ライフサイエンスコーパス: spatiotemporally

1 repeated for NCD mortality and did not vary spatiotemporally.

2 nt and physiology, although how motile cells spatiotemporally activate signaling events remains large

3 AutoPilot framework, an automated method for spatiotemporally adaptive imaging that integrates (i) a

4 s' ability to individuate those objects in a spatiotemporally ambiguous event.

5 Both FRNs were spatiotemporally and functionally equivalent.

6 gaps in our knowledge of how RA is generated spatiotemporally and may, along with Raldh1 and Raldh3,

7 onsciously perceived motion signals that are spatiotemporally associated with this color throughout t

8 pids allows GLP-1R signaling to be regulated spatiotemporally at a constant basal GLP-1 level.

9 opment progresses, and thus may be regulated spatiotemporally at the level of translation.

10 ing means to direct and confine drug release spatiotemporally at the site of interest with high speci

11 insight into this phenomenon and demonstrate spatiotemporally coherent, cognitive representations tha

12 units of implicit attentional selection are spatiotemporally colocalized feature clusters that are a

13 will provide powerful strategies to dissect spatiotemporally complex biological processes.

14 ors extinguish their dependence upon HH in a spatiotemporally complex manner, completing cell-fate sp

15 hemical (acetylcholine) activation triggered spatiotemporally complex, propagating inositol trisphosp

16 tegrate cross-modal stimuli, but exposure to spatiotemporally concordant cross-modal stimuli was high

17 mance of animals in localizing and detecting spatiotemporally concordant visual and auditory stimuli

18 ocess that allows the brain to bind together spatiotemporally congruent inputs from different sensory

19 The spatiotemporally constrained delivery of the effector an

20 ll signaling modulates Notch activation by a spatiotemporally constrained mechanism.

21 sexpression experiments in frog embryos, for spatiotemporally context-dependent activity of Ptf1a as

22 Optical inputs were designed to spatiotemporally control levels of second messengers, IP

23 malian cells and discuss the mechanisms that spatiotemporally control PI conversion in endocytosis an

24 We developed a novel method to spatiotemporally control the activity of signaling molec

25 nto RNP granules, such as transcription, can spatiotemporally control the organization and dynamics o

26 Zn-directed RIDC3 assemblies can be used to spatiotemporally control the templated growth of small P

27 The ability to regulate gene activity in a spatiotemporally controllable manner is vital for biolog

28 lasticity of tumor cell migration and EMT is spatiotemporally controlled and connected upon challenge

29 rovide a basis for the future development of spatiotemporally controlled antinociceptive and antiinfl

30 The conduction blocks were spatiotemporally controlled by electrode geometry and st

31 Pectin methylesterification is spatiotemporally controlled by pectin methylesterases (P

32 can generate vapor microbubbles that can be spatiotemporally controlled by pulsed laser irradiation.

33 Cohesin cleavage is spatiotemporally controlled by separase-associated regul

34 Spatiotemporally controlled collection, transport, and d

35 one-homing polymeric nanoparticles (NPs) for spatiotemporally controlled delivery of therapeutics to

36 We achieved spatiotemporally controlled delivery with subcellular pr

37 hogenesis in vivo occurs through a series of spatiotemporally controlled events under the control of

38 elopment, such as cell specification and the spatiotemporally controlled formation of a three-dimensi

39 her expansion of the CRISPR/Cas9 system as a spatiotemporally controlled gene regulatory system, seve

40 cle Myosin II, but how this motor protein is spatiotemporally controlled is incompletely understood.

41 To regulate the recombination in a spatiotemporally controlled manner, we constructed a rec

42 rmation, we conditionally ablated Olig2 in a spatiotemporally controlled manner.

43 ls that arise from the microenvironment in a spatiotemporally controlled manner.

44 ork utilizes polymeric scaffold systems with spatiotemporally controlled morphogen cues to develop pr

45 of the data presented here, we propose that spatiotemporally controlled Myosin flows in conjunction

46 y pancreatin, providing the possibility of a spatiotemporally controlled release and protection of bo

47 light (red and NIR) has great potential for spatiotemporally controlled release of therapeutic agent

48 th photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger.

49 ur custom microfluidic control system allows spatiotemporally controlled stimulation with extracellul

50 tweezing cytometry (TB-ATC), for generating spatiotemporally controlled subcellular mechanical force

51 MIS type I receptors, Alk2 and Alk3, is also spatiotemporally controlled; Alk2 expression appears ear

52 al interactions can be probed in 2D or 3D by spatiotemporally controlling the gel microenvironment, w

53 n example of how differential receptor usage spatiotemporally controls and diversifies the effects of

54 date how localized Plexin-B1 stimulation may spatiotemporally coordinate its downstream targets in gu

55 HGEF7 and rhotekin, one Rho effector and the spatiotemporally coordinated activation of Rho GTPases (

56 lses in wild-type embryos and how pulses are spatiotemporally coordinated is unknown.

57 This decision is often spatiotemporally coordinated such that a spatial pattern

58 This remodeling is spatiotemporally coordinated with a cytoskeletal structu

59 PH) gene whose activity is indispensable for spatiotemporally correct expression of CYTOKININ INDEPEN

60 mechanism that increases RGC sensitivity to spatiotemporally correlated input, such as that produced

61 rphosphorylation in anterior bulbar cells is spatiotemporally correlated with a highly stereotyped se

62 ation and dynamics of synaptic podosomes are spatiotemporally correlated with changes in AChR aggrega

63 all puncta adjacent to AChR clusters and was spatiotemporally correlated with the formation and maint

64 multaneous hemodynamic imaging confirms that spatiotemporally coupled functional hyperemia is not pre

65 This receptive field is spatiotemporally coupled, applying differential temporal

66 go light-activated phase separation, forming spatiotemporally definable liquid optoDroplets.

67 lecules to cellular compartments and thereby spatiotemporally define cellular signaling events.

68 -protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic protein

69 oping brain AUF1 proteins are expressed in a spatiotemporally defined manner, and p37 and p40/42 isof

70 for modulating GABAA receptor function in a spatiotemporally defined manner.

71 To enable spatiotemporally defined, rapid and reproducible manipul

72 aging provide order-of-magnitude speedups in spatiotemporally demixing calcium video data into estima

73 ve shown that this process relies on signals spatiotemporally deployed in the extra-embryonic tissues

74 ould be visualized across the age range in a spatiotemporally detailed time-lapse sequence.

75 the Soil and Water Assessment Tool to model spatiotemporally differentiated effects on maize yield,

76 AF is traditionally characterized by spatiotemporally disorganized electrical activation and,

77 V1 and V2 of behaving monkeys, we identified spatiotemporally dissociable processes for grouping cont

78 that the modular network in mouse V1 selects spatiotemporally distinct clusters of neurons within the

79 The rhombic lip is thus emerging as a spatiotemporally distinct epithelium whose late appearan

80 governed by its own promoter, resulting in a spatiotemporally distinct expression profile from that o

81 al induction is controlled by conserved, yet spatiotemporally distinct mechanisms that co-ordinate de

82 ia, and instead indicate the presence of two spatiotemporally distinct modes of cross-linking in S. a

83 that propofol-induced LOC is accompanied by spatiotemporally distinct oscillatory neuronal dynamics

84 that propofol-induced LOC is accompanied by spatiotemporally distinctive neuronal dynamics in this n

85 vibrissa array strongly shapes the coding of spatiotemporally distributed deflections.

86 ogenous P2Y receptors in COS 7 cells reveals spatiotemporally divergent PKC responses.

87 unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this

88 The spatiotemporally dynamic distribution of instructive lig

89 o reveal that in the embryonic midbrain, the spatiotemporally dynamic Shh domain defines multiple pro

90 in a highly autonomous manner, recapitulate spatiotemporally each of the main steps of retinal devel

91 icts that the Ca(2+) and NO levels alternate spatiotemporally, establishing complementary feedback lo

92 nstrate the efficacy of this estimator using spatiotemporally explicit simulations and apply it to a

93 n North American fossil occurrences within a spatiotemporally explicit stratigraphic framework that a

94 articipate in directing the highly regulated spatiotemporally expressed genetic network during implan

95 miRNAs, mmu-miR-101a and mmu-miR-199a*, are spatiotemporally expressed in the mouse uterus during im

96 The results showed that spatiotemporally focused TMS may enhance extinction lear

97 here the incidence of Ebola virus disease is spatiotemporally heterogeneous, and is decreasing rapidl

98 icrofluidic diffusive mixers can be used for spatiotemporally high-throughput characterization of bac

99 The ability to spatiotemporally identify the formation of specific anio

100 lly new way to engineer molecular assemblies spatiotemporally in cellular microenvironment for inhibi

101 ng axon navigation-can be precisely achieved spatiotemporally in response to semaphorins.

102 n biogeochemistry, and their abundances vary spatiotemporally in the global oceans, with upper estima

103 We mapped strain rates spatiotemporally in three models of tissue morphogenesis

104 on of its effectors are precisely controlled spatiotemporally in vivo.

105 al cues received at the plasma membrane (PM) spatiotemporally integrate to the functional chromatin o

106 date how MAPK and PKA signaling cascades are spatiotemporally integrated in a single neuron to suppor

107 agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activi

108 so describes TPLSM laser ablation, which can spatiotemporally manipulate specific cellular population

109 UBR2 and ubiquitinated H2A (uH2A) spatiotemporally mark meiotic chromatin regions subject

110 the visual processing of frontal neurons is spatiotemporally matched with, and functionally dependen

111 n with mechanistic implications as to how it spatiotemporally mediates integrin signaling and cell ad

112 We used a genetic strategy to spatiotemporally modulate canonical Wnt signaling activi

113 show theoretically and experimentally that a spatiotemporally modulated device can be designed to hav

114 ual stimulus dome that allowed us to present spatiotemporally modulated UV and green luminance in any

115 provides a direct and noninvasive method to spatiotemporally monitor biofilm accumulation in the sub

116 We perform spatiotemporally multiplexed experiments to collect 1,86

117 Built on spatiotemporally multiplexed two-photon excitation, this

118 e receptive fields of both T4 and T5 exhibit spatiotemporally offset light-preferring and dark-prefer

119 Here, we study the shape of 472,040 spatiotemporally optimized travel routes in the 92 most

120 at slow brain rhythms predominantly indicate spatiotemporally organized activity in local nerve cell

121 Such networks are spatiotemporally organized and capable of gradual, oscil

122 Aggregate signals in cortex are known to be spatiotemporally organized as propagating waves across t

123 We show here that cortical spindles are spatiotemporally organized into circular wave-like patte

124 fundamental roles for Merlin/ERM proteins in spatiotemporally organizing the cell cortex and suggest

125 Our experiments are accomplished by spatiotemporally overlapping electron and light pulses o

126 is implemented in the brain in fine-grained spatiotemporally patterned activity.

127 a lack of versatile devices that can deliver spatiotemporally patterned light while performing simult

128 lular human embryonic stem cell colonies are spatiotemporally patterned onto arbitrary substrates.

129 Using optogenetic techniques, we delivered spatiotemporally patterned stimuli to neurons and confir

130 We spatiotemporally perturbed electrical activity in beta-c

131 widespread recognition of the importance of spatiotemporally precise causal control over cellular si

132 of user-selected neurons to be targeted for spatiotemporally precise concurrent optogenetic activati

133 rs, technological limitations have prevented spatiotemporally precise control over intracellular sign

134 ancers, play a central role in orchestrating spatiotemporally precise gene-expression programs during

135 a receptor-specific, cell-type-specific, and spatiotemporally precise manner.

136 t ultrasonic stimulation is an effective and spatiotemporally precise method to activate the retina.

137 developed a motor task for rats that trains spatiotemporally precise movement patterns without requi

138 ich denotes the noninvasive, reversible, and spatiotemporally precise perturbation by light of living

139 s technology promises to enable evocation of spatiotemporally precise responses in targeted cells or

140 sules offer a powerful method for delivering spatiotemporally precise signals to cells.

141 rect cortical inputs to the same neurons are spatiotemporally primed.

142 It was shown that MOMP can spatiotemporally propagate through cells, in particular

143 We presented spatiotemporally randomized, balanced theta-modulated ex

144 oding directions were acquired sequentially, spatiotemporally registered, and retrospectively selecte

145 Our findings highlight the spatiotemporally regulated action mechanism of eRNAs dur

146 Spatiotemporally regulated actomyosin contractility gene

147 Dril1 mRNA expression is spatiotemporally regulated and is detected in the involu

148 er cell migration and that Yan expression is spatiotemporally regulated as border cells migrate from

149 ously proposed, because its activity must be spatiotemporally regulated both preanaphase and postanap

150 Spatiotemporally regulated domains of BMP, FGF, and othe

151 blast-specific amelogenin gene expression is spatiotemporally regulated during tooth development.

152 dynamics, we show that leader cells form by spatiotemporally regulated endoreplication, caused prima

153 enous cannabinoid ligand, and its levels are spatiotemporally regulated in the uterus during early pr

154 Here we used spatiotemporally regulated inactivation of Fog2 to delin

155 r, our data underscore the central role of a spatiotemporally regulated key cell survival and growth

156 ow these many functions are carried out in a spatiotemporally regulated manner in a single cytoplasm

157 heparan sulfate proteoglycans expressed in a spatiotemporally regulated manner in many developing tis

158 cell types and growth factors that act in a spatiotemporally regulated manner, is triggered by a mec

159 planar polarity is rapidly established in a spatiotemporally regulated pattern that is dynamically r

160 l of material properties through independent spatiotemporally regulated photocleavage of crosslinks a

161 HKM is a dynamic and spatiotemporally regulated process in the developing ret

162 anized tissue structure is generated through spatiotemporally regulated responses to EGF receptor act

163 how RopGEF function is controlled to allow a spatiotemporally regulated Rop activity.

164 ults suggest that CRL5 adaptor expression is spatiotemporally regulated to modulate Reelin signaling

165 Cofilin is spatiotemporally regulated; at the plasma membrane, it c

166 This process requires spatiotemporally-regulated localization of signaling and

167 hat the cofilin phosphatase chronophin (CIN) spatiotemporally regulates cofilin activity at the cell

168 Histone methylation spatiotemporally regulates neural crest gene expression;

169 assive membrane properties of cells that are spatiotemporally relevant to the pattern of retraction i

170 , but how these actin dynamics are regulated spatiotemporally remains poorly understood.

171 We use ultrafast optical techniques to spatiotemporally resolve spin dynamics in strained galli

172 ured at stationary monitoring sites, and for spatiotemporally resolved estimates of PM2.5 and BC at t

173 f sampling multiple chemical messengers in a spatiotemporally resolved manner.

174 is a novel, nondestructive tool that allows spatiotemporally resolved measurement of CaMKII activati

175 llular-resolution expression data produced a spatiotemporally resolved metazoan transcription factor

176 estimated using a validated satellite-based spatiotemporally resolved prediction model.

177 rameters) and can thus be exploited to offer spatiotemporally resolved prediction of UFPs on freeways

178 ) measurements have the potential to provide spatiotemporally resolved predictions of both long and s

179 c analysis of imaging data allowed accurate, spatiotemporally resolved quantification of two differen

180 BF) at the river Thur was studied using both spatiotemporally resolved sampling and single-well push-

181 Spatiotemporally resolved system-scale investigation of

182 whole-plant level, allowing for a systemic, spatiotemporally resolved understanding of metabolic pro

183 the loop between sensing and actuation (both spatiotemporally resolved).

184 g of programed cells, including logic gates, spatiotemporally responsive patterning, and wearable dev

185 These results suggest that spatiotemporally restricted ADF/cofilin-mediated actin d

186 sophosphatidic acid (LPA) gradient induces a spatiotemporally restricted decrease in the mobility of

187 Haematopoietic cells arise from spatiotemporally restricted domains in the developing em

188 enhancers to mediate quantitative changes in spatiotemporally restricted expression patterns during a

189 Here, implementing spatiotemporally restricted gene ablation by way of the

190 These results lead us to propose that spatiotemporally restricted generation of cytoplasmic Ra

191 d reversible, rapidly switchable patterns of spatiotemporally restricted GPCR activity in a single ce

192 nd development of various skin appendages at spatiotemporally restricted intervals.

193 To modulate Shh signaling in a spatiotemporally restricted manner, we carried out gain-

194 from Rose, Jin, and Craig demonstrating that spatiotemporally restricted NMDA receptor excitation at

195 each makes a unique cell fate decision in a spatiotemporally restricted pattern.

196 MatIS is spatiotemporally restricted to the prezygotic stage of t

197 These spatiotemporally segregated processes are not known to b

198 ubdivided individuals into 14 "contingents" (spatiotemporally segregated subgroups).

199 king advantage of the wireless, scalable and spatiotemporally selective capabilities that light allow

200 This computational tool relies on spatiotemporally selective filters that capture the chan

201 ons of the NAc during a behavioral task that spatiotemporally separated sequential goal-directed stim

202 thylated motifs were highly conserved across spatiotemporally separated Trichodesmium isolates, there

203 Conservation of these intergenic regions in spatiotemporally separated Trichodesmium populations sug

204 stimate motion by cross-correlating pairs of spatiotemporally separated visual signals, but recent ex

205 e lipids bind its C-terminal SH2 domain in a spatiotemporally specific manner and thereby exert exqui

206 l concentrations are tightly controlled in a spatiotemporally specific manner, the simultaneous quant

207 nd sex steroids shape brain development in a spatiotemporally specific manner, within neural systems

208 l three septal ephrins, A2, A3, and A5, play spatiotemporally specific roles in guiding topographic p

209 ns were also mapped, but were typically less spatiotemporally specific to stimulus delivery.

210 ainfall shows large variability and exhibits spatiotemporally sporadic extreme rainfall events.

211 ensembles of CA3 pyramidal neurons produces spatiotemporally structured input patterns arriving onto

212 ther the production of twitches is random or spatiotemporally structured, or whether the patterning o

213 in a variety of animals including humans, is spatiotemporally structured.

214 The hypomorphic L allele can be spatiotemporally switched to the hypermorphic H allele b

215 stress transmission along the actin bundle, spatiotemporally synchronizes actin disassembly and fibe

216 nclear how the activity of ACF7 is regulated spatiotemporally to achieve focal adhesion-specific guid

217 he distinct CAD and SAD functions are linked spatiotemporally to the differential biosynthesis of gua

218 Harnessing spatiotemporally tunable near-fields for the steering of

219 muli that selectively targeted four distinct spatiotemporally tuned channels with center frequencies

220 dependence in perception characterized by a spatiotemporally tuned, orientation-selective operator-w

221 We demonstrate that spatiotemporally uniform regulation, with constant trans

222 eeping the cytosolic pool of building blocks spatiotemporally uniform.

223 equent in paroxysmal than persistent AF, are spatiotemporally unstable, are not the source of centrif

224 keleton, where myosin activity is controlled spatiotemporally using light.

225 The strength of these effects is spatiotemporally variable, and several sets of authors h

226 e, and high-emitting facilities appear to be spatiotemporally variable.

227 r prevalence throughout the arbour is highly spatiotemporally variable.

228 and detection planes are common owing to the spatiotemporally varying optical properties of living sp

229 Macrophage infiltration correlates spatiotemporally with this deleterious phenomenon, but t

230 endent and its activity is tightly regulated spatiotemporally within the cell.