ライフサイエンスコーパス: specific gene

1 hough there was no consistent evidence for a specific gene.

2 performed to identify mutations in esophagus-specific genes.

3 cetylation and a robust activation of neuron-specific genes.

4 n by co-binding enhancers associated with EC-specific genes.

5 hypothalamus are oligodendrocyte- and myelin-specific genes.

6 G1 binding to distal enhancers of melanocyte-specific genes.

7 her validated by the expression of AF tissue-specific genes.

8 pha controls the transcriptional activity of specific genes.

9 with concomitant block of expression of rod-specific genes.

10 s, including up-regulation of several retina-specific genes.

11 s of deletions and duplications that overlap specific genes.

12 an example of a role for this class of plant-specific genes.

13 wnregulated with age, often including tissue-specific genes.

14 ansforming lesions at cell type- and lineage-specific genes.

15 at regulates the expression of photoreceptor-specific genes.

16 ous, phospho-Thr4 is reported to only impact specific genes.

17 t by directing the expression of chondrocyte-specific genes.

18 DNA methylation and histone modifications at specific genes.

19 y for expression of four embryonic stem cell-specific genes.

20 formatics analysis to identify a set of PVAN-specific genes.

21 or not a given ancestral genome will acquire specific genes.

22 s and similar expression profiles of cardiac-specific genes.

23 ly control the expression of a set of muscle-specific genes.

24 ogical processes by repressing expression of specific genes.

25 genetic variation indicative of selection at specific genes.

26 ct developmental states, including germ cell-specific genes.

27 an important resource for future studies of specific genes.

28 plexes, resulting in the hyperacetylation of specific genes.

29 tal process by activating a group of lineage-specific genes.

30 nding of phenotypic behavior associated with specific genes.

31 egions of low gene density and maize lineage-specific genes.

32 ification and expression patterns at MAC-/OC-specific genes.

33 ident from the enhanced expression of the AF-specific genes.

34 derstood small transmembrane proteins neural-specific gene 1 and 2 (Nsg1/NEEP21 and Nsg2/P19).

35 y identified in fibroblasts as growth arrest specific gene 3 (gas3) and is expressed broadly in the b

36 We used constitutive and neuron-specific gene ablation models targeting an integral subu

37 by retinoic acid gene 8 (Stra8), a germ cell-specific gene activated during meiotic commitment.

38 ork presents a novel mechanism for tamoxifen-specific gene activation by ER, secondary to its TOT pre

39 In addition, we explored tissue-specific gene activation using positive feedback loops.

40 nificant upregulation of a cohort of cardiac-specific genes, activation of pathways associated with m

41 sly reported that induction of the adipocyte-specific gene adiponectin (Adipoq) during 3T3-L1 adipocy

42 or mutations leading to R-loop formation at specific genes affect the normal physiology of the cell.

43 In addition, literature that indicates specific gene alterations that did not affect the diseas

44 the base of looping interactions between NPC-specific genes and enhancers.

45 processes involved in regulation of parasite-specific genes and gene families are examined.

46 d associated with highly expressed germ cell-specific genes and histone retention in mature spermatoz

47 urthermore, we show that SOX2 targets acinar-specific genes and is essential for the survival of acin

48 ) enhances the expression of differentiation-specific genes and leads to premature conjugation.

49 gether, terminal selectors activate identity-specific genes and make non-identity-defining genes less

50 es through coordinated expression of lineage-specific genes and modification of complex chromatin con

51 In this context, B cell-specific genes and mTOR signaling were associated with a

52 on of stress response pathways, although the specific genes and pathways involved differ depending on

53 lammation' signature was noted, although the specific genes and pathways involved varied amongst dend

54 pression that involves activation of lineage specific genes and repression of pluripotency genes driv

55 to interruption, deletion, or duplication of specific genes and should also incorporate regulatory do

56 proximal tubule cells showed upregulation of specific genes and significantly elevated p-glycoprotein

57 distinct phenotypes-raises questions of how specific genes and their protein products interact to co

58 the role of monoallelic expression in their specific genes and tissues of interest.

59 role in repressing the irrelevant cell type-specific genes and were essential for preventing irrelev

60 versifying selection, by dispersed, pathogen-specific genes, and/or by individual genes providing MDR

61 cannot account for the contribution of human-specific genes, animal models are needed to more closely

62 y, p300 transcriptionally activates AT1 cell-specific gene Aqp-5.

63 f lung alveolar epithelial type I (AT1) cell-specific gene aquaporin-5 (Aqp5).

64 ssue types revealed that cis-eQTLs for islet-specific genes are specifically and significantly enrich

65 a transcriptional level, multiple erythroid-specific genes are upregulated and megakaryocyte-specifi

66 n cancers harboring amplifications in mTORC2-specific genes as the only actionable genomic alteration

67 Whole-genome sequencing identified specific genes associated with a "not-cured" outcome tha

68 , in NSCs, MBD1 binds and represses directly specific genes associated with differentiation.

69 e transcription factor STAT5 to control cell-specific genes at a larger scale than universal genes, w

70 pled with gene duplication, even though silk-specific genes belong to multi-paralog gene families.

71 chromatin remodeling in promoter regions of specific genes, blockade of NF-kappaB pathway activation

72 program is followed by activation of TS cell-specific genes by CAG factors.

73 Our results suggest that sperm-specific genes can evolve rapidly and that natural genet

74 ound the loss-of-function allele of a myelin-specific gene (CNP rs2070106-AA) associated with cataton

75 he identification of two over-represented PD-specific gene co-expression network modules: the Brown M

76 velop a principled method to recover context specific gene co-expression networks from the estimated

77 s show that GMMs help discover tumor subtype specific gene co-expression patterns (modules) that are

78 ermore, we constructed cancer or tissue type-specific, gene co-expression based protein interaction n

79 ivers often represents a major challenge, as specific gene combinations may be required for reprogram

80 survival in the presence of mutations in rod-specific genes, consequently preventing secondary cone d

81 Here, we report that a plant-specific gene containing a bromo-adjacent homology and t

82 haplotypes that differ in structure and male-specific gene content.

83 On the other hand, expression of nodule-specific genes correlated with ploidy-dependent opening

84 The treatment-specific genes could be used to study the roles of pleur

85 vor has been hampered by the small number of specific genes currently known to function in social beh

86 Stage-specific gene deletion in trophoblasts reveals that loss

87 e is commonly used for conditional hair cell-specific gene deletion/reporter gene activation in the i

88 Using a combination of cell-type-specific gene deletions, pharmacology, and chemogenetics

89 Allele-specific gene disruption induced by non-homologous end-j

90 However, current cell type-specific gene disruption techniques in flies often reduc

91 ted promoter/proximal enhancer of the neuron-specific gene doublecortin (Dcx) Once differentiation is

92 secondary analyses designed to highlight the specific genes driving the aggregate signal, we confirme

93 as a mechanism that regulates expression of specific genes during development of the pupal nervous s

94 complexes to repress transcription of neural-specific genes during early development.

95 results demonstrate that AAV-mediated muscle-specific gene editing has significant potential for ther

96 n library identified a mutation within a GBS-specific gene encoding a putative glycosyltransferase th

97 al absence within STc648 of uidA, an E. coli-specific gene encoding beta-glucuronidase.

98 molecular and systemic mechanisms underlying specific gene-environment interactions may provide insig

99 ation of more than 1800 messenger RNAs shows specific gene expansions that can be related to invasive

100 Finally, homoeolog-specific gene expression analyses identify TaAGL33 and i

101 ional enhancers play a key role in cell type-specific gene expression and cell fate transition.

102 This allowed us to study sex-specific gene expression and gonadal development.

103 nocompromised mice yielding cells with human-specific gene expression and human albumin levels in mur

104 ogenesis, concomitant with reduced cartilage-specific gene expression and incomplete matrix component

105 e results highlight the complexities of site-specific gene expression and its disruption in skin dise

106 Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds

107 of the molecular players that regulate stage-specific gene expression and Pol II pausing will contrib

108 amined the role of BRD4 in promoting lineage-specific gene expression and show that BRD4 is essential

109 crucial role in the establishment of tissue-specific gene expression and the regulation of key biolo

110 n emerging model for the evolution of tissue-specific gene expression and the role of gene duplicatio

111 cations regulate developmental and cell type-specific gene expression and underpin animal complexity,

112 f-of-concept that a cell-specific and region-specific gene expression approach can provide potential

113 matin looping interactions mediate cell type-specific gene expression are an active area of investiga

114 Enhancers act to regulate cell-type-specific gene expression by facilitating the transcripti

115 d RNA-seq data from tendon identified gender specific gene expression changes highlighting disparity

116 wever, the mechanisms controlling how tissue-specific gene expression changes over time are less well

117 ith testosterone-propionate (TP) reveals sex-specific gene expression changes, causing 2854 and 792 t

118 ethylation was a better predictor of subtype-specific gene expression compared to CpG methylation.

119 Sex-specific gene expression could be observed during embryo

120 ificity of EC-tagging by obtaining cell type-specific gene expression data from intact Drosophila lar

121 These data support the notion that sex-specific gene expression differences at baseline influen

122 We also observe increased sex-specific gene expression differences in neutrophils.

123 rs that all show a similar pattern of tissue-specific gene expression divergence following WGD, with

124 RT-qPCR suggests model specific gene expression for nine putative fungal secret

125 ey transcriptional regulators that direct AM-specific gene expression have been established.

126 VM infections resulted in reduced osteoblast-specific gene expression in bone, loss of osteoblasts, a

127 nces, beta-adrenergic activation-induced BAT-specific gene expression in brown adipocytes.

128 Many examples of region-specific gene expression in the adult intestine are know

129 Prebiotics modified specific gene expression in the hippocampus and hypothal

130 the effect of germ-line variation on tissue-specific gene expression in the presence of effects due

131 erentiation in which induction of melanocyte-specific gene expression is closely linked to chromatin

132 r invasion; and showed the lowest metastasis-specific gene expression levels and TP53 mutation rates.

133 We developed two species-specific gene expression microarrays, each targeting ove

134 We observed recovery-specific gene expression networks upon return to favorab

135 Placentas retained monoallelic allele-specific gene expression of IGF2, but 32.4% of cord bloo

136 ioned approach: to predict if a CRM drives a specific gene expression pattern, assess not only how si

137 s, Plet1 is required to confer a trophoblast-specific gene expression pattern, including up-regulatio

138 olality within the renal medulla modulates a specific gene expression pattern.

139 ic expression show that iPSCs retain a donor-specific gene expression pattern.

140 BECs) from children with asthma would induce specific gene expression patterns and whether such patte

141 projection tomography to rapidly image brain-specific gene expression patterns in 3D at cellular reso

142 wo states that exhibited different condition-specific gene expression patterns.

143 et binding of the fusion proteins leading to specific gene expression patterns.

144 Here, we have explored the hypothesis that specific gene expression profiles arise since promoters

145 her coding or noncoding, according to tissue-specific gene expression profiles.

146 downregulation caused the loss of the BPDCN-specific gene expression program and apoptosis.

147 -containing protein, thereby mediating stage-specific gene expression programs and post-meiotic chrom

148 a key role in the establishment of cell-type specific gene expression programs characteristic of diff

149 nery, are essential for establishing lineage-specific gene expression programs during cell differenti

150 that tailor the chromatin landscape for cell-specific gene expression programs.

151 onal regulator that antagonizes T and B cell-specific gene expression programs.

152 , which are transcription factors that drive specific gene expression programs.

153 ption factors are required to control tissue-specific gene expression programs.

154 ating alterations of PPARG or RXRA lead to a specific gene expression signature in bladder cancers.

155 c program, and inhibiting Hdac1 promotes BAT-specific gene expression through a coordinated control o

156 ial histone enrichment associated with tumor-specific gene expression variation, sites of HPV integra

157 ssociated with UM risk; M1 and M2 macrophage-specific gene expression was associated with disease-fre

158 Cell-specific gene expression was widely disturbed in interfe

159 gical processes that are upregulated (testis-specific gene expression) or downregulated (metabolism a

160 yte differentiation and regulation of myelin-specific gene expression, as the cause underlying a prev

161 within promoter regions to regulate lineage-specific gene expression, either as activators or repres

162 n post-engulfment, forespore and mother cell-specific gene expression, suggesting a channel-like func

163 -1 activation, and epithelial to mesenchymal-specific gene expression, ultimately attenuating melanom

164 of cis-elements determining parent of origin-specific gene expression, with each recruiting different

165 2 (EBF2) selectively activates brown lineage-specific gene expression.

166 n by gamma-secretase cleavage, induces NOTCH-specific gene expression.

167 ge regulatory interactions typical of tissue-specific gene expression.

168 that loss of GATA6 greatly affects beta-cell-specific gene expression.

169 ace of the nucleus is coupled with cell type-specific gene expression.

170 to this tightly controlled tissue- and stage-specific gene expression.

171 which factors are needed to activate cumulus specific gene expression.

172 Drug-specific gene-expression profile (GEP) signatures that a

173 factor that controlled an iNKT-cell lineage-specific gene-expression program and epigenetic landscap

174 In parallel, activation initiates context-specific gene-expression programs that drive effector fu

175 resistance to the treatment associated with specific gene expressions or mutations has been observed

176 rategies are linked to radiations of lineage-specific gene families.

177 idly evolving and belong to large Nematocida-specific gene families.

178 ourd and other cucurbits, as well as lineage-specific gene family expansions in bottle gourd.

179 onal regulators include the family of Neuron-Specific Gene family members (Nsg), NEEP21 (Nsg1), and P

180 espite commonalities that promote infection, specific gene-family radiations contribute to distinct i

181 form trimeric complexes with Smad4 to target specific genes for cell fate regulation.

182 cases associated with pathogenic variants in specific genes from each other or from those with no pri

183 ifferentiation with curated phenotypes, cell-specific gene functions and a multiscale model.

184 N. caninum is a useful tool for the study of specific gene functions and may allow the identification

185 ight of the strictly light-dependent, gamete-specific gene GAS28 pCRY acts as a negative regulator fo

186 te stage of recovery; and (3) recovery phase-specific gene groups cooperating in the rapid replenishm

187 down-regulation of stage- and subpopulation-specific gene groups during the course of maturation rev

188 The human-specific gene hydrocephalus-inducing 2, HYDIN2, was gene

189 hestrates the expression of many endothelial-specific genes, illustrating its crucial importance for

190 astly, we validate the overexpression of one specific gene in the FLC signature, carbonic anhydrase X

191 F2 regulates chromatin to activate brown fat-specific genes in adipocytes were unknown.

192 genes while repressing white fat and muscle-specific genes in adipocytes.

193 (FRAEM) now enables the complete deletion of specific genes in C. trachomatis L2.

194 TGF-beta/bone morphogenetic protein pathway-specific genes in DCs and identified Acvrl1, a type I TG

195 cle progression on the expression of lineage specific genes in precursor cells, and suggests that hem

196 -determining transcription factors to target specific genes in TGF-beta and BMP pathways.

197 y promoting the ectopic expression of tissue-specific genes in the thymic medullary epithelium.

198 iation of carcinomatous ccRCCs and implicate specific genes in this process.

199 e by regulating the expression of epithelial-specific genes including TP63 and Grainy Head-like trans

200 esponse by down-regulating the expression of specific genes, including ARNTL, CEACAM7, GATA2, HHEX, K

201 egulate the expression of multiple germ cell-specific genes, including Asz1 In addition, conditional

202 behavioral QTL and eQTL results to implicate specific genes, including Azi2 in sensitivity to methamp

203 SD) gonad, and high activation of the female specific genes, including FOXL2, RSPO1, CYP19A1, WNT4, E

204 d in only a small subset of symbiotic nodule-specific genes, including more than half of the NCR gene

205 xpression analysis uncovered new immune-cell-specific genes, including novel immunoglobulin-like rece

206 heir functions and the expression of lineage-specific genes, including those encoding effector cytoki

207 dissociation of HDAC1 from promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) an

208 ndothelial cell gene expression of lymphatic specific genes, including VEGFR-3 and Prox1.

209 icated that they directly couple trophoblast-specific gene induction with suppression of pluripotency

210 Here we show that NLRP11, a primate specific gene, inhibits TLR signalling by targeting TRAF

211 iated virus (AAV) donor vectors enables site-specific gene insertion by homology-directed genome edit

212 tudies are needed to investigate the role of specific genes involved in the identified pathways and t

213 ific genes while activating target cell-type-specific genes is unclear.

214 in the fibrotic tissue facilitated sequence-specific gene knockdown and prevented fibrosis progressi

215 could not detect robust associations between specific gene KOs and quantitative anthropometric traits

216 activity and relocation of the keratinocyte-specific gene loci away from the sites of active transcr

217 transcription drives spatial organization at specific gene loci.

218 The discovery of salamander lineage-specific genes (LSGs) expressed during limb regeneration

219 adly applicable technology to carry out site-specific gene modification in hESCs.

220 dren, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-t

221 In many cases, this is the consequence of specific gene mutations that have the potential to be ta

222 in the selective expansion of HSPCs carrying specific gene mutations.

223 ine-learning approach based on a human brain-specific gene network to present a genome-wide predictio

224 riptional responses and suggest that context-specific gene networks and pathways may shape how the im

225 scriptional mechanism whereby cocaine alters specific gene networks in dlPFC neurons.

226 We identify key regulators of sex-specific gene networks underlying MDD and confirm their

227 hanges in the spatial arrangement of lineage-specific genes, nuclear bodies, and heterochromatin.

228 hod that works well in creating mutations in specific genes of interest followed by complementation r

229 n C. geophilum with symbiosis-induced, taxon-specific genes of unknown function and reduced numbers o

230 e provirus was integrated near host genes in specific gene ontological classes, including cell activa

231 expression and 5hmC profiles that mapped to specific gene ontology pathways.

232 ing most of these loci and resolving them to specific genes or genetic variants is challenging.

233 s that suggest a syndrome, and sequencing of specific genes or next-generation sequencing can determi

234 e 1 (MUCL1) was first identified as a breast-specific gene over a decade ago.

235 uence profiling identifies a suite of pollen-specific genes overexpressed during haploid induction, s

236 icantly reduced the expression of osteoclast-specific genes (p < 0.05) alongside decreased osteoclast

237 r than activation of a distinct regeneration-specific gene program.

238 with human immune dysfunction alters context-specific gene programs.

239 e clonal diversity of epialleles analysed at specific gene promoter regions.

240 inhibiting polycomb protein activity on the specific gene promoters.

241 veal that TE-eQTL are involved in population-specific gene regulation as well as transcriptional netw

242 ortance of DNA binding specificity for organ-specific gene regulation by modulating promoter activity

243 Identifying tissue-specific gene regulation is critically important to unde

244 ics-based approach to assess the activity of specific gene regulation pathways involved in inflammati

245 Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in n

246 ighly dynamic epigenomic correlate of allele-specific gene regulation.

247 tissues or cell types due to highly context-specific gene regulation.

248 or enables robust orchestration of cell-type-specific gene regulation.

249 Integration with cell type-specific gene regulatory circuits highlight pathways inv

250 atic cell differentiation is exerted through specific gene regulatory network motifs.

251 gard to the extent to which cell- and tissue-specific gene regulatory networks are established.

252 ctionable mutation' impacts distinct context-specific gene regulatory programs and signalling network

253 how common and cultivar exclusive changes in specific genes related to photosynthesis, carbohydrate,

254 e developed new viral-based platforms with 2 specific gene reporters.

255 ing approach more efficiently identified the specific gene responsible for the phenotype.

256 opposite changes in expression of a neuronal-specific gene set, notably nociceptive neuropeptides.

257 RMs with logical connection to regulation of specific gene sets and biological pathways.

258 temic processes relying on the activation of specific gene sets and biosynthesis of distinct MIAs fol

259 n of 53 Synechococcus genomes revealed clade-specific gene sets regulating membrane lipids.

260 e validated the growth-inhibiting effects of specific gene sets, including epigenetic regulators KDM4

261 fferent benchmarking conditions: (i) species specific gene sets; (ii) neighbouring versus orphan pair

262 ithin 4 days; however, several highly female-specific genes showed weak or no feminization, even afte

263 In addition to sharing a gut-specific gene signature with memory IgA(+) B cells, memo

264 Therefore, we link the cell-type-specific gene signatures to aggressive subtypes of prost

265 valuable for monitoring the impact of allele-specific gene silencing strategies currently being explo

266 Study-specific gene-smoking interaction effects were calculate

267 d led to maintained expression of progenitor-specific genes such as Vsx2 and Hes1 with concomitant bl

268 chanism, and AP-1 effects were confirmed for specific gene targets in primary human cells.

269 ld selectively increase the mutation rate of specific genes that are actively under positive selectio

270 We furthermore identify specific genes that are shared within these disease grou

271 d and extensive down-regulation of microglia-specific genes that were induced in primitive mouse macr

272 ents' survival time after diagnosis with one specific gene, the disease subtypes, and their interacti

273 ctor conveys a general chromatin modifier to specific genes, thereby allowing the execution of hepato

274 nables immunologists who are interested in a specific gene to visualize the reads aligned to this gen

275 notype of CAKUT frequently does not indicate specific genes to be examined.

276 the expression of ubiquitous and lymphocyte-specific gene transcripts to control the differentiation

277 We attempted kidney-specific gene transfer following hydrodynamic tail vein

278 Methods enabling kidney-specific gene transfer in adult mice are needed to devel

279 injection enables transposon mediated-kidney specific gene transfer in adult mice.

280 robability is the probability of observing a specific gene tree topology under the multispecies coale

281 ls (iPSCs) derived from individuals carrying specific gene variants or mutations provide an alternati

282 ces transcriptional regulation of osteoclast-specific genes via NFATc1, which facilitate bone resorpt

283 Rybp upregulation and suppression of lineage-specific genes via RYBP-dependent ubiquitination of H2AK

284 t cells can use to target rapid evolution to specific genes was discovered.

285 Widespread expression of donor-cell-specific genes was observed in inappropriate cell types

286 of known uterine receptivity genes and gland-specific genes were altered in the PUGKO uterus.

287 Lineage-specific genes were differently expressed between cells,

288 Clade-specific genes were distinct for genetic exchange and si

289 These specific genes were found to be highly enriched for vira

290 Genotype-specific genes were more likely to have tissue/condition

291 ranscriptional changes observed in esophagus-specific genes were reproduced in vitro in esophageal ep

292 involved in immune processes and epididymis-specific genes were upregulated in the testes.

293 tors mediate repression of initial cell-type-specific genes while activating target cell-type-specifi

294 ranscription factor that activates brown fat-specific genes while repressing white fat and muscle-spe

295 A single copy anther-specific gene with a male sterile Arabidopsis knockout p

296 results highlight novel variants in or near specific genes with important roles in sex steroid hormo

297 le, and, specially, analyze up-regulated HdT specific genes with inducible resistant and defense sign

298 ssion and clustering upregulated endothelial-specific genes with key roles in vascular stabilization

299 significant changes in expression levels of specific genes, with significant overlapping with altera

300 tion, as seen via signatures of selection in specific genes within a population of baculoviruses.IMPO