ライフサイエンスコーパス: species specificity

1 ution, lentiviruses exhibit a high degree of species specificity.

2 if so to investigate its tissue tropism and species specificity.

3 synergistically result in the appearance of species specificity.

4 ally, suggesting fhaS may contribute to host-species specificity.

5 mechanistic link between incompatibility and species specificity.

6 Three near-neighbor genomes are critical for species specificity.

7 t position 128 was a critical determinant of species specificity.

8 arly embryogenesis with remarkable stage and species specificity.

9 h residues 99 and 146 also contribute to the species specificity.

10 ory elements that modulate cell, tissue, and species specificity.

11 the rat, human, and mouse genes, suggesting species specificity.

12 ial cells and in vivo in the rat, showing no species specificity.

13 te interactions during fertilization exhibit species specificity.

14 ons at fertilization is relative or absolute species specificity.

15 ry of anti-adhesives targeted for strain and species specificity.

16 es, the vaccinia IFN-gamma R has novel broad species specificity.

17 luenza B virus is unique in that it exhibits species specificity.

18 human IL-6R, indicating that p28 exhibits no species specificity.

19 nts that contribute to inhibitor binding and species specificity.

20 thereby influencing viral pathogenicity and species specificity.

21 tain high infectivity, strain properties and species specificity.

22 ial advantages in terms of effectiveness and species specificity.

23 the MD-2 residues that determine lipid IV(A) species specificity.

24 ing these stretches as major determinants of species specificity.

25 interface, defining the basis of lipid IV(A) species specificity.

26 oxA and BoxB, the latter of which determines species specificity.

27 wal times; these effects exhibited drug- and species-specificity.

28 dicating a role for the initiator element in species-specificity.

29 n humans and vice versa, reflecting dramatic species-specificity.

30 , including disparate cellular receptors and species specificities.

31 al ribosome entry site (IRES) in determining species specificity, a recombinant poliovirus (P1/HRV2)

32 H-A3F showed no change in its species specificity against HIV-1 or SIVagm Vif when a n

33 prion protein itself is responsible for its species specificity, although questions remain about whe

34 nique BoxB hexamer motifs within parS define species specificities among previously described family

35 Our results reveal a higher degree of species specificity among TCF proteins for coactivator i

36 The results show species specificity among the I-2 family within the cont

37 tis B virus (HBV) is characterized by a high species specificity and a distinct liver tropism.

38 Interestingly, two of the compounds exhibit species specificity and are inactive toward murine perit

39 We also assessed the species specificity and biochemical characteristics of m

40 acellular matrix contains proteins mediating species specificity and components needed for efficient

41 , there is a direct mechanistic link between species specificity and partition-mediated incompatibili

42 into the origin and evolution of AiV and the species specificity and pathogenesis of kobuviruses.

43 This elegant solution ensures species specificity and promptness of imitation.

44 Strong species specificity and similar tropisms suggest mouse c

45 The viral determinants for the pronounced species specificity and the high efficacy to address hep

46 However, species specificity and the lack of codominance make RAP

47 Noroviruses display tight species specificity and there is no evidence supporting

48 tinomycetemcomitans adhesin Aae demonstrated species specificity and tissue tropism to buccal epithel

49 as long been recognized for its role in host species specificity and transmission, membrane fusion an

50 Our results revealed both high species-specificity and elevated rates of evolution in p

51 To investigate species-specificity and potential for cross species tran

52 scribed spacer region sequencing, by testing species specificity, and by assessing its capacity to id

53 ew insights into astrovirus host cell entry, species specificity, and evolution.

54 WNV has broad species specificity, and replicates efficiently in many

55 he rate of recombination exhibits remarkable species specificity, and, within a species, recombinatio

56 s showed widely varying neurosteroid levels, species specificity appeared to exist.

57 tes and CD47-displaying CHO cells affirm the species specificity as well as the importance of the new

58 s rationalization of the molecular basis for species specificity based on the use of spatially contig

59 BoxB sequence changes that switch species specificity between P1, P7, and pMT1 species swi

60 cess for this system may depend on achieving species specificity between the related human host and t

61 of the primer pairs was further assessed for species specificity by using a panel of 102 isolates obt

62 Here we investigate the nature of this species-specificity by examining whether chimeric Escher

63 Species-specificity checking against 15 important meat a

64 To determine the reason for this species specificity, chimeras were constructed linking t

65 ementing Pichia angusta ortholog showed that species specificity could not be explained by the presen

66 Here, we examine the species specificity differences between Yersinia pestis

67 The second set of epitopes as well as the species specificity domain cluster around the loop 3-hel

68 e structures support the hypothesis that the species specificity exhibited by the A-site cleft inhibi

69 de one explanation for this restriction: the species specificity exhibited by the NS1 protein of infl

70 the I domain, a property that determines the species specificity exhibited by this toxin.

71 ate that this site is involved in conferring species specificity for binding GH.

72 y factor and the primary determinant of host species specificity for group A streptococcal infection.

73 ls was lower than to human cells, suggesting species-specificity for adherence.

74 receptor that may be involved in determining species specificity, i.e. the transmembrane VI, the thir

75 allmark of fertilization is a high degree of species specificity, implying gamete-specific recognitio

76 This also indicated species specificity in biomineralization depending on nu

77 ids, Mormyrids, and Pomancentrids--for which species specificity in both signal production and differ

78 and emotional behavior, in discrimination of species specificity in chemosignals.

79 Unexpectedly, we found no evidence of species specificity in cross-seeding polymerization assa

80 ing the protein-coding region, suggestive of species specificity in evolution and function of this oo

81 This difference highlights the importance of species specificity in IL-1alpha transport and may partl

82 These viruses show marked species specificity in receptor utilization, as HCV-229E

83 mouse and rat V1R gene clusters to test for species specificity in rodent pheromone systems.

84 te to differences in outcomes, and we report species specificity in the impact of CR in terms of opti

85 amino acids (A288L and T330R) that regulate species specificity in the mouse.

86 ovides insight into the structural basis for species specificity in the tissue factor-factor VIIa int

87 t networks of interactions might account for species specificity in these low affinity and high avidi

88 on correlates with, and may account for, the species specificity in transmission of transmissible spo

89 well as the critical importance of defining species specificity in visual signaling.

90 (RCMV) and murine CMV (MCMV) exhibit extreme species specificity in vivo, they differ in their abilit

91 TFIIB plays an important role in determining species specificity in vivo.

92 adherence is supported by the observation of species-specificity in adhesion: microgametes of the hum

93 Lysins from seven California abalone exhibit species-specificity in binding to their egg receptor, an

94 Lysin, the 16-kDa protein, exhibits species-specificity in dissolving a hole in the egg vite

95 These interactions show strong species specificity, indicating that conserved residues

96 We demonstrate that the species specificity is caused by a single amino acid dif

97 To investigate how this species specificity is conformationally encoded, we used

98 Here, the cellular basis for this species specificity is demonstrated to result from diffe

99 T from human cells, which indicates that the species specificity is determined by differences in the

100 Molecular modeling suggests that species specificity is determined by the capacity to for

101 t have the ClpB middle domain, implying that species-specificity is due to an interaction between Dna

102 Nacre species-specificity is interpreted as a result of adapta

103 erpretation of electron density, rather than species specificity, may be responsible for many of the

104 The differential host species specificities of Bordetella pertussis, B. parape

105 TCPs have increased our understanding of the species specificities of HBV and HDV, and could lead to

106 ng the primary components that determine the species specificities of influenza A viruses.

107 generation of the novel receptor binding and species specificities of these bacteriocins has been dri

108 EGF receptor (EGFR) ligand and species specificities of Y-142 were tested.

109 y normal mouse serum, highlighting the human species specificity of A. baumannii serum resistance.

110 of P. gingivalis to S. gordonii and that the species specificity of adherence arises from its interac

111 s directly, the mechanisms involved, and the species specificity of algal-coral interactions remain u

112 These results support species specificity of amino acid racemization dating.

113 The species specificity of binding of human fH adds another

114 The species specificity of Bordetella gene targets and their

115 is used to carry the system, overcoming the species specificity of conventional Epstein-Barr virus v

116 wild-type CRP activated mouse C3, indicating species specificity of CRP-C1q interaction.

117 ikely one of the factors that contributes to species specificity of cytomegalovirus replication.

118 Due to the species specificity of cytomegaloviruses, murine cytomeg

119 moved from an editing site, can transfer the species specificity of editing between RNA substrates.

120 that polymorphisms in another can change the species specificity of erythrocyte binding.

121 We investigated the species specificity of fH binding and the effect of huma

122 The species specificity of FH binding to BBA68 was also test

123 e findings provide further insights into the species specificity of gonococcal infections and proof-o

124 However, because of the species specificity of herpesviruses, only a limited num

125 ord and suggest that the IRES determines the species specificity of HRV2 infection.

126 hogenesis of adenovirus myocarditis, and the species specificity of human adenoviruses has limited th

127 The strict species specificity of Human Cytomegalovirus (HCMV) has

128 tural host has been limited by the exquisite species specificity of human gammaherpesviruses and the

129 panzees with human IFN-alpha were not due to species specificity of IFN-alpha.

130 ent species are critical determinants in the species specificity of infection.

131 Species specificity of influenza virus is determined by

132 e results indicate that there is significant species specificity of intrinsic complement regulatory p

133 oferrin will now facilitate the study of the species specificity of lactoferrin action in a mouse mod

134 eta(2)-integrins on leukocytes, and that the species specificity of Lkt-induced effects is resident i

135 hly similar to the S-component of LukED, the species specificity of LukPQ and LukED differs.

136 repetitive human genome and illustrates the species specificity of mechanisms that control it.

137 Our data suggest that the species specificity of MHV-68 RTA resides in the N-termi

138 rics model, provide an understanding for the species specificity of MK.

139 The receptor and species specificity of MV-uPAs was shown in human and mu

140 field isolates might thus contribute to the species specificity of MYXV and to the attenuation in th

141 However, the species specificity of non-human in-vivo models and the

142 Recent notable discoveries are the broad species specificity of orthopoxvirus interferon receptor

143 We have defined the genetic basis of the species specificity of OTai by evaluating the properties

144 s and HIV/SIV isolates reveal the host/virus species specificity of pDC sensing.

145 residues in BSG that are responsible for the species specificity of PfRH5 binding.

146 To explain these data, and the species specificity of PlyL, we propose that the C-termi

147 ograft nephropathy (PVAN) is hampered by the species specificity of Polyomaviridae family members.

148 Although mechanisms that control species specificity of prion transmission are poorly und

149 ers of its microbiota revealed the bacterial species specificity of selected host responses.

150 patients, we used T cell clones to probe the species specificity of the Ags recognized.

151 We characterized the species specificity of the antibody other investigators

152 ells but not in human cells, suggesting host species specificity of the antiviral effect.

153 nes, demonstrating the potential to tune the species specificity of the catalytic domain of an endoly

154 Restriction of viral DNA replication due to species specificity of the DNA polymerase, coupled with

155 The species specificity of the glmM PCR assay was demonstrat

156 ceptor* on differentiated hepatocytes, while species specificity of the HBV infection requires select

157 The species specificity of the interaction is controlled by

158 We took advantage of the species specificity of the interferon receptors by analy

159 anocortin receptors, indicating a remarkable species specificity of the MC1 receptor requirements.

160 human TFH cell differentiation, reflecting a species specificity of the miR-31 action.

161 ensin receptors, and structural elements for species specificity of the neurotensin receptors, and ma

162 Species specificity of the PCR amplicons was further dem

163 lymerase I transcription factors may lead to species specificity of the rDNA transcription machinery.

164 nosa, and Citrobacter freundii to ensure the species specificity of the selected aptamers.

165 Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TL

166 The molecular basis for species specificity of the two toxins in animal models i

167 As predicted, the species specificity of the two types proved identical.

168 By taking advantage of the species specificity of the type II pathway, we have used

169 ion of pathogen and host and often lead to a species specificity of the virus that can make interspec

170 ne hamster scrapie strain to investigate the species specificity of these conversion reactions.

171 However, the significance and species specificity of these proposed functions in vivo

172 developmental regulation and the tissue and species specificity of these variants and showed that th

173 the absence of leukocytes by exploiting the species specificity of this cytokine in a chimeric model

174 To identify the molecular basis for the species specificity of this interaction, hPg and mPg var

175 ible region can either abolish or change the species specificity of this interaction.

176 rface, suggesting a structural basis for the species specificity of this interaction.

177 tivation in vivo on the cell surface and the species specificity of this molecule remain to be fully

178 sodium chloride; however, the characteristic species specificity of this parasite suggested the exist

179 The species specificity of this property is unique among kno

180 eptor external domains are important for the species specificity of transferrin binding and imply tha

181 neumocystis carinii showed just the opposite species specificity of tRNA recognition.

182 a revealed that, in otherwise intact Pg, the species specificity of VEK-30 binding in these two cases

183 range restriction, which contributes to the species specificity of virus replication, and that human

184 ades a key aspect of innate immunity and the species specificity of Vpu using an anti-parallel helix-

185 To investigate host species' specificity of mycobacterial virulence, growth

186 To investigate possible species-specificity of aryl hydrocarbon receptor (AhR)-m

187 Species-specificity of HCV host factor usage for cell en

188 e Hsp104 and ClpB middle domains dictate the species-specificity of Hsp104 and ClpB for cell survival

189 This finding indicates an intrinsic species-specificity of ICP47 and suggests that no additi

190 cross-species coaggregation, suggesting that species-specificity of prion transmission is controlled

191 Due to the species-specificity of renin activity, transgenic mice a

192 Finally, the species-specificity of the human language faculty is sup

193 The species-specificity of the PCR amplicons was further dem

194 osa, and Citrobacter freundii, to ensure the species-specificity of the selected aptamers.

195 d evolutionary rate is likely related to the species-specificity of the transcriptional regulation mo

196 Our findings highlight the species-specificity of these developmental events and pr

197 The species-specificity of this interaction may play a role

198 Understanding the rodent/human species-specificity of urokinase inhibitors is therefore

199 one ParB residue and one BoxB base can alter species specificity, plasmids may use such simple change

200 nal amino acid residues of alpha ENaC confer species specificity regarding ENaC inhibition by activat

201 signals that appear to cross germ layer and species specificities should prove valuable in understan

202 of bacterial ClpB, and vice versa, switches species specificity so that our chimeras now cooperate w

203 This reciprocal switch of species specificity strongly supports the notion that co

204 The absence of species specificity suggested that the conserved lipid A

205 n microarray, to understand the mechanism of species-specificity switch better.

206 fferent HAs may be important determinants in species-specificity switch.

207 ar the N terminus; this antibody has broader species specificity than the other well-characterized al

208 ntial applications is their high potency and species specificity that enables a single pathogenic spe

209 have demonstrated that CTE function displays species specificity, that is, the CTE functions in human

210 Individual par systems can show distinct species specificities; the proteins from one type cannot

211 We took advantage of this species specificity to gain further insight into the mec

212 action of rapidly evolving molecules imparts species specificity to sperm-egg recognition in marine i

213 ed disruption of Zan that zonadhesin confers species specificity to sperm-ZP adhesion.

214 fy a small motif on rodent TfR1 that conveys species specificity to the entry of viruses into cells.

215 We mapped the region of FtsK implicated in species specificity to the extreme 140-amino-acid C-term

216 posttranslational modification, that confers species specificity to these two RecQ-like proteins.

217 duced in embryonated eggs similarly provided species specificity toward chicken sera.

218 ic PCR amplification protocol with a broader species specificity using newly designed primers targeti

219 To understand the basis of species specificity, we investigated the structure of an

220 companied by the corresponding switch in the species specificity with which the enzyme physically ass