ライフサイエンスコーパス: spermatogonial stem cell

1 s their repressive state when present in the spermatogonial stem cell.

2 on, and resulted in a 166-fold enrichment of spermatogonial stem cells.

3 tial for reproduction, little is known about spermatogonial stem cells.

4 e cyst cells break apart and probably become spermatogonial stem cells.

5 nuclear factor-Y is required for maintaining spermatogonial stem cells.

6 is: regulation of meiosis and maintenance of spermatogonial stem cells.

7 pment, hematopoiesis, and differentiation of spermatogonial stem cells.

8 es impaired differentiation of embryonic and spermatogonial stem cells.

9 ach for purification and characterization of spermatogonial stem cells.

10 l systems, we used primary cultures of mouse spermatogonial stem cells, a mouse spermatogonial stem c

11 arch surrounds the regenerative potential of spermatogonial stem cells, a recent article highlights t

12 Thus, to proliferate, spermatogonial stem cells activate mechanisms that are s

13 n provides insight into the amplification of spermatogonial stem cells and the origin of primordial f

14 are prospermatogonia), increases steadily as spermatogonial stem cells appear, plateaus as the first

15 This results, in part, from the fact that spermatogonial stem cells are an extremely rare cell pop

16 e generated a transgenic mouse line in which spermatogonial stem cells are marked by expression of an

17 Spermatogonial stem cells are required for the initiatio

18 Although spermatogonial stem cells are unipotent, these cells are

19 ovessels may contribute to the regulation of spermatogonial stem cells, as well.

20 In contrast, the recently developed spermatogonial stem cell assay system allows quantitatio

21 We demonstrate spermatogonial stem cell-associated antigens by using an

22 tal period in the non-dividing precursors of spermatogonial stem cells at a stage where retrotranspos

23 required for the survival of mouse PGCs and spermatogonial stem cells by suppressing apoptosis.

24 Spermatogenesis is the process by which spermatogonial stem cells divide and differentiate to pr

25 Spermatogonial stem cells divide throughout life, mainta

26 The lifelong spermatogonial stem cell divisions unique to male germ c

27 Thus, molecular markers specific for spermatogonial stem cells establish a reliable and rapid

28 Recently, transplantation of mouse donor spermatogonial stem cells from a fertile testis to an in

29 Thus, transplantation of spermatogonial stem cells from an infertile donor to a p

30 we examine the feasibility of transplanting spermatogonial stem cells from other species to the mous

31 highlights the in-vitro propagation of human spermatogonial stem cells from testicular biopsies for f

32 First, spermatogonial stem cells from the adult cryptorchid tes

33 consistent with germline selection: mutated spermatogonial stem cells gained an advantage that allow

34 In contrast to spermatogonial stem cells, gonocytes can be identified e

35 Whereas in-vitro propagation of spermatogonial stem cells has been established in animal

36 Human adult spermatogonial stem cells (hSSCs) must balance self-rene

37 antation experiments revealed a depletion of spermatogonial stem cells in the adult.

38 We establish a spermatogonial stem cell index (SSCI) that reliably pred

39 The spermatogonial stem cell initiates and maintains spermat

40 rmatogenesis involves the differentiation of spermatogonial stem cells into spermatocytes via mitotic

41 of the genome, and telomerase expression in spermatogonial stem cells is responsible for the mainten

42 sequent extensive apoptosis occurring at the spermatogonial stem-cell level.

43 of mouse spermatogonial stem cells, a mouse spermatogonial stem cell line and freshly isolated testi

44 and revealed a novel function in regulating spermatogonial stem cell maintenance.

45 erm cells and the identification of a set of spermatogonial stem cell marker transcripts.

46 proliferation is impaired and expression of spermatogonial stem cell markers c-Ret, Plzf, and Stra8

47 manner, implying failure of maintaining the spermatogonial stem cell niche in somatic cells.

48 urotrophic factor (GDNF), a component of the spermatogonial stem cell niche produced by the somatic S

49 g a classic stem cell system, the Drosophila spermatogonial stem cell niche, we reveal daily rhythms

50 nd blood flow are known to contribute to the spermatogonial stem cell niche.

51 vitro retroviral-mediated gene delivery into spermatogonial stem cells of both adult and immature mic

52 permatogenesis in mouse testes suggests that spermatogonial stem cells of many species could be trans

53 was not functionally redundant with NSun2 in spermatogonial stem cells or Sertoli cells.

54 The identity of the spermatogonial stem cell population in the undisturbed t

55 Division of spermatogonial stem cells produces daughter cells that e

56 We report here that GDNF promotes spermatogonial stem cell proliferation through activatio

57 ave now devised culture conditions where rat spermatogonial stem cells renew and proliferate in cultu

58 sexes, with males also exhibiting defective spermatogonial stem-cell renewal.

59 Maintenance of spermatogonial stem cells requires the transcriptional r

60 view the developments that have been made in spermatogonial stem cell research and potential future u

61 Spermatogonial stem cells reside in specific niches with

62 estigation of molecular mechanisms governing spermatogonial stem cell self renewal and hierarchical d

63 ruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in

64 toli cells in the testis and is required for spermatogonial stem cell self-renewal.

65 TAF4b may be required for the regulation of spermatogonial stem cell specification and proliferation

66 We evaluated spermatogonial stem cell (SSC) activity in the developin

67 importance of individual miRs in controlling spermatogonial stem cell (SSC) homeostasis has not been

68 and pale (Ap) spermatogonia that make up the spermatogonial stem cell (SSC) pool.

69 s suggest that exogenous factors crucial for spermatogonial stem cell (SSC) self-renewal are conserve

70 , a Bmp type I receptor inhibitor, prolonged spermatogonial stem cell (SSC) survival in culture and e

71 The spermatogonial stem cell (SSC) that supports spermatogen

72 The mechanisms that guide the continuum of spermatogonial stem cell (SSC) to progenitor spermatogon

73 Spermatogonial stem cell (SSC) transplantation has been

74 In this study, spermatogonial stem cells (SSC) that harbor paternalized

75 selfish mutations: substitutions that grant spermatogonial stem cells (SSCs) a selective advantage i

76 Spermatogonial stem cells (SSCs) are a subpopulation of

77 Spermatogonial stem cells (SSCs) are at the foundation o

78 Male germline or spermatogonial stem cells (SSCs) are conserved across ma

79 Spermatogonial stem cells (SSCs) are responsible for mai

80 Spermatogonial stem cells (SSCs) are the basis of sperma

81 Spermatogonial stem cells (SSCs) are the foundation for

82 he untimely and excessive differentiation of spermatogonial stem cells (SSCs) by disturbing the expre

83 Spermatogonial stem cells (SSCs) capable of self-renewal

84 ction of functional sperm from self-renewing spermatogonial stem cells (SSCs) in cell culture conditi

85 erm line stem cells (GSCs) in Drosophila, or spermatogonial stem cells (SSCs) in mammals.

86 Self-renewal and differentiation by spermatogonial stem cells (SSCs) is the foundation for c

87 Self-renewal of spermatogonial stem cells (SSCs) is the foundation for m

88 Spermatogonial stem cells (SSCs) maintain spermatogenesi

89 Spermatogonial stem cells (SSCs) maintain spermatogenesi

90 Postnatal spermatogonial stem cells (SSCs) progress through prolif

91 Self-renewal and differentiation of spermatogonial stem cells (SSCs) provide the foundation

92 Spermatogonial stem cells (SSCs) self-renew and produce

93 permatogenesis is initiated and sustained by spermatogonial stem cells (SSCs) through self-renewal an

94 ent results have demonstrated the ability of spermatogonial stem cells (SSCs) to de-differentiate int

95 In spermatogonial stem cells (SSCs), Myc controls SSC fate

96 We observed a paucity of mutant spermatogonial stem cells (SSCs), which appears independ

97 eating transchromosomic mice by manipulating spermatogonial stem cells (SSCs), which exhibited superi

98 level is essential for homeostasis in murine spermatogonial stem cells (SSCs).

99 population size and differentiation fate of spermatogonial stem cells (SSCs).

100 n the GFRA1(+) spermatogonia, which includes spermatogonial stem cells (SSCs).

101 gametes originate from a small population of spermatogonial stem cells (SSCs).

102 ermore, the presence of surface integrins on spermatogonial stem cells suggests that these cells shar

103 Despite the central importance of the spermatogonial stem cell to male reproduction, little is

104 ideal surrogate for transplantation of donor spermatogonial stem cells to expand the availability of

105 Spermatogonial stem cell transplantation began as a theo

106 Restoration of fertility following spermatogonial stem cell transplantation in animals sugg

107 Given STAT3's function in mouse spermatogonial stem cells, we suggest that this interact

108 after treatment, suggesting that persistent spermatogonial stem cells were not sensitive to NOVP.

109 al germ cells in the embryo and give rise to spermatogonial stem cells, which establish and maintain

110 Transfection of the spermatogonial stem cells with a plasmid containing the

111 ance and differentiation of gonocytes and/or spermatogonial stem cells would be modulated through thi