ライフサイエンスコーパス: specificity

1 acupoints along specific meridians (meridian specificity).

2 ial macules with 91.7% sensitivity and 86.8% specificity.

3 he abdomen and pelvis while maintaining high specificity.

4 and traditional recombinase with single-cell specificity.

5 related hapten-BSA adducts confirmed antigen specificity.

6 ce/tongue connections, indicating anatomical specificity.

7 th 90% (79% CV) sensitivity and 83% (76% CV) specificity.

8 erically modulate PCSK9's substrate sequence specificity.

9 element that accounts for guanine nucleotide specificity.

10 sed to attain overall pooled sensitivity and specificity.

11 ransporters accompanied changes in substrate specificity.

12 sequence-level determinants of MMP-substrate specificity.

13 ely active UNC-9::GFP protein, demonstrating specificity.

14 arated from HCs with 77% sensitivity and 78% specificity.

15 with >90% sensitivity and approximately 100% specificity.

16 l progenitor cells to oncogenesis and tissue specificity.

17 capacity, spectral clarity and fragmentation specificity.

18 2) sensitivity and 0.92 (95% CI: 0.81, 0.96) specificity.

19 genetic variation on both on- and off-target specificity.

20 on was 5.35 with 88.6% sensitivity and 86.2% specificity.

21 tomolar sensitivity and single-base mismatch specificity.

22 proach characterized by high sensitivity and specificity.

23 and interaction contribute to PIN functional specificity.

24 ct on these enhancers to determine cell-type specificity.

25 d the best trade-off between sensitivity and specificity.

26 antibodies is predicted by DSA strength and specificity.

27 ions in human RR additively affect substrate specificity.

28 A was lower than tGADA at similar diagnostic specificities.

29 , indicating a predominance of "private" TCR specificities.

30 ssumed that genetic homology conveys similar specificities.

31 ut compromising their binding affinities and specificities.

32 omes have overlapping but distinct substrate specificities.

33 a high detection limitation (0.03 ng/mL) and specificity (0-0.002%) for detection of GPC3.

34 To test for neuroanatomical specificity, 16 specific tracts were additionally consid

35 and 9 of 14 patients with grade 0 toxicity (specificity 64%).

36 ensitivity (12 papers; sensitivity, 92%) and specificity (7 papers; specificity, 82%); identification

37 100%) but, because of viral persistence, low specificity (76%).

38 umonia (sensitivity 77%) from RSV pneumonia (specificity 82%).

39 of small diameter stents (</=3 mm; n = 95), specificity(82% vs. 62%), positive predictive value(66%

40 sensitivity, 92%) and specificity (7 papers; specificity, 82%); identification of site of unknown pri

41 significantly higher than those for females (specificity, 94.3% versus 77.3%, chi(2) = 44.90, P < 0.0

42 3%) and 85% (65%-95%), respectively, whereas specificity (95% CI) was 81%(62%-92%) for both nurses.

43 % sensitivity (95% CI, 94.3-94.9%) and 96.1% specificity (95% CI, 96.0-96.3%) for correctly identifyi

44 with two additional false-positive results (specificity 99.9%; 99.7-100).

45 plastic polyps with 96.3% sensitivity, 78.1% specificity, a PPV of 89.6%, and a NPV of 91.5%.

46 ible, small-molecule inhibitors with greater specificity against hRRM1 is a key step in the developme

47 ction of DNA aptamers with high affinity and specificity against S.

48 ic cancer-specific promoters and, to enhance specificity, an RNA-based AND gate that generates combin

49 ine deaminases that exhibit unique substrate specificities and thermosensitivities.

50 3 TAS2R16 residues that contribute to ligand specificity and 38 residues whose mutation eliminated si

51 0702) and SR14 (DSM100701) demonstrated 100% specificity and 90% sensitivity to human sewage without

52 The 98.5% diagnostic specificity and 92% sensitivity of CSF RT-QuIC in a blin

53 nded retrospective analysis matched the 100% specificity and 95% sensitivity of a blind prospective s

54 eir cognate chain types reveal mechanisms of specificity and a K11 cross-reactivity in the K33 affime

55 our method has achieved average sensitivity, specificity and accuracy of 99.09%, 99.82% and 99.70%, r

56 ntial signature sequence for their substrate specificity and activity.

57 molecules has had a major effect on analytic specificity and allergy diagnosis.

58 Improved sensitivity, specificity and area under curve (AUC) were observed whe

59 y this newly developed CLIA test showed high specificity and correlated with the "gold standard" GPC3

60 CREs show tissue- and cell-type specificity and disease-associated variants are often en

61 TeSLA improves the specificity and efficiency of TL measurements that is fa

62 er optimization of Cas9-based genome-editing specificity and efficiency.

63 Rgamma mice were used to assess for pathogen-specificity and evidence of nonspecific alloreactivity.

64 lecular basis for pocket protein-E2F binding specificity and how cyclin-dependent kinases differentia

65 s were revealed among the three sites, while specificity and NPV of MALDI-TOF MS for males were signi

66 chytrids, their life cycles, phylogeny, host specificity and range.

67 ); this subtype could be predicted with high specificity and sensitivity based on the Nugent score (>

68 [(89)Zr]Zr-DFO-daratumumab/PET demonstrated specificity and sensitivity for detecting CD38(+) myelom

69 howed predominantly renal clearance and high specificity and sensitivity for detecting low levels of

70 Specificity and sensitivity for prediction of poor outco

71 tion in several animals and imperfect marker specificity and sensitivity.

72 eras to gain a deeper understanding of toxin specificity and stability.

73 II cadherins may uniquely contribute to the specificity and strength of synaptic changes associated

74 structurally close analogs explain the FD44 specificity and the mechanism of inhibition, in which th

75 cted at synaptic level, which determines the specificity and the precision in structural synaptic pla

76 ive (33%-45% sensitivity), specific (90%-95% specificity), and early (3-4 years in advance on average

77 erior coronary imaging, excellent macrophage specificity, and better power to discriminate high-risk

78 inent design factor affecting tracer uptake, specificity, and clearance.

79 e relationship, animal experiments, analogy, specificity, and consistency.

80 damage with relatively high sensitivity and specificity, and detects extramedullary sites of prolife

81 an an hour while preserving method accuracy, specificity, and dynamic range.

82 ution leading to improved or novel substrate specificities are not wholly defined.

83 d 2 (mTORC2), whose activities and substrate specificities are regulated by complex co-factors.

84 Mechanisms of the altered 15-LO substrate specificity are enigmatic.

85 but the mechanisms underlying the tumor type specificity are unknown.

86 lts support in silico CDR design of antibody specificity as an emerging antibody engineering strategy

87 assays, we evaluated the magnitudes, epitope specificities, avidities, and functions of systemic and

88 tivation showed a unique pattern of thrombus specificity, because unlike r-tPA, it did not degrade fi

89 There was significant discordance in epitope specificity between BM and maternal sera ranging from on

90 chnology delivers high assay sensitivity and specificity, but the sample preparation procedure involv

91 reaction was investigated with quantum state specificity by high-resolution photoelectron spectroscop

92 tionalization is the acquisition of neuronal specificity by immune formyl peptide receptors (Fprs).

93 Such approaches promise to improve drug specificity by reducing off-target effects.

94 earity, limit of detection, sensitivity, and specificity by using either live viruses (dengue, mumps,

95 Taken together, our work reveals the specificity by which the handling by NCLX of calcium exc

96 depths necessary to achieve sensitivity and specificity comparable to current laboratory assays.

97 The trade-off between sensitivity and specificity compared with SPPIDER suggests that the choi

98 ement fixation (62 cases) was 66.1%, but the specificity could not be determined.

99 CD8(+) T cell specificity depends on the recognition of MHC class I-ep

100 roportion of children with pneumonia) and/or specificity (eg, detection of pathogens in upper respira

101 e method presented very high selectivity and specificity, excellent linearity (R(2)>0.988) low decisi

102 n signal by the cleavage and polyadenylation specificity factor (CPSF) complex.

103 a component of cleavage and polyadenylation specificity factor (CPSF).

104 uman CRM1 Lys568 side chain, which acts as a specificity filter that prevents binding of non-NES pept

105 trated that PhyAsr and PhyAmm have different specificities for Ins(1,2,4,5,6)P5, have identified stru

106 n be used to investigate protease activities/specificities for peptides containing post-translational

107 a trypsin-like serine protease with a narrow specificity for arginine in the P1 position, which catal

108 The CIPs had high affinity and specificity for bacterial detection and provided a switc

109 r "lysibody") with high-affinity binding and specificity for carbohydrate determinants on the bacteri

110 sponse, they lack sufficient sensitivity and specificity for clinical use.

111 Sensitivity and specificity for CNV detection with en face OCTA combined

112 well on different platforms, exhibited high specificity for crab over other types of crustaceans, an

113 d by ROC curve analysis, the sensitivity and specificity for diagnosing malignant lesions were 86% (C

114 of 6.4microgL(-1) and excellent recognition specificity for DNZ over its analogs.

115 The remarkable specificity for dye uptake suggests that pericytes have

116 general splicing machinery and thus have low specificity for individual genes.

117 ation, donor exosomes with respective tissue specificity for islet beta cells and renal epithelial ce

118 inflammatory cells in granulomas, but lacks specificity for particular cell types.

119 tosis based on histopathology findings (100% specificity for PDFF).

120 three models had the highest sensitivity and specificity for predicting 6-y lung cancer incidence in

121 inting approaches that differ in time scale, specificity for protein residue side chains vs backbone

122 ion in the Ulp2 C terminus that mediates its specificity for rDNA-associated proteins and show that t

123 which may additionally have evolved enhanced specificity for selenate over sulfate.

124 been identified, the respective enzymes with specificity for serine were missing.

125 raphy signs assessed (pooled sensitivity and specificity for the double contour sign: 74% [95% CI, 52

126 y activity of a TAG-synthesizing enzyme with specificity for this acyl group and more desaturation of

127 he molecular basis for enhanced affinity and specificity for USP7.

128 ivity from 75.8% to 93.5%, but decreased the specificity from 95.8% to 89.3% (P < 0.05).

129 ne loss can drive the evolution of substrate specificity from retained enzymes.

130 diography arm, with sensitivities >79.8% and specificities >62.3%.

131 ies of the human Y chromosome - namely, male specificity, haploidy and escape from crossing over - ma

132 y large range of macrocycles or to molecular specificity, i.e., the autocatalytic emergence of a sing

133 Results Specificity improved with the addition of DBT for all re

134 nd induce a broader repertoire of new T-cell specificities in cancer patients, tipping the intra-tumo

135 osis (TB) and have various sensitivities and specificities in different populations.

136 ss performance, risk model sensitivities and specificities in the PLCO were compared to those based o

137 It shows high sensitivity and specificity in 19 plant and animal genome assemblies, of

138 le) predicts overall survival and has better specificity in comparison to conventional imaging.

139 achieve detection with high sensitivity and specificity in complex media.

140 vers of the evolution of divergent substrate specificity in enzymes with identical active sites and g

141 peptides are host determinants of symbiotic specificity in M. truncatula and possibly in closely rel

142 alysis, SOJO provided better sensitivity and specificity in predicting the number of alleles associat

143 B. brongniartii showed a greater specificity in substrate utilization.

144 n PBMNCs had high diagnostic sensitivity and specificity in the context of schizophrenia.

145 8% and 47.4% sensitivity and 94.4% and 82.4% specificity in the Danish and Scottish cohorts, respecti

146 itutes a key signature providing PIC binding specificity in the human genome.

147 They instead suggest task specificity in the learning of oculomotor plans in respo

148 tor-1 (KLF1) leads to degenerate DNA-binding specificity in vivo, resulting in ectopic transcription

149 for RNA editing, we elucidated endonuclease specificity in vivo.

150 binding site, whereas the lack of interface specificity indicates that interaction with a particular

151 ]8 showed rapid brain uptake and high target specificity, indicating that [(18)F]8 is a promising PDE

152 pment, promoting enrichment of self-reactive specificities into the follicular mature compartment and

153 engineered Cas9-VQR variant with 5'-NGA PAM specificities is used to induce base conversion in zebra

154 Specificity is a core principle of exercise training to

155 zyme active sites to alter their function or specificity is a difficult yet appealing challenge.

156 This tracer, if its specificity is confirmed, has the potential to become a

157 For a subset of ESS3 variants, we show that specificity is determined by association rate constants

158 tion factor dimerization impacts DNA-binding specificity is poorly understood.

159 r functions; however, the extended substrate specificity is still unknown for many of these kinases.

160 of candidate genes with high sensitivity and specificity, making it a useful complement to any NGS pi

161 Here, we used a multiplexed assay for kinase specificity (MAKS) to identify the substrates directly a

162 re we report that the inducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a known

163 There were no differences in any specificity measures.

164 w biomarkers that have either enhanced liver specificity (microRNA-122 [miR-122]) or provide mechanis

165 the predictive power of quantitative binding specificity models across 27 transcription factor famili

166 ime course of adaptation and when 'phenotype specificity' occurs has important implications for exerc

167 t, and the metallo-beta-lactamase Etest, had specificities of >90% for detecting carbapenemase-produc

168 aphy showed sensitivities of 37% to 100% and specificities of 68% to 97%, depending on the ultrasonog

169 Sensitivities of 68 to 69% and 76 to 77% and specificities of 97% and 98 to 99% resulted when the two

170 llowing one to rapidly analyze the substrate specificities of chitosan hydrolases that can be used to

171 el, we have largely defined the carbohydrate specificities of each PTS transporter.

172 Here, we investigate the ligand specificities of the human and murine forms of the myelo

173 We probed the peptide acceptor specificities of the OSTs in vivo using a transgenic gly

174 The Ag specificities of these activated T cells were determined

175 Characterizing the binding specificities of transcription factors (TFs) is crucial

176 sponses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) a

177 sieve analysis', one can identify functional specificities of vaccine-induced immune responses.

178 stic performance with a sensitivity of 0.94, specificity of 0.71 and a diagnostic odds-ratio of 36.8.

179 ts as "frail" with a sensitivity of 0.50 and specificity of 0.82, whereas the RAI-A was less sensitiv

180 rs was 0.973 with a sensitivity of 0.999 and specificity of 0.959.

181 general, HRCM had a sensitivity of 75% and a specificity of 100% in identifying recurrent or persiste

182 /=16 mg/mL showed a sensitivity of 87% and a specificity of 36%.

183 riteria yielded a sensitivity of 71.4% and a specificity of 62.2%.

184 ositive factors generated a mean sensitivity/specificity of 70.4%/89.2% and a probability of developi

185 eart failure had a sensitivity of 50-60% and specificity of 79-81% for detecting top quartile hospita

186 V infections with a sensitivity of 87.5% and specificity of 81.3%.

187 ify the legions with a sensitivity of 96%, a specificity of 84%, and an AUC of 0.97.

188 RRMS with a sensitivity of 90.9% and with a specificity of 87.1% against AQP4-ab NMOSD, 95.2% agains

189 an overall sensitivity of 91.3% (21 of 23), specificity of 90.9% (10 of 11), accuracy of 91.2% (31 o

190 ivity of 94.7% (95% CI, 73.5 to 99.9), and a specificity of 94.8% (95% CI, 88.9 to 97.8).

191 This yielded sensitivity/specificity of 95%/100% for the detection of MR overall,

192 nsitivity of 98.2% (400 of 407 patients) and specificity of 97.1% (1530 of 1575 patients).

193 We assumed a NAAT cost of US$25, NAAT specificity of 99.6%, NAAT sensitivity of 100% for infan

194 termined the affinity, immunoreactivity, and specificity of [(89)Zr]Zr-DFO-daratumumab.

195 Calcium plays a key role in determining the specificity of a vast array of signalling pathways in pl

196 mine the effect of variants on the targeting specificity of approximately 3,000 gRNAs across 30 thera

197 ee regulatory mechanisms contributing to the specificity of ATXR5/6.

198 is inadequate due to the low sensitivity and specificity of blood smears.

199 The sensitivity and specificity of CNV detection compared to the gold standa

200 A potentially increased specificity of CT was found in detecting cases of small

201 se disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear.

202 Cellular specificity of dmd-3 action is ensured by its collaborat

203 -type transcription factors, whereas the sex specificity of dmd-3 action is ensured by the hermaphrod

204 and binding orientation.Mapping the sequence specificity of DNA ligands remains a challenge, particul

205 CESA proteins and hence what determines the specificity of each CESA class.

206 , our data demonstrate that TMM dictates the specificity of ERfs for the perception of different EPFs

207 uorescence, we evaluated the sensitivity and specificity of EV labeling assays in a manner that has n

208 erating curve (AUROC) value, sensitivity and specificity of GPC3 for HB pretreatment group versus all

209 The specificity of interim PET/CT based on RIW criteria (61.

210 ty within premotor circuits, but whether the specificity of learning depends on structured changes to

211 D structure, we were able to shift substrate specificity of MCD toward succinyl-CoA through active-si

212 ynapses is thought to be detrimental for the specificity of memory storage.

213 Sensitivity and specificity of MR imaging were 96% and 78% respectively,

214 The specificity of nucleic acid amplification tests (NAATs)

215 is study was to evaluate the sensitivity and specificity of parameters derived from a Scheimpflug ima

216 Characterizing the substrate specificity of protease enzymes is critical for illumina

217 n may exist, which likely contributes to the specificity of signal-response coupling.

218 Specificity of small ions, the Hofmeister ranking, is lo

219 al method that increases the sensitivity and specificity of SNV and indel detection at very low varia

220 The specificity of structural OCT alone was 97.5% for grader

221 However, mechanisms contributing to the specificity of such interactions remain poorly understoo

222 ricted inclusion of non-CP-CRE to assess the specificity of the assays.

223 The current understanding of the specificity of the bacterial class I release factors (RF

224 The sensitivity and specificity of the biosensor was characterized using two

225 ven the exceptional mutagenic efficiency and specificity of the Cas9 strains we engineered, they can

226 e the subcellular localization and substrate specificity of the catalytic subunit of protein phosphat

227 latory (Tfr) cells control the magnitude and specificity of the germinal centre reaction, but how reg

228 the three-dimensional structure and receptor specificity of the H15 hemagglutinin, revealing distinct

229 ological mechanisms that underlie the tissue specificity of the m.3243A > G mutation, and importantly

230 clinical features of disease to increase the specificity of the new criteria for underlying PSP patho

231 ularly of sites corresponding to the binding specificity of the overexpressed SH2 domain.

232 We further refined the specificity of the proteins identified by combining bioc

233 ones, so to characterize the selectivity and specificity of the system.

234 nd contain the commensal microbiota, yet the specificity of these antibodies remains elusive.

235 opathies and attempt to reconcile the tissue specificity of these disorders with the ubiquitous requi

236 However, the specificity of these effects is unknown.

237 Understanding the substrate specificity of these enzymes could create opportunities

238 We demonstrate the specificity of these membrane interactions and the devel

239 rotein (RNP) complex that is critical to the specificity of these small molecules for SMN2 over other

240 Next, we tested the evolutionary specificity of this interaction in a background in which

241 revealed the molecular basis for the strict specificity of this lectin.

242 ering the mechanisms that affect the binding specificity of transcription factors (TFs) is critical f

243 The AUC and sensitivity at 95% specificity of vessel densities within the ONH (0.76 and

244 for measuring the average rate and substrate specificity of XNA polymerases in a standard qPCR instru

245 l concentrations is a prerequisite for metal specificity of Zur, ZntR, RcnR and FrmR in Salmonella Ty

246 the effect of MED12 mutations has cell-type specificity on IEG expression.

247 catula NFS2 gene that regulates this type of specificity pertaining to S. meliloti strain Rm41.

248 hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the ac

249 of the deep, well-accessible hydrophobic S1' specificity pocket of the metalloprotease thermolysin wi

250 , despite their mutually exclusive substrate specificities, PON1 and diisopropyl fluorophosphatase (D

251 Compared with nested PCR, the sensitivity, specificity, positive predictive value (PPV), and negati

252 Sensitivity, specificity, positive predictive value, and negative pre

253 Sensitivity, specificity, positive predictive value, and negative pre

254 d toxin-positive samples with a sensitivity, specificity, positive predictive value, and negative pre

255 Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in

256 ged from 67% (rio zona) to 100% (soft) while specificity ranged from 71% (rio) to 100% (rioysh, hard)

257 e engineering, but our understanding of Cas9 specificity remains incomplete.

258 We reveal that phosphite and hypophosphite specificity results from a combination of steric selecti

259 Studies on the substrate specificity revealed that the alpha1,6-fucosidase mutant

260 expressing their toxins are driven by their specificity, safety and the move away from chemical cont

261 CPKs are composed of a dual specificity (Ser/Thr and Tyr) kinase domain tethered to

262 Encapsidation specificity suggests that aptamers may encounter dimeriz

263 ion of different EPFs, thus functioning as a specificity switch for the regulation of the activities

264 Specificity tests reveal that BR scrambles fluorescent a

265 magglutinin, revealing distinct features and specificities that can aid in global surveillance of suc

266 e has been less systematic study of antibody specificities that must rely mainly or exclusively on ot

267 emonstrate labeling of fixed cells with high specificity that correlates well with fluorescent labels

268 The improvement in specificity that DRELFA exhibits is an advantage over th

269 c phenotypes of graded severity and/or stage specificity that together delineate a phenotypic roadmap

270 We show that human CENP-N confers binding specificity through interactions with the L1 loop of CEN

271 ine the minimal requirements for TCR antigen specificity, through an analysis of TCR sequences using

272 of CCNA in the reference method improved CT specificity to 78.0% (95% CI, 70.7% to 84.2%).

273 ir rapid response time (seconds to minutes), specificity to a target, and selectivity to function in

274 aptamer sequence has shown high affinity and specificity to both beta-LG A and B with dissociation co

275 f RNAs within the neurons, showing a spatial specificity to either the soma or the axon.

276 asticity as a mechanism providing functional specificity to human ribosomes.

277 ith that of human graders and had sufficient specificity to make them cost-effective alternatives to

278 nfers the substrate binding adaptability and specificity to OGA in O-GlcNAc regulation.O-linked beta-

279 r these findings suggest that there is niche-specificity to the placental microbiota and placental mi

280 absence of these features results in a broad specificity toward Ins(1,2,4,5,6)P5 These features are m

281 EC3A, but pinpoints the residues that confer specificity towards CC/TC motifs.

282 ood sensitivity (up to 88%) and fair to good specificity (up to 96%) for diagnosing gout (moderate SO

283 Assay specificity was 100%.

284 The cohort's average sensitivity and specificity was 68% (95% confidence interval [CI]: 59%,

285 ersus 195 of 601 (23% vs 32%, P < .001); and specificity was 86% (95% CI: 84, 88) versus 75% (95% CI:

286 ortality was 20.0% (95% CI, 8.9%-39.1%), and specificity was 92.3% (90.7%-93.7%).

287 dation of probe targets and "G" and "H" site specificity was carried out using a series of competitio

288 Disease association and disease specificity was determined using 5090 exomes from the Sw

289 s 100%, for (111)In-octreotide it was 78.2%; specificity was not available).

290 This specificity was not due to sterol dependence of bacteria

291 However, a decrease in specificity was observed across most tests, likely due t

292 rat insulinoma INS-1E cells, and the binding specificity was validated by a CRISPR/Cas9 mediated ZnT8

293 on polymorphism-driven expression levels and specificities, we predicted and tested inhibitory and cy

294 Single-modality sensitivities and specificities were 66.7% and 88.4% for color Doppler US,

295 CR, TESA-blot, and micromethod sensitivities/specificities were 68.6%/99.1%, 58.3%/99.1%, and 16.7%/1

296 ing-characteristic analysis, sensitivity and specificity were 95.2% and 77.8% on standard and delayed

297 of epsilon4, and to 72% sensitivity and 77% specificity when individuals did not carry epsilon4 alle

298 164) was identified with 70% sensitivity and specificity, which after the incorporation of apolipopro

299 In tests of marker specificity with an independent behavioral sample (n = 2

300 ution, and we compare its in vitro substrate specificity with those of fungal Icp55 enzymes.