ライフサイエンスコーパス: spermatogenic

1 CRES (cystatin-related epididymal spermatogenic), a member of the cystatin superfamily of

2 differences in cytosine methylation between spermatogenic and brain cells, identifying 223 new candi

3 ochondrial electron transport chain (ETC) in spermatogenic and in colon carcinoma cells, and silencin

4 vealed enlarged intercellular spaces between spermatogenic and Sertoli cells as well as the spermatid

5 esis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction

6 also exhibited reduced penile length, focal spermatogenic anomalies, diminished sperm motility and s

7 miwi(null) mice display spermatogenic arrest at the beginning of the round sperm

8 However, spermatogenic arrest at the pachytene spermatocyte stage

9 nt in the Arid4a(-/-)Arid4b(+/-) mice showed spermatogenic arrest at the stages of meiotic spermatocy

10 S-AR(-/y) mice were infertile, with spermatogenic arrest predominately at the diplotene prem

11 g cell hyperplasia, apoptosis of germ cells, spermatogenic arrest, seminiferous tubule degeneration,

12 nto Sxrb-deletion mice fails to overcome the spermatogenic block.

13 phenotype in the F1 generation of decreased spermatogenic capacity (cell number and viability) and i

14 -Kit levels could contribute to the elevated spermatogenic cell apoptosis and Leydig cell hyperprolif

15 idate the roles of the Utp14 genes in normal spermatogenic cell development as a basis for understand

16 has shown that this protein is required for spermatogenic cell differentiation in adult mice.

17 Both populations expressed the spermatogenic cell marker, DAZL, but not the somatic cel

18 that forms cell-specific complexes with rat spermatogenic cell nuclear factors distinct from cyclic

19 agnitude of heritable effects depends on the spermatogenic cell stage treated.

20 strate a strict requirement of Six5 for both spermatogenic cell survival and spermiogenesis.

21 y was measured in mixed germ cell (i.e., all spermatogenic cell types in adult testis) nuclear extrac

22 ts from premeiotic, meiotic, and postmeiotic spermatogenic cell types obtained from young mice.

23 l as RNA expression analysis using separated spermatogenic cell types revealed that Ant4 expression w

24 increased spontaneous mutant frequencies in spermatogenic cell types, AP endonuclease heterozygous (

25 hat base excision repair activity is high in spermatogenic cell types.

26 scripts from multiple miRNA genes in various spermatogenic cell types.

27 In testis, Fzd9 is expressed in all spermatogenic cell types.

28 ne by using enriched populations of specific spermatogenic cell types.

29 ocessing regulatory sequence elements in all spermatogenic cell types.

30 element binding protein 2gc (SREBP2gc) is a spermatogenic cell-enriched isoform of the ubiquitous tr

31 propose that SREBP2gc is part of a cadre of spermatogenic cell-enriched isoforms of ubiquitously exp

32 perm and regulation of F-actin dynamics by a spermatogenic cell-specific CAPZ heterodimer is essentia

33 speriolin and determined that it is a novel spermatogenic cell-specific Cdc20-binding protein, is pr

34 amilies containing paralogous genes encoding spermatogenic cell-specific isoforms, the large number o

35 Similarly, the degradation of spermatogenic cell-specific lncRNAs by piRNAs is mediate

36 MCP originated from an EDC gene and acquired spermatogenic cell-specific transcriptional and translat

37 ited significantly lower activity than mixed spermatogenic cell-type nuclear extracts, thereby sugges

38 The highest levels were observed in spermatogenic cells (but not in spermatozoa), and in neu

39 t Fer and FerT reside in the mitochondria of spermatogenic cells and are harnessed to the reprogramme

40 ariant of Fer, FerT, is uniquely detected in spermatogenic cells and is absent from normal somatic ti

41 SED1 is expressed in spermatogenic cells and is secreted by the initial segme

42 -associated genes that are expressed only in spermatogenic cells and malignant cells, and the overbea

43 The Pcdp1 gene is expressed in spermatogenic cells and motile ciliated epithelial cells

44 widespread and fundamental characteristic of spermatogenic cells and Sertoli cells.

45 to the role of X chromosome inactivation in spermatogenic cells and the developmental order of molec

46 rmatozoa of these animals, even though their spermatogenic cells are destined to die (bs/bs and qk/qk

47 the peculiar patterns of gene expression in spermatogenic cells are the consequence of powerful evol

48 The Hsp70-2 gene is expressed only in spermatogenic cells at a significant level.

49 n assays with enriched populations of murine spermatogenic cells at stages prior to, during, and foll

50 sulted in male chimeras which produced sperm/spermatogenic cells bearing the mutant allele, however t

51 nce-specific RNA binding activity present in spermatogenic cells contains the two Y-box proteins MSY2

52 riched in Drosophila testes, particularly in spermatogenic cells during the early stages of spermatog

53 cells appear, plateaus as the first wave of spermatogenic cells enters meiosis (10 days after birth)

54 Spermatogenic cells exhibit a lower spontaneous mutation

55 Spermatogenic cells express cell-specific molecules with

56 Here, we show that murine spermatogenic cells express numerous endo-siRNAs, which

57 The Man2a2 null spermatogenic cells fail to adhere to Sertoli cells and

58 eculate that transcriptional derepression in spermatogenic cells favors the creation of expressed ret

59 Spermatogenic cells from 9-month-old Apex(+/-) lacI(+) m

60 However, spermatogenic cells from old lacI mice display a 10-fold

61 In addition, spermatogenic cells from old mice have significantly inc

62 gulation of this Ca2+ channel in dissociated spermatogenic cells from the mouse using the whole-cell

63 rter localizes to the plasma membrane in all spermatogenic cells from the primary spermatocyte stage

64 ous mutant frequency for a lacI transgene in spermatogenic cells from young mice suggest that base ex

65 increased mutation frequencies compared with spermatogenic cells from young or middle-aged mice.

66 cally expressed in both normal and malignant spermatogenic cells in a maturation stage-dependent patt

67 lts suggest that each ADAM is transcribed in spermatogenic cells in a regulated pattern at a specific

68 inactivating Drosha or Dicer exclusively in spermatogenic cells in postnatal testes using the Cre-lo

69 aired cell-cell contact and sloughing off of spermatogenic cells in seminiferous epithelium, and lack

70 lar epithelial cells in the renal cortex, in spermatogenic cells in the testis, and in epithelial cel

71 he inability of lentiviral vectors to infect spermatogenic cells in vivo.

72 many atypical features of gene expression in spermatogenic cells including the gross overexpression o

73 A paternal age effect in spermatogenic cells is recognized for the human populati

74 iptional inactivation of the X chromosome in spermatogenic cells may not be as complete as that in so

75 requency of the lacI transgene is greater in spermatogenic cells obtained from old mice, suggesting t

76 Spermatogenic cells obtained from young adult lacI trans

77 ished in vivo expression of this promoter in spermatogenic cells of transgenic mice.

78 h this proposal, patch clamp recordings from spermatogenic cells reveal an amiloride-sensitive inward

79 Immunofluorescence of spermatogenic cells revealed BRD4 in a ring around the n

80 Spermatogenic cells synthesize a unique 70-kDa heat shoc

81 o germ cells and somatic tissues of mammals, spermatogenic cells synthesize HSP70-2 during meiosis.

82 oposons are expressed in meiotic and haploid spermatogenic cells than in any other tissue and specula

83 entified a population of cellular mRNAs from spermatogenic cells that appear to serve as templates fo

84 Primary cultures of rat spermatogenic cells that did not bind to collagen matric

85 s absence severely impairs the transition of spermatogenic cells through the late meiotic stages and

86 uding developing testes and also in purified spermatogenic cells using semi-quantitative PCR analyses

87 iogenesis in postreplicative cell types when spermatogenic cells were obtained from old mice.

88 e possible effects of these radionuclides on spermatogenic cells, a study has been undertaken to obta

89 by in situ hybridization specifically in the spermatogenic cells, and is downregulated during termina

90 n of Pabp2 mRNA in meiotic and early haploid spermatogenic cells, and the Pabp2 mRNA encodes a protei

91 attern was caused by killing differentiating spermatogenic cells, but there was little cytotoxicity o

92 In spermatogenic cells, PR1C is still a relatively strong c

93 sues and delayed epigenetic reprogramming in spermatogenic cells, providing evidence that gonadotropi

94 nal regulation of gene expression in haploid spermatogenic cells, spermatids.

95 ulated, especially suppressed in postmitotic spermatogenic cells, to guarantee robustness of spermato

96 ch as Mili are localized in the cytoplasm of spermatogenic cells, where they are associated with a ge

97 ilize the folding of Cdc20 during meiosis in spermatogenic cells.

98 ient males were derived from the transferred spermatogenic cells.

99 2, which is highly enriched in rat and mouse spermatogenic cells.

100 cytes and round spermatids relative to other spermatogenic cells.

101 Similar attrition occurred in spermatogenic cells.

102 r DND-26 also labeled the Golgi apparatus in spermatogenic cells.

103 orrelated with meiotic and early postmeiotic spermatogenic cells.

104 at is expressed in meiotic and early haploid spermatogenic cells.

105 resent at high levels in meiotic and haploid spermatogenic cells.

106 H1t is not expressed in somatic or in early spermatogenic cells.

107 due to X-chromosome inactivation in meiotic spermatogenic cells.

108 r factor binding and transgene expression in spermatogenic cells.

109 rol of mRNA fate in late meiotic and haploid spermatogenic cells.

110 expression is confined almost completely to spermatogenic cells.

111 tor of the post-meiotic development of mouse spermatogenic cells.

112 omponent of the selenium delivery pathway to spermatogenic cells.

113 oach reduced 1,099 proteins co-purified with spermatogenic chromatin, currently the most extensive ca

114 alysis in Caenorhabditis elegans to identify spermatogenic chromatin-associated proteins that are imp

115 neonate, pup, and adult donor testes produce spermatogenic colonies of similar size.

116 be made to various clinical states of severe spermatogenic compromise.

117 l cystatin CRES (cystatin-related epididymal spermatogenic), cst8, a reproductive-specific member of

118 to show that during the first, prepubertal, spermatogenic cycle (i) RALDH-dependent synthesis of RA

119 of damaged paternal DNA, and that the entire spermatogenic cycle can be at risk after mutagenic expos

120 Similar rates of expansion per spermatogenic cycle in man would yield the large expansi

121 1R) that is alternatively spliced during the spermatogenic cycle in the rat testis.

122 ated in a cyclical fashion during the 12-day spermatogenic cycle of the adult rat testis.

123 here Sertoli cell function is coupled to the spermatogenic cycle.

124 y in spermatocytes and spermatids during rat spermatogenic cycle.

125 in is no longer necessary for the subsequent spermatogenic cycles but essential to spermiation.

126 The primary spermatogenic defect in Csnk2a2-/- testis is a specific

127 gonial depletion mutation (jsd), a recessive spermatogenic defect mapped to mouse chromosome 1.

128 The onset of the spermatogenic defect occurs in the first wave of spermat

129 ile (bs), a spontaneous mutation that causes spermatogenic defects and germ cell loss.

130 DNA repair defects cause a variety of spermatogenic defects in mouse models.

131 Homozygous males are sterile and show spermatogenic defects in sperm individualization and nuc

132 ctions could readily account for the diverse spermatogenic defects observed in human males with AZF d

133 The technique also is being used to examine spermatogenic defects, correct male infertility, and gen

134 ermore, Mili and Tdrd1 mutants share similar spermatogenic defects.

135 background have largely emphasized postnatal spermatogenic defects.

136 divided into concentric layers representing spermatogenic development in the seminiferous epithelium

137 gress through DNA repair-competent phases of spermatogenic development.

138 e TGCTs result from disrupted testicular and spermatogenic developmental programs.

139 cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive

140 The decision to commit to spermatogenic differentiation coincides with the loss of

141 ranscription factor essential for subsequent spermatogenic differentiation.

142 to enable TRF2 targeting to genes regulating spermatogenic differentiation.

143 n in GSC daughter cells but does not prevent spermatogenic differentiation.

144 These results indicate that the various spermatogenic disruptions associated with X heterochroma

145 sha cKO testes appeared to be more severe in spermatogenic disruptions than Dicer cKO testes.

146 The developmental course of spermatogenic disruptions was similar at morphological l

147 Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhi

148 far prevented the complete reconstruction of spermatogenic events in cell culture.

149 aintained its conserved functional motif and spermatogenic expression from insects to humans.

150 Here, we characterize in detail the spermatogenic expression of the core particle subunit Pr

151 he most common known genetic cause of severe spermatogenic failure (SSF).

152 regions of the human Y chromosome results in spermatogenic failure and infertility.

153 mes, impaired meiotic progression and led to spermatogenic failure and infertility.

154 with hybrid sterility in male house mice via spermatogenic failure at the pachytene stage.

155 isplay gonadal atrophy, and Atm-/- mice show spermatogenic failure due to arrest at prophase of meios

156 identified in all three regions, no case of spermatogenic failure has been traced to a point mutatio

157 Histology and fertility tests confirmed spermatogenic failure in GCKO males.

158 offers a plausible mechanism to account for spermatogenic failure in patients bearing deletions of t

159 e restriction of the associated phenotype to spermatogenic failure indicates the remarkable functiona

160 some are found in a small number of men with spermatogenic failure involving, predominantly, three re

161 ion has far lower penetrance with respect to spermatogenic failure than previously characterized Y-ch

162 of the human Y chromosome cause irreversible spermatogenic failure that presents clinically in men as

163 mes, with clinical consequences ranging from spermatogenic failure to sex reversal and Turner syndrom

164 ified a single-gene deletion associated with spermatogenic failure, again involving USP9Y, by re-anal

165 etions correlate poorly with the severity of spermatogenic failure, and a deletion does not preclude

166 l development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adreno

167 In two men with spermatogenic failure, sister-chromatid crossing-over re

168 -dose thiamin was effective in reversing the spermatogenic failure, suggesting that the absence of th

169 etailed studies on human spermatogenesis and spermatogenic failure.

170 lled gr/gr, is a significant risk factor for spermatogenic failure.

171 hromosome are the most common known cause of spermatogenic failure.

172 versal, Turner syndrome, graft rejection and spermatogenic failure.

173 region, whose deletion is a common cause of spermatogenic failure.

174 r, suggesting that the USP9Y mutation caused spermatogenic failure.

175 d and did not correlate with the severity of spermatogenic failure.

176 region of the human Y chromosome results in spermatogenic failure.

177 n the Arid4a(-/-)Arid4b(+/-) mice, including spermatogenic failures and the impaired blood-testis bar

178 s from entering meiosis and direct them to a spermatogenic fate.

179 stulated notion that there is a tendency for spermatogenic functions to transfer from autosomes to th

180 Only a handful of spermatogenic genes are within this region, including on

181 hypothesis predicts a redistribution of late spermatogenic genes from the X chromosome to the autosom

182 Extracts from mixed spermatogenic germ cells displayed the greatest activity

183 regulates the cell cycle, differentiation of spermatogenic germ cells, and/or differentiation of supp

184 e factors in regulating either prior or post spermatogenic, i.e., early embryonic events.

185 rgence, relative to behavioral sterility and spermatogenic infertility.

186 yte-neuron, lactate-alanine, peroxisomal and spermatogenic lactate shuttles.

187 We propose a regulatory pathway in which spermatogenic leucine zipper 1 (SPZ1) promotes EMT throu

188 ies demonstrate that Foxo1 expression in the spermatogenic lineage is intimately associated with the

189 es in proportion during establishment of the spermatogenic lineage, eventually comprising approximate

190 ndent kinase partners, Cdk1 and Cdk2, in the spermatogenic lineage.

191 proliferation that is obligatory for normal spermatogenic maintenance in the adult.

192 m, but that host conditions are critical for spermatogenic maturation.

193 The kinase Fer and its spermatogenic meiotic variant, FerT, are coexpressed in

194 riphery of the seminiferous tubule where the spermatogenic niche will form, for mitotic reactivation

195 ors, but whether they exert related roles in spermatogenic or malignant cells has not been known.

196 ic wave are conserved features of vertebrate spermatogenic organisation that reflect the need for the

197 A recent examination of the mammalian spermatogenic pathway supports the view that cell fate i

198 Yq11.2 within the interval defining the AZFa spermatogenic phenotype.

199 of germ cells and microinjection of immature spermatogenic precursor cells.

200 These results indicate that the whole spermatogenic process can be represented in cell culture

201 e at the foundation of the highly productive spermatogenic process that continuously produces male ga

202 differentiating spermatogonia and subsequent spermatogenic processes.

203 entiation, proliferation, and/or survival of spermatogenic progenitors.

204 machinery required for the activation of the spermatogenic programme of transcription.

205 Spermatogenic progression begins with spermatogonia, pop

206 on localization of recombination-related and spermatogenic-related proteins suggest that the spermato

207 USP9Y, is the favored candidate for an early spermatogenic role.

208 n impairs the expression of many postmeiotic spermatogenic-specific as well as metabolic genes.

209 of chromatin remodeling factors in different spermatogenic stages and narrowed it down to bromodomain

210 define an alternative and dynamic model for spermatogenic stem cell function in the mouse testis.

211 circuitry that controls progression through spermatogenic stem cell lineages, we are identifying mut

212 le phenotypes, including failure to maintain spermatogenic stem cells and failure to progress into vi

213 The identity and behavior of mouse spermatogenic stem cells have been a long-standing focus

214 plies that mutations accumulate with time in spermatogenic stem cells.

215 production or action, to achieve consistent spermatogenic suppression.

216 These findings suggest there are multiple spermatogenic targets for genomically defective sperm wi

217 yndrome present with sequels of hormonal and spermatogenic testicular failure like infertility, low t

218 Expression is limited to spermatogenic tissue, and a transcriptional GFP fusion s

219 n nonetheless be sexually transformed from a spermatogenic to an oogenic fate.

220 omatic housekeeping transcripts but lost the spermatogenic transcripts to the newly arisen CDY.

221 The seminiferous epithelial cycle and spermatogenic wave are conserved features of vertebrate

222 cycle of the seminiferous epithelium and the spermatogenic wave, respectively.

223 cycle of the seminiferous epithelium and the spermatogenic wave.