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1  aberrant Wnt signaling activation have been speculated.
2                             Finally, we will speculate about anaphylaxis from an evolutionary perspec
3 asthma (EIBwA ) occurring in athletes led to speculate about different endotypes inducing respiratory
4 timal level leads to low-value screening and speculate about pressures that encourage overly intensiv
5                                  Finally, we speculate about the future of this field.
6 nal data in light of these gating models and speculate about their mechanistic consequences on ion pe
7                                           We speculate an altered lung microbiome in HIV infection ma
8 e allele is fixed or near fixation, which we speculate are likely to be important for attenuation.
9 rams through modulation of the epigenome and speculate as to how this may influence context-specific
10 tify trends in model development and use and speculate as to the future use of models in infectious d
11 o use coherence-exploiting materials, and we speculate as to the prospects for a coherent energy conv
12 texts in which these giant flagellins occur, speculate as to their functions, and highlight the poten
13                   This observation led us to speculate as to whether our data may form the basis for
14                                  Finally, we speculate as to why retrieval circuits change with time,
15 plex has long remained elusive, but has been speculated as having infinite chains of iodine.
16 nd differences between kinase functions, and speculates as to why mammalian germ cells require expres
17 only be to ratchet upward: Newly observed or speculated attack capabilities can argue a countermeasur
18                                  The authors speculate based on these data that sedation with inhalat
19 ory role of lipid interactions could only be speculated from the snapshot provided by the crystal str
20                                  Finally, we speculate how further studies of sequence-specific sensi
21                                           We speculate how the activity we observe is consistent with
22 hinery and interferon-regulated GTPases, and speculate how these pathways engage each other to balanc
23 onents of the oocyte cytoplasmic lattice and speculate how this interaction could preserve ERV/host c
24 es extractable from bone matrix, it has been speculated how targeting of BMPs to the extracellular ma
25  not variable antigens as has been so widely speculated; however, they do clearly play important role
26 vement between parenchyma and SCS in what we speculate is a program of immune surveillance that helps
27 PL becomes inhomogeneous below 75K, which we speculate is caused by the formation and subsequent dyna
28 ith unique viscoelastic properties, which we speculate may play a key role in generating heterogeneou
29                                This gain, we speculate, might derive from the ability of the mutant p
30 d from the border of magnetism has long been speculated, no experimental confirmation has been made.
31                                      We also speculate on future directions in this field.
32 dies within the domain of emotions, and then speculate on how genomic and epigenetic mechanisms can m
33                                  Finally, we speculate on how technological advances will revolutioni
34 ozoal pathogen-microbiome interaction and to speculate on how that might be leveraged for treatment.
35 ntext of immunity to influenza infection and speculate on how the simultaneous evolutionary races of
36 -induced intestinal mucositis, and GVHD, and speculate on possibilities of therapeutically targeting
37 s could be regulated by neuronal signals and speculate on possible mechanisms for such regulation.
38                                  Finally, we speculate on preventive and therapeutic strategies that
39      We also discuss current limitations and speculate on the developments that are necessary to adva
40                                  Finally, we speculate on the functional significance of these divers
41                                           We speculate on the neural mechanisms that link sampling of
42 perspectives, highlight new discoveries, and speculate on the opportunity created by merging the rese
43                                      We also speculate on the possibility of a third level, reporting
44                                           We speculate on the possible role that FSA may play in the
45                                      We also speculate on the potential role of NETs in the pathogene
46                                           We speculate on the relationship between the two systems an
47   With reference to the capsid structure, we speculate on the roles of these residues in capsid stabi
48                                           We speculate on the various mechanisms by which this may be
49 erature that illustrate these principles and speculate on their implications for further study.
50 s distinguishable by regulatory proteins and speculate on their possible consequences.
51  of electrostatics to CH-pi interactions and speculate on what our observations imply about the absol
52                            Previous work has speculated on the phenomenological similarities between
53 is unexpected, O-linked ADP-ribosylation are speculated on.
54 es in stress-related depression behavior and speculates on how currently understood mechanisms contri
55 thetic chromosome construction in plants and speculates on how they might be applied to various uses
56 ociated with survivin-targeted therapies and speculating on the future strategies to surmount these i
57 ered role for AFPs may help explain the long-speculated role of AFPs in freeze-tolerant species.
58                                           We speculate such up-regulations may represent the early st
59 bsequently trigger chemotaxis have long been speculated, such a chemoreceptor has not been demonstrat
60 Sjogren syndrome, where it is interesting to speculate that a disruption in ER redox-signaling (due t
61                                           We speculate that a flexible loop linking strands beta4 and
62                                Thus, one may speculate that a GAL3 antagonist could have antidepressa
63                                           We speculate that a short circadian period was advantageous
64                                           We speculate that a similar cognitive architecture may unde
65 rA polymerization and gradient formation and speculate that a transient, dynamic network of intersect
66                                           We speculate that accumulation of alternatively activated m
67 s of circuit formation in the cerebellum and speculate that adaptive reprogramming of progenitors in
68                                           We speculate that adenosine modulation may provide a mechan
69                                  Overall, we speculate that ADH-41 directs Abeta into off-pathway str
70                                           We speculate that adhesion/excitability nodes are key sites
71                                           We speculate that Al8 may form in natural water systems thr
72                                           We speculate that animals that can survive extremes may be
73                                     Thus, we speculate that AP2 has evolved as a key regulatory node
74                                           We speculate that As adsorption to Fe in periphyton may pla
75 bats in the final stages of prey pursuit and speculate that beam broadening is a feature characterizi
76                                           We speculate that biased nucleosome and hexasome sliding du
77                            In particular, we speculate that body image may be an intervening variable
78                              Furthermore, we speculate that both the alteration in OT delivery and OT
79                                     Thus, we speculate that CDKL5 deficiency disrupts activity-depend
80 is of their chromatin occupancy profiles, we speculate that Cg limits Eya-So activation of select tar
81 muscle proliferation and differentiation, we speculate that changes in lncRNAs might contribute to th
82                                           We speculate that Chd1 senses the sequence-dependent respon
83                                           We speculate that chromosomal inter-chain interactions form
84                                           We speculate that cilia gene mutations contribute to both s
85 complex disorder is unclear, leading many to speculate that concurrent delirium, psychiatric disease,
86 a in W1282X cells from one human subject, we speculate that corrector and potentiator combinations ma
87 tion to sparse neuronal lesions leads one to speculate that corticobasal degeneration may begin as an
88                                           We speculate that cytotoxic dengue-specific CD4(+) T cells
89                                           We speculate that differences in microtubule orientation be
90                                           We speculate that different scales of diversity could provi
91                     Based on our results, we speculate that discernible wSuz variants may associate w
92 sential for prostate differentiation, and we speculate that disruption of such a network predisposes
93                                           We speculate that distension of the MPA may play a major ro
94                                           We speculate that DMDD inhibits cytokine production in the
95 by responding to only the entry side, and we speculate that dual entry/exit sensitivity is also impor
96 t dUTPases bind the same repressor led us to speculate that dUTPase activity may be important to the
97                                   We further speculate that each SC layer may connect two nonsister c
98                                           We speculate that elevated miR-874-3p expression during wea
99                                           We speculate that elevator-type antiporters such as NapA, a
100                                           We speculate that estrogen replacement might ameliorate dis
101                                           We speculate that estrogen replacement might partially rest
102            Based on these considerations, we speculate that eukaryotic sex likely developed as a cell
103                                           We speculate that expression of different molecular weight
104                                           We speculate that expression of different molecular weight
105                                           We speculate that female adolescents living in high-inequal
106 terol synthesis pathway, it is intriguing to speculate that gammaherpesviruses have evolved to usurp
107                                      We thus speculate that global change will have a larger effect o
108                                   Rather, we speculate that H4K20me3 plays a role in heterochromatini
109                                      We also speculate that homocysteine, cysteine, or a related liga
110                                     Thus, we speculate that if we induce the binding of platelets to
111                                           We speculate that in our patient the functional advantage o
112                                           We speculate that interbacterial antagonism mediated by LXG
113                                           We speculate that intermittent tethering of claudins to act
114                                           We speculate that invasions of the House Crow have been fac
115 cause dynamin is a GTPase, it is tempting to speculate that it has a motor activity that assists the
116 lity and lower individual variances, thus we speculate that it may indicate a better clinical efficac
117 ortant for the end resection step of HR, and speculate that its adjacent-localization relative to DSB
118       Based on these data, it is tempting to speculate that light-induced changes in the protein resu
119                                   We further speculate that local competition between acetylation and
120                                 We therefore speculate that local sterol-hemagglutinin interactions i
121                                           We speculate that locust mortality increased as a result of
122  DBP or the shorter half-life of 25(OH)D3 We speculate that low 25(OH)D in obesity is due to a greate
123                                   We further speculate that marked phase heterogeneity may be a hithe
124                                           We speculate that measures to reduce maternal smoking not o
125                                           We speculate that microbial derangements, as indicated in o
126                                           We speculate that micromolar H2O2 is created both biologica
127 udin-2 forms gated paracellular channels and speculate that modulation of tight junction channel gati
128                                           We speculate that N-terminal acetylation imposes conformati
129                                           We speculate that neovascular buds may be a precursor to ne
130 y shown to bind viral adhesion receptors, we speculate that NKp46/NCR1 may be a novel type of pattern
131                                           We speculate that non-clinical factors (e.g. genetics, epig
132                                           We speculate that nuclear import of the PIC may proceed con
133                                           We speculate that NUSAP1 contributes to accurate chromosome
134                                           We speculate that oil drops may provide a hydrophobic inter
135                                           We speculate that once the initial test is passed, the mism
136                                           We speculate that paracellular permeability may have evolve
137                                     Thus, we speculate that Pep2.5 may be able to prevent down-regula
138                                           We speculate that phase V may be the precursor to the non-m
139                                           We speculate that platelet integrins are mechanosensors tha
140                                           We speculate that polymerization reactions may be occurring
141                                           We speculate that pools of transfer RNA available for prote
142                                           We speculate that proteolytic fragmentation may represent a
143                                           We speculate that reduced expression of Fgf13 impairs excit
144 nucleus in the presence of tamoxifen, and we speculate that remodeler recruitment may be directly med
145                   These findings allow us to speculate that retrograde signaling might involve GUN1-d
146 ein folding is largely unexplored, one might speculate that reversed native protein sequences should
147 yotic d-ribulokinase remains unclear, but we speculate that S. cerevisiae Ydr109c and human FGGY coul
148 rs are key players in human reproduction, we speculate that schistosome estrogen-like molecules may c
149                        It is now tempting to speculate that similar 'many-but-one' lineage repressors
150                                           We speculate that similar control of dsRNA movement could m
151                                           We speculate that SMG-1 kinase activity could be activated
152                    In light of this, one can speculate that some of the GC-mediated side effects can
153  cells in vitro and DC migration in vivo, we speculate that SP-D may constitutively stimulate IFN-gam
154                                           We speculate that SQRD-1 activity in H2S may coordinate pro
155                                           We speculate that SUN1/SUN2 may function redundantly in ear
156                                           We speculate that surface-exposed PS directs the protease t
157                                            I speculate that sustained up-regulation and/or acute acti
158                                           We speculate that telomeric aggregates and ongoing breakage
159                                 We therefore speculate that temperature drives Aqy1 from a loosely- t
160                             Specifically, we speculate that the "epigenetic landscapes" that define i
161  tumor suppressor proteins in cancer, and we speculate that the additional loss of function of MOAP-1
162                                           We speculate that the allosteric regulation of FVIIa activi
163 lure in translation has led investigators to speculate that the animal models being used do not predi
164                                           We speculate that the association with non-specific DNA aff
165                                           We speculate that the consequent increase in distal arteria
166                                           We speculate that the D145E mutation destabilises the nativ
167                                           We speculate that the directionality of pI's intermolecular
168                                           We speculate that the distinctive structural difference in
169                                           We speculate that the early airway microbiome may prime the
170                                           We speculate that the energy transported by that undulation
171                                           We speculate that the frequency of p-ClPh is traced back to
172                                           We speculate that the genotype-specific differences may res
173                                           We speculate that the greater plasticity in silicon uptake
174                                           We speculate that the interferon-induced Mx proteins might
175                                   We further speculate that the intrinsic dynamics of thalamocortical
176                                           We speculate that the mechanism of the mutation underlying
177                                           We speculate that the minimal kinetochore configuration, wh
178                                           We speculate that the negative habenula responses we observ
179                                           We speculate that the newly identified CatSperzeta subunit
180                                           We speculate that the observed impact of salt bridges on th
181                                           We speculate that the observed maximum in the lac expressio
182                                           We speculate that the potential for severe group disruption
183                                           We speculate that the preferential spatial localization of
184                                           We speculate that the pressures that drive the acquisition
185                                           We speculate that the Rcf1/Hig1 proteins play a role in the
186                                           We speculate that the repeated evolution of testis specific
187                                           We speculate that the resulting farnesyl protrusion toward
188                                           We speculate that the right-sided predominance reflects asy
189                                           We speculate that the selective pressure imposed by competi
190                                           We speculate that the specialized nature of germline chroma
191                                           We speculate that the striking difference in compulsive-lik
192                                           We speculate that the strong tendency to high-angle grain b
193                                           We speculate that the structural change in subunit a upon r
194                                           We speculate that the superfamily active-site architecture
195                                           We speculate that the unusual sensitivity of skeletal muscl
196                                           We speculate that the weak motifs enable processivity throu
197 hly achieving young vocal artists, one might speculate that there is a relationship between the abili
198                                     Thus, we speculate that there might be two peaks of microglial ac
199                                           We speculate that these changes may be explained by an incr
200                                           We speculate that these declines indicate a priming effect,
201                                           We speculate that these foraminifera were transported inlan
202                                           We speculate that these functional classes map onto canonic
203                                           We speculate that these incumbent cells are conditioned or
204                                           We speculate that these mechanisms may play a maladaptive r
205                                           We speculate that these properties are optimized to meet th
206                                           We speculate that they serve as channels for the genome rel
207                                           We speculate that this "non-selective" form of mitophagy ma
208 trate that GPVI is a receptor for fibrin and speculate that this contributes to development of an occ
209                                           We speculate that this differential property reflects islan
210 r the first time in S. aureus, leading us to speculate that this dinucleotide may have a regulatory r
211                                           We speculate that this heterogeneity may reflect a relaxati
212 atively regulate EB1:MT interactions, and we speculate that this interaction may assist cells in diff
213                                           We speculate that this interplay between peptide structure
214                                           We speculate that this interruption is due to a predominanc
215 iously assigned to OsMAS/SDR110C-MS1, and we speculate that this latter SDR may have an alternative f
216                                      We also speculate that this mechanism helps segregate tubular an
217                                           We speculate that this might relate to the introduction of
218 pts normally repressed in Treg cells, and we speculate that this network-level bias may account for N
219                                Therefore, we speculate that this new family of Ras/Rap1-specific endo
220                                           We speculate that this plasticity could be maintained beyon
221                                           We speculate that this protein splicing activity arose to p
222 nger pediatric intensive care unit stays, we speculate that this SNP results in hyperinflammation in
223                                           We speculate that this stiffening reflects the development
224                                           We speculate that UV sensitivity conferred by these isoform
225                                           We speculate that, as in sensory processing, optimization o
226                                  Finally, we speculate that, if repurposed for the problem of neural
227                                           We speculate that, in the shark, the differential activatio
228                              Thus, it can be speculated that a failure of dopamine receptor and trans
229                              For ADEM, it is speculated that a preceding infection is the trigger of
230 se C1q is produced by monocytes, it has been speculated that allogeneic hematopoietic stem cell trans
231 activation) is typically observed in IRI, we speculated that aPC ameliorates IRI by inhibiting inflam
232                                           We speculated that binding of lymphoma BCRs to self-antigen
233                       On this background, we speculated that blockade of Na/K-ATPase-induced ROS ampl
234  is identical to miR-16-2; thus, it could be speculated that both clusters control a similar set of t
235                             Researchers have speculated that clonidine limits the amount of mental se
236                                           We speculated that CN(-) and the CO precursor (-):CO2H may
237 ch depends on transcription, and it has been speculated that cohesin movements along DNA could create
238 g the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates co
239                                        It is speculated that Fe3O4 nanoparticles accumulated in the c
240 nctional horizontal gene transfer (fHGT) and speculated that fHGT was likely formative in the evoluti
241                                        It is speculated that genetic variants are associated with dif
242 sk factor for the development of BM, thus we speculated that higher circulating estrogens in young, p
243                                           We speculated that hyperglycemia inhibits skin DC migration
244                                        It is speculated that immunoglobulin G (IgG) plays a regulator
245                                           We speculated that low-frequency oscillations observed in t
246                                  It has been speculated that LVAD support itself may cause angiodyspl
247 derlying this process remain unknown, it was speculated that mediators released from platelet granule
248                    Only very recently it was speculated that metal cations could also play an importa
249                                  It has been speculated that microtubules can serve as tracks to deli
250                   Plant biologists have long speculated that outcrossing mating systems are more comm
251                                  It has been speculated that PAI-1 may regulate cardiac fibrosis by i
252                         Although it has been speculated that proteasome dysfunction may contribute to
253                       Therefore, it has been speculated that pyruvate oxidation through PDH is decrea
254 plex OM is often a polymicrobial disease, we speculated that reduction of complex OM by PCVs would be
255 thors reporting this methodical breakthrough speculated that SCNT would allow the creation of patient
256                                           We speculated that serum pantetheinase might contribute to
257                                  It had been speculated that sIL-6R was generated at the site of infl
258                         Although it has been speculated that stem cell depletion plays a role in the
259                         From this, it can be speculated that tetrapyrroles attached to phycobiliprote
260                        Many researchers have speculated that the clinical progression from monoclonal
261                       While it has long been speculated that the cyclohexene moiety found in many sec
262                                 We therefore speculated that the dissociation requires a conformation
263 rns relative to full-term infants, and it is speculated that the hospital room environment may contri
264                              Thus, it can be speculated that the latter pathway might be beneficial t
265                                  It has been speculated that the mechanism by which thick filament le
266 lasticity in other hippocampal subfields, we speculated that the metabotropic glutamate receptor mGlu
267 -(1-->3)-alpha-d-GlcNAc-(1-->OPO3-->]n ), we speculated that the two predicted CPs (CslA and CslB) wo
268  reports in some scientific and public media speculated that the virus had evolved to more effectivel
269                                  It has been speculated that these early enzymes had low specificitie
270 nes during dedifferentiation of PHHs, and we speculated that these modulations could drive the hepati
271 rent gross structural chromosomal damage, we speculated that they may arise from chromothripsis, a re
272                       Furthermore, it may be speculated that this pair of side chains could promote o
273                                           We speculated that this plays important roles in the struct
274 r stage development of malaria parasites and speculated that TMP-SMX prophylaxis during repeated mala
275     On the basis of in vitro studies, it was speculated that transferrin can bind Ti(IV) assisted by
276                             It has long been speculated that Varroa via immunosuppression of the bees
277                                           We speculated that: (i) young children could respond random
278 t-term effect on HPV-associated disease; and speculates that even a single dose of these vaccines, wh
279                                  We can only speculate the reasons for many of these results at this
280                                  We can only speculate the reasons for many of these results at this
281                                           We speculate these are potential mechanisms by which nAChR
282 tal variability are ubiquitous in nature, we speculate this evolutionary mode to be of general releva
283 ve disorders to muscular dystrophy, which we speculate to be consistent with oligogenic mechanisms re
284                          Cellular lipids are speculated to act as key intermediates in Hedgehog signa
285 c disorders is unknown, although it has been speculated to be a combination of environmental, stress
286                                 Collagen was speculated to be an allergen in this study.
287 reviously studied by electron microscopy and speculated to be for cuticle formation.
288 on mechanism of these submesoscale eddies is speculated to be related to the horizontal velocity shea
289 on by the photoactive layer itself, has been speculated to contribute to the high open-circuit voltag
290                           This phenomenon is speculated to correlate with the rotational effects of p
291  tissues and organs over time, and have been speculated to have a role in ageing.
292    Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impac
293  in which an increased lipid signal has been speculated to indicate neoatherosclerosis, and NIRS find
294            The mechanism for this process is speculated to involve dynamics of solvent cluster format
295 scopal effect, but historically, it has been speculated to reflect the generation of a host immunothe
296                            Although they are speculated to regulate gene expression in developmental
297 nitiation of explosions, which has long been speculated to result from 'hot spot' generation at local
298                      Although infections are speculated to trigger the syndrome, a specific infectiou
299 tant case is molybdenum, which has long been speculated to undergo an exceptionally steep increase in
300                                 We therefore speculated whether increased expression of EBI2 would le

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