ライフサイエンスコーパス: specification

1 code specification, ciliogenesis, germ layer specification).

2 gulatory modules (CRMs) during mesendodermal specification.

3 g and transcriptional regulation in RGC type specification.

4 ls (ESCs) to a state capacitated for lineage specification.

5 r system for design constraints or parameter specification.

6 ord116 may play a role in islet cell lineage specification.

7 proneural cluster orchestrates sensory organ specification.

8 gression of pioneer cells instructs neuronal specification.

9 trol gene expression programs during lineage specification.

10 echanism regulating definitive hematopoietic specification.

11 tial for proper neuronal and glial cell type specification.

12 ster hematopoietic regulators during lineage specification.

13 oietic system causes skewed lymphoid lineage specification.

14 AR, supporting a facultative model for CARN specification.

15 xpectedly appears to be dispensable for lung specification.

16 s development linking lineage allocation and specification.

17 rgo tri-lineage differentiation and germline specification.

18 netic regulation of definitive hematopoietic specification.

19 through the earliest moments of lung lineage specification.

20 trates that Jarid2 functions after endocrine specification.

21 termine the pattern of endoderm and mesoderm specification.

22 tor survival as well as acinar and endocrine specification.

23 he formation of micro emulsions to a desired specification.

24 tors that regulate arterial endothelial cell specification.

25 inking a regulator of progenitor growth with specification.

26 ent cellular state and another for cell type specification.

27 inated growth inhibition and arterial-venous specification.

28 ing the earliest stages of mammalian lineage specification.

29 mmetry-breaking step of left-right asymmetry specification.

30 to identify molecules involved in DC subset specification.

31 Neural patterning involves regionalised cell specification.

32 uses hyperproliferation and loss of arterial specification.

33 ell proliferation and enhanced cardiomyocyte specification.

34 or of two crucial pathways necessary for HSC specification.

35 nd, in fact, essential during early ectoderm specification.

36 X2-1, a transcription factor controlling MGE specification.

37 ory hair cell differentiation, and cell fate specification.

38 All sealers complied with ISO specifications.

39 us do not provide traceable partition volume specifications.

40 ion phase that leads to alternative neuronal specifications.

41 assemblies in close agreement with geometric specifications.

42 eparins that met USP heparin activity and Mw specifications.

43 developmental stages of alternative lineage specifications.

44 ression in the DA, but is dispensable for HE specification after hemangioblasts have been formed.

45 existence of some key differences in lineage specification among mammals.

46 as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular

47 Accordingly, CHD2 deficiency impaired cIN specification and altered later electrophysiological fun

48 tanding the mechanisms of prostate stem cell specification and cancer initiation.

49 ed genes with enriched expression during MGE specification and cIN differentiation, including known a

50 We find that TE specification and commitment coincide and occur at the t

51 s molecular function(s) in early B cell fate specification and commitment is unknown.

52 anscription factors directing B cell lineage specification and commitment.

53 indicating the impairment of B cell lineage specification and commitment.

54 thylation in the regulation of ocular tissue-specification and described hypermethylation of retinal

55 ng and BMP2/4 signaling are required for the specification and determination of different embryonic r

56 emporal mechanisms governing their cell-fate specification and differential integration into cortical

57 Arterial specification and differentiation are influenced by a nu

58 nt expression images for close to 100 neural specification and differentiation genes, our atlas ident

59 While the specification and differentiation of these neurons have

60 essential regulator for early lung endoderm specification and differentiation.

61 deletion in mice does not impair initial CP specification and early cardiac differentiation but indu

62 , we use expression of FoxD3 to pinpoint the specification and emigration of trunk neural crest cells

63 nscription factor GATA4 controls murine LSEC specification and function.

64 major question in plant biology concerns the specification and functional differentiation of cell typ

65 wever, the protracted timing of human neuron specification and functional maturation remains a key ch

66 n signaling domains, ensuring correct domain specification and gynoecium development.

67 e dorsal aorta concurrent with arteriovenous specification and intersegmental vessel (ISV) sprouting,

68 nucleosome to enforce epigenetic centromere specification and kinetochore assembly.

69 ating cell survival, lineage allocation, and specification and linking these processes by regulating

70 homeostasis, play important roles in lineage specification and maintaining cellular identity.

71 atic gonadal cells are required for male GSC specification and maintenance in planarians.

72 as well as for an FGFR-like molecule, in the specification and maintenance of this cell type.

73 m of bHLH51 and bHLH122, controlling tapetal specification and maturation.

74 that are crucial for oligodendrocyte lineage specification and nerve myelination.

75 o control injury-induced cell proliferation, specification and patterning, but comparatively little i

76 he Hippo pathway controls liver cell lineage specification and proliferation separately from Notch si

77 owth factor receptor (EGFR) in cholangiocyte specification and proliferation, and in hepatocyte trans

78 reby indicating that Pax6 initiates both eye specification and proliferation.

79 e findings reveal the intricacies of lineage specification and provide new insight into the context-d

80 ene-regulatory networks underlying human MGE specification and suggested mechanisms by which NKX2-1 a

81 ds to failure of anterior cardiac progenitor specification and the development of heartless embryos.

82 ion factor ERG is key to endothelial lineage specification and vascular homeostasis.

83 ined as finding a design that fulfills given specifications and has a high probability of still doing

84 Additionally, the WGS performance specifications and modular template are adaptable for th

85 The network specifications and solver definitions are provided in Su

86 erility, altered Megaspore Mother Cell (MMC) specification, and delayed programmed cell death in mega

87 hancers in controlling patterning, cell fate specification, and morphogenesis during development.

88 tion factor targets with likely roles in MGE specification, and other target classes regulating cIN m

89 ealing the importance of TFAP2A in NC and CP specification, and performing a small-molecule screen th

90 regulation of human definitive hematopoietic specification, and provides a mechanistic basis for WNT-

91 ion by modulating ligase activity, substrate specification, and subcellular localization.

92 lating neural cell proliferation and lineage specification, and suggest mechanistic explanations for

93 (RPC)-to-RGC and human stem cell-to-RGC fate specification, and take a significant step toward unders

94 Establishment, specification, and validation of synaptic connections ar

95 ches, tabulate state-of-the-art examples and specifications, and discuss data life cycle consideratio

96 ry that hosts digital design files, assembly specifications, and open-source software to enable users

97 Employing a novel developmental specification approach, this review places recent neurod

98 romatin features needed for meiotic hot spot specification are largely unknown.

99 regulatory genes that orchestrate cell-type specification, are continuing challenges for development

100 are critical to ensure precision in lineage specification as multipotent progenitors become restrict

101 nous cell division to G1 arrest and neuronal specification at the morphogenetic furrow.

102 role of FGF/ERK signalling in PrE versus EPI specification between mouse and other mammals.

103 ythroid progenitors demonstrate an erythroid-specification bias, evident from increased erythroid col

104 icipate in a combinatorial code for RGC type specification, but their exact molecular roles are still

105 esults highlight the complexity of cell fate specification by cell-cell interactions in a rapidly div

106 We show that organ boundary specification by correct spatial expression of CUC genes

107 ed26 together ensure the fidelity of lineage specification by enhancing the expression of neural gene

108 We show that A2BP1 regulates sensory organ specification by potentiating Notch signaling.

109 ys that underlie WBC development and lineage specification can contribute to inter-individual as well

110 t a transcription factor involved in lineage specification can induce LTTM and that failure to rerepr

111 roscopy to study processes such as cell-fate specification, cell death, and transdifferentiation thro

112 g, neural crest development, sensory placode specification, ciliogenesis, germ layer specification).

113 y among growth, oriented divisions, and cell specification could contribute to the characteristic pat

114 lti-lineage competence and responsiveness to specification cues.

115 A gene regulatory network (GRN) controls the specification, delamination, migration, and differentiat

116 is initially normal and increasing endoderm specification does not rescue mesendodermal cell migrati

117 Recapitulation of endogenous specification during development is a promising approach

118 nce of elevated c-Myc and enhances endocrine specification during ductal reprogramming.

119 gene expression is central for cell-lineage specification during embryonic development and is achiev

120 the p53 family is essential for mesendoderm specification during exit from pluripotency in embryos a

121 her are required to achieve precise neuronal specification during mouse development.

122 g, was as efficient as Mesp1 at promoting CP specification, EMT, and cardiovascular differentiation.

123 ProPublica's outcome measure specifications exclude 82% of cases, miss 84% of postope

124 ill doing so if the system parameters or the specifications fluctuate randomly.

125 lso introduce new distortions via misleading specifications for bias parameters.

126 The methodology has been designed to meet specifications for GMP production, required for manufact

127 p, described separately, was to identify the specifications for such an app.

128 ity for use beyond the Aptima package insert specifications for temperature and duration of storage (

129 ed: (i) the establishment of the performance specifications for WGS applications in PHLs according to

130 is for WNT-mediated definitive hematopoietic specification from hPSCs.

131 Using specifications from the CJR model and the clinically nar

132 comprehensively updated model of the T-cell specification gene regulatory network presented herein.

133 onal systems approach can identify cell type specification genes (master regulators) that act synergi

134 lso ensures a battery of ventral neural tube specification genes such as Olig1, Olig2 and Prdm12 are

135 works underlie the long-term changes in cell specification, growth of synaptic connections, and adapt

136 anscriptional hierarchy controlling arterial specification has not been fully delineated.

137 cription factors regulating pancreas lineage specification have been identified, and Notch signalling

138 6D), synapse formation (NTNG1), and neuronal specification (HOXB cluster family and MYT1).

139 taining lineages (denoted herein as the "PGC-specification hypothesis").

140 s can rescue Notch activity and duct lineage specification in adjacent cells lacking jag1b and jag2b

141 pathway in the regulation of female germline specification in Arabidopsis.

142 molecular signaling inputs during germ layer specification in bilaterian metazoans, but there has bee

143 ral and spatial control of tissue growth and specification in developing gut.

144 tal for the initial stages of PrE versus EPI specification in mammals.

145 s that culminate in neutrophil or macrophage specification in mice.

146 nterior pituitary development and lactotrope specification in mice.

147 acts as a molecular switch for monocyte fate specification in response to micro-environmental factors

148 a basis for understanding neuronal cell type specification in RGCs.

149 he causes of the shift to germ plasm for PGC specification in some animal clades remain largely unkno

150 though Nkx2.2 regulates enteroendocrine cell specification in the duodenum at all stages examined, it

151 c role for BMP signaling during endomesoderm specification in the early branching metazoan Nematostel

152 xin response as a regulator of ground tissue specification in the embryonic root, and reveals that gr

153 of the zebrafish heart tube soon after their specification in the nkx2.5(+) field of anterior lateral

154 Understanding lineage allocation and specification in the pancreas will shed light in the ori

155 activation is crucial for Treg cell lineage specification in the thymus and that its perturbation is

156 and solely responsible for all duct lineage specification in these organs in zebrafish.

157 ent is a promising approach to directing HSC specification in vitro, but current protocols are not ca

158 s claimed to regulate their distinct lineage specification in vivo or in vitro have varied in previou

159 he developmental pathways required for their specification in vivo.

160 opes with capabilities beyond their hardware specifications in terms of sensitivity and resolution.

161 ired for the initial events in otic neuronal specification including expression of NEUROG1, although

162 common reasons for failure were SUV outside specifications, incomplete submission, and uniformity is

163 mmitment and their subsequent maturation and specification into alphabeta TCR versus gammadelta TCR T

164 A derepression mode of cell-fate specification involving the transcriptional repressors T

165 Subtype specification is controlled by a stochastic decision in

166 e fundamental mechanisms controlling cardiac specification is critical for our understanding of how h

167 Neuronal specification is driven by transcriptional programs that

168 The transition from proliferation to specification is fundamental to the development of appro

169 ls directly in contact with the vein or that specification is induced in cell files beyond the vein.

170 pmental stage of the block in haematopoietic specification is not known.

171 f cell behaviour and morphogenesis on neural specification is not understood.

172 emethylation in neuronal lineage and subtype specification is not well understood.

173 Germ layer specification is tightly coupled with zygotic gene activ

174 testine, but the mechanism for their lineage specification is unclear.

175 ain hydrocarbons which have multi-structural specifications is introduced to clarify how kinetics and

176 tamyltranspeptidase), whereas the hepatocyte specification marker HNF4alpha was suppressed.

177 factors, but precedes appearance of lineage specification markers.

178 crucial for the regulation of megakaryocyte specification, maturation, and thrombopoiesis.

179 nalization of key functions; the faded whorl specification mechanism was fundamental under the divers

180 The 'specification model' postulates that Toddler signaling e

181 Neuronal birth and specification must be coordinated across the developing

182 Key aspects of T-cell specification network architecture have been illuminated

183 Products meeting all defined specifications occurred in 93% of enrolled patients.

184 In our model, specification occurs during somite stages due to varying

185 ; however, the syntactic level includes some specification of "missing" elements that are not realize

186 ecifying movement direction; it requires the specification of a sensorimotor control policy that sets

187 t control sprouting angiogenesis and lineage specification of blood vessels.

188 strates that Wt1 is required for the lineage specification of both Sertoli and granulosa cells by rep

189 Specification of cardiomyocytes is associated with reorg

190 Host defense requires the specification of CD4(+) helper T (Th) cells into distinc

191 ecular determinants that controlled the fate specification of CD8(+) T lymphocytes.

192 the CENP-A histone variant contribute to the specification of centromere identity.

193 morphogenesis, by regulating arterial-venous specification of DA ECs to ensure proper separation of t

194 b morphology, yet it remains unclear how the specification of digit-innervating motor neuron subtypes

195 opmental program is sufficient to induce the specification of digit-innervating motor neurons, emphas

196 ranscription factors (TFs) can influence the specification of distinct CD8(+) T cell fates, but the o

197 ation of Fgf signaling in these cells allows specification of endoderm progenitors, while the cells f

198 Knockdown of adtrp1 expression inhibits the specification of hemangioblasts, as shown by decreased e

199 f pu.1, mpo, and l-plastin; and disrupts the specification of hematopoietic stem cells (definitive he

200 to the DC lineage occurred in parallel with specification of hematopoietic stem cells (HSCs) to the

201 re are marked mechanistic differences in the specification of human and mouse PGCs.

202 The origin and specification of human dendritic cells (DCs) have not be

203 c knockdown of DYRK1A interferes with neural specification of human pluripotent stem cells, a process

204 Specification of inner ear progenitors is initiated by F

205 During the anterior-posterior fate specification of insects, anterior fates arise in a none

206 and ERK pathways reversed the skewed lineage specification of Klf5 KO blastocysts.

207 this neuroepithelium and the time-dependent specification of layer V SST(+) CINs.

208 The specification of left-right asymmetry of the visceral or

209 chemosensory cell fate determination and the specification of lingual mechanoreceptors.

210 -A is a histone H3 variant key to epigenetic specification of mammalian centromeres.

211 exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic let

212 pression of Hox genes that contribute to the specification of motor neuron (MN) subtype identity.

213 hematopoietic stem cells, guides the lineage specification of MPPS.

214 interaction ensures the differential lineage specification of MS and its sister blastomere, whereas t

215 these data establish a link between temporal specification of neuronal identity and circuit assembly

216 The genetic programs that guide specification of neuronal types during neurogenesis prec

217 mary neurogenesis, implicating n1-src in the specification of neurons early in neural development.

218 patterns and coding properties for flexible specification of opposing behavioral learning states.

219 nsable in endothelial cells but required for specification of osteoprogenitor cells that differentiat

220 enerated and whether they are coupled to the specification of other identity aspects of a terminally

221 However, currently it is unclear how specification of phloem cells is controlled.

222 Specification of PM 2.5 transmission characteristics is

223 Endogenous callus formation precedes specification of postembryonic root founder cells, from

224 th factor 4 (FGF4) is the key signal driving specification of primitive endoderm (PrE) versus pluripo

225 of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive h

226 rt comprises of three main components: (i) a specification of R classes that encapsulate study data,

227 We show that specification of reproductive organs is associated with

228 ta allows differentiation between targets in specification of reproductive versus perianth organs in

229 douts of opposing small RNA gradients enable specification of robust, uniformly positioned developmen

230 ll) modeling framework, permitting graphical specification of rules and merger of networks generated

231 It is required for specification of the blood program during development, a

232 The SUPERMAN gene is required for proper specification of the boundary between stamens in whorl 3

233 tic neurogenesis, but its requirement in the specification of the CVG neurons has not been establishe

234 limit bias if blinding is not possible, and specification of the delay between randomization and ini

235 ts into the mechanisms that control regional specification of the developing human intestine and prov

236 NA methylation landscape is established upon specification of the embryo proper and subsequently disr

237 and Notch attenuation are necessary for the specification of the endocrine lineage.

238 ur study uncovers genes required for lineage specification of the intrahepatopancreatic duct cells, c

239 al precursors at gastrulation and the proper specification of the neural ectoderm during neural induc

240 n the presomitic mesoderm and by controlling specification of the paraxial mesoderm fate in the tail

241 materials, but rarely with successful prior specification of the resulting structure.

242 Specification of the three germ layers by graded Nodal s

243 Specification of tissue identity during development requ

244 f TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defi

245 Here, we show clearly demarcated tissue specifications of Rorc-dependent ILCs across lymphoid an

246 First, the specifications of this 3D printing method that are impor

247 nts with defects in dopaminergic head neuron specification or differentiation, we isolated a new alle

248 eins may play distinct roles in cell lineage specification or maintenance, and establish the basis fo

249 lying ocular CCDDs alter either motor neuron specification or motor nerve development, and highlight

250 ch phenotypic variations are shaped by early specification or regional cellular environment.

251 luding gastrulation, anterior-posterior axis specification, organ and tissue development, and homeost

252 luding a stage-related initiation of lineage specification, our results demonstrate the existence of

253 th decreased expression of markers along the specification pathway, specifically the early mesodermal

254 genetic networks underlying vascular tissue specification, patterning, and differentiation.

255 During the specification phase (days 8-20), RUNX1(+) FGRS-transduce

256 mesoderm partially rescues the defective CM specification phenotype in embryos lacking both Forkhead

257 expressing blastocysts showed skewed lineage specification phenotypes, similar to FGF4-treated preimp

258 High specification, polymer capsules, to produce inertial fus

259 tic genomic sequence and the primary spatial specification processes operating development.

260 We identified two neural lateral specification processes where Dl signals in an ubi-indep

261 nships among cell types in diverse cell-fate specification processes.

262 l to mounting an effective endocrine lineage-specification program within the multipotent cell popula

263 preventing precocious activation of the PrE specification programme.

264 YAP stabilisation and endocrine cell specification rely on Galphai subunits, revealing an une

265 nderlie their transcriptional and functional specification remain elusive.

266 anisms that direct atrial versus ventricular specification remain largely unknown.

267 ecular mechanisms responsible for flower sex specification remain unclear for most plant species.

268 sential role in gene regulation and cellular specification required for multicellular organism develo

269 r for hematopoietic self-renewal and lineage specification-requires HDAC activity for gene activation

270 gulate distinct lung- versus thyroid-lineage specification, respectively, from foregut endoderm.

271 CDX4 expression exclusively during mesoderm specification resulted in a >90% repression in primitive

272 rated tables which describe the types, model specifications, sensing mechanisms, target biomarkers, a

273 been used for euechinoid echinoid micromere specification since at least the Late Triassic.

274 e identify a rare case of developmental cell specification that is highly dependent on miRNA control

275 ect effects were robust to alternative model specifications that excluded participants with diabetes

276 controlling the timing and pace of cell fate specification, the embryo temporally modulates plasticit

277 ite the key principle of ABCE model in whorl specification, the underlying mechanism of fine-tuning d

278 We find that Rspo1 is required for HSC specification through control of parallel signaling path

279 ted protein (YAP) is essential for endocrine specification, thus linking a regulator of progenitor gr

280 ision fundamentally contributes to cell fate specification, tissue development and homeostasis, and c

281 We propose a model in which specification to the DC lineage is driven by parallel an

282 uman CD34(+) progenitor cells, we found that specification to the DC lineage occurred in parallel wit

283 efore, the superiority of the aforementioned specification to the other previously published methods

284 with a more plastic process of neuronal fate specification, to produce brain circuits that mediate ph

285 Specification towards otic fate requires diverse signals

286 FGF signaling, although required for thyroid specification, unexpectedly appears to be dispensable fo

287 SOX2's requirement during inner ear neuronal specification using a conditional deletion paradigm in t

288 Our study provides a detailed specification, validation, and quantification of 15 co-o

289 Notch1 activation, known to promote arterial specification, was decreased in mutant DA endothelial ce

290 lity models with a difference-in-differences specification were used for estimation.

291 Batch release quality control specifications were established to meet investigational

292 iption factor CDX2 is required for proper TE specification, where it promotes expression of TE genes,

293 (ey) and twin of eyeless (toy), initiate eye specification, whereas eyegone (eyg) and the Notch (N) p

294 quired during data analysis to achieve these specifications, which corrects delta(34)S measurements f

295 rving as a checkpoint to coordinate identity specification with restriction of cellular plasticity.

296 We hypothesized that coordination of HSC specification with vessel patterning might involve modul

297 development, evidence for regulated ribosome specification within individual cells has remained elusi

298 by epiblast (EPI) or primitive endoderm (PE) specification within the ICM.

299 parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1.

300 uripotent embryonic cells, prior to germline specification, yet the frequency and predominant develop