaped cells to investigate the roles of spatial regulation of peptidoglycan synthesis, glycan-st

151 escribing novel features of the temporal and spatial regulation of phosphoinositides and their downst

152 leading edge, achieved through temporal and spatial regulation of PI3 kinases and the tumor suppress

153 Spatial regulation of PI4P levels thereby plays an impor

154 and others have shown that the temporal and spatial regulation of PIE-1 degradation is controlled by

155 These data demonstrate that spatial regulation of PKA via anchoring is an important

156 er, these data suggest that the temporal and spatial regulation of polarized growth converges at the

157 ORC and Cdc6 ensure the correct temporal and spatial regulation of pre-RC formation.

158 Temporal and spatial regulation of proliferation and differentiation

159 ic development requires precise temporal and spatial regulation of protein activity.

160 s and exportins plays a critical role in the spatial regulation of protein activity.

161 In eukaryotic cells, the spatial regulation of protein expression is frequently c

162 egulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA in

163 uggesting that Hsp42 plays a central role in spatial regulation of proteins in quiescent cells.

164 ration and describes a new mechanism for the spatial regulation of Rac1 activity that is critical for

165 ular status suggests a role for Gpd1p in the spatial regulation of redox potential, a process critica

166 of SOX2 dosage is critical for temporal and spatial regulation of retinal progenitor cell differenti

167 sary for invasion, but also that subcellular spatial regulation of RhoA activity, as opposed to its g

168 ts delineate a PTK7-Src signaling module for spatial regulation of ROCK activity, actomyosin contract

169 Both of these loci affect the spatial regulation of runt transcription and appear gene

170 ns, and support a role for motor proteins in spatial regulation of signal transduction pathways.

171 thereby providing the first clear example of spatial regulation of signaling in this organelle that i

172 nd support the role of motor proteins in the spatial regulation of signaling modules.

173 e first meiotic division requires the proper spatial regulation of sister chromatid cohesion and its

174 siological adjustments in quiescent cells is spatial regulation of specific proteins and RNA importan

175 Previous studies support a model in which spatial regulation of SpHE transcription relies on multi

176 ivation, a mechanism that contributes to the spatial regulation of spindle assembly and possibly to o

177 reviously unrealized mitotic roles involving spatial regulation of spindle assembly checkpoint (SAC)

178 Better understanding of the spatial regulation of surface anchoring may lead to the

179 smata reveals there is distinct temporal and spatial regulation of symplastic domains at the apex, de

180 fication of lateral organ fate relies on the spatial regulation of the ABC floral organ identity gene

181 Temporal and spatial regulation of the actin cytoskeleton is vital fo

182 romoter in order to examine the temporal and spatial regulation of the ANF gene in vivo using transge

183 ing cochlear duct relies on the temporal and spatial regulation of the bHLH transcription factor Atoh

184 Spatial regulation of the cAMP-dependent protein kinase

185 We examine the temporal and spatial regulation of the Caulobacter cell cycle, bacter

186 Defects in spatial regulation of the cell attachment at the leading

187 s in our understanding of the components and spatial regulation of the contractile ring (CR), the pre

188 In many bacteria, MinD is involved in spatial regulation of the cytokinetic Z ring, and ParAs

189 eading to a coupled oscillation required for spatial regulation of the cytokinetic Z ring.

190 nterplay between elements is involved in the spatial regulation of the genes present on the pregenomi

191 m (CNS), the molecular mechanisms underlying spatial regulation of the neuropeptide genes are largely

192 The precise temporal-spatial regulation of the p21-activated serine-threonine

193 Spatial regulation of the plant hormone indole-3-acetic

194 and the Sox-domain protein Dichaete, to the spatial regulation of the proneural gene achaete (ac) in

195 fusion protein function can be controlled by spatial regulation of the proteolytic priming site, with

196 of SUMO-1 conjugation to RanGAP1 may be the spatial regulation of the Ran pathway during mitosis.

197 Temporal and spatial regulation of the replication factory is importa

198 We propose that spatial regulation of the SAX pathway modulates TKV sign

199 xo-cycling synaptic vesicle pool and loss of spatial regulation of the vesicular recycling intermedia

200 nd in the case of MinC were shown to mediate spatial regulation of the Z ring demonstrating that MinC

201 oRNA loss-of-function phenotypes, define the spatial regulation of their effectors and uncover intera

202 n vivo would be more feasible if temporal or spatial regulation of their enzymatic activity were poss

203 ese genes are determined by the temporal and spatial regulation of their expression patterns.

204 However, little is known about the spatial regulation of their synthesizing machinery.

205 Even though the temporal and spatial regulation of these integrin clusters is essenti

206 actin track influence the motor activity and spatial regulation of these myosins.

207 Spatial regulation of this pathway is determined by the

208 These results indicate that the spatial regulation of TOR complex 1 (TORC1) might be inv

209 identify Ack1 as an essential player in the spatial regulation of TRAIL-R1/2.

210 lopment requires well-organized temporal and spatial regulation of transcription factors that are ass

211 itions, mediated in part by the temporal and spatial regulation of transcription factors.

212 ansgenic approaches we achieved temporal and spatial regulation of transgene expression and performed

213 ne control systems that provide temporal and spatial regulation of transgene expression in response t

214 The spatial regulation of Trk processing is thought to be me

215 Spatial regulation of tyrosine phosphorylation is import

216 ng protein that is required for temporal and spatial regulation of vascular endothelial growth factor

217 The results show a complex temporal and spatial regulation of vn transcription involving multipl

218 kinesin-8 motor Kip3p plays a minor role in spatial regulation of yeast kMT assembly.

219 This cooperativity may confer temporal and spatial regulation on HIV-1 assembly.

220 ation, particularly in terms of temporal and spatial regulation, over a wide range of biological syst

221 t factors, but its biochemical mechanism and spatial regulation remain poorly understood.

222 in centomeric regions suggests temporal and spatial regulation roles for H2A phosphorylation in chro

223 This tight temporal-spatial regulation suggests that FMRP plays a dynamic ro

224 This spatial regulation suggests that these filaments have ad

225 lex pattern of expression, with temporal and spatial regulation that is not accounted for by elements

226 For spatial regulation, transgenes were expressed by using p

227 To define the relevance of this spatial regulation, we developed an in vitro invasion as