ライフサイエンスコーパス: specific binding

1 imal blocking buffer for restraining the non-specific binding.

2 a benchmark to distinguish specific from non-specific binding.

3 leotide polymorphisms associated with allele-specific binding.

4 ed for cellular uptake with little or no non-specific binding.

5 lanin containing tissues, suggesting melanin specific binding.

6 ined in buffer indicating the absence of non-specific binding.

7 ift at the distinct plasmon band maxima upon specific binding.

8 PET imaging, mostly because of insufficient specific binding.

9 igh degree of activity and low levels of non-specific binding.

10 -range adjustment sliding on DNA and finally specific binding.

11 d mismatch DNA sequences, overcoming the non-specific binding.

12 take remained unchanged, demonstrating PD-L1-specific binding.

13 An aptamer, CJ2-06, which had high and specific binding ability to Cry j 2 (K(d)=24 nM), detect

14 ls were fabricated into thin films and their specific binding ability was tested.

15 The erythrocyte-specific binding activities of PvGAMA were significantly

16 ious quinolones with high specificity, while specific binding activities to structurally unrelated dr

17 Protein expression and glycan-specific binding activity also increase in the livers of

18 ssembly proteins, IscA also has a strong and specific binding activity for Cu(I) in vivo and in vitro

19 In vivo, this could be provided by specific binding affinities between components of the li

20 of aromatic side-chains fine-tunes sequence specific binding affinities.

21 ugs to Plec-1-derived peptide would increase specific binding affinity and impart high specificity fo

22 surface, with no detrimental effects on the specific binding affinity of the NCs toward streptavidin

23 were further studied and found to show genus-specific binding affinity when screened against five dif

24 The ITs demonstrated specific binding against native antigens on persistently

25 Thus, specific binding alters the entire RNA unfolding landsca

26 o modulation of the bilayer properties or to specific binding and allosteric regulation of protein ac

27 Our mechanistic results on site-specific binding and catalysis together with the lack of

28 the histone chaperone ASF1a to mediate H3.3-specific binding and chromatin deposition.

29 oristoneura fumiferana AFP, including stereo-specific binding and consequential melting and freezing

30 dy points to UBN1 as the determinant of H3.3-specific binding and deposition by the HIRA complex.

31 that this motif is non-essential for damage-specific binding and DNA bending.

32 ize 64 candidate variants and perform allele-specific binding and expression analyses at seven top ca

33 We annotate variants associated with allele-specific binding and expression in 382 individuals by un

34 Here, we report 14-3-3 isoform-specific binding and functional regulation of GluN2C.

35 as biomolecular handles that permit sequence-specific binding and immobilization of DNA.

36 Resistance correlated with lack of specific binding and reduced oligomerization of Cry1Ac i

37 Aside from individual sequence-specific binding and regulation, examples of interaction

38 ion of TALEs is required for the initial non-specific binding and subsequent rapid search along DNA,

39 ve a useful tool for the characterization of specific binding and the engineering of binding preferen

40 In vitro (47)Sc-cm10 showed folate receptor-specific binding and uptake into KB tumor cells.

41 high specificity, it was insensitive to non-specific binding, and detected target sequences in the p

42 peptide and protein aggregation can obscure specific binding, and since non-stoichiometric binding n

43 A significant reduction in HCV envelope-specific binding antibody and nAb titers was detected in

44 utations were nine times enriched for mutant specific binding, as compared with non-synonymous SNV de

45 ture-activity relationship (SAR) effort, and specific binding assessment using a LC-MS/MS "cold trace

46 nteractions, which are often obscured by non-specific binding at concentrations approaching in vivo a

47 61%) has been identified to contain the WRI1 specific binding AW motif.

48 Specific binding between biomolecules, i.e., molecular r

49 Specific binding between PGA and LPS was consistently de

50 The specific binding between short peptide fragments may pro

51 Specific binding between the extruded hairpin and a dist

52 ein isothiocyanate-labeled PEMV; however, no specific binding between the insect glycan and PEMV was

53 le kinetics in nonhuman primates, as well as specific binding blockable by a PDE2A inhibitor.

54 these "metalloriboswitches," emphasizing ion-specific binding by structured RNA aptamers and associat

55 and lymphoma precursor lesions require site-specific binding by the BCL6 transcriptional repressor a

56 Specifically, we interrogated site-specific binding by the transcription factor PU.1 and it

57 Flow cytometry examination revealed the specific binding capacity of fluorescein isothiocyanate-

58 truction of electronic devices, due to their specific binding, catalytic, nucleating or electronic pr

59 he simultaneous modeling of sparse condition-specific binding changes, sequence dependence, and repli

60 atures alone perform better in predicting TF-specific binding compared to SM-based classifiers.

61 e to complement the crystal structure of the specific binding complex, providing a basis for understa

62 A single sorbate-specific binding constant, the median Langmuir binding c

63 Multiphoton FRAP provided the specific binding constants for alpha-synuclein's binding

64 Although NMDAR-specific binding could be demonstrated for [(125)I]11d a

65 of the impact of ChIP-seq designs on allele-specific binding detection and highlights the power of p

66 y, peak resolution, and most notably, allele-specific binding detection.

67 ic features, peak identification, and allele-specific binding detection.

68 neural cell populations by deleting its non-specific binding domain and replacing it with a C. botul

69 N1 Hpc2-related domain (HRD) is a novel H3.3-specific-binding domain.

70 Therefore, adding protein-specific binding domains to DNA nanostructures can be us

71 y with two different membranes through lipid-specific binding domains, suggesting a general mechanism

72 Specific binding events of target analyte induced collis

73 The technique is sensitive to surface-specific binding events which we demonstrate through bio

74 le of the Zic family of proteins as enhancer-specific binding factors functioning in development.

75 dentify activators and blockers with strong, specific binding for engineering and therapeutic applica

76 ng patterns in DNA that can mediate sequence-specific binding for proteins such as transcription fact

77 uncertainties remain, in part because septal-specific binding has yet to be studied in a purified sys

78 Substantial TrkB/C-specific binding in human brain tissue is observed in vi

79 to rs6971 when tested in vitro and had high specific binding in monkey brain.

80 tions, shows optimum specific and little non-specific binding in phosphate buffered saline.

81 tumor uptake for [(68)Ga]6 and [(68)Ga]8 and specific binding in small-animal PET studies.

82 lent brain permeability, and a high level of specific binding in the "cold tracer" study.

83 e that specifically targets GRP78 for cancer-specific binding (in vitro) and noninvasive tumor imagin

84 f these related to central D2 receptor (D2R) specific binding independent of BMI.

85 se of (+)-pentazocine abolished (11)C-Me-NB1-specific binding, indicating an indirect effect of Sigma

86 Unlike those methods, PLIMSTEX provides site-specific binding information.

87 The bio-specific binding interaction among the molecules was inv

88 Dozens of proteins and hundreds of specific binding interactions are needed to coordinate a

89 with cholesterol and sphingolipids, or from specific binding interactions between hemagglutinin, cho

90 In this system, which lacks any specific binding interactions between the phase-forming

91 factors such as IgG size, shape, charge and specific binding interactions with ECS components.

92 sonances upon filament formation monitor the specific binding interfaces of ASC-PYD association.

93 Specific binding is inhibited by a L348R mutation in Mun

94 Parental-origin allele-specific binding is methylation-dependent and maps only

95 , but it is not yet known how EBNA1 sequence-specific binding is responsible for host cell survival.

96 with magnetic tweezers demonstrate that non-specific binding leads to DNA condensation that is rever

97 rtical flow phase that acts on proteins with specific binding lifetimes.

98 This increase is achieved while keeping non-specific binding low as established in control tests wit

99 encounters large background arising from non-specific bindings, material autofluorescence and leakage

100 both MIT and MIM contribute to determine the specific binding mechanism.

101 n turn, locks CueR binding at PcopA into its specific binding mode, likely helping amplify the differ

102 n a large increase in off-rate while the non-specific binding model cannot be reconciled with the lar

103 iosensing, a nanopore coated with an analyte specific binding molecule (e.g., an antibody, an aptamer

104 We selected FcgammaRIIB-specific binding molecules from a library of designed an

105 increased affinity of the holo-DnrF for its specific binding motif in the napD promoter.

106 A method was developed to identify disease-specific binding motifs through integration of bacterial

107 winding of RNA:DNA hybrids is due to neither specific binding nor differences in the rate of strand s

108 Specific binding of (11)C-BMT-136088 can be reliably mea

109 raclopride per kilogram reduced the apparent specific binding of (18)F- AMC20: in the striatum.

110 D(2/3)R-specific binding of (18)F- AMC20: was evaluated in brain

111 Specific binding of (18)F-fallypride to hD2R hMPCs was d

112 Specific binding of (18)F-florbetapir was calculated by

113 Increased uptake and specific binding of (18)F-GE180 in whole brain and hippo

114 ng aged, female, retired breeder rats showed specific binding of (64)Cu-DOTA-alendronate in mammary g

115 Specific binding of 16 to CB2-positive spleen tissue of

116 Our structural studies captured the specific binding of 3',8-cH2GTP in the active site of Mo

117 release was quantified as the difference in specific binding of [(11)C]raclopride (nondisplaceable b

118 In contrast to SIRT2, specific binding of [(3)H]AziPm or propofol to recombina

119 of AAG, DNA intercalation contributes to the specific binding of a damaged nucleotide, but this enhan

120 We observe tight and specific binding of a ParB homodimer to the parS sequenc

121 is a prerequisite for the subsequent highly specific binding of a second RR dimer to the low-affinit

122 We thus demonstrate that specific binding of a small molecule can produce a xenon

123 and humid atmospheres, changing from a site-specific binding of alcohols to the open metal sites und

124 The specific binding of an MIP to a nonimprinted polymer (NI

125 procedure was optimized to eliminate the non-specific binding of antigen on the membrane surface.

126 Direct and specific binding of bacitracin by BceB was demonstrated

127 To elucidate the molecular basis for specific binding of c-di-AMP by a gene-regulatory mRNA d

128 ular dynamics simulations to investigate the specific binding of cardiolipins to yAAC3.

129 ning electron microscopy, we demonstrate the specific binding of cathepsin K at the edge of the fibri

130 These results suggest that specific binding of cellular RNAs by FMRP may involve hy

131 cacy, the long circulation half-life and non-specific binding of cytotoxic ADCs can result in systemi

132 on-induced fragmentation, were identified by specific binding of deuterated liposomes to antibodies d

133 Here, we use the programmable and specific binding of dye-labeled DNA probes to count inte

134 ) binding protein 2 (PCBP2), and starts with specific binding of eIF4G/eIF4A to d11.

135 Specific binding of ENTH to phosphatidylinositol 4,5-bis

136 ly, in vivo imaging did not show measureable specific binding of F-Dapa in heart, muscle, salivary gl

137 Receptor-specific binding of gallium-labeled HZ220 was characteri

138 ith chemical analogues of synaptamide reveal specific binding of GPR110 to synaptamide, which trigger

139 ave studied by fluorescence spectroscopy the specific binding of HSA with eight compounds that belong

140 Specific binding of inhibitor compound VU0463271 was dem

141 In vitro specific binding of ligands was tested by fluorescence-a

142 Specific binding of mAb 26.4, both native and recombinan

143 hich enables real-time quantification of the specific binding of magnetic beads to the sensor surface

144 A microRNA luciferase assay confirmed the specific binding of miR-224 to the 3' untranslated regio

145 role of Ca(II) in enabling high-affinity and specific binding of Mn(II) to the His6 site of human cal

146 nization in the cell relies on the rapid and specific binding of molecules to their cognate targets.

147 The UPAR specific binding of MSN-UPA nanoparticles was confirmed

148 del, and subsequent testing has verified the specific binding of multiple docking hits to this site.

149 lipid monolayers allowed confirmation of the specific binding of myristoylated recoverin to phosphati

150 The non-specific binding of non-target species to functionalized

151 Non-specific binding of NPs to tumor ECM components was asse

152 A general method for sequence-specific binding of peptides remains elusive despite dec

153 tion of the SF1 SPSP motif slightly enhances specific binding of phospho-SF1 to its cognate U2AF(65)

154 Altogether, specific binding of phosphorylated CREB to the G allele-

155 ar genetics, and immunofluorescence to study specific binding of PI(4,5)P2 by the HCV NS5A protein.

156 te selection is directed in part by sequence-specific binding of PRDM9, a polymorphic histone H3 (H3K

157 ion of adjacent residues that facilitate the specific binding of proteins and modulate the global fol

158 cal adsorption of protein A, followed by the specific binding of rabbit anti-sheep immunoglobulin (Ig

159 Furthermore, specific binding of rhAPC to human neutrophils via VLA-3

160 retic mobility shift assay revealed sequence-specific binding of rSaWRKY1 with MYB20 promoter.

161 Specific binding of RvD2 to recombinant GPR18 was confir

162 from complex food samples as well as the non-specific binding of S-AuNPs.

163 ), suggesting possible resilience to the non-specific binding of serum proteins.

164 Here, we present the structural basis for specific binding of Smad3 and Smad4 to GC-rich motifs in

165 th domains of A3G contribute to the sequence specific binding of ssDNA.

166 time measurements of the hierarchal promoter-specific binding of TFIID, TFIIA, and TFIIB.

167 nderlying mechanisms that explain the highly specific binding of TFs to their genomic target sites ar

168 These actions result from the specific binding of the antibody to the beta-subunit of

169 As an example, we show the specific binding of the common antihypertension drug fel

170 We report here that sequence-specific binding of the conserved Rbfox RRM to miRNA pre

171 ophan residues in the interface which enable specific binding of the isoalloxazine heterocycle of rib

172 bset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 protein.

173 In all species, specific binding of the radioligand was seen in the stri

174 ocking with unlabeled duramycin demonstrated specific binding of the radiotracer.

175 Specific binding of the three proteins to an Rsm-binding

176 me-activity curves, suggesting no off-target specific binding of the tracer in the healthy rat brain.

177 reports modulation of Smad signaling by the specific binding of the VDR along with its heterodimeric

178 We show that specific binding of these biomolecules can be reliably m

179 onic acid (APBA) to such vesicles results in specific binding of this reagent to some of the pendent

180 ence-nuclear magnetic resonance demonstrated specific binding of UM101 to the computer-aided drug des

181 t has been difficult to discriminate between specific bindings of a ligand to a multiprotein complex

182 mation of any biomolecule or nanoentity upon specific binding on the surface of an acoustic wave devi

183 tput current is first observed upon antibody specific binding onto the organic semiconductor.

184 has not been developed to predict either TF-specific binding or general binding properties of TFs.

185 ng protein A (DIPA) as the first head domain-specific binding partner and candidate mediator of isofo

186 found that the cellular protein, DCTN3, is a specific binding partner for 3A.

187 (amplified in osteosarcomas) as a novel and specific binding partner of NKCC2.

188 Incorporation of specific binding peptide (His Pro Gln: HPQ) gives M13 ba

189 hain of the antibody) fused to iRGD, a tumor-specific binding peptide with high permeability.

190 ot a mannopine-binding protein and reveals a specific binding pocket for DFG in SocA with an affinity

191 t the brightest readouts are attained when a specific binding pocket for the fluorophore is present o

192 new subfamily of lipolytic enzymes with the specific binding pocket located at the cap domain instea

193 A1 is accommodated in a specific binding pocket that raises its pKa toward neutr

194 tivalent electrostatic interactions, without specific binding pockets or penetration into the lipid b

195 Furthermore, we found a strong and specific binding preference of Naa60 toward membranes co

196 Whereas TDRD3 has a structure-specific binding preference, it does not discriminate be

197 l properties of the PANI/DNNSA layer and non-specific binding prevention were all crucial factors for

198 The simple radiosynthesis, high specific binding profile, and absence of PET signal in b

199 tion-for example, facilitating transient but specific binding, promoting allostery, or allowing effic

200 mediating their assembly and receptors with specific binding properties have been elusive.

201 More recently, the sequence-specific binding properties of DNA have been exploited t

202 (Sephadex G100), and a glucose- and mannose-specific binding protein - Concanavalin A (ConA).

203 h contain binding sites for the DNA sequence-specific binding protein CENP-B.

204 EBNA1 is a sequence-specific binding protein important for viral genome main

205 n of a regularized and truly modular peptide-specific binding protein, based on designed armadillo re

206 non-contacted base recognition by a sequence-specific binding protein.

207 Specific binding proteins are crucial for the correct sp

208 Recent discoveries of demethylases and specific binding proteins of m(6)A as well as m(6)A meth

209 preselected repeats could be assembled into specific binding proteins on demand and thereby avoid th

210 Specific binding proteins, called readers, recognize the

211 ic SUMOylation, we analyzed SUMOylated PARP1-specific binding proteins.

212 The observed spectra of lectin-protein specific binding rates result in characteristic patterns

213 window for (18)F-FE-PE2I and to validate the specific binding ratio (SBR) as a simplified quantificat

214 o validate the trapping of the molecules via specific binding reactions in the nanoledge cavities.

215 o map the folate binding pocket and identify specific binding residues, like Asn126, whose mutation e

216 able to the sedimentation of the cells and a specific binding response on top of the initial response

217 IL8 and TNFAIP2, we were unable to correlate specific binding sequences for GR or occupancy patterns

218 d to DNA non-specifically, and (ii) that non-specific binding shares common characteristics between v

219 ic dissection of the in vivo (11)C-GSK215083-specific binding showed the ligand bound mostly the 5HT6

220 ysis-1 (MA1) method, as a measure of in vivo specific binding signal, were 2.18, 1.39, 1.08, 1.04, 1.

221 c and selective binding to the KOR, and high specific binding signals.

222 lation of VDAC1 may be facilitated through a specific binding site at the functionally important Glu(

223 We find that spreading condensation from a specific binding site can take place in a path-independe

224 he gammaC domain of fibrinogen as the fibrin-specific binding site for alphaIIbbeta3 involved in plat

225 Ligation by calcium at the PC-specific binding site II influences the active-site geom

226 TFs recognize short, but specific binding sites (TFBSs) that are located within t

227 d RCK2 domains move independently when their specific binding sites are occupied.

228 f alcohols on MscL gating arises not through specific binding sites but through a combination of the

229 The specific binding sites for acetylene are validated by mo

230 These sites coincide with non-specific binding sites for multiple transcription factor

231 ively (S)GTP-binding proteins along with the specific binding sites from the entire human proteome.

232 Nevertheless, specific binding sites have not been identified definiti

233 previous reports of many TFs exchanging with specific binding sites in living cells on a timescale of

234 ental to its activity are recruited to Snail-specific binding sites is unclear.

235 RBPs recognize their RNA target via specific binding sites on the RNA.

236 e of regulating proteins is often limited to specific binding sites such as the ends of microtubules

237 of molecularly imprinted polymer (MIP) with specific binding sites, the sensor responded quickly to

238 associations observed for other proteins at specific binding sites, TRF proteins possess reduced bin

239 nding model to explain genome-wide cell-type-specific binding sites.

240 the polythiophene film and the nature of TNV specific binding sites.

241 extend occupancy across DNA regions far from specific binding sites.

242 bumin (BSA) was used for blocking of the non-specific binding sites.

243 relative affinity of the proteins for their specific binding sites.

244 ries of H2A.Z residues that form a chaperone-specific binding surface.

245 our in vivo PET results: enhanced uptake and specific binding (SUV75%) of (18)F-GE180 in hippocampus

246 loosens cell walls (CWs) of grasses, but its specific binding target is unknown.

247 mics approach was applied to distinguish the specific binding targets from the non-specific ones.

248 Sox2 searches for specific binding targets via a 3D-diffusion dominant mod

249 To prevent non-specific binding the gold surface was treated with 3% BS

250 tute a family of bioactive compounds showing specific binding thermodynamics and following similar ph

251 ues are essential for Cox19 function and its specific binding to a cysteine-containing sequence in Co

252 lectivity from a mix of related agonists for specific binding to a GPCR.

253 Specific binding to a region in the untranslated leader

254 ion of HIV-1 RT in extension assays while no specific binding to avian myeloblastosis or Moloney muri

255 n to improve its cancer targeting ability by specific binding to cancer cell over-expressed biotin re

256 The model is generalizable, using non-specific binding to capture drug-polymer interactions vi

257 tion of the latter module revealed tight and specific binding to chitin, thereby unraveling a new fam

258 Coupling ODNs to alginate strands led to specific binding to complementary-ODN-carrying alginate

259 o determine whether LL-37 signaling reflects specific binding to CsrS or rather a nonspecific respons

260 (18)F- AMC20: shows specific binding to D(2/3)R in the striatum of living ra

261 Sequence-specific binding to DNA is crucial for targeting transcr

262 estrogen receptor (ER) with copper disrupts specific binding to DNA response elements.

263 assessed the feasibility of applying allele-specific binding to filter potential regulatory single-n

264 ale control of gene expression by direct and specific binding to gene regulatory sequences.

265 We found that mir-145 targeted OCT4 via specific binding to its 3'-UTR.

266 tabilization of the psaA-psaB-rps14 mRNA via specific binding to its 5' untranslated region.

267 bution of LacI in live cells, confirming its specific binding to lac operator regions on the chromoso

268 Specific binding to LPS triggers the release of the pept

269 , MBD2 does not show high affinity or methyl-specific binding to mCA.

270 ntial BTZ release in tumor-microenvironment, specific binding to MM cells, and an improved drug cellu

271 chemically distinct P2X7R ligand, indicating specific binding to P2X7R in the monkey brain.

272 Both [(11)C]-12 and [(18)F]-17 showed specific binding to PDE5 in myocardium of transgenic mic

273 of MA targets Gag to the plasma membrane via specific binding to phosphatidylinositol-4,5-bisphosphat

274 in human serum for more than 6 h and showed specific binding to PSMA-expressing cells (concentration

275 use of their high porosity and capability of specific binding to small molecules, thus underpinning a

276 nds were [(18)F]-labeled, and both displayed specific binding to striatal D2/3R in rat brain slices i

277 ore than one zDABM sequence, whereas isoform-specific binding to the AR of zDHHC17 was identified for

278 n a high-avidity interaction that may confer specific binding to the Atg8-coated autophagosomal membr

279 We demonstrated specific binding to the cognate tRNA(Ile) and tRNA(Ile)-

280 nge the equilibrium between specific and non-specific binding to the DNA.

281 g, radiocaine proved to exhibit high in vivo specific binding to the myocardium of non-human primates

282 ular uptake via electron microscopy, and non-specific binding to the substrates through a combination

283 533 and EP-3612 were utilized to distinguish specific binding to tumour collagen from non-specific up

284 he best studied PPR proteins, where sequence-specific binding to two RNA transcripts, ATPH: and PSAJ,

285 UG1p18 shows highly reduced NAC activity but specific binding to Ty1 RNA, whereas AUG2p18 shows the c

286 side effects, either through specific or non-specific binding to unintended membrane protein targets.

287 ity for importin alpha7 while preventing non-specific binding to viral RNA.

288 Pretreatment specific binding volume of distribution (VS/fP) on PET i

289 Non-specific binding was prevented by blocking free spaces o

290 Specific binding was shown in vitro, whereas fast metabo

291 No specific binding was, however, found on human progressiv

292 ading to a 50% reduction of (11)C-BMT-136088 specific binding were 73 +/- 30 nmol/kg and 28 +/- 12 nM

293 Twenty-one fragments with predicted A3AR-specific binding were evaluated in live-cell fluorescenc

294 selectively to target molecules, and the non-specific binding where adsorption of BSA protein molecul

295 PsAP2 showed specific binding with both DRE and GCC box elements and

296 s are underpinned by properties that include specific binding with high affinity and selectivity, coo

297 ), followed by (2) blocking the areas of non-specific binding with mercaptosuccinic acid.

298 micellar and micellar concentrations via non-specific binding with undetectable secondary structural

299 ose-dependent reduction of (18)F-PF-05270430 specific binding, with a half maximal effective concentr

300 is revealed the importance of minimizing non-specific binding within the relatively adhesive, 'sticky