ライフサイエンスコーパス: specialize

1 ition, suggesting that their function can be specialized.

2 Using specialized 3' end deep sequencing methods, we undertook

3 romoter complexes that require activation by specialized AAA(+) ATPases.

4 overed specific proteinase genes and defined specialized activities in different cellular processes.

5 cialized fatty acid biosynthetic enzymes and specialized acyltransferases.

6 volutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remain

7 s typically required activated substrates or specialized additives.

8 involved 5 tertiary referral centers with a specialized adult congenital heart disease unit.

9 enabled the evolution of pathways to produce specialized amino acids, thereby increasing the diversit

10 to prefrontal cortex, which is arguably less specialized and more flexible than other parts of the br

11 GRCD genes show both specialized and pleiotropic functions contributing to or

12 Here we report the oldest, morphologically specialized, and obligate termitophiles from mid-Cretace

13 ion and activation of aPKC involve distinct, specialized aPKC-containing assemblies: a PAR-3-dependen

14 to be a versatile and useful technology for specialized applications in industry and also for scient

15 ne potential and PIP2, especially within the specialized architecture of axons.-Neverisky, D.

16 of whether signaling pathways have developed specialized architectures that overcome retroactivity an

17 cortices (PMd and PMv, respectively) are two specialized areas involved in the control of hand moveme

18 rsatile N-Cbz group, avoiding the use of the specialized aryl directing groups previously required in

19 Targeted confirmatory testing and testing by specialized assays were done at a central reference labo

20 re astrocyte properties, reveal evidence for specialized astrocytes within neural circuits, and provi

21 Vision and hearing do not appear specialized based on the relative size of the superior a

22 First, we show that individuals develop specialized behavioral competences, originating already

23 roughput RNA sequencing methods coupled with specialized bioinformatic analyses have recently uncover

24 irectional interactions between functionally specialized brain regions.

25 be distributed across multiple functionally specialized brain structures, including the striatum and

26 ot only depends on the integrity of language-specialized brain systems, but also on 'domain-general'

27 he selective synchronization of functionally specialized but widely distributed cortical areas.

28 cincticrus (Stal) is an assassin bug with a specialized camouflaging behavior to ambush ants in the

29 outcomes and health resource utilization in specialized cardiac surgical ICUs.

30 use 24/7 intensivist coverage on outcomes in specialized cardiac surgical ICUs.

31 In some specialized cases, though, plant cells are programmed to

32 blast fungus Magnaporthe oryzae elaborates a specialized cell called an appressorium, which is used t

33 The fungus infects plants with a specialized cell called an appressorium, whose developme

34 scovery of neutrophil extracellular traps, a specialized cell death process in which DNA-based struct

35 Meiosis is a specialized cell division that generates gametes, such a

36 Meiosis is a specialized cell division, essential in most reproducing

37 l process that results in the acquisition of specialized cell fates.

38 For specialized cell function, as well as active cell behavi

39 Specialized cell types and organoids have been derived f

40 These specialized cell types not only characterize the normal

41 It is now possible to investigate how specialized cell types of these systems work together, a

42 Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta.

43 proper morphology and functional behavior of specialized cell types.

44 Differentiation of specialized cells such as those forming stomata and tric

45 iptional regulatory mechanism by which these specialized cells utilize homologous members of a core c

46 um within the thymic stroma comprises highly specialized cells with a high degree of anatomic, phenot

47 oted in soft tissues, and are regenerated by specialized cells.

48 interest in this regard since they provide a specialized cellular microenvironment guiding proper mor

49 severe airflow obstruction in the Pittsburgh Specialized Center of Clinically Oriented Research cohor

50 Hispanic white individuals in the Pittsburgh Specialized Center of Clinically Oriented Research cohor

51 dy recognized in the 1970s when the need for specialized centers with multidisciplinary teams was pro

52 ammaliaform with an unusual mosaic of highly specialized characteristics, and the results of phylogen

53 Centromeres are highly specialized chromatin domains that enable chromosome seg

54 Telomeres are specialized chromatin structures that protect chromosome

55 Telomeres form specialized chromatin that protects natural chromosome t

56 es in the computational principles governing specialized circuits versus more general-purpose learnin

57 anced biosensing, neuromorphic function, and specialized circuits.

58 has acquired, in the course of evolution, a specialized clathrin-independent function necessary for

59 suggesting the copepod gut hosts long-term, specialized communities.

60 Container aquatic habitats support a specialized community of macroinvertebrates (e.g. mosqui

61 roughput low-power-consumption operation for specialized computational tasks.

62 In Caenorhabditis elegans, a specialized condensin forms the core of the dosage compe

63 s of foreseeable potential for employment of specialized contrast agents.

64 Altogether, our results highlight the specialized contribution of P/Q- and N-types VGCCs to ne

65 h microscopy-derived models proposing PMS as specialized cortical actin.

66 FFA and subsequently many other functionally specialized cortical regions.

67 Thus, secretory autophagy utilizes a specialized cytosolic cargo receptor and a dedicated SNA

68 specialists; nevertheless, >50% of foragers specialized daily on a given reward.

69 tical analysis and visualization, as well as specialized data classes for a variety of high-throughpu

70 This suggests the need for specialized designation of rectal cancer centers to supp

71 Species with restricted distribution range, specialized diet or dry grassland habitat were more like

72 In translesion DNA synthesis (TLS), specialized DNA polymerases replicate the damaged DNA, a

73 These cultures contain the specialized domains formed by axonal interaction with my

74 March 1, 2010, to September 30, 2014, in 10 specialized early psychosis treatment services in Austra

75 Our results open a path towards specialized embedded memory-logic applications and ultra

76 They emerge from a specialized endothelial population, termed hemogenic end

77 pecific, advancing our understanding of this specialized enzyme family and shedding critical light on

78 Cells have specialized enzymes to degrade nanoRNAs, such as the DHH

79 olic networks driven by efficient and highly specialized enzymes.

80 This process is orchestrated by specialized epithelial cells known as ameloblasts which

81 umans, the alpha defensin HD5 is produced by specialized epithelial cells of the gastrointestinal and

82 catalyst concentrations without the need for specialized equipment.

83 e fungal ER represent a conserved process in specialized eukaryotic cells such as in mammalian hepato

84 lly variant in the plant kingdom, arise from specialized fatty acid biosynthetic enzymes and speciali

85 y seen for Synechocccus PCC6301 Rubisco, the specialized folding and assembly requirements of Te-Rubi

86 Rapid byssal secretion is enabled by a specialized foot and multiple proteins including expande

87 ions demonstrate that regions that typically specialize for voice processing in the hearing brain pre

88 ith more than 80% of flowering plant species specialized for animal pollination, understanding how wi

89 roximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins

90 r temporal gyrus (STG) in the human brain is specialized for aspects of music processing (for review,

91 Neuronal synapses are adhesions specialized for communication and they come in two types

92 Axons are neuronal processes specialized for conduction of action potentials (APs).

93 changes and smaller tonically active muscles specialized for continuous fine-scaled adjustments.

94 regions of the lung contain epithelial cells specialized for different functions: basal, secretory an

95 simum), a large African herbivore with lips specialized for grazing in open savannahs, relates to it

96 We demonstrate that the VWFA is highly specialized for lexical processing of real words, and th

97 a unique modification of the primary cilium, specialized for light perception.

98 ically and physiologically distinct and also specialized for processing particular features of the vi

99 thelial cells present in mucosal tissues and specialized for the capture of luminal microparticles an

100 The lymphoid tissues of the gut are specialized for the induction of regulatory cells, which

101 of literate individuals that is purportedly specialized for visual word recognition.

102 ytogenes because of deficits in xenophagy, a specialized form of autophagy that mediates clearance of

103 These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino

104 mpositions, Pols IV and V clearly evolved as specialized forms of Pol II, but their catalytic propert

105 to understand dinosaur origins may represent specialized forms rather than the ancestral avemetatarsa

106 to be 0.13 degrees , enabled by an extremely specialized, forward pointing fovea ( approximately 5 om

107 distribution of a second subclade suggests a specialized function in supporting beneficial microbial

108 to how vesicular transport is adapted to the specialized functions of differentiated cell types and o

109 bosomes varying in RP composition may confer specialized functions, and RP paralog specificity define

110 hat the thallus is likely to have zones with specialized functions.

111 g in neuronal dendrites and spines through a specialized GA-independent trafficking network.

112 These data indicate that the specialized gene expression profile of mature microglia

113 s may be a general mechanism to exchange non-specialized genetic cargo between bacterial species.

114 ations, each typically provided by a unique, specialized geometry.

115 Highly specialized glial cells wrap axons with a multilayered m

116 irteen unrelated probands with HCM seen in a specialized HCM center between 2002 and 2015 and genetic

117 Specialized helicases play an important role in unwindin

118 A specialized High Risk Clinic in Sydney, Australia was fo

119 However, relatively few specialized homogeneous platforms have garnered signific

120 Incidence of AMD recorded in specialized hospital-based care.

121 of cold tolerance, fungal pathogenicity and specialized host infection.

122 edefine the AVRs as Tie2 signaling-dependent specialized hybrid vessels and provide genetic evidence

123 Recent works have attempted to specialize hydrogels for cancer research; we comprehensi

124 s attributed primarily to transfer from less specialized ICUs (p = 0.037) as compared with more resou

125 hestrated development and function of highly specialized immune cells in secondary lymphoid organs.

126 In the absence of specialized immune cells, the need for plants to reprogr

127 ving bioaugmentation with dedicated bacteria specialized in degrading the pollutant is suggested as a

128 rting enzyme retinaldehyde dehydrogenase and specialized in forkhead box p3-positive regulatory T-cel

129 to whether they function redundantly or are specialized in terms of substrates and mechanism.

130 rtex is composed of several distinct regions specialized in the identification of different object ki

131 It specializes in infection of the ciliated respiratory epi

132 hey also have a bearing on the idea that OFC specializes in stimulus- or object-based choices in cont

133 es, to a monofunctional, yet not necessarily specialized, inefficient form in genomes undergoing redu

134 vascular shear stress requires mechanically specialized interaction mechanisms, including force-stre

135 biodiversity in the tropics is maintained by specialized interactions among plants and their natural

136 cular combination mode in which functionally specialized ipsilateral inputs joined broadly distribute

137 (Arabidopsis thaliana) seed coat mucilage, a specialized layer of the extracellular matrix composed o

138 Here, we report on identification of a specialized LD subpopulation characterized by a unique p

139 C population comprises two main functionally specialized lineages, whose origins and differentiation

140 he formation of membrane domains composed of specialized lipids, proteins, and nucleic acids.

141 transcriptional control GATA4 exercises over specialized liver vascular development and function.

142 into TAG through the combined activities of specialized LPAT and DGAT activities and demonstrate the

143 infected cells through directed secretion of specialized lytic granules.

144 ns and then imported into the organelles via specialized machineries.

145 Specialized magnetic resonance imaging techniques are ex

146 d, necessitated by the diurnal turnover of a specialized membrane-rich organelle, the outer segment,

147 patic Plasmodium development occurs inside a specialized membranous compartment termed the parasitoph

148 on of primary metabolism to the evolution of specialized metabolic pathways.

149 s (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to survive

150 Because BAT is a specialized metabolic tissue that takes up and burns lip

151 onary processes shape the micro-diversity of specialized metabolism observed in closely related envir

152 Plant specialized metabolism produces hundreds of thousands of

153 ole that intracellular localization plays in specialized metabolism, and sets the stage for understan

154 exhibits a possible dual role in general and specialized metabolism.

155 argue that BGCs are not a hallmark of plant specialized metabolism.

156 example of the convergent evolution of plant specialized metabolism.

157 ry cells where CO2 is released by the active specialized metabolism.

158 chromosome sequences identified 49 putative specialized metabolite biosynthetic gene clusters.

159 ins that control transcription initiation of specialized metabolite gene clusters have been identifie

160 ngation as a point of regulatory control for specialized metabolite pathways and introduce a subgroup

161 ole in the diversity and reactivity of plant specialized metabolites by catalyzing the transfer of th

162 t of these microorganisms synthesize complex specialized metabolites exhibiting biomedically importan

163 on their involvement in the biosynthesis of specialized metabolites in plants, including Catharanthu

164 ing the chemical composition and function of specialized metabolites in the rhizosphere is a key elem

165 erstanding of the biological implications of specialized metabolites in this genus.

166 Flavonoids represent a large family of specialized metabolites involved in plant growth, develo

167 Monoterpene indole alkaloids, a class of specialized metabolites that includes the anticancer age

168 Here, we review key classes of specialized metabolites that occur as mostly non-volatil

169 utions of genes encoding the biosynthesis of specialized metabolites.

170 known to contain an astonishing diversity of specialized metabolites.

171 inable ways to improve the production of the specialized metabolites.

172 anscriptional control of the biosynthesis of specialized metabolites.

173 alamin, which is used as a cofactor in their specialized methionine synthase (MetH).

174 be further analyzed with more sensitive and specialized methods.

175 Social bees harbor a simple and specialized microbiota that is spatially organized into

176 in the intestine after birth to constitute a specialized microenvironment that maintains IESCs at hom

177 lium is a highly conserved organelle housing specialized molecules responsible for receiving and proc

178 is controversial, as it already acquired the specialized morphology that characterizes modern caecili

179 ative networks with experienced clinicans in specialized multidisciplinary clinics.

180 (120 nm, 80 nm and 40 nm) were fabricated by specialized nano-sphere lithography technology.

181 ese genomic reprogramming events depend on a specialized network of transcription factors, a diverse

182 the leech genome, is highly expressed on the specialized neural cells that are uniquely found in adul

183 ke adipokinetic hormone (AKH) secretion from specialized neuroendocrine cells.

184 ent location, but how the functions of these specialized neuron types are acquired remain to be under

185 Mounting evidence points to specialized neuronal subtypes within the serotonergic ne

186 his process relies on nociceptors, which are specialized neurons that detect and respond to potential

187 Taken together, these results show that specialized nipple epidermis is maintained by estrogen-i

188 Bat flies, in particular, are highly specialized obligate hematophagous ectoparasites that in

189 Animals detect odorous chemicals through specialized olfactory sensory neurons (OSNs) that transd

190 Later areas specialize on processing of specific features.

191 production among microbial species that are specialized on direct N2O reduction from the environment

192 ee-living cnidarians, yet they have retained specialized organelles known as polar capsules, akin to

193 These processes occur in specialized organelles, requiring membrane-bound intrace

194 Specialized organotrophic Bacteria 'syntrophs' and metha

195 ency on an extracellular bacterium housed in specialized organs connected to the foregut.

196 neuron type, suggestive of two functionally specialized output channels.

197 We asked whether bumblebees specialize over timescales shorter than their lifetime.

198 ned that BCR repertoires become increasingly specialized over a span of decades, but less plastic.

199 Diverse and morphologically specialized oxyporines from the Early Cretaceous suggest

200 Mutualisms that involve symbioses among specialized partners may be more stable than mutualisms

201 thelial cell cycle arrest and acquisition of specialized phenotypes are interdependent is unknown.

202 hisms may be critical for the development of specialized plant feedstocks for bioenergy.

203 abolic regulation for the diversification of specialized plant metabolism.

204 d nitrogen-fixing soil bacteria results in a specialized plant organ (i.e., root nodule) where the ex

205 lability to maintain the fitness benefits of specialized plant-pollinator relationships.

206 ins (MAPs), which include a subset of highly specialized plus-end-tracking proteins (+TIPs) that resp

207 rvature, have enabled plants to exploit many specialized pollinator groups.

208 We report a specialized population of septal GABAergic neurons, the

209 progenitors has identified a blockade in the specialized positive transcription elongation factor b (

210 ensory signaling, photoreceptor synapses use specialized presynaptic proteins that support neurotrans

211 ecently described chemical mediators, termed specialized pro-resolving mediators that actively regula

212 such as physicochemical parameters and more specialized procedures need to be developed.

213 For complex, highly specialized procedures, hospital market consolidation ma

214 vertebrates, CSPGs are involved also in more specialized processes such as neurogenesis and growth fa

215 icking, protein import and export, and other specialized processes.

216 nctional separation that may allow multiple, specialized processing circuits to emerge during a rever

217 GN with retinotopic precision that preserves specialized processing of foveal versus peripheral visua

218 and University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellence).

219 ncreased the concentration of the downstream specialized proresolving lipid mediators (SPMs) 14-hydro

220 acute inflammation requires biosynthesis of specialized proresolving lipid mediators, such as E-seri

221 Maresin 1 (MaR1) is a highly conserved specialized proresolving mediator (SPM) hosting potent a

222 Specialized proresolving mediators (SPMs), identified in

223 g evidence indicates that imbalances between specialized proresolving mediators and proinflammatory m

224 genous factors, including fatty acid-derived specialized proresolving mediators and proteins, such as

225 Specifically, specialized proresolving mediators comprise a family of

226 Emerging evidence that specialized proresolving mediators of inflammation accel

227 e formation of nonphysiological complexes by specializing protein-protein interactions.

228 ction of neurons in early visual cortex have specialized receptive fields that allow them to selectiv

229 etrotransposons migrate to the germ plasm, a specialized region of the oocyte that prefigures germ ce

230 The fovea is a specialized region of the retina that dominates the visu

231 , PubMed, and the Cochrane Tobacco Addiction Specialized Register were searched for randomized contro

232 ssibility that astrocytes are neural circuit specialized remains largely unexplored.

233 anscriptome of brainstem interneurons in the specialized respiratory rhythmogenic site dubbed preBotz

234 Although the specialized response to faces observed in humans [1, 3,

235 Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the e

236 subsets of mRNAs, yet it is unclear whether specialized ribosomes exist and if paralog specificity c

237 stributed in depots throughout the body with specialized roles in energy storage and thermogenesis.

238 y; however, they have additional diverse and specialized roles in various organs.

239 2 and suggest that some mitotic kinases have specialized roles supporting enucleation of maturing ery

240 n centimeter sized glass samples without any specialized sample preparation or nanofabrication.

241 Specialized secondary metabolites serve not only to prot

242 ry autophagy cargo IL-1beta is recognized by specialized secretory autophagy cargo receptor TRIM16 an

243 Mammalian sperm feature a specialized secretory organelle on the anterior part of

244 nt membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that su

245 Hair cells are specialized sensors located in the inner ear that enable

246 The cerebral cortex is organized into specialized sensory areas, whose initial territory is de

247 enlarged apical labial palpomeres with dense specialized sensory organs, match those of modern taxa a

248 membrane of most mammalian cells that serve specialized signaling functions.

249 Emerging research establishes a role for specialized signalling filopodia, or cytonemes, in morph

250 traditional requirement for clean rooms and specialized skills has inhibited many biologists from pu

251 Recognition of these specialized soft tissues in Confuciusornis is enabled by

252 subsequently be analyzed by use of relevant specialized software.

253 o a "winner-take-all" scenario, leading to a specialized spacer distribution.

254 onship between this general function and the specialized spatial activity patterns is unclear.

255 it did this as well or better than its more specialized state-of-the-art competitors.

256 t-innervating motor neurons, emphasizing the specialized status of digit control in the evolution of

257 ism involving protection of meristems within specialized structures named buds in order to survive lo

258 indings, coordinated recruitment of mRNAs at specialized structures such as P-bodies during stress di

259 PP2A gene families, members of functionally specialized subclades quickly revert to singleton status

260 f invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes.

261 DC) lineage, they are now considered to be a specialized subset of tissue-resident macrophages.

262 y heterogeneous population with functionally specialized subsets that are developmentally imprinted a

263 3 through a non-canonical interaction with a specialized surface on LC3 where host proteins with esse

264 mean excision rate for suspicious lesions in specialized surveillance (0.81; 95% CI, 0.72 to 0.91) co

265 There were also fewer invasive procedures in specialized surveillance compared with standard care in

266 s built to compare the costs and benefits of specialized surveillance compared with standard care ove

267 Results Specialized surveillance through the High Risk Clinic wa

268 Conclusion Specialized surveillance was a cost-effective strategy f

269 as being pivotal in the evolution of highly specialized systems in which the differentiated rhizobia

270 lae, composed of an epithelium that includes specialized taste buds, the basal lamina, and a lamina p

271 l that nocturnal predators are probably more specialized than previously assumed, irrespective of amb

272 lants with AM fungi are suggested to be more specialized than those of green plants, although direct

273 lutamylation may be a conserved mechanism to specialize the form and function of cilia.

274 to facilely interpret the results is highly specialized, the variables involved in designing and dep

275 regulated by female sex hormones, which may specialize them for specific physiological functions.

276 age occurs entirely through transcytosis, as specialized tight junctions are functional as early as v

277 to the formation of distinct germ layers and specialized tissues.

278 isolated lysosome-derived membrane structure specialized to breach tissue barriers.

279 s, indicating that circulating monocytes are specialized to engage E-selectin and providing key insig

280 Parasitoid species were almost entirely specialized to individual galler species, so the observe

281 and accessory kinesin-3 motor, CEM cilia are specialized to produce extracellular vesicles.

282 injury, Schwann cells convert to a phenotype specialized to promote repair.

283 pertoire of DNA methyltransferases that have specialized to target cytosines for methylation in speci

284 el to investigate how generic chaperones can specialize toward the control of TA systems.

285 SecB family members have diverged to become specialized toward the control of toxin-antitoxin (TA) s

286 ion without any dedicated instrumentation or specialized training by the operator for interpretation.

287 that have led subterranean species to evolve specialized traits, many of which evolved convergently.

288 RP composition of ribosomes might allow for specialized translation of different subsets of mRNAs, y

289 e by translesion synthesis in the absence of specialized translesion synthesis polymerases.

290 he existence of diverse Agaricomycetes and a specialized trophic interaction and ecological community

291 nces in kinesin activity that likely reflect specialized tuning for localized cytoskeletal determinan

292 a, dopamine is synthesized and released by a specialized type of amacrine cell, the dopaminergic amac

293 is typically associated with apoptosis or a specialized type of autophagy termed mitophagy, SLC25A46

294 nd granules at one pole and the nucleus in a specialized uropod, the "nucleopod," which is capped wit

295 tinal and renal glomerular functions rely on specialized vasculature maintained by VEGF that is produ

296 he mammalian brain is supplied with blood by specialized vasculature that is structurally and functio

297 s by which cellular waste is isolated inside specialized vesicles called autophagosomes for recycling

298 se activity or proteasomal degradation using specialized, virus-like particles-potentiates the cytoto

299 To support these studies, a specialized vitamin D food composition dataset, based on

300 e it remains unclear how their expression is specialized when under the command of a common regulator