ライフサイエンスコーパス: specific recognition

1 ive events that are uniquely associated with specific recognition.

2 e sequence-interrogation phase that precedes specific recognition.

3 cient coupled binding and folding for facile specific recognition.

4 the screening reveals no change in sequence-specific recognition.

5 t exhibit sequence-specific and non-sequence-specific recognition.

6 PEP dependent and require sigma factors for specific recognition.

7 he TCR either obliterated or enhanced target-specific recognition.

8 e Ag-nonspecific and thus, independent of Ag-specific recognition.

9 f variable domains in Dscam mediates isoform-specific recognition.

10 inding, thermodynamic stability and sequence specific recognition.

11 alues of 450 nM and 4 microM-demonstrated Ag-specific recognition.

12 tant increment of binding energy to sequence-specific recognition.

13 f the exocyclic amino group of G in sequence-specific recognition.

14 advantage of signal amplification and highly specific recognition.

15 rease provides full assurance of a perfectly specific recognition.

16 ew paradigm for mixed-base-pair DNA sequence-specific recognition.

17 g an additional means of confirmation of the specific recognition.

18 Specific recognition ability is directly built into the

19 to produce complementary binding sites with specific recognition ability.

20 Examples of the use of both specific recognition and array-based "chemical nose" app

21 al first step in Escherichia coli MMR is the specific recognition and binding of MutS to a heterodupl

22 sets of DNA-protein contacts to mediate site-specific recognition and cleavage.

23 T cells imparted high-avidity phosphopeptide-specific recognition and cytotoxic and cytokine-secretin

24 e enzymes' highly evolved mechanisms for the specific recognition and discrimination of native dNTPs.

25 cteristic spectral shifts resulting from the specific recognition and dose-dependent interaction of a

26 th the structural basis of this modification-specific recognition and how this recognition informs Rt

27 activity, these data provide a model for the specific recognition and hydrolysis of 3mA from DNA.

28 ressed the TCR and showed HLA-A2-restricted, specific recognition and killing of tumor antigen peptid

29 ced by ZBP1 binding provides a mechanism for specific recognition and may facilitate the assembly of

30 DNA minor groove microstructure for sequence-specific recognition and offer new avenues to design syn

31 It reveals base-specific recognition and offers a molecular explanation

32 ctural features of the Ty3 PPT contribute to specific recognition and processing by its cognate RT.

33 l features of the PPT that contribute to its specific recognition and processing by reverse transcrip

34 mpatibility (SI) prevents inbreeding through specific recognition and rejection of incompatible polle

35 in specific cells within the tissues and the specific recognition and removal of dying cells by a cle

36 Specific recognition and response occurs without regard

37 olecularly imprinted sensor was designed for specific recognition and sensitive ratiometric detection

38 lock-and-key system to perform cell-subtype-specific recognition and siRNA delivery.

39 Many experimental techniques rely on specific recognition and stringent binding of proteins b

40 This network may play a key role in the specific recognition and strong binding of mannose oligo

41 R-Cas systems) that protect through sequence-specific recognition and targeted destruction of viral n

42 es with aptamer targeting ligands allows for specific recognition and ultrasensitive detection of can

43 dinucleotide steps and may be important for specific recognition and/or cleavage by the MMLV integra

44 echanisms of how E3 ligases confer substrate-specific recognition, and their role in substrate retrot

45 ix-turn-helix motif is critical for sequence-specific recognition, as the R432A mutation abolishes it

46 features of carrier proteins that determine specific recognition at distinct points in assembly line

47 s on metal surfaces as an event triggered by specific recognition between a probe and a target nuclei

48 trochemical signal can be achieved after the specific recognition between antibodies and antigens.

49 On the basis of the specific recognition between aptamer and MUC1 protein th

50 an mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which t

51 tion of packaging specificity, either (a) by specific recognition between capsid protein(s) and repli

52 cur during the first steps of infection, for specific recognition between host and bacteria, but also

53 of pathogenic bacteria, suggesting that the specific recognition between Pa-BfrB and Pa-Bfd is of wi

54 Protein-RNA complexes formed by specific recognition between RNA and RNA-binding protein

55 The fidelity of chain growth depends on specific recognition between successive subunits in each

56 Adaptive immunity depends on specific recognition by a T-cell receptor (TCR) of an an

57 in, indicating that either motif may support specific recognition by Cdh1.

58 folds and revealed structural principles for specific recognition by cognate metabolites.

59 erminal region of helix 2 are sufficient for specific recognition by conserved and functionally impor

60 ine the features in sigma(S) responsible for specific recognition by Crl.

61 n the beta3 strand that are known to mediate specific recognition by DH domain containing GEFs.

62 crobes of many types, and are the targets of specific recognition by many different viruses.

63 mature conformation and immune function via specific recognition by MHC-I-restricted CD8(+) T lympho

64 heir resolution in vivo is likely to require specific recognition by specialized enzymes.

65 Antigen-specific recognition by T cells is via the T cell recept

66 he initiation of the immune response, before specific recognition by T cells that could be beneficial

67 differentially displayed on tumor cells for specific recognition by T cells.

68 of the CenH3 alpha2 helix is sufficient for specific recognition by the chaperone for both budding y

69 Restriction activity requires capsid (CA)-specific recognition by the PRYSPRY domain of TRIM5alpha

70 novel proteins Ere1 and Ere2 mediates cargo-specific recognition by the retromer pathway.

71 Combining specific recognition capabilities with the excellent spa

72 Highly specific recognition cavities can be made into polymer m

73 s 140-fold stabilization of the extrahelical specific recognition complex, and that Y162 functions as

74 ression of AAG from nonspecific searching to specific-recognition complexes.

75 uence-independent interactions and vectorial-specific recognition domains.

76 Herein, we report a S. aureus-specific recognition element, isolated from phage monocl

77 e generic biosensor after incorporation of a specific recognition element, such as an aptamer for exa

78 comprising such redox groups, together with specific recognition elements (here antibodies), this ch

79 of which contains mismatch sites serving as specific recognition elements for mercury(II) or silver(

80 d as a screening method to identify pathogen-specific recognition elements.

81 ne monitoring require very rugged yet highly specific recognition elements.

82 by subtle differences between small, highly specific recognition elements.

83 comes can be quantified readily, the initial specific recognition events have been difficult to asses

84 preventing amyloidogenic oligomerization and specific recognition events that nucleate prion assembly

85 epeat (PPR) motif-containing family are site-specific recognition factors for either chloroplast or m

86 ling-circle mechanism that requires sequence-specific recognition for initiation, nicking of one of t

87 To determine the factors involved in the specific recognition function of a bacterial 8-oxoguanin

88 ride motifs may modulate carbohydrate-lectin specific recognition in a lectin-dependent manner when p

89 the gametophytic self-incompatibility (GSI) specific recognition in Prunus.

90 Residues involved in unusual base-specific recognition in the minor groove of dsRNA are co

91 t, implicating the loop of Rtt106 in H3K56ac-specific recognition in vivo.

92 Semi-specific recognition, in which a molecular class rather

93 peat" (NLR) proteins that translate pathogen-specific recognition into disease-resistance signaling.

94 The specific recognition is achieved by use of biotinylated

95 Current models suggest that specific recognition is driven by DGCR8 detection of sin

96 Achieving facile specific recognition is essential for intrinsically diso

97 Specific recognition is even maintained in biological ma

98 lignancies, but the nature of the induced Ag-specific recognition is largely unknown.

99 chia coli, acts by methylation- and sequence-specific recognition, leading to either methylation of D

100 surface, including protein determinants for specific recognition, linked to immune responses.

101 Understanding the molecular basis for this specific recognition may lead to novel therapeutic strat

102 However the specific recognition mechanism between TRIM24 and histon

103 correlated with the development of category-specific recognition memory.

104 and remaining challenges; and explores other specific recognition modalities that might be employed f

105 tch from a nonspecific search mode to a more specific recognition mode.

106 iour in the manner predicted by our sequence-specific recognition model for CCT-actin interaction.

107 une response at the cellular level relies on specific recognition molecules to rapidly signal viral i

108 To explore whether the T-synthase encodes a specific recognition motif for Cosmc, we used deletion m

109 zyme that is required for SipA cleavage at a specific recognition motif that divided the protein into

110 ol of 1.4 million unique peptides identified specific recognition motifs for KalbTG in these peptides

111 eins these findings raise the possibility of specific recognition motifs within replication origins o

112 eaction that is most critically dependent on specific recognition of -11A.

113 in defines the family and is responsible for specific recognition of a common sequence motif, 5'-GGA(

114 ntly shown to bind at least six proteins, by specific recognition of a consensus sequence in them.

115 site on each complex vary, providing for the specific recognition of a diverse repertoire of (D/E)XXX

116 in has served as a model for studies of site-specific recognition of a eukaryotic replication origin

117 domain-phosphopeptide binding mode, but with specific recognition of a glutamate at the +1 position r

118 ated neutralization involving both structure-specific recognition of a gp41 protein epitope and nonsp

119 oteins, which are processed by sortases upon specific recognition of a highly conserved LPXTG motif.

120 tion of protein synthesis occurs through the specific recognition of a stop codon in the A site of th

121 A critical function of HP is its specific recognition of a viral RNA signal termed epsilo

122 n-pi interaction contribute to selective and specific recognition of A- and H-type HBGAs.

123 The site-specific recognition of abasic sites and single base bul

124 king in somatic cells is also facilitated by specific recognition of acetylated MTs by motor proteins

125 quaternary structure of VH1 is essential for specific recognition of activated STAT1, which prevents

126 re consistent with and support the idea that specific recognition of adenine at the nontemplate -11-p

127 The specific recognition of adenovirus was investigated in t

128 Only moderate evidence of infection stage-specific recognition of Ags was observed.

129 The immunoassay, based on specific recognition of an antigen by its antibody, has

130 Based on a sandwich ELISA and the specific recognition of antibody to E. coli O157:H7, the

131 This process is initiated by specific recognition of antigen through the B cell recep

132 Specific recognition of arabinosyl residues may help exp

133 d that the host specificity is determined by specific recognition of bacterially derived Nod factors

134 de a potential novel tool to investigate the specific recognition of base pairs, which is the basis o

135 Prf is absolutely required for specific recognition of both effectors.

136 e a new way to generate molecular probes for specific recognition of cancer cells.

137 T cells target and kill cancer cells by the specific recognition of cancer-associated antigens.

138 The aptasensor exploits the specific recognition of carbendazim by the aptamer immob

139 residues 125 to 241 of PrgY are required for specific recognition of cCF10 and that PrgY recognizes d

140 einhardtii cells to pan for VH H clones with specific recognition of cell-surface epitopes.

141 eceptor subfamilies have evolved towards the specific recognition of certain animal groups or chemica

142 of the ectodomains of these proteins is the specific recognition of cognate ligands, which are often

143 Riboswitches regulate gene expression via specific recognition of cognate metabolites by their apt

144 eparate regions of the interface account for specific recognition of colicin E5 by Im5.

145 ation and adhesion of platelets, through the specific recognition of collagen by the alpha2-I domain

146 and we elucidate the molecular basis for its specific recognition of diaminopimelate-type peptidoglyc

147 ed that Thr-84 and Lys-169 play key roles in specific recognition of dicarboxylic keto (prephenate) a

148 is, promotes inclusion of weak exons through specific recognition of diverse cis-elements.

149 umber of combinatorial possibilities for the specific recognition of DNA (or RNA).

150 The mechanism of site-specific recognition of DNA by proteins has been a long-

151 Specific recognition of DNA by transcription factors is

152 Sequence-specific recognition of DNA is a critical step in gene t

153 ional exchange process that was modulated by specific recognition of DNA, indicating allosteric proce

154 Specific recognition of dopamine by the aptamer allowed

155 C-terminal MYB/homeodomain mediates sequence specific recognition of double-stranded telomeric DNA.

156 sulting label-free configuration enabled the specific recognition of EcOMPs in water by monitoring th

157 We propose that specific recognition of endogenous presented peptides, r

158 k docking interactions facilitate the highly specific recognition of ERK2 by Ets-1, and enable the op

159 We report the presence of antigen-specific recognition of ESAT-6 and KatG in T cells from

160 The specific recognition of FAP is based on the interaction

161 we find that DEP domains are responsible for specific recognition of GPCRs.

162 Here we demonstrate the molecular basis for specific recognition of H3(1-15)K4me3 (residues 1-15 of

163 s, but the molecular 'effectors' involved in specific recognition of H3K4me3 tails remain poorly unde

164 ysine, thus explaining the methylation state-specific recognition of H4-K20.

165 These data show that sequence-specific recognition of helices in TM proteins can be ac

166 Specific recognition of hinge epitopes was dependent on

167 Here we show a critical role for specific recognition of histone H3 trimethylated at lysi

168 riking mechanistic commonality for the state-specific recognition of histone lysine methylation, it i

169 ate tumor regression in melanoma through the specific recognition of HLA-restricted peptides.

170 cidate the structural basis for the sequence-specific recognition of human ISG15, we determined the c

171 Specific recognition of Hyaloperonospora parasitica isol

172 Full details of the specific recognition of hypoxanthine are revealed, allow

173 ysis in solution was independent of the very specific recognition of immobilized peptides by MMP-13;

174 bute to TlyA domain interactions, as well as specific recognition of its two structurally distinct ri

175 niles and neonates, sensory cues that enable specific recognition of juvenile mice are unknown.

176 l active-site interactions important for the specific recognition of l-malate, but not other alpha-hy

177 domain of VioA is mainly responsible for the specific recognition of l-tryptophan.

178 roup of aptamers have been generated for the specific recognition of leukemia cells.

179 ies show that Yos9(22-421) exhibits sequence-specific recognition of linear peptides from the ERAD su

180 d for the generation of molecular probes for specific recognition of liver cancer cells.

181 The selectivity depended on specific recognition of LTR loop residues; the mechanism

182 acts as one functional unit in the sequence-specific recognition of lysine-14-acetylated histone H3

183 llows more specific interactions such as the specific recognition of melanophilin by the myosin Va is

184 sm for the generation, stabilization, and/or specific recognition of membrane discontinuities.

185 In this study, we demonstrate that specific recognition of messenger RNAs (mRNAs) by RNA-bi

186 Specific recognition of methylated DNA constrains the st

187 r probe designs result in very efficient and specific recognition of model dsDNA targets in buffers o

188 ficant contribution of the 343 side chain to specific recognition of multivalent microbial ligands, i

189 olecularly imprinted polymers (MIPs) for the specific recognition of NMP22 target molecules.

190 substitutions that dramatically enhanced the specific recognition of NY-ESO-1(+)/HLA-A*02(+) tumor ce

191 urally related metallopeptidases require the specific recognition of O-linked glycan modifications vi

192 This SPR assay allows specific recognition of oligomeric intermediates that ra

193 A pair of antibodies was used to achieve the specific recognition of OP-AChE that was prepared with p

194 providing a generally applicable method for specific recognition of PC.

195 To ensure specific recognition of PEGylated species, an immunoaffi

196 membrane binding, including electrostatics, specific recognition of phospholipid headgroups, sensiti

197 ure of an OCRE-SmN peptide complex reveals a specific recognition of poly-proline helical motifs in S

198 ew STUbL, which used three adjacent SIMs for specific recognition of poly-SUMO2/3 chains, and used Ub

199 ve avidity to achieve stable, but reversible specific recognition of polyvalent targets.

200 rom healthy donors or CLL patients conferred specific recognition of primary B-CLL and mantle cell ly

201 The specific recognition of protein surface elements is a fu

202 activates ectopic transcription not through specific recognition of PTA gene promoters but by releas

203 midazole and pyridinium chemotypes allow for specific recognition of RNA motifs.

204 h the role of the zinc finger domain in base-specific recognition of RNA.

205 sed conformation with base flipping and base-specific recognition of RSSs.

206 Lys-313 and Val-316 involved in the species-specific recognition of Rubisco are located near the tip

207 LC6 and LC15 exhibited strong binding to and specific recognition of S. japonicum eggs, but not eggs

208 s permitted us to delineate details of clade-specific recognition of SAMHD1 by lentiviral Vpx protein

209 The molecular basis for specific recognition of sigma(S) by Crl, rather than the

210 ly regulated infection process, in which the specific recognition of signal molecules is a key step t

211 Protein phosphorylation, driven by specific recognition of substrates by kinases and phosph

212 a sequence-dependent process which relies on specific recognition of TA base pairs in the minor groov

213 ssembled onto gold electrode surface for the specific recognition of target dsDNA (dsDNA-T), which in

214 cillus thuringiensis , often depend on lipid-specific recognition of target membranes.

215 nizes the structure of the seed sequence for specific recognition of target mRNAs.

216 trode and used as the capture probes for the specific recognition of target single-stranded DNA (ssDN

217 CAR T cells were developed that upon specific recognition of TEM8 secreted immunostimulatory

218 e strand of bacterial promoters for sequence-specific recognition of the -10 promoter element in sing

219 structure elucidates the basis for sequence specific recognition of the -24 element, orients sigma(5

220 To investigate whether specific recognition of the -35 element would affect the

221 with RNA by a bipartite mechanism involving specific recognition of the 5'-terminal triphosphate and

222 y of the Abl kinase domain by VX-680 and the specific recognition of the active conformation explain

223 techniques to create a sensor layer for the specific recognition of the bacterial surface markers li

224 atypical activation segment well adapted for specific recognition of the basic histone tail.

225 Specific recognition of the cargo that molecular motors

226 hat, when applied in this method, allows for specific recognition of the cells from complex mixtures

227 are expected to result in strong binding and specific recognition of the DNA minor groove.

228 Specific recognition of the DRE is determined locally by

229 Base-specific recognition of the flanking DNA by conserved am

230 different acetylation patterns may result in specific recognition of the H4 histone tails by protein

231 rine and phosphoinositides are well defined, specific recognition of the headgroup of the zwitterioni

232 Kinetochore assembly depends on specific recognition of the histone variant CENP-A in th

233 stronger CD8(+) T-cell responses through the specific recognition of the HIV-1 capsid by the immune s

234 3' end processing by modulating the sequence-specific recognition of the HIV-1 pre-mRNA by 9G8.

235 The specific recognition of the intermediate promoter in MOC

236 This work demonstrates that the specific recognition of the norovirus subgenomic promote

237 After specific recognition of the panhandle structure by N pro

238 as solved at a resolution of 1.15 A, reveals specific recognition of the peptide alpha-amino group vi

239 proposed models for the homologous ERAP1, no specific recognition of the peptide C terminus by ERAP2

240 the P450 enzymes with the NRPS, followed by specific recognition of the peptide cyclization state by

241 Consistent with their role in base-specific recognition of the promoter, R91, D81 and D84 a

242 agA directly associates with RUNX3 through a specific recognition of the PY motif of RUNX3 by a WW do

243 Furthermore, specific recognition of the pyrophosphate by a conserved

244 Specific recognition of the RNA element occurs via an ar

245 -binding domain is not required for sequence-specific recognition of the targeted mRNA transcript.

246 he beta' RNAP subunit is sufficient to allow specific recognition of the TG motif of the extended -10

247 Mia40 accelerates Cox19 folding through the specific recognition of the third Cys in the second heli

248 the protein import process is maintained by specific recognition of the transit peptide of preprotei

249 Previously, we showed that base-specific recognition of the tRNA(Pro) acceptor stem is c

250 hermore, point mutations in Zta that disrupt specific recognition of the UEE hairpin are defective fo

251 ene of tomato (Solanum lycopersicum) confers specific recognition of the unrelated bacterial effector

252 such a circular array of HTH motifs enables specific recognition of the viral genome for initiation

253 a virus (EBOV) infections, but their species-specific recognition of the viral glycoprotein (GP) has

254 specificity of Rev for the RRE and thus the specific recognition of the viral RNA.

255 This is proposed to involve sequence-specific recognition of the X at approximately 150-300 c

256 It is not clear how GluRS2 achieves specific recognition of tRNA(Gln) while rejecting the tw

257 Unfortunately, specific recognition of two of the four possible base pa

258 However, specific recognition of two of the four possible base pa

259 ovel mechanism for the simultaneous sequence-specific recognition of two UGUA elements within the pre

260 inity complexes with ARE substrates based on specific recognition of U-rich sequences by both the ATP

261 the molecular basis underlying the sequence-specific recognition of UACAU and the role of residues i

262 H2A-Lys15 highlighting the diversity in site-specific recognition of ubiquitylated nucleosomes.

263 CR alpha/beta assembly process, which allows specific recognition of unassembled clonotypic chains by

264 RNAs from exonuclease digestion via sequence-specific recognition of UUU-3'OH.

265 ree receptor-based pathways activated by the specific recognition of various virus-associated pattern

266 Thus, specific recognition of viral DNA by the packaging appar

267 and a small subunit that is responsible for specific recognition of viral DNA.

268 with strong pathogen preference by virtue of specific recognition of viral proteins.

269 Thus, specific recognition of VWF depends on cooperative, modu

270 Specific recognitions of GNRA tetraloops by small helica

271 reveal that pol II has an asymmetric (strand-specific) recognition of phosphodiester linkage.

272 sets of HDs with overrepresented residues at specific recognition positions, implying the selection o

273 Hereby these oligonucleotides can act as specific recognition probes.

274 nent supramolecular hybrid system built from specific recognition processes involving a Dawson-type p

275 ption (FACT), a heterodimer of the structure-specific recognition protein 1 (SSRP1) and the human hom

276 show, using mammalian cells, that structure-specific recognition protein 1 (SSRP1) is a novel regula

277 Among these proteins, structure-specific recognition protein 1 (SSRP1), a subunit of the

278 HP1c interacts with the SSRP1 (structure-specific recognition protein 1) subunit and the intact F

279 fish mutants for the gene encoding Structure specific recognition protein 1a (Ssrp1a), which, togethe

280 has indicated that absence of a single site-specific recognition protein can result in loss of editi

281 ind that high local stability at the variant-specific recognition residues rationalizes its known sel

282 al dsDNA loop translocation rightward of the specific recognition sequence 5'-CTnGAyG-3' as written (

283 es (ZFNs) induce DNA double-strand breaks at specific recognition sequences and can promote efficient

284 ns unclear how the interaction of gamma with specific recognition sequences coordinates directional D

285 binding of proteins and/or noncoding RNAs to specific recognition sequences or secondary structures w

286 the entire length of coding regions only at specific recognition sequences.

287 Identification of a specific recognition site on PrP(C) that traps Abeta in

288 l analysis to show that FANCJ possesses a G4-specific recognition site.

289 Introduction of two specific recognition sites into the primary sequence of

290 together determine the overall structure and specific recognition sites of small molecules or protein

291 tic oligonucleotides containing zero to five specific recognition sites, called metboxes.

292 ersion of genomic DNA flanked by recombinase-specific recognition sites, coupled with gene targeting

293 is required for transitioning into the site-specific recognition state.

294 c characterization identified three distinct specific recognition surfaces of VibBArCP for three cata

295 can be extended to other forms of cell type-specific recognition to mediate targeting.

296 ein A and antibody binding) for tailored and specific recognition to take place.

297 tion within 100min and exhibited significant specific recognition toward the ascorbic acid (AA) with

298 Based on direct sequence-specific recognition, TRIM5alpha delivered its cognate c

299 matrix (ECM) promotes both cell adhesion and specific recognition, which is essential for central dev

300 Given their often structured nature, specific recognition with an antibody fragment becomes f