ライフサイエンスコーパス: specific

1 the RAI-A was less sensitive (0.25) and more specific (0.97), classifying only 3.7% as "frail." The R

2 eath both in vitro and in vivo through tumor-specific (1) O2 generation and subsequent ROS mediated m

3 e efforts in both inhibiting and stabilizing specific 14-3-3 protein complexes by small molecules, pe

4 infarction, myofibroblast- and cardiomyocyte-specific activation of Smad3 has contrasting functional

5 t sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits is

6 supports that 38u might act as a potent and specific AEP inhibitor useful for cancer treatment.

7 sidential changes and their importance among specific age and sex groups are still poorly understood.

8 BPS804 treatment increased mean ALP and bone-specific ALP enzymatic activity between days 2 and 29.

9 en region, which suggests important roles of specific amino acid polymorphisms in the antigen-binding

10 roups for post-translational labeling at the specific amino acid positions.

11 Therefore, four olive-specific amplification systems based on the trnL gene we

12 mall samples in the dyadic analysis and site-specific analysis call for caution in interpreting quali

13 noframe showed approximately 10 times higher specific and approximately 6 times higher mass activity

14 SpyTag002 reaction enabled specific and covalent decoration of intimin for live cel

15 dence of herd protection against the vaccine-specific and cross-protective types in unvaccinated indi

16 ARTS allows for specific and efficient genome mining for antibiotics wit

17 noLC-NSI/MS/MS assay is highly sensitive and specific and it requires only 50 mug of leukocyte DNA is

18 harnessing the SET8-NQO1/TRXR1 axis with its specific and potent inhibitors could lead to promising h

19 n3a in mouse early foregut endoderm led to a specific and profound defect in lung development with lu

20 crease experimental sensitivity, we combined specific and segmental isotopic labeling schemes with dy

21 provided a better perspective for developing specific and sensitive devices with wide potential appli

22 henotypes and genotypes might result in more specific and tailored management of patients with type 2

23 outcomes and 5-year recurrence-free, disease-specific, and overall survival.

24 non-linear least squares to estimate the age-specific annual rate of HBsAg seroclearance.

25 Interestingly, liver specific Ant2 knockout mice are leaner and resistant to

26 borated when WT mice were treated with a CB2-specific antagonist that caused a pronounced inhibition

27 ociated viral vectors (AAVs) encoding ligand-specific antagonists into the tibialis anterior (TA) mus

28 Strikingly, cGAMP exerts cell-type-specific anti-inflammatory effects on macrophages, hepat

29 historical influenza viruses influenced HAI-specific antibodies and protective efficacy using a broa

30 scopy was combined with immunodetection with specific antibodies for gliadins, gamma-gliadins, LMW su

31 ity to screen, isolate, and characterize HIV-specific antibodies have led to the identification of a

32 Here, we describe how F-specific antibodies protect against RSV and why specific

33 We thus developed novel glycylation-specific antibodies with which we detected glycylation i

34 (LFA) for detection of Mycobacterium leprae-specific antibodies: the visual immunogold OnSite Lepros

35 f tau species, whereas the distal C-terminal-specific antibody (Tau46) had little effect.

36 METHODS AND We combined a model of specific antibody deficiency, B cell-specific CD79a-Cre

37 tive biopsy findings with increased prostate-specific antigen (PSA) level, or (c) had a prior history

38 This hypoxia-specific apoptosis induction by YC-1 involved excessive

39 all zeolites, strategies to tailor them for specific applications include controlling their crystal

40 Upon the addition of AFB1, the specific aptamers are attracted to AFB1, getting distanc

41 choline moiety of its substrates via an NPP7-specific aromatic box composed of tyrosine residues.

42 ing from mapping errors and other technology specific artifacts including strand bias and low base qu

43 tic of D. hamiltonii could be used to design specific assays, enhancing its applicability for direct

44 cortex, but how they interact to orchestrate specific band activity remains largely unknown.

45 inhibit IgE recognition of Cyp c 1, Cyp c 1-specific basophil degranulation, and Cyp c 1-induced all

46 ture-activity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS "cold trace

47 Specific binding between biomolecules, i.e., molecular r

48 dentify activators and blockers with strong, specific binding for engineering and therapeutic applica

49 ion of adjacent residues that facilitate the specific binding of proteins and modulate the global fol

50 ading to a 50% reduction of (11)C-BMT-136088 specific binding were 73 +/- 30 nmol/kg and 28 +/- 12 nM

51 Infusion of the CP-AMPAR-specific blocker Naspm into the NAc shell reversed the c

52 oOmega m(2) or 24.9 mOmega cm(2) ) and large specific capacitance, is among the highest for planar mi

53 multi-phase lithium titanate hydrates show a specific capacity of about 130 mA h g(-1) at 35 C (full

54 A more thorough understanding of sex-specific cardiovascular differences both at baseline and

55 at imports nuclear localization signal (NLS)-specific cargoes (NLS-cargoes) into the nucleus.

56 METHODS AND We generated cardiomyocyte-specific Cas9 mice and demonstrated that Cas9 expression

57 vo proliferative capacity of M. tuberculosis-specific CD4 T cells was markedly impaired in HIV-infect

58 The TCR repertoire of Gag293-specific CD4(+) T cells proved highly biased, with a pre

59 t include immunodominant epitopes for gluten-specific CD4-positive T cells.

60 odel of specific antibody deficiency, B cell-specific CD79a-Cre x XBP1 (X-box binding protein-1) flox

61 ors, CXCR3 and CCR10, are upregulated on HSV-specific CD8 T cells in blood.

62 In our in vitro T cell culture system, MART1-specific CD8 T cells were expanded from healthy donors u

63 Transfer of MPO431-439-specific CD8(+) cells without CD4(+) cells mediated glom

64 Although specific cell populations mediated the effects of age an

65 for association mapping to be conducted for specific cell wall polymers.

66 ound significant, coherent and non-cell line specific changes in fatty acids, glycerophospholipids an

67 s indicate prenatal WD exposure leads to age-specific changes in voluntary physical activity in femal

68 Treatment-specific changes were observed only during cognitive rea

69 ive defects and cerebellar hypoplasia in GCp-specific Chd7 mouse mutants.

70 otic DNA and NPC segregation via the mitotic specific chromatin association of Nup2.

71 These data suggest that D2 MSNs and specific circuits within the basal ganglia are preferent

72 rary screening, we identified an immune cell-specific, co-stimulatory receptor B7.2 (CD86) as a co-re

73 t effectiveness of PCV by analyzing serotype-specific colonization prevalence and IPD incidence prior

74 accurate m/z values, was helpful to annotate specific compounds, such as alkaloids, saponins, flavono

75 nd contingency reversal to establish outcome-specific conditioned inhibitors for two distinct appetit

76 l of generality that fails to appreciate the specific conditions of the Mongol invasion, do not offer

77 we predict that within rosemary extract two specific constituent components; gallic acid and carnosi

78 to diverse targets without distorting target-specific contrast preferences and spatial receptive fiel

79 Despite considerable research, specific contributions of BMAA toxicity to neurodegenera

80 urons exert a frequency-dependent, cell-type-specific control over BA circuitry via 5-HT and glutamat

81 ies that seek to assign FP/LFP recordings to specific cortical layers.

82 ning to produce AG sounds resulted in region-specific cortical reorganization within the inferior por

83 This identification of region- and lineage-specific crosstalk between epithelium and their neighbor

84 to 47-fold greater frequencies of neoantigen-specific CTLs than soluble vaccines and even 31-fold gre

85 ons into various arms of the circuit through specific DA subpopulations to assess: (1) whether the ci

86 tween the four processes, or are tailored to specific datasets with matching model assumptions and co

87 Pooling the study-specific Decipher HRs across the five studies resulted i

88 ll (SMC, SmmhcCreER(T2)- or TaglnCre-driven)-specific deficiency of CXCR4 in an apolipoprotein E-defi

89 Here, we show that specific deletion of CB1R in the renal proximal tubule c

90 Here, we show that NKT-specific deletion of Hdac3 results in a severe reduction

91 T cell-specific deletion of talin in Tln1(fl/fl)Cd4(Cre) mice r

92 We used sialic acid linkage-specific derivatization methods to improve separation an

93 However, a specific description of subtypes of atopic dermatitis de

94 To have access to specific detection, we prevented the nonspecific adsorpt

95 Increased understanding of specific diabetes phenotypes and genotypes might result

96 ation (whether "nonspecific" or related to a specific diagnosis), infections, such as polyomavirus-as

97 Immunofluorescence is a highly specific diagnostic test for PCD, and it improves the sp

98 Our results suggest an age-specific difference in human postvaccination responses.

99 l testosterone rise in the boys nor a gender-specific difference in testosterone levels, which sugges

100 ed a normalization strategy to reduce method-specific differences related to the length of genic regi

101 Efficient lineage-specific differentiation was confirmed by uniform NCAM1

102 Linkage specific distribution of these sialic acids was quantita

103 tion factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes.

104 TDIvol), dose-length product (DLP), and size-specific dose estimate (SSDE).

105 ed a point-source outbreak associated with 2 specific duodenoscopes.

106 ated associations in this study between cell-specific dynamic signaling pathways and drug sensitivity

107 omprehensive analysis so far of variation in specific EBV genes relevant to these diseases and propos

108 domain, instructs the distinct, neuron-type-specific elaboration of ciliated endings of different ol

109 the US Food and Drug Administration examined specific eligibility criteria (ie, brain metastases, min

110 ne paracrystalline surfaces able to catalyse specific enantioselective chemical reactions.

111 Encapsulation of specific enzymes in self-assembling protein cages is a h

112 ad quantifiable concentrations, with climate-specific estimates of annual leachate volumes.

113 nanobiosensor could be a promising tool for specific evaluation of food stuff.

114 We consider specific examples where the application of these approac

115 Gene-specific expansion of the genetic code allows for UGA co

116 ements in diploid organisms may cause allele specific expression (ASE) - unequal expression of the tw

117 n quantitative trait loci (eQTLs) and allele-specific expression (ASE).

118 ripts were validated by qPCR to confirm cell specific expression in microdissected tissues, as well a

119 Our data reveal that tissue and stage-specific expression of ankyrin isoforms relies on differ

120 Genetic mosaic and cell type-specific expression studies indicate that vpr-1 activity

121 In a murine model of lymphoid-specific EZH2 deficiency we found that EZH2 was required

122 The specific fatty acid pattern may be influenced by metabol

123 Specific findings were confirmed at the protein level by

124 With regard to intraoperative navigation, a specific fluorescence signal was detected in PSMA-expres

125 te to detect bacterial infection and are not specific for living bacteria.

126 behavioral analyses, we uncovered a circuit specific for mechanonociception but not thermonociceptio

127 les were assayed for levels of IgG1 and IgG3 specific for MSP119, MSP2 (both allelic families, 3D7 an

128 omputes object representations that are both specific for object identity and robust against identity

129 ar normal value, and the fact that it is not specific for the microvasculature but interrogates the e

130 ippocampal and amygdala neurons was stimulus-specific, formed stable attractors and was predictive of

131 owth under conditions for which growth has a specific functional form.

132 ormal development, little is known about the specific functions of the different MLL lysine methyltra

133 Although the specific gasotransmitter for this biofilm response is no

134 etic evidence that impairment of trophoblast-specific GATA2/GATA3 function could lead to early pregna

135 rategies are linked to radiations of lineage-specific gene families.

136 y promoting the ectopic expression of tissue-specific genes in the thymic medullary epithelium.

137 ctor conveys a general chromatin modifier to specific genes, thereby allowing the execution of hepato

138 ogical processes by repressing expression of specific genes.

139 genetic variation indicative of selection at specific genes.

140 techniques is that they do not provide site-specific glycosylation information.

141 revealed overlapping epitopes with murine C1-specific group A mAbs including 2A9.

142 identification of 337 high-stringency allele-specific H3K4me3 and H3K36me3 peaks in maize endosperm.

143 Of 794 joints with baseline joint-specific hard tissue diagnoses of DJD, progression was o

144 ls engineered to express a hepatitis B virus-specific (HBV-specific) T cell receptor (TCR) may supple

145 We show how myocardial region-specific heterogeneity in cell function emerges during e

146 We demonstrate that Env-specific HLA-B*14-restricted activity is substantially m

147 Age group-specific hospitalization rates were consistently higher

148 form DNA-RNA heteroduplex structures through specific hybridization with target DNA.

149 the simultaneous detection of food allergen-specific IgE and IgG4 , and compared it with ImmunoCAP a

150 Probability curves for Ana o 3-specific IgE have been calculated, and a 95% probability

151 mmunotherapy increased serum Phleum pratense-specific IgE levels (P = .001) compared with those in th

152 Total and allergen-specific IgE, IgG and basophil sensitivity were measured

153 icity, the magnitudes of the gp120- and V1V2-specific IgG responses were comparable between adults an

154 Allergen-specific IgG was administered to mice undergoing sensiti

155 ic) T cell receptor (TCR) may supplement HBV-specific immune responses in chronic HBV patients and fa

156 Combination of site-specific incorporation of a clickable p-azido-L-phenylal

157 nic pair of wild-type and mutant RTT patient-specific induced pluripotent stem cell (iPSC) line carry

158 The specific infectivities (PFU per viral genome) of HSV(cho

159 ctron probes often fail to provide interface-specific information in such systems.

160 associated with the overexpression of HIFs, specific inhibition of HIFs might represent a new powerf

161 s of programmable molecular systems, wherein specific input sequences create distinct outputs.

162 We also showed that the specific interactions between Gag and viral RNA are requ

163 ut were resumed in G2-phase, indicating that specific interactions need to be dissolved for replicati

164 Here, we show that by using specific intracellular immunolabelling protocols, FACS s

165 Specific ion binding to such sites induces changes in th

166 nd the retrotrapezoid nucleus (RTN), but the specific ion channels essential to these activities rema

167 geometry-specific molecular cues or force on specific kinetochore linkages that other attachment geom

168 biochemical and genetic approaches including specific knockdowns of genes of interest from primary CD

169 In contrast, mice with LPC-specific knockout of Ripk1 showed reduced diethylnitrosa

170 ere we show that mice with an adipose-tissue-specific knockout of the microRNA (miRNA)-processing enz

171 Cell-specific labeling of RNA can be profiled and imaged usin

172 duals with GRIA1 mutations shows evidence of specific learning disabilities and autism.

173 the CLAMP (chromatin-linked adaptor for male-specific lethal [MSL] proteins) zinc finger protein bind

174 eedback and redundancy to generate cell type-specific levels of dve expression and stable photorecept

175 d enrichment, but also with zonal changes of specific lipids and their associated metabolic pathways.

176 ight into the dynamic processes occurring at specific locations within G-quadruplex nucleic acids, pr

177 Of these vaccine-elicited V3-specific MAbs, nearly 20% (6/33) displayed cross-reactiv

178 and 651 novel genes were predicted by the GC-specific MAKER protocol.

179 The LTRs function in a stage-specific manner during the oocyte-to-embryo transition b

180 l proliferation is controlled in an identity-specific manner.

181 of Sp1 targets' expression in a cell/tissue specific manner.

182 the miRNAs were regulated in a tissue/organ-specific manner.

183 These cells also expressed Opn1mw, a cone-specific marker and nestin, a marker for neural precurso

184 l. (2017) and Kirkeby et al. (2017) identify specific markers of midbrain dopaminergic progenitors to

185 and denticle spacing can be recapitulated by specific mathematical equations in embryos and larvae an

186 insertion of fine needles at acupoints along specific meridians (meridian specificity).

187 n vitro conditions by RB-TnSeq, highlighting specific metabolic functions associated with root coloni

188 The identity of stage-specific metabolic programs and their impact on adult ne

189 The aim of the study was to explore specific microRNAs (miRs) in rectal cancer that would pr

190 However, the in vivo functions of specific microRNAs in controlling mammary stem cell (MaS

191 vivo and in vitro, implying roles for these specific miRNAs.

192 Smk1 is a meiosis-specific mitogen-activated protein kinase (MAPK) in Sacc

193 Thus, end-on attachment provides geometry-specific molecular cues or force on specific kinetochore

194 it was possible to unambiguously assign one specific molecular formula to an experimental isotopic p

195 ides have unique, and in some cases sequence-specific molecular interactions with the surface of carb

196 We aimed to assess whether a patient-specific molecular signature of radiation sensitivity co

197 nd 95% confidence intervals (CIs) for cancer-specific mortality by low-dose aspirin use after adjusti

198 Risk of all-cause and cause-specific mortality was assessed with Cox proportional ha

199 the surface, surrounded by five encephalitic-specific motifs implicated in receptor binding.

200 Within specific mutated genes, frequency, mutation hotspot resi

201 recognition of neoantigens, which are tumour-specific, mutated peptides presented on the surface of c

202 he influenza genome and the accessibility of specific mutational trajectories are significantly impac

203 ls of genetic renal diseases bearing patient-specific mutations.

204 associated proteins discretely expressed in specific neuronal pathways; these accessory proteins pro

205 ransfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp(2))-H bonds using ch

206 Co-assembly of binary systems driven by specific non-covalent interactions can greatly expand th

207 signaling, is here shown to regulate ligand-specific Notch signaling.

208 omes challenges the identification of target-specific oligonucleotides, which limits genetics and gen

209 LA-ICP-MS analyses revealed element-specific ontogenetic variability in metal concentrations

210 ng an endothelial cell (BmxCreER(T2)-driven)-specific or smooth muscle cell (SMC, SmmhcCreER(T2)- or

211 ers focused on improving draft assemblies of specific organisms.

212 of recombination steps at the DNA level with specific organizational features of meiotic-prophase chr

213 Cellular imaging using a phospho-specific p-T153/Y155 antibody showed that phosphorylated

214 cysteine-protease gene (BnCysP1) with anther-specific P12 promoter of rice for facilitating productio

215 Species-specific PCR and real-time PCR with EvaGreen dye targeti

216 pipeline utilizing KASP (Kompetitive Allele-Specific PCR) genotyping technology to create scarless i

217 ion of the results was achieved by preparing specific PdBiTe catalyst formulations via a wet-impregna

218 essments largely focused on national bans of specific pesticides (12 studies of bans in six countries

219 dow was also associated with increased theta-specific phase coupling between piriform cortex and hipp

220 However, the specific phenotypes were different.

221 hift mutation in MATRILINEAL (MTL), a pollen-specific phospholipase, and that novel edits in MTL lead

222 barrel columns in the BC, albeit with target-specific precision.

223 or translating this information into patient-specific predictions of disease progression.

224 d we observed striking enrichment for region-specific processes.

225 THEMIS, a T cell-specific protein with high expression in CD4(+)CD8(+) th

226 er number of comorbidities, and lower vision-specific quality-of-life (NEI VFQ-25) scores were associ

227 ssion across normal tissues confirmed tissue-specific RD3 mRNA levels.

228 s suggest that designing compounds to target specific receptor states, rather than specific receptor

229 target specific receptor states, rather than specific receptor types, may be a viable strategy for fu

230 bitory lineage III KIR, likely encoding a C1-specific receptor.

231 trotemporal modulations enables accurate and specific reconstruction of real-life sounds from high-re

232 mesic microenvironments will act as species-specific refugia only if the nature and space/time varia

233 e precise localization of these receptors at specific region of the cell; it also regulates the activ

234 istent with previous observations of species-specific regulation of immunity by vitamin D, the VDREs

235 , allowing us to better understand cell-type-specific regulation of inflammation mediators and sheddi

236 Our results thus define a specific requirement for primary cilia-mediated GPCR sig

237 egans strains, indicating species and strain-specific responses.

238 They can catalyze site-specific RNA cleavage, and as a result, they have releva

239 enopus system, we show that RARbeta2 plays a specific role in somite number and size, restriction of

240 We tested the proposal that the MTL has a specific role in topographical memory as assessed in tas

241 ion and transformation, and suggest oncogene-specific roles for DUSP5 in controlling ERK signaling an

242 These results delineate that C3 plays specific roles in platelet activation independent of for

243 strate the advantage of including population-specific sequences in imputation panels and exemplify th

244 Instead, we identified a specific set of markers associated with the caudal midbr

245 iscovery tools typically miss these position-specific short motifs, we developed kpLogo, a probabilit

246 ish that EVs secreted by AFSC could target a specific signaling pathway within the glomerulus, thus r

247 Using the telomere-specific single-molecule analysis of replicated DNA tech

248 riptional activity, and colocated with AR at specific sites on chromatin to regulate genes relevant t

249 Viruses build icosahedral capsids of specific size and shape by regulating the spatial arrang

250 Mice with fibroblast-specific Smad3 loss had accentuated adverse remodeling a

251 this study was to develop and characterize a specific small-molecule tracer for PET imaging that bind

252 Species-specific SNP position (230 bp) in the matK region that i

253 tissues are an important link between organ-specific spatial molecular information, patient patholog

254 sound representations in terms of frequency-specific spectrotemporal modulations enables accurate an

255 pared with crystalline alloys, MGs have some specific structural responses to neutron irradiation.

256 We show that specific structural variants may be causative for quanti

257 ax) and biodistribution determination, a PET-specific structure-activity relationship (SAR) effort, a

258 cal strategies based on more stable and more specific structures.

259 data is how best to interrogate increasingly specific subphenotypes while retaining statistical power

260 y dormancy also depend on the degradation of specific subsets of mRNA.

261 at each enzyme independently follows its own specific substrate gradient, which in turn is produced b

262 contact domain comprising IGF2 and a lineage-specific super-enhancer, resulting in high-level gene ac

263 tant materials, featuring lightweight, large specific surface area and high porosity.

264 e associated with worse colon cancer disease-specific survival [(+)transfusion: hazard ratio (HR) 1.1

265 7, 95% CI 1.87-2.76], cardiovascular disease-specific survival [(+)transfusion: HR 1.18, 95% CI 1.04-

266 s-free survival [DMFS], 53%; prostate cancer-specific survival [PCSS], 78%; overall survival [OS], 69

267 Overall survival, disease-specific survival, and progression-free survival were th

268 tributes to poorer overall and breast cancer-specific survival.

269 regarding other cells demonstrated cell-type-specific synthesis of, among others, eicosanoid-forming

270 T cells revealed the presence of H-2L(d)/AH1-specific T cells and an expansion of sequence diversity

271 ovide insights into the nature of neoantigen-specific T cells and the effects of checkpoint blockade

272 Determination of HCMV-specific T cells by cultured ELISPOT, in pregnant women

273 ne checkpoint therapies target tumor antigen-specific T cells, but less is known about their effects

274 port we describe the appearance of transgene-specific T-cell responses in two subjects that were part

275 to express a hepatitis B virus-specific (HBV-specific) T cell receptor (TCR) may supplement HBV-speci

276 high expression of the SOD-3 gene (a DAF-16-specific target gene) were observed as a result of BB68

277 thus representing a new potential glomerulus-specific targeted intervention.

278 tests to predict whether cancers respond to specific targeted therapies are performed increasingly o

279 ognised for its antibacterial properties and specific taste.

280 uninfected TB patients and corresponded with specific TB clinical phenotypes.

281 The availability of specific technology permitted detailed imaging of the cl

282 This protocol provides comparative cell-type-specific telomere-length measurements in relatively smal

283 is ensured by its collaboration with non-sex-specific terminal selector-type transcription factors, w

284 regulations that carry a significant risk or specific threat to animal welfare.

285 f RNA molecules are dependent upon sustained specific three-dimensional (3D) structures of RNA, with

286 does not depend on neural processes that are specific to auditory speech perception.

287 in identification revealed subspecies clades specific to body sites; it also quantified species with

288 A3s are specific to eutherian mammals because no direct homologs

289 Toxicity tests proved strong enantiomer-specific toxicity in the case of Tetrahymena thermophila

290 dmd-3 action is ensured by the hermaphrodite-specific transcriptional master regulator of hermaphrodi

291 Cell-specific transcriptional profiling revealed that microgl

292 Dendritic cell-specific transmembrane protein (DC-STAMP) plays a key ro

293 at critical residues of different classes of specific transport proteins.

294 Yet, no pharmacological prevention or specific treatment for acute pancreatitis exists.

295 hapes the relative abundance of self-epitope specific Treg cells that leads to protection or causatio

296 ated detection and visualization of position-specific ultra-short motifs from a set of aligned sequen

297 dvances in DNA sequencing indicate that cell-specific variants affect a number of phenotypes and path

298 Relative perfusion, specific ventilation (sV), and gas fraction (Fgas) in th

299 Fgas) in the 25% of the lung with the lowest specific ventilation (sVlow) and the remaining lung (sVh

300 Computer simulations of species-specific whole-muscle models indicate that maximum dynam