ライフサイエンスコーパス: specific activity

1 ke of (18)F-TFB in hNIS-expressing tumor and specific activity.

2 nge gives suboptimal radiochemical yield and specific activity.

3 -ALT-836 was achieved in high yield and good specific activity.

4 of regulatory element activity and cell-type-specific activity.

5 is(monoacylglycero)phosphate (BMP) with high specific activity.

6 e produced with good radiochemical yield and specific activity.

7 esized in high radiochemical purity and good specific activity.

8 ell differentiation factor is limited by low specific activity.

9 onjugates of antibodies with (225)Ac at high specific activity.

10 xchange reaction in high yield and with high specific activity.

11 tant with nearly 3-fold higher H2 production specific activity.

12 ol the levels of some tRNAs as well as their specific activity.

13 e ((18)F-6b) in high radiochemical yield and specific activity.

14 nontoxic for healthy cell, indicating a high specific activity.

15 3 that exhibits strong SMC-selective, allele-specific activity.

16 orylated substrates leads to enhanced kinase-specific activity.

17 sodine to norbelladine with a 400-fold lower specific activity.

18 eater than 98% radiochemical purity and high specific activity.

19 n than the wide type and displayed increased specific activities.

20 itable processing, with potential to improve specific activities.

21 ommon microbial patterns as well as pathogen-specific activities.

22 ed value of ChIP data for modeling cell type-specific activities.

23 out in the synthesis of radiotracers in high specific activities.

24 nstrated the general irrelevance of promoter-specific activities.

25 )), a high mass activity (398 mA mg(-1)) and specific activity (0.98 mA cm(-2)), and a good If/Ib rat

26 lucose oxidase enzyme on filter paper strip (specific activity 1.4 U/strip) and then reacting it with

27 ts with conventional (18)F-DOPA-L with a low specific activity (11 +/- 2 GBq/mmol).

28 For high-specific-activity (11)C-GSK1482160, receptor density and

29 High-specific-activity (11)C-ORM-13070 (1-[(S)-1-(2,3-dihydro

30 for healthy men and women injected with high-specific-activity (123)I-iobenguane showed organ distrib

31 vide compelling evidence for the use of high-specific-activity (123)I-iobenguane.

32 rformed a direct comparison of high- and low-specific-activity (18)F-DOPA in a neuroendocrine tumor m

33 The synthesis of high-specific-activity (18)F-TFB should enable future clinica

34 ng Gln51 or Val129 to alanine reduced kinase specific activity 3-fold.

35 is method, yielding (18)F-DOPA-H with a high specific activity (35,050 +/- 4,000 GBq/mmol).

36 in good radiochemical yields (15-39%), high specific activities (45-95 GBq/mumol), and excellent rad

37 mately 70 min (radiochemical yield, 35%-45%; specific activity, 650-870 GBq/mumol; radiochemical puri

38 99m)Tc from non-fission reactor-produced low-specific-activity (99)Mo.

39 Preparation was achieved containing specific activity about 60 times higher than that of the

40 trastuzumab was shown to be achievable at a specific activity above the reported literature value of

41 lly induced hypoxic conditions, displaying a specific activity against cancer cells characterized by

42 rrow spectrum molecule with a unique species-specific activity against Pseudomonas aeruginosa.

43 inhibitory peptides in that it shows broad, specific activity against pseudoviruses bearing Old and

44 Carolacton has remarkably specific activity against S. mutans, causing acid-mediat

45 reens in embryos, to identify compounds with specific activity against tet2 mutant cells.

46 spond similarly to both Michaelis-Menten and specific activity analyses.

47 This allowed much higher specific activities and enhanced stability and solubilit

48 n different tissues and have distinct tissue-specific activities and functions.

49 s all donors, including a portion of disease-specific activities and health systems development.

50 nstructs were evaluated in production level, specific activities and kinetic parameters.

51 ctional gamma-secretase complexes displaying specific activities and maturations.

52 systems, including engineered molecules with specific activities and model systems that mimic complex

53 under all conditions had similar ecto-enzyme specific activities and types of RNA, and all ACVs conta

54 ACSL1 deficiency caused a 91% loss of ACSL-specific activity and a 60-85% decrease in muscle FA oxi

55 observed high hydrolysis yields to the high specific activity and affinity of the individual enzymes

56 arum previously engineered to exhibit higher specific activity and broader pH adaptability, holds gre

57 sociated with an 8-17-fold increase in VLCAD-specific activity and concomitant correction of acylcarn

58 -TTCO-Cys(40)-exendin-4 was obtained in high specific activity and could specifically bind to GLP-1R

59 vity and binding assays demonstrated reduced specific activity and decreased binding of the novel N9

60 ide (BF3) to enhance both labeling yield and specific activity and evaluation of specific activity in

61 a small volume, while maintaining high area-specific activity and favourable pore-transport properti

62 radiochemical yields, with 40-207 GBq/mumol specific activity and greater than 95% radiochemical pur

63 sily synthesized in high yield and very high specific activity and is a promising candidate for precl

64 The specific activity and mass activity of 4.2/0.8 nm core/s

65 ial, SrCoO2.7, with a high, room temperature-specific activity and mass activity towards alkaline wat

66 (67%) mice treated with intermediate or high specific activity and none of 6 (0%) mice treated with l

67 structural basis of glucan phosphatase site-specific activity and open new avenues for their biotech

68 The tracer was synthesized in high specific activity and purity.

69 Their specific activity and regioselectivity were studied in t

70 fications of ceramide synthase increased its specific activity and stimulated channeling of long-chai

71 d for a commercial Pt/C electrocatalyst, the specific activity and the electrochemical surface area f

72 tion (ORR) requires optimization of both the specific activity and the electrochemically active surfa

73 residues that are responsible for SEX4 site-specific activity and, using these insights, we engineer

74 ut yeast-based assays: one that assesses AGT specific activity, and one that assesses protein stabili

75 efficiency (radiochemical yield and purity, specific activity, and radio-scalability).

76 tch mode, evaluating the enzyme loading, the specific activity, and the kinetic parameters in model w

77 were >2.6% of the total lens protein and the specific activity, assayed using Ac-Ala-p-nitroanilide s

78 (f) The specific activity assessed for ROS formation compared wi

79 and found that the proteases exhibit similar specific activities at 25 degrees C.

80 lms of SrIrO3 This catalyst has demonstrated specific activity at 10 milliamps per square centimeter

81 half-life at 60 degrees C, 5-fold increased specific activity at 65 degrees C, 1.3-fold improved kca

82 We also quantify the site-specific activity at different regions within a nanoplat

83 Using a trypsin-specific activity-based probe, we detected three distinc

84 yielded detectable products, nearly all had specific activities below 10% of the reference natural P

85 of phenolic contaminants and increasing the specific activity by a factor of 2.

86 antibodies with any desired radionuclide and specific activity, calculate the absorbed dose to each c

87 s performed on 12 healthy adults with a high-specific-activity carrier-free formulation of (123)I-iob

88 sing plasmin generation and reducing protein-specific activity, changes that are reversible with mode

89 With certain specific activities, cocktails outperformed single antib

90 iants that display significantly reduced non-specific activities compared with its wild-type counterp

91 results in a more pronounced decline in VieA specific activity compared to the classical biotype.

92 basal ganglia have suggested that frequency-specific activities correlate with force or effort, but

93 t of transcription factors, including neuron-specific activity-dependent factors.

94 esults show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendrit

95 treatment with a low dose of the potent and specific activity-dependent mGluR1-negative allosteric m

96 This first evidence for a polarity-specific, activity-dependent effect of tDCS on false mem

97 The transport of pyruvate shows specific activities depending on the growth substrate us

98 Specific activity determined whether a cocktail or a sin

99 E was radiolabeled in high yield and at high specific activity, did not require high-performance liqu

100 , two cultivars, which displayed highest PPO specific activity, differed in the 38 amino acid stretch

101 pport an alternative model: BMPs have signal-specific activities directing particular IN fates.

102 Additionally, low specific activity due to poor labeling efficiency can re

103 Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex

104 expose neuronal projection- and compartment-specific activity dynamics that encode and predict actio

105 ral outcomes could be modulated by frequency-specific activity emerging from a single cortical region

106 d, and these recent findings begin to define specific activities for Maf1 in multicellular organisms

107 Adult-specific activities for miRNAs have been described in va

108 e same enzyme include the following: (i) the specific activity for both substrates was comparable in

109 The specific activity for catalyzed CO evolution systematica

110 n systematically rises by three-fold and the specific activity for catalyzed H2 evolution systematica

111 The specific activity for hydrogen evolution diminishes by 1

112 The heart-to-mediastinum ratios for the high-specific-activity formulation were statistically higher

113 In quantifying amylase specific activity from a commercial source (P>0.02) and

114 tor, affording the radiopharmaceuticals with specific activities greater than 1,000 MBq/nmol.

115 only numerical task that did not show number-specific activity (greater than control) in the intrapar

116 decay-corrected radiochemical yield = 31.6%, specific activity >/= 48.5 GBq/mumol).

117 cal yields and purity (>98%) as well as high specific activities (>20 GBq/mumol).

118 ctivities of (18)F-FDOPA (>45 GBq) with high specific activity (>/= 753 GBq/mumol) are now available

119 s with high radiochemical yield (>87%), high specific activity (>/=9.8 MBq/nmol), and purity (>99%).

120 reater than 99% radiochemical purity at high specific activity (>111 GBq [3 Ci]/mumol).

121 odel to determine whether this difference in specific activity has implications for the biologic beha

122 thways are poorly understood because pathway-specific activity has rarely been monitored during a per

123 18)F-labeled hNIS substrates offering higher specific activity, higher affinity, and simpler radioche

124 18)F-labeled hNIS substrates offering higher specific activity, higher affinity, and simpler radioche

125 y constructs were labeled to a wide range of specific activities in 1 chemical step at 37 degrees C.

126 All investigations, to characterize miR-155 specific activities in MCs, were conducted comparing WT

127 ol antibody, gave potent and immunologically specific activities in vitro and in vivo.

128 After testing candidate SNPs for allele-specific activity in a luciferase-based enhancer scannin

129 stretch enhancer sequences exhibited tissue-specific activity in cell culture experiments and in tra

130 fMRI studies focusing on saccade- and reach-specific activity in human cortex, however, provided con

131 n infant, was associated with greater infant-specific activity in key parental brain regions, includi

132 ve and the comparative analysis demonstrated specific activity in paclitaxel-resistant cells.

133 nsor assay that detects continuous, protease-specific activity in target cells.

134 usion was supported by the fact that the APC-specific activity in the medium of COS-1 cells is exclus

135 Direct observation of deep projection-specific activity in this way captures a fundamental and

136 that top-down signals elicit retinotopically specific activity in visual cortex both in the dorsal an

137 )I]NaI, where products were isolated in high specific activity in yields ranging from 46% to 86%.

138 Remarkably, Endostatin has a specific activity, independent of baseline synapse devel

139 (177)Lu-PSMA-617 (120 MBq) with high specific activity induced superior tumor growth inhibiti

140 ield and specific activity and evaluation of specific activity influence on tumor uptake.

141 Apo3A at acid pH, a 13-30-fold reduction in specific activity is accompanied by relaxed C deaminatio

142 ermine that their diverse phosphate position-specific activity is governed by the phosphatase domain.

143 Second, kinase-specific activity is inversely correlated with substrate

144 pathway contributes to the pathway's context-specific activity is not known.

145 anscripts, we conclude that the mechanism of specific activity is unlikely to be based simply on pref

146 The V1 location-specific activity leads hippocampal place cell activity

147 half-life, 635 keV positron energy) and high specific activity make it an attractive nuclide for labe

148 rgy and fluid homeostasis by using cell-type-specific activity manipulations in mice.

149 evaluated, and the results obtained via BChE-specific activity measurements were confirmed by quantif

150 th radiochemical purity greater than 98% and specific activities of 326 +/- 20 MBq/nmol are obtained

151 ical yields relative to (18)F-fluoride, with specific activities of 666 +/- 51.8 GBq (18 +/- 1.4 Ci)/

152 Specific activities of 8.84 +/- 0.56 GBq/mumol (n = 3) w

153 This study provides evidence that the cell-specific activities of different PKM isoforms generated

154 was achieved without an incubation period at specific activities of less than 148 MBq/mg; however, sp

155 peptides and monoclonal antibodies, the low specific activities of the products, and the lack of cos

156 4 and -6 but did not significantly alter the specific activities of TSSK1 and -2.

157 However, the high-specific activity of (249)Bk (t1/2 = 320 d) causes oxida

158 polyclonal antibody has a titer of 250 and a specific activity of 0.05 mL/mug.

159 approximately 0.80 mM for l-aspartate with a specific activity of 0.09 mumol min(-1) mg(-1) at 70 deg

160 ent electrophoretic homogeneity with a final specific activity of 1,372 U/mg.

161 Ni/C showed the best ORR performance, with a specific activity of 10.3 mA/cm(2) and mass activity of

162 SA of 118 square meters per gram of Pt and a specific activity of 11.5 milliamperes per square centim

163 , radiochemical purity greater than 99%, and specific activity of 111-148 MBq/mg.

164 nalysis was greater than 98%, with a minimum specific activity of 12.6 and 42 GBq/mumol, respectively

165 radiochemical purity of 96.7% +/- 2.0%, and specific activity of 14.6 +/- 6.5 GBq/mumol.

166 The specific activity of 2 representative preparations of (1

167 ize with a high radiochemical purity (>99%), specific activity of 2.2 mCi/mg of NP, and high stabilit

168 adiochemical yield (decay-corrected), with a specific activity of 279 +/- 75 GBq/mumol.

169 radiochemical purity of more than 97% and a specific activity of 3,700 MBq/mg and retaining biochemi

170 the FePtPd/FePt NWs (0.8 nm shell) show the specific activity of 3.47 mA.cm(-2) and the mass activit

171 for further purification and resulting in a specific activity of 35 MBq/nmol.

172 led form, designated [(3)H]PSB-13253, with a specific activity of 36 Ci (1.33 TBq)/mmol.

173 0-35% (n > 20, non-decay corrected) and high specific activity of 40-111 GBq/mumol (1.1-3.0 Ci/mumol)

174 P2'GT of Malus x domestica (MdP2'GT) with a specific activity of 46.82 mukat/Kg protein toward phlor

175 radiochemical yield of greater than 96% at a specific activity of 5.2 MBq/nmol.

176 A specific activity of 55.5 MBq/nmol (0.37 MBq/mug) was re

177 in 50 min (uncorrected radiochemical yield, specific activity of 815 +/- 185 GBq/mumol).

178 citrate buffer (pH 4) with 10% ethanol, the specific activity of [(18)F]3 at the end of synthesis (E

179 ic to SAMDC homologues in anther and tapetal-specific activity of A9 promoter as shown with GUS repor

180 Moreover, excessive doses of PN reduce the specific activity of AGT in a PH1 cellular model.

181 The specific activity of AgTG3 was measured as 4.25 x 10(-2)

182 rent tissues or compartments, and the tissue-specific activity of alternative Pk-Sple protein isoform

183 iated phosphorylation of AMPK, increased the specific activity of AMPK, and was necessary and suffici

184 The specific activity of AnGDH for xylose at 5mM concentrati

185 d (68)Ga was straightforward, resulting in a specific activity of approximately 20 GBq/mumol and a ra

186 ted histones are regulated, nor how the gene-specific activity of Brd4 is determined.

187 lifetimes by modulating the concentration or specific activity of cellular ribonucleases or by unmask

188 rate and spectra are low, suggesting tissue-specific activity of common mutational processes through

189 Mechanism and sport-specific activity of concussion.

190 We also determined the specific activity of endogenous telomerase and of overex

191 e data provide fundamental insights into the specific activity of glucan phosphatases against diverse

192 The experimental expression of HYDA and the specific activity of hydrogenase demonstrate that C. vul

193 We characterized the specific activity of individual SOS molecules catalyzing

194 alking was slightly enhanced as well as some specific activity of knee flexor muscles.

195 hydrate to monomeric residues, abrogated the specific activity of M. tuberculosis whole-cell lysates,

196 upregulated in pDCs, correlating with stage-specific activity of multiple enhancer elements.

197 Moreover, the specific activity of overall LPCAT1 and DGAT1-1 coupling

198 tudy was to investigate the influence of the specific activity of preparations of both tracers on in

199 al dependent, but reaches over half the area-specific activity of Pt nanoparticle catalysts and is mo

200 at the Crm polypeptide modulates a circadian-specific activity of RpaA.

201 Here we show that the specific activity of SOD3, but not SOD1, is decreased, w

202 aging yeast cells by tracking the generation-specific activity of the canonical GAL1 promoter.

203 an essential residue for catalysis, with the specific activity of the enzyme being completely abolish

204 Although the D148E mutant reduces the specific activity of the enzyme, we identified a suppres

205 The specific activity of the extracellular xylanase increase

206 t increases the turnover rate to restore the specific activity of the high fidelity mutant to the wil

207 The specific activity of the plasma-engraved Co3 O4 nanoshee

208 The specific activity of the product was 640 +/- 390 GBq/mum

209 Depending on the antibody combination and specific activity of the radiolabeled antibodies, cockta

210 is; microinjection; validation of the target-specific activity of the sgRNAs; founder screening to id

211 in the esk1 mutant deregulates the position-specific activity of the xylan glucuronosyltransferase G

212 The specific activity of the xylanase was decreased by intro

213 her explore the basis for phosphate position-specific activity of these enzymes and determine that th

214 rt of metformin across membranes, but tissue-specific activity of these transporters in vivo is incom

215 The specific activity of this compound was 853 +/- 29.6 GBq/

216 similar to that of Arabidopsis SFR2, but the specific activity of tomato SFR2 in vitro is almost doub

217 The specific activity of TopA expressed from His-tagged fusi

218 a radiochemical yield of more than 96% at a specific activity of up to 13 MBq/nmol.

219 Accordingly, a significant increase in the specific activity of Vps34 lipid kinase was observed aft

220 For mass doses (specific activities) of less than 20 pmol (>1,000 MBq/nm

221 The 5a and 5e compounds was showing the more specific activity on L-type calcium channels, i.e. A7r5

222 grafted tumors to determine the influence of specific activity on tumor uptake.

223 ity and none of 6 (0%) mice treated with low specific activity or formulation demonstrated significan

224 nically simple, the marked changes in plasma specific activity or the tracer-to-tracee ratio, if stab

225 ntermediate, 31 MBq/nmol; or low 15 MBq/nmol specific activity) or total activity (30, 60, or 120 MBq

226 achieving an order of magnitude increase in specific activity over commercial catalysts for methanol

227 what has often been interpreted as language-specific activity, particularly in midline and contralat

228 arity of these patterns motivated the use of specific activity pattern shapes to classify entorhinal

229 and spatial positions and extracted stimulus-specific activity patterns by MVPA in a simultaneous ele

230 remotor cortex (PMd), we found that sequence-specific activity patterns correlated higher for extrins

231 The analysis of cell type-specific activity patterns during behaviors is important

232 ce that spontaneous reactivation of stimulus-specific activity patterns during resting state can be i

233 real-time fMRI neurofeedback to induce color-specific activity patterns in early visual cortex as par

234 se shapes the relative arrangement of finger-specific activity patterns in sensory-motor cortex.

235 We found that specific activity patterns in the postsynaptic TC cell i

236 tral midline thalamus abolished only the SWM-specific activity patterns that were seen during dual-ta

237 Although the spatial layout of finger-specific activity patterns was variable across participa

238 stimuli are represented in sparse, stimulus-specific activity patterns, relatively little is known a

239 evealed chemotherapeutic and tumor cell line specific activity patterns.

240 The specific activity per ECSA of each material is also repo

241 st OER catalysts showed comparable or better specific activity per ECSA when compared to Ir and Ru ca

242 Topographically specific activity persists as early as V1, and activity

243 llatory entrainment, as visible in frequency specific activity phase-locked to stimulation offset.

244 Using this system, we observed a cell type-specific activity profile of NV Pro and Pro precursors,

245 Using NoroGLuc, we demonstrated a cell type-specific activity profile of the viral protease and its

246 The effects of improving the specific activity, prolonging residence time by introduc

247 ully radiolabeled with a PET nuclide at high specific activity, radiochemical purity, and yield.

248 Our results show that high-specific-activity radiolabeled mAbs that are bound to a

249 of FIX-Padua with an 8- to 12-fold increased specific activity reaching 25% to 40% activity without a

250 ot known whether there are species- or clade-specific activity-regulated genes that control features

251 ate that this polymerase undergoes extensive specific-activity regulation in the initial and final tr

252 an excitatory neuron-specific but non-layer-specific activity reporter.

253 s to identify tissue-specific and temporally specific activities required to obtain the individual sh

254 for 10k cycles; 8.5 times and 13.8 times for specific activity, respectively, compared to commercial

255 s activity and a factor of 22 enhancement in specific activity, respectively, for this reaction (rela

256 for high, intermediate, and low (each n = 3) specific activity, respectively.

257 Heading was the most common soccer-specific activity, responsible for 30.6% of boys' concus

258 ence divergence as a factor, including human-specific activity-responsive AP-1 sites.

259 High when compared with intermediate or low specific activity resulted in a lower mean +/- SEM tumor

260 nclusion:(177)Lu-PSMA-617 (120 MBq) and high specific activity resulted in the highest efficacy in a

261 3-3 in NIH3T3 cells led to decrease in DNMT1 specific activity resulting in hypomethylation of the ge

262 nd observe distinct patterns of eHL-II clade specific activity (rRNA cell(-1) SSC(-1)) with depth tha

263 Such networks transiently amplify specific activity states and can be used to reliably exe

264 Further analysis showed that the WAVE1-specific activity stemmed from an inhibitory effect on f

265 total protein in the sample and calculating specific activity substantially improved quantification

266 Recently, more-specific activities such as road-tunnel washing have bee

267 as well as in their level of anxiety towards specific activities, such as mathematics and spatial tas

268 ubstantial ( approximately 85%) reduction in specific activity, suggesting that FAS inhibits OGA.

269 A rapid, practical, and high-specific-activity synthesis of the NIS reporter probe (1

270 sis of T2O from T2, providing access to high-specific-activity T2O.

271 COD gVS(-1) d(-1) at 65 degrees C), based on specific activity testing of reactor contents.

272 Exg8 has a higher specific activity than Eng1 for beta1,3-glucans; yet des

273 , while most HER catalysts showed much lower specific activity than Pt in both acidic and alkaline so

274 r ORR and are nearly 10 times more active in specific activity than the commercial Pt catalyst.

275 e SiO(x) sites exhibit up to 3.5-fold higher specific activity than the parent alumina with identical

276 The locus shows allele-specific activity that is concomitantly modulated by and

277 ded (18)F-fluoride, yielded a product with a specific activity that was 3 orders of magnitude higher

278 For lower specific activities, the penetration rate and dose distr

279 by which cellular Mn:Zn ratios dictate PhpP specific activity thereby regulating pneumococcal cell d

280 a polar lipid fraction with highly enriched specific activity; this activity was further enriched by

281 nover to generate clearly resolved substrate-specific activity thresholds, which in turn ensures the

282 ion, thus maintaining near-constant ribozyme specific activity throughout protocell growth.

283 ptor antagonist [(11)C]raclopride at varying specific activities to anesthetized nonhuman primates, w

284 size the importance of using drugs with high specific activity to avoid exceeding receptor capacity b

285 activities of less than 148 MBq/mg; however, specific activities up to 592 MBq/mg could be achieved w

286 The (14)C specific activity varied from 280.4 Bq kg(-1) C in 2010

287 nzyme showed an apparent Km of 0.4 mM, and a specific activity (Vmax) of 20.0 mumol min(-1) mg(-1) co

288 ter 5 min of incubation at room temperature; specific activity was 55-200 MBq/nmol.

289 18)F-DEG-VS-NT was greater than 98%, and the specific activity was about 19.2 +/- 4.3 TBq/mmol.

290 The highest specific activity was found on 6th day, with 33.08 U on

291 By leveraging this specific activity, we demonstrate that abolishment of th

292 Specific activities were 41.2 +/- 18.1 MBq/mug (uncorrec

293 In addition, total PDE- and PDE3-specific activities were not altered in pediatric IDC pa

294 ields were approximately 10-fold higher, and specific activities were up to 30-fold higher than with

295 e in mass activity and over 300% increase in specific activity when compared with the disordered Pt(3

296 vity and 3% of its oxygen reduction reaction-specific activity, whereas the corresponding losses for

297 for quantifying butyrylcholinesterase (BChE) specific activity which is BChE activity normalized to t

298 rin expression levels by virtue of adjusting specific activity, which can be exploited for visualizat

299 and Sulfolobus solfataricus display sequence specific activity, with a clear preference for the nucle

300 cell-bound radionuclides, an increase in the specific activity would further increase the tumor dose