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2 area under the curve (AUC), sensitivity, and specificity for 87 metrics, and logistic regression mode
4 -UBI(dend)) demonstrates bacterial labelling specificity for a broad panel of pathogenic bacteria and
5 , we calculated the baseline sensitivity and specificity for a combined endpoint of high-grade squamo
6 clease that has a high cleavage activity and specificity for a conserved sequence within the ribosoma
7 he role of enzyme conformational dynamics in specificity for a high-fidelity DNA polymerase responsib
8 eting of BCL6 represents a new approach with specificity for a master GC regulator that would extend
9 ying <=8 fibronectin domains with engineered specificity for a model antigen, epithelial cell adhesio
10 is work, we studied the binding affinity and specificity for a series of TALE proteins under a variet
11 separates into four distinct groups based on specificity for a serine versus threonine phospho-accept
13 e show that an artificial aldolase with high specificity for acetone as the aldol donor can be reengi
16 obtained evidence that nsp8 has a pronounced specificity for adenylate and is unable to incorporate g
17 display several unusual properties, such as specificity for aggregated forms of the peptide, the abi
18 For the eight nonexpert radiologists, mean specificity for AI TI-RADS (55%) was also higher (P < .0
19 nition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 i
23 algorithms had moderate sensitivity and poor specificity for all infections compared with gold standa
26 ursor spans, and can balance sensitivity and specificity for an overall greater prediction accuracy,
27 N-terminal domain of KSHV ORF57, and showed specificity for an RNA fragment containing a GAAGRG moti
29 reating one with the desired sensitivity and specificity for any given ligand is an unsolved problem.
30 or the various ubiquitin chains to find less specificity for any particular linkage type compared to
31 ermore, its structure reveals that HMCES has specificity for AP sites in ssDNA at junctions found whe
33 In contrast, HAs from avian viruses exhibit specificity for "avian-type" alpha2-3-linked (NeuAcalpha
34 ntry tachycardia (AVRT) lack sensitivity and specificity for AVRT circuits located away from the site
35 specificity 97.4%), high sensitivity but low specificity for bacterial vaginosis (sensitivity 95.2%,
36 within the constituent molecules and how the specificity for being in different phases is established
37 leckstrin homology (PH) domains that exhibit specificity for binding phosphatidylinositol-4,5-bisphos
38 efining property of these catalysts is their specificity for binding the transition state with a much
39 small molecules while providing high binding specificity for biomolecular partners typically observed
45 ty (30 seconds) at ambient temperature, high specificity for BPs amidst other alcohol-containing anal
46 ate that the small molecule GAT1508 has high specificity for brain GIRK1/2 channel subunits, directly
47 H algorithms had a good sensitivity and high specificity for C trachomatis (sensitivity 71.7%, specif
49 efore diagnosis for all cases and 50% at 99% specificity for cases diagnosed with early-stage disease
51 pectively, and have overlapping but distinct specificities for Cdk9-dependent phosphorylations of Spt
54 D) is part of the CCNC by virtue of its high specificity for CENP-A nucleosomes and ability to stabil
55 e central domain of CENP-C achieves its high specificity for CENP-A nucleosomes and how CENP-C and CE
57 ime after onset of symptoms; sensitivity and specificity for chest CTs without time stratification.
60 odels provided about 78% sensitivity and 86% specificity for classifying resilient participants, and
61 ticipants, and about 70% sensitivity and 89% specificity for classifying vulnerable participants.
62 rotease legumain exhibits a strict substrate specificity for cleavage after asparagine and aspartic a
64 ficial urine with sufficient sensitivity and specificity for clinical use, while being compatible wit
65 al S6 kinase II (RSK2), which have different specificities for cMyBP-C's multiple phosphorylation sit
66 feature of modern RuBisCOs, enabling greater specificity for CO(2) This paper identifies a key struct
68 he subcortical or visual network, suggesting specificity for cognitive networks that decline earliest
69 oenzyme A's to alkanes with strict substrate specificity for compounds containing more than 29 carbon
70 e recommendations achieved a sensitivity and specificity for correct treatment assignment of 99.6% an
71 erved and expected results and sensitivities/specificities for correctly identifying an isolate as su
75 Ts had adequate performance, sensitivity and specificity for CRC for 1 qualitative FIT were 0.90 and
76 n FITs have moderate to high sensitivity and specificity for CRC, depending on the positivity thresho
79 Structures of two distinct intact IgE with specificity for cross-reactive carbohydrate determinants
81 otion that the CysRS variant provides higher specificity for Cys as a mechanism for plants to grow in
82 hypothesize that YbaK binds to ProRS to gain specificity for Cys-tRNAPro and avoid deacylation of Cys
83 lls but were less frequent than T cells with specificity for cytomegalovirus, Epstein-Barr virus, or
84 /Fpd1) is a secreted enzyme with exceptional specificity for d-glucosamine at its -1 subsite, thus pr
86 lusters in a left or downward direction, the specificity for detecting "likely nonprogression" was 94
90 w aptasensor with high-sensitivity, and high-specificity for detection of diazinon, was discovered, b
93 BD MAX MDR-TB assay had high sensitivity and specificity for detection of MTB and RIF and INH drug re
94 BD MAX MDR-TB assay had high sensitivity and specificity for detection of MTB, and RIF and INH drug r
97 raphy demonstrated excellent sensitivity and specificity for detection of thoracic central vein steno
98 00 pg/ul would provide ideal sensitivity and specificity for determination of malarial etiology among
100 ite residues responsible for controlling the specificity for different 2-oxo substrates and the deter
101 such as ZED1, interact with ZAR1 and provide specificity for different effector proteins, such as Hop
102 gn was leveraged to generate biosensors with specificity for different heterotrimeric G-proteins or f
104 monstrated higher diagnostic sensitivity and specificity for differentiating biomarker positive versu
105 demonstrate the importance of catalytic site specificity for directing protein kinase signal transduc
106 and demonstrates the importance of phenotype-specificity for discovery of asthma genes and epistasis.
109 insically disordered N- and C-termini, loses specificity for DNA lesions and shows less pausing on da
110 tandem GRF-ZFs of NEIL3 provide affinity and specificity for DNA that is greater than each individual
111 ion down to a few picomoles of and excellent specificity for each dNTP against the other dNTPs, rNTPs
112 n this review, we report the sensitivity and specificity for each stage of syphilis (primary, seconda
115 ions against plant and human GBPs with known specificities for either alpha2-3- or alpha2-6-linked si
116 sociated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tum
117 lecular mechanism of HM-type recognition and specificity for EndoBT-3987 and an important group of th
118 s showed more than 90% accuracy and near 93% specificity for EPA as an independent diagnostic tool.
119 echanistic insights into the determinants of specificity for ERAP1, ERAP2, and IRAP and offer a new t
121 al examination signs, pooled sensitivity and specificity for fever was 46.0% and 77.0% respectively,
123 enabled confirmation of altered DNA-binding specificity for FOXL2(C134W) and identification of uniqu
127 ogene Strep A assay had high sensitivity and specificity for GAS detection and provides a faster alte
128 s NAD(+) synthetase (hsNadE) lacks substrate specificity for glutamine over ammonia and displays a mo
130 CAPD) scores >=9 had 94% sensitivity and 33% specificity for grade >=3 neurotoxicity, and 91% sensiti
133 how that common core interactions define the specificity for hAPN and that the peripheral RBD sequenc
134 owever, identifying the repertoire of T cell specificities for HCMV is hampered by the immense protei
136 recognition of H3K9me to an increase in the specificity for hemimethylated versus unmethylated DNA.
137 ,083 ug/L was at 92.5% sensitivity and 91.9% specificity for hemophagocytic lymphohistiocytosis (area
139 y, we have established the WW domain binding specificity for Hippo pathway components and uncovered a
142 n their intracellular localization modulated specificity for host versus viral RNA, which resulted in
147 targeted EMB because of its sensitivity and specificity for identification of myocardial pathologica
148 his represented a 100% sensitivity and 99.6% specificity for identification of PPS maculopathy by mas
152 output criteria for acute kidney injury lack specificity for identifying patients at risk of adverse
153 ATS CAP guidelines have poor sensitivity and specificity for identifying patients with positive tests
154 rapy (PT) exists, but current tests have low specificity for identifying who, among those infected, i
156 s, whereas the other APOBEC3 members display specificity for immune processes and immune cell populat
157 dicate that individual variability and ELISA specificity for inactive aggregates are key factors to c
158 anced prothrombin activation, indicating its specificity for inhibition of myosin-dependent procoagul
160 n isoforms, which have remarkable homophilic specificity for interactions between cellular surfaces.
162 machine learning approach was 74%, while the specificity for LASSO was 41% and for the machine learni
163 identifying related P450s with complementary specificities for lignin-relevant guaiacols, this study
164 tuted stilbenes, LsdA exhibited the greatest specificity for lignostilbene (k (cat) (app) = 1.00 +/-
165 AeOBP22 binding to fatty acids, and that the specificity for longer chain fatty acids is regulated by
166 although MSI/IHC had significantly superior specificity for LS (81.3% v 20.1%; P < .001; 92.3% v 24.
170 both KIBRA and PKMs that define the isoform specificity for maintaining synaptic strength in distinc
173 biting a distinct transcriptome and indirect specificity for matched MHC class II and mismatched clas
176 ngs, we propose a model in which recombinase specificities for meiotic accessory proteins enhance sep
177 er, and costs) and per-organ sensitivity and specificity for metastases and per-patient agreement for
178 dary outcomes were difference in per-patient specificity for metastatic disease detection between sta
179 omodomain has demonstrated weak affinity and specificity for methylated histones in vitro, leaving do
182 ern where the antiserum showed near complete specificity for MUC4 TR glycopeptides and peptides, rela
186 r S. pneumoniae and 81% sensitivity and 100% specificity for N. gonorrhoeae from isolates with a repr
190 odes, the overall PPV, NPV, sensitivity, and specificity for nonproliferative diabetic retinopathy (N
192 alled FLAgs, enables tailored engineering of specificity for one, two or multiple members of the Friz
193 aracteristics curve (AUCs), sensitivity, and specificity for ordinal and dichotomized data in a regio
194 idates with increased affinity and modulated specificity for other closely-related small GTPases.
195 n CD4(+) Th17 cells that harbor heterologous specificity for other fungi, which may explain evolution
196 nimally important difference of 2, with good specificity for outcomes of asthma improvement and worse
199 5 (0.53-0.94)/0.77 (0.65-0.90); that is, the specificity for PET/MRI was 1.00 as compared with 0.75 f
201 Site-specific recognition selectivity and specificity for phosphorylated serine was demonstrated w
202 isolated a mutant form (mSH2) with enhanced specificity for phosphorylated Tyr(992) (pTyr(992)) of E
203 a clinical candidate due to its potency and specificity for PI3K and mTOR kinases, and its pharmacok
204 n limit of 0.34 nM and excellent recognition specificity for PNG over its analogs were also observed.
205 deubiquitinase (DUB) enzymes, with different specificities for polyubiquitinated linkages, were fused
209 ime of ICU discharge had low sensitivity and specificity for predicting adverse events, ICU readmissi
210 lume of 25 cm(3) had 72% sensitivity and 81% specificity for predicting inducible VT (area under the
211 f of 14.5 to have 100% sensitivity and 91.9% specificity for predicting poor prognosis in women young
212 sis (DISH) criteria had high sensitivity and specificity for predicting the development of DISH.
213 ty-based receptors leads to an unprecedented specificity for primary ammonium ions over secondary, te
215 th "specificity determinants", which provide specificity for prokaryotic cells over eukaryotic cells.
217 NAD(+) exhibits unexpected high activity and specificity for protein PARylation catalyzed by human po
218 icient to generate the biologically required specificity for protein targeting to the endoplasmic ret
220 ntal carcinogen urethane exhibits a profound specificity for pulmonary tumors driven by an oncogenic
221 The Aries assay had high sensitivity and specificity for qualitative detection of group A Strepto
223 e based on miBF shows higher sensitivity and specificity for read-binning than sequence alignment-bas
225 characteristic curve (AUC), sensitivity, and specificity for referable GON and glaucomatous ONH featu
227 chemokine with distinct stage and cell-type specificities for regulating inflammation, but how these
230 protocol with reduced toxicity and enhanced specificity for robust hematopoietic stem cell (HSC) tra
231 ance within 10 min (91% sensitivity and 100% specificity for S. pneumoniae and 81% sensitivity and 10
232 sample collection (75% sensitivity and 100% specificity for S. pneumoniae) for clinical metagenomic
234 neered SpCas9-gRNA variants with altered PAM specificities for short, PAM-containing DNA probes.
235 al1 and glycerol ester hydrolase (Geh), with specificities for short- and long-chain fatty acids, res
237 r protease biologists interested in protease specificity for specific assays and inhibitors and to fa
238 , the SUMO E3 ligase that provides substrate specificity for SUMO2-PCNA conjugation in response to TR
240 Here, we defined the mechanism of species specificity for T. gondii sexual development and break t
241 to conventional antibiotics because of their specificity for target pathogens and their potential to
243 rotein specificity (dashed line) and epitope specificity; for ten HlyE-specific clones (pixilated squ
244 is a C-type lectin characterized by a unique specificity for terminal GalNAc residues present in the
246 sitivity in convalescent-phase sera and high specificity for the Abbott, Euroimmun, and Ortho-Clinica
247 f the colorimetric reaction exhibits certain specificity for the acid type, distinguishing acid mixtu
248 an IOU, F1 score, accuracy, sensitivity, and specificity for the AI to identify Go zones were 0.53 (+
249 osed approach achieved 0.86/0.93 sensitivity/specificity for the binary classification task of HC ver
250 (IELs) with innate cytolytic properties and specificity for the butyrophilin-like (BTNL) molecules B
251 Vicia villosa agglutinin biosensor that has specificity for the cancer-associated Tn antigen, to com
254 s of 10 or greater alone (0.86 [0.80-0.90]); specificity for the combination was significantly but mi
256 ly available imaging techniques have limited specificity for the detection of active myocardial infla
257 evice was found to have high sensitivity and specificity for the detection of any grade of DR with go
259 engineered immunosensor displayed excellent specificity for the detection of CEA even in the real hu
260 b anatomic detail and offers high diagnostic specificity for the detection of duodenal pathologies be
262 technology has unparalleled sensitivity and specificity for the detection of prions, making it an id
263 ens correlated with 91% sensitivity and 100% specificity for the diagnosis of S. aureus infection by
265 dy not only elucidates the WW domain binding specificity for the Hippo pathway, but also reveals STXB
267 lls, expressing the CD4 ectodomain to confer specificity for the HIV envelope, to mitigate HIV-induce
268 and pI + 2 respectively provided exceptional specificity for the ionic wash, the hydrophobic wash, an
269 PA patients versus controls, sensitivity and specificity for the LDBio Aspergillus ICT were 91.6% and
270 de arrays to define the phosphorylation site specificity for the majority of STE20 kinases and catego
271 romatic cage supports its role in conferring specificity for the methylated adenines, whereas an exte
274 (95% CI = 0.88-0.93); at 24 hours or later, specificity for the prediction of good outcome was <0.90
278 Our method also exhibits an exceptional specificity for the surfactant analytes even in the pres
279 The BsAb blinatumomab, for example, has specificity for the T cell-activating cell surface prote
280 a 97% success rate, 99% sensitivity, and 94% specificity for the tested samples, in a time span of fe
281 ivity or on establishing the sensitivity and specificity for the tests performed with new drugs.
282 substrates HPr and NPr, yet they show strict specificity for their cognate partner both in stereospec
283 ta reveal that ERAD branches have remarkable specificity for their membrane substrates, suggesting th
284 dings suggest that thioredoxins evolved high specificity for their sole electron donor TrxR while mai
285 ive NPs is a valuable strategy to enhance NP specificity for therapeutic and diagnostic applications.
289 enzyme, and the subsequent evolution of the specificity for thioalcohol precursors implies that body
291 correlation reveals that TDG attains context specificity for thymine excision through modulation of n
293 multidrug efflux, with overlapping substrate specificities for TolC and FtlC and a distinct substrate
298 titers with greater cross-clade reactivity, specificity for V1V2, and effector functions than in mac
299 novel variants of FeLV with altered receptor specificity for viral entry have emerged by mutation or
300 ificity 41.2%), and moderate sensitivity and specificity for vulvovaginal candidiasis (sensitivity 64