ライフサイエンスコーパス: sperm

1 utosome set to generate a functional haplo-X sperm.

2 g active glycolytic and OxPhos metabolism in sperm.

3 lla, similar to the CatSper complex in mouse sperm.

4 to support elongation of the extremely long sperm.

5 oRNA-449b (miR-449b) was highly expressed in sperm.

6 longer telomeres to their offspring in their sperm.

7 er envelope, an inner matrix, and a bolus of sperm.

8 severe damage to the testes, epididymis and sperm.

9 Seminal fluid does more than transport sperm.

10 er FRT facilitates clearance of poor-quality sperm.

11 esulted in sterility due to a lack of mature sperm.

12 tile sperm, no sperm (sterile), and immotile sperm.

13 in the miRNA expression profile in paternal sperm.

14 ncrease in tyrosine phosphorylation in mouse sperm.

15 filament accessory microtubules of mantidfly sperm.

16 elatively little is known with regard to the sperm.

17 ype, as these males release fewer but faster sperm.

18 tile sperm and backcross males with immotile sperm.

19 th the concentration of progressively motile sperm.

20 rils inhibited fertilization by immobilizing sperm.

21 ative number and fitness of X- vs. Y-bearing sperm.

22 ion that generates gametes, such as eggs and sperm.

23 e bonds on DNA condensation in the mammalian sperm.

24 te to the functional sperm to create diplo-X sperm.

25 sition within 30 seconds after fusion with a sperm [3], thereby preventing further fertilization even

26 mitochondria delivered to the zygote by the sperm [4-13].

27 cies, XO males exclusively produce X-bearing sperm [6, 7].

28 with 43.8% (64 of 146) successfully banking sperm (82.1% of attempters).

29 ds to calcium influx via CatSper and ensures sperm activation.

30 comparable to the standard computer-assisted sperm analysis (CASA) system.

31 Cross-species transfer of sperm and active seminal fluid proteins including HP-I m

32 short time window, while many animals store sperm and are long-lived.

33 pression between backcross males with motile sperm and backcross males with immotile sperm.

34 ordial germ cells (hPGCs), the precursors of sperm and eggs, originate during weeks 2-3 of early post

35 ential for generating chromosomally balanced sperm and eggs.

36 e germ lines, the cell lineages that produce sperm and eggs.

37 for coral larvae produced from cryopreserved sperm and established important ground-work principles f

38 ridization showed that CrANT is expressed in sperm and fertilized eggs.

39 combining surgical harvesting of testicular sperm and ICSI.

40 pared with those backcross males with motile sperm and immotile sperm, but no significant differentia

41 an of 24 myoepithelial cells that houses the sperm and is the site of fertilization.

42 Mammalian sperm and oocytes have different epigenetic landscapes a

43 nst ZIKV-associated damage to the testes and sperm and prevents viral persistence in the testes follo

44 m cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after va

45 cessful fertilisation (union between egg and sperm), and chronically rare species are more likely to

46 squitoes, but can persist in human semen and sperm, and sexual transmission has been documented.

47 changes critical for fertilization in mouse sperm, and they are only sensitive to pH i However, in h

48 Sperm aneuploidy in Faroese men with lifetime exposure t

49 ection and facilitating the rapid removal of sperm antigens.

50 In humans, as well as cattle, sperm are naturally deposited at the entrance to the cer

51 As spermatogenesis concludes, sperm are streamlined by discarding unnecessary cellular

52 re correlated with macrozoospermia and these sperm are tetraploid.

53 aboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite

54 Mammalian Sperm Associated Antigen 6 (SPAG6) is the orthologue of

55 Sperm associated antigen 6 (SPAG6), a component of the c

56 hat epigenetic instructions delivered by the sperm at fertilization are required for correct regulati

57 ffect target antigen selection in testis and sperm autoimmunity and the immune responses to CTA in ma

58 Purpose To estimate the prevalence of sperm banking among adolescent males newly diagnosed wit

59 were associated with increased likelihood of sperm banking completion.

60 ntrosomal to non-centrosomal sites at the RB-sperm boundary whereas actin reorganizes through cortica

61 ckcross males with motile sperm and immotile sperm, but no significant differential gene expression b

62 assess the safety of red light treatment of sperm by analyzing, (1) the levels of double-strand brea

63 lization facilitated uptake and clearance of sperm by macrophages, which are known to infiltrate the

64 The 2AG inhibits the sperm calcium channel (CatSper), and its removal leads t

65 rkably, some eggs fertilized by PLCzeta-null sperm can develop, albeit at greatly reduced efficiency,

66 tophagy regulation, the acrosome reaction in sperm, cancer cell migration, and intracellular traffick

67 nd fertilization success in half, thus fresh sperm, capable of becoming highly motile, is key; 2) the

68 The calcium channel of sperm (CatSper) is essential for sperm hyperactivated mo

69 ion of a zygote via the fusion of an egg and sperm cell and its subsequent asymmetric division herald

70 actor DUO1 to specify male germline fate and sperm cell differentiation.

71 us on histone butyrylation in the context of sperm cell differentiation.

72 g may have contributed to the evolution of a sperm cell equivalent to female polar bodies.

73 res and centromeres in the mid region of the sperm cell.

74 ves like the wild type and demonstrates that sperm cells are dispensable for normal pollen tube devel

75 ptive synergid and PT rupture, releasing the sperm cells for double fertilization.

76 Sperm cells of seed plants have lost their motility and

77 Ejaculated CatSperz-null sperm cells retrieved from the mated female uterus parti

78 he GLR genes GLR1 and GLR2 causes failure of sperm cells to target the female reproductive organs.

79 len tube (PT) for the successful delivery of sperm cells to the embryo sac.

80 = 0.05), while the number of dead and defect sperm cells was 27% (p = 0.07) and 15% (p = 0.33) higher

81 the green alga Chlamydomonas reinhardtii, on sperm cells, and on cells that line the trachea and fall

82 ranscription factors produces pollen without sperm cells.

83 somes formed the same centromere clusters in sperm cells.

84 crystalline DNA packaging in most vertebrate sperm cells.

85 ogether, these findings demonstrate that the sperm centrioles are remodeled both in their protein com

86 Post-testicular sperm maturation, in which sperm centrioles found in the caput are destroyed prior

87 Sperm characters strongly support several major branches

88 r work reveals functions for GLR channels in sperm chemotaxis and transcriptional regulation.

89 Sperm chemotaxis is essential for fertilization in both

90 ulfide linkages for in vivo DNA packaging in sperm chromatin.

91 1 proteins), also known as SCP superfamily (sperm-coating proteins), have been implicated in many ph

92 e oocyte and the paternal genome provided by sperm coexist as separate haploid nuclei in the zygote.

93 ly expressed between backcross males with no sperm compared with those backcross males with motile sp

94 ction of post-reproductive traits related to sperm competition among males.

95 in polygamous species with higher levels of sperm competition and production.

96 with relative testicle size, an indicator of sperm competition and sexual selection.

97 on theory, provide unequivocal evidence that sperm competition risk drives plastic adjustment of ejac

98 ents to ejaculate performance in response to sperm competition risk; however, the mechanisms behind t

99 ombined findings, completely consistent with sperm competition theory, provide unequivocal evidence t

100 sheep, a primitive breed experiencing strong sperm competition.

101 elocity when faced with an increased risk of sperm competition.

102 cted F0 and DeltaF in species with increased sperm competition.

103 ly, males with more motile sperm had greater sperm competitiveness, but only under current pCO2 level

104 We found a clear association between sperm concentration below 15 million/mL and all-cause ho

105 irst time 7 years later than were men with a sperm concentration of 0-5 million/mL.

106 Men with a sperm concentration of 195-200 million/mL were, on avera

107 week apart, which were analyzed for volume, sperm concentration, and motility.

108 After controlling for sperm concentration, increased progressive sperm motilit

109 Total sperm count, sperm concentration, morphology, motility, and ejaculate

110 (18, 66%), 29% (3, 64%), and 30% (2, 70%) in sperm concentration, total sperm count, and total motile

111 CDD and PCDD TEQs were associated with lower sperm concentration, total sperm count, and total motile

112 se failure rates of 0.6% (95% CI 0.3-1.1) if sperm concentrations of less than 1 million per mL are m

113 Instead, sperm contents connect to the cortical F-actin to preven

114 tration, total sperm count, and total motile sperm count (p-trends </= 0.05).

115 alizations were also higher with a low total sperm count and low motility.

116 xhibit defective spermatogenesis and reduced sperm count as young adults.

117 t cryptorchidism, lower testis weight, lower sperm count, and subfertility.

118 ciated with lower sperm concentration, total sperm count, and total motile sperm count (p-trends </=

119 d 30% (2, 70%) in sperm concentration, total sperm count, and total motile sperm count, respectively,

120 tration, total sperm count, and total motile sperm count, respectively, compared with the lowest quar

121 Total sperm count, sperm concentration, morphology, motility,

122 uctions in serum testosterone and epididymal sperm count.

123 V levels in brains and testes, and preserved sperm counts.

124 ld-type MTL protein localizes exclusively to sperm cytoplasm, and pollen RNA-sequence profiling ident

125 enome, which we confirmed using public human sperm data.

126 One of the two sperm delivered by the pollen tube (PT) fuses with the e

127 Here, we show that sperm derived from Plcz1(-/-) male mice fail to trigger

128 io (PSR) induces complete elimination of the sperm-derived hereditary material in the jewel wasp Naso

129 Unusual patterns such as sperm dimorphism, the formation of bundles, or aflagella

130 y a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially

131 ich raises the question of what prevents the sperm DNA from interacting with the meiotic spindle.

132 s study, we find that Caenorhabditis elegans sperm DNA stays in a fixed position at the opposite end

133 a unit with the yolk granules, resulting in sperm DNA within 2 microm of the meiotic spindle.

134 we pre-equilibrated ETV6 with excess salmon sperm DNA, a heterogeneous polymer, before exposing the

135 In the absence of F-actin, the sperm DNA, centrioles, and organelles were transported a

136 in the DNA, and (2) oxidative damage in the sperm DNA.

137 In their absence, sperm does not form and male mice are sterile.

138 We reveal that motile sperm domain-containing protein 2 (MOSPD2), a protein wi

139 isease incidence and also mutation assays of sperm donors.

140 and spread through the populations due to a sperm-egg incompatibility called cytoplasmic incompatibi

141 translocation severely impaired the block to sperm entry, suggesting that translocation defects could

142 e no functional tests supporting the role of sperm epigenetic marking on embryonic gene expression.

143 ose maturation is arrested by the absence of sperm exhibit hallmarks of proteostasis collapse, includ

144 Rab3A is an essential component of human sperm exocytotic machinery.

145 Mammalian sperm feature a specialized secretory organelle on the a

146 -remedial ductal obstruction, and absence of sperm fertilising ability, assisted reproductive technol

147 triterpenoids pristimerin and lupeol, affect sperm fertility.

148 ing individual swimming sperm indicated that sperm-fluid interaction was facilitated by the elastic c

149 in milliseconds after encountering the first sperm, followed by a slow block generated through enzyma

150 rinciples for the use of cryopreserved coral sperm for future reef restoration efforts.

151 As sperm formation begins, hundreds of doomed mitochondrial

152 ility and functional analysis confirmed that sperm from bulls possessing the haplotype showed signifi

153 ornaments may be more capable of protecting sperm from oxidative stress in the event of sublethal Pb

154 ell wall is important for protection of male sperm from physical stresses and consists of an inner ga

155 olves double fertilization, the union of two sperm from pollen with two sex cells in the female embry

156 s the 3D flagellar envelope, thus preventing sperm from reorienting against fluid flow in vitro and e

157 To determine their potential roles, sperm from wild type and transgenic mice harboring a sin

158 d females fail to develop when fertilized by sperm from Wolbachia-infected males.

159 ot important as the fertilization success of sperm frozen for less than 1 month was similar to that f

160 ental exposures early in male life may alter sperm function and fertility.

161 INSL3 has been implicated in testicular and sperm function in adult males via interaction with relax

162 gene, a transcription factor which regulates sperm function in mice.

163 a role for beta-defensins in regulating bull sperm function.

164 s shared between HIV fusion to host cell and sperm fusion to oocyte led us to examine whether these f

165 esults in reduced EC1 expression and delayed sperm fusion, which can be rescued by expressing SUF4-be

166 llenged the existence of epigenetic marks on sperm genes, and there are no functional tests supportin

167 in sperm phenotype to offspring fitness and sperm genotype in a vertebrate and have major implicatio

168 Similarly, males with more motile sperm had greater sperm competitiveness, but only under

169 larvae produced with fresh or cryopreserved sperm had the same settlement success (p > 0.05); and 4)

170 tion of bundles, or aflagellate and immotile sperm have evolved independently in several groups.

171 c enzymes on the fibrous sheath of mammalian sperm, here we show a complex reaction of 10 enzymes tet

172 difference in cytoplasmic content of egg and sperm; however, active programs enforce uniparental inhe

173 channel of sperm (CatSper) is essential for sperm hyperactivated motility and fertility.

174 n act as contraceptive compounds by averting sperm hyperactivation, thus preventing fertilization.

175 ) is actively eliminated from the developing sperm in Drosophila.

176 eport striking collective swimming of bovine sperm in dynamic clusters, enabled by the viscoelasticit

177 AURKC) is essential for formation of euploid sperm in humans because mutations in AURKC are correlate

178 ction crucially depends on the production of sperm in males and oocytes in females.

179 fluid motion surrounding individual swimming sperm indicated that sperm-fluid interaction was facilit

180 ro fertilisation (IVF) with intracytoplasmic sperm injection (ICSI), can be used as an adjunctive mea

181 (2+) oscillations following intracytoplasmic sperm injection or expression of phospholipase C zeta.

182 l sperm that can be used in intracytoplasmic sperm injection to produce chromosomally normal, fertile

183 sophila, the cidA-cidB operon mimics CI when sperm introduce it into eggs, and a catalytically inacti

184 Activation of the egg by the sperm is the first, vital stage of embryogenesis.

185 These states may be observable in groups of sperm, Japanese tree frogs, colloidal suspensions of mag

186 to reveal complex dynamics that may underlie sperm-length evolution.

187 Using a series of in vitro sperm manipulation and competition experiments, we show

188 Post-testicular sperm maturation, in which sperm centrioles found in the

189 lfur-sulfur bonds during the final stages of sperm maturation.

190 cluding immune defenses, venom toxicity, and sperm maturation.

191 iotic spindles and, after fertilization with sperm, meiosis completion and formation of normal diploi

192 The technique of dDNP allows 'snapshots' of sperm metabolism to be tracked over the different stages

193 antial global epigenomic change in mammalian sperm methylomes and point to a divergence in trans-epig

194 Applying this model to the sperm methylomes, we uncovered an overall evolutionary e

195 ng induced by elasticity may thus facilitate sperm migration and contribute to successful fertilizati

196 us, leading to the absence of the protein in sperm, mislocalization of the protein when injected in m

197 the 26S proteasome, explaining how the whole sperm mitochondria are degraded inside the fertilized ma

198 islocation and presentation of ubiquitinated sperm mitochondrial proteins to the 26S proteasome, expl

199 Sperm mitophagy in higher mammals thus relies on a combi

200 : 1) cryopreservation of coral sperm reduced sperm motility and fertilization success in half, thus f

201 ts also displayed a substantial reduction in sperm motility and infertility, whereas those carrying m

202 y provide help to uncover the causes of poor sperm motility and suggest new approaches for novel trea

203 r sperm concentration, increased progressive sperm motility generated more pyruvate conversion to lac

204 Both in humans and in animals, sperm motility has been used as a metric for the viabili

205 icular histology, daily sperm production and sperm motility in knock-out and wild-type mice.

206 Poor sperm motility is a common cause of male infertility for

207 Sperm motility is powered by adenosine triphosphate but

208 icient in these sensory neurons to influence sperm motility parameters.

209 ffect of 633 nm coherent, red laser light on sperm motility using a novel wavelet-based algorithm tha

210 e relationship between energy metabolism and sperm motility we used dissolution Dynamic Nuclear Polar

211 y lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of

212 Sperm motility, viability, fertilization and blastocyst

213 lt of significantly reduced sperm output and sperm motility.

214 exposure for cellular repair and increasing sperm motility.

215 To fertilize an oocyte, sperm must first undergo capacitation in which the sperm

216 SRB chemoreceptors are not essential for sperm navigation under low oxygen conditions that C. ele

217 despite a similar genomic background: motile sperm, no sperm (sterile), and immotile sperm.

218 PLCzeta-null sperm now make it possible to resolve long-standing ques

219 e reprogramming of terminally differentiated sperm nuclei and suggest that different epigenetic pathw

220 The organization of chromosomes in sperm nuclei has been proposed to possess a unique "hair

221 nd centromeres were observed to aggregate in sperm nuclei, forming an average of 20 and 7 clusters, r

222 retory organelle on the anterior part of the sperm nucleus, the acrosome, which is essential for male

223 nome, single-CpG DNA methylation profiles in sperm of seven species-human, chimpanzee, gorilla, rhesu

224 us and is differentially expressed in mature sperm of the two species yet is similarly abundant in th

225 s substitute for human SLO3 (hSLO3) in human sperm or whether human SLO3 channels have acquired Ca(2+

226 Sperm oriented in the same direction within each cluster

227 in part, the result of significantly reduced sperm output and sperm motility.

228 er cessation of male hormonal contraception, sperm output fully recovers in a predictable manner, res

229 d fetal malformation rates after recovery of sperm output overlap those in the general population.

230 cale reproduction trials using cryopreserved sperm (p < 0.05); 3) cryopreservation did not affect set

231 Several sperm parameters showed positive relationships with colo

232 s clearly link within-ejaculate variation in sperm phenotype to offspring fitness and sperm genotype

233 ise to recombinant males with three distinct sperm phenotypes despite a similar genomic background: m

234 must first undergo capacitation in which the sperm plasma membrane becomes hyperpolarized via activat

235 s life cycle stages, e.g., competition among sperm/pollen or meiotic drive during gamete/spore produc

236 etophytic competition typically occurs among sperm/pollen, and meiotic drive typically occurs during

237 Sperm pools selected by motile phenotypes differed genet

238 f mate guarding are used by males to promote sperm precedence with little cost, but these tactics can

239 y by determining testicular histology, daily sperm production and sperm motility in knock-out and wil

240 tects the germline genome and ensures normal sperm production in mice.piRNAs are regulatory RNAs that

241 LAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in seve

242 irment might result from factors that affect sperm production, quality, function, or transport.

243 ls exhibit defects in meiotic maturation and sperm production.

244 The major sperm protein domain (MSPd) has an extracellular signali

245 proteins (VAPs) contain an N-terminal major sperm protein domain (MSPd) that is associated with amyo

246 g coat protein, VERL, complexed with cognate sperm protein lysin.

247 The sperm protein PLCzeta has been proposed as the physiolog

248 nhance oocyte production-spermatogenesis and sperm quality abnormalities are much more difficult to a

249 In general, a healthy lifestyle can improve sperm quality.

250 and found that: 1) cryopreservation of coral sperm reduced sperm motility and fertilization success i

251 Disruption of Mkrn2 also caused failure of sperm release (spermiation failure) and misarrangement o

252 transcription factors that are required for sperm release from the pollen tube to the female gametes

253 d in turn leading to pollen tube rupture and sperm release.

254 The sperm-restricted single-pass transmembrane protein HAP2-

255 ysis of chromatin accessibility in F3 and F4 sperm reveals significant differences between control an

256 tion of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe

257 iched and spread to ectopic positions on the sperm's chromatin before entry into mitosis.

258 The sperm's crucial function is to locate and fuse with a ma

259 s unlikely to cause problems in terms of the sperm's fundamental ability to activate an oocyte.

260 nstream signaling events with effects on the sperm's mitochondria and navigational capacity.

261 ne expression during spermatogenesis and the sperm's mitochondria, thereby increasing migration veloc

262 and oxygen-sensing circuits that affect the sperm's navigational capacity.

263 Remarkably, sperm-secreted hormones re-establish oocyte proteostasis

264 y a role in reproduction by participating in sperm selection and facilitating the rapid removal of sp

265 ty relies on the quantity and quality of his sperm, semen analysis is generally used as the proxy to

266 The resulting aberrant sperm show histone retention, abnormal morphology, and s

267 Longer-lived sperm sired embryos with increased survival and a reduce

268 Our results suggest that sperm-specific genes can evolve rapidly and that natural

269 Sperm-specific SLO3 K(+) channels are responsible for th

270 similar genomic background: motile sperm, no sperm (sterile), and immotile sperm.

271 Sperm stimulate V-ATPase activity in oocytes by signalli

272 th, there are few functions known aside from sperm storage and nutrition.

273 optera (Amphiesmenoptera), differ greatly in sperm structure.

274 c analyses suggest the presence of different sperm subpopulations, using distinct PLA2 pathways to ac

275 didymitis mouse model, and sialidases on the sperm surface are considered to be activated via proteas

276 In contrast, sperm swam randomly and individually in Newtonian (nonel

277 to the male germ cell lineage and functional sperm that can be used in intracytoplasmic sperm injecti

278 are only sensitive to pH i However, in human sperm, the major K(+) conductance is both Ca(2+)- and pH

279 ous X chromatids segregate to the functional sperm to create diplo-X sperm.

280 event provisions the female with sufficient sperm to fertilize the >500 eggs she will produce during

281 ne encoding PLCzeta abolishes the ability of sperm to induce Ca(2+) oscillations in eggs.

282 le of becoming highly motile, is key; 2) the sperm-to-egg ratio and the concentration of the cryoprot

283 rs the mechanism for the rapid adjustment of sperm velocity and that fitness benefits accrue to males

284 n experiments, we show that rapid changes in sperm velocity are mediated by seminal fluid and the eff

285 nal fluid and the effect of seminal fluid on sperm velocity directly impacts paternity share and ther

286 hat in less than 48 hr, males can upregulate sperm velocity when faced with an increased risk of sper

287 mone progesterone activates CatSper of human sperm via binding to the serine hydrolase ABHD2.

288 ence of semen fibrils, damaged and apoptotic sperm were more rapidly phagocytosed than healthy ones,

289 propensity of the completely helical protein sperm whale apomyoglobin (sw ApoMb) for amyloid formatio

290 methods, and large-scale redistributions of sperm whale cultural clans in the Pacific have likely ch

291 HNE became covalently bound to sperm whale Mb at up to five sites based on ESI-MS analy

292 Engineered variants of sperm whale myoglobin catalyze this synthetically valuab

293 ve the 3-dimensional structure of a protein, sperm-whale myoglobin, worthy of a Nobel Prize in Chemis

294 pygmy (Kogia breviceps) and dwarf (K. sima) sperm whales were used to characterize the gut microbiom

295 thesis for this low diversity, especially in sperm whales.

296 ed by the intimate association of developing sperm with accessory cells.

297 equently, partitioning yields one functional sperm with the X-bearing chromosome complement and an RB

298 sociated with changes in epigenetic marks in sperm, with a primary focus on the reprogramming of DNA

299 ogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring

300 on phenotypic variation among intact fertile sperm within an ejaculate affects offspring fitness.

301 g sperm within testes as well as with mature sperm within epididymis.

302 howed association of virions with developing sperm within testes as well as with mature sperm within

303 (p > 0.05); and 4) the residence time of the sperm within the bank was not important as the fertiliza