ライフサイエンスコーパス: spermidine

1 rates, such as polyamines (e.g. spermine and spermidine).

2 of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine).

3 ic molecules bearing multiple charges (e.g., spermidine).

4 ccharide and protein, requires the polyamine spermidine.

5 utophagy dependent manner using the compound spermidine.

6 condensation induced by the trivalent cation spermidine.

7 key step in the production of the polyamine spermidine.

8 e tested for Hst 5 sensitivity and uptake of spermidine.

9 administration of rapamycin, resveratrol, or spermidine.

10 CANSDH led to loss of sym-norspermidine and spermidine.

11 ogenously supplied sym-norspermidine but not spermidine.

12 for synthesis of both sym-norspermidine and spermidine.

13 ive to oxygen stress in the absence of added spermidine.

14 ndensate morphology when DNA is condensed by spermidine.

15 yamines and in particular polyamines such as spermidine.

16 most normally with homospermidine instead of spermidine.

17 (EC50 = 1.4 muM) in inhibiting the uptake of spermidine (1 muM) in DFMO-treated L3.6pl human pancreat

18 (0.2-1.7), N(1),N(10)-bis-(dihydrocaffeoyl) spermidine (1.1-2.6), and N(1),N(5),N(14)-tris-(dihydroc

19 Very low concentrations of spermidine (10(-8) M) are sufficient for the growth of S

20 Spermidine (2 mM) completely inhibited anti-association

21 sults presented here, high concentrations of spermidine(3+) did not produce the premature stalling ob

22 The only exception to these behaviors is spermidine(3+), whose weaker influence on the docking eq

23 K(+), Mg(2+), Ca(2+), Co(NH(3))(6)(3+), and spermidine(3+).

24 re permeable not only to NMDG(+) but also to spermidine, a large natural cation involved in ion chann

25 ential appearance of fluorinated putrescine, spermidine, acetylated spermidine, and spermine.

26 ine, and N(1),N(5),N(10)-tri-p-(E)-coumaroyl spermidine amides.

27 oside and N(1),N(5),N(10)-triphenylpropenoyl spermidine amides.

28 ylcholine, diacylglycerol, monoacylglycerol, spermidine, amyloid-beta, amylin, and osmotic shock.

29 Biosynthesis of spermidine analogue aminopropylcadaverine, but not exoge

30 Intracellular biosynthesis of another spermidine analogue, aminopropylcadaverine, from exogeno

31 The differential ability of C-methylated spermidine analogues to functionally replace spermidine

32 ation of spermine and N(1)-acetylspermine to spermidine and 3-aminopropanal or N-acetyl-3-aminopropan

33 (SMO) catalyzes the oxidation of spermine to spermidine and 3-aminopropanal.

34 ite as well as that of two other polyamines: spermidine and agmatine is investigated through metaboli

35 n intracellular and extracellular acetylated spermidine and by a 6-20-fold increase in biosynthetic e

36 polyamine oxidase specific for spermine and spermidine and diamine oxidase specific for putrescine,

37 SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2), which causes apoptosi

38 Spermidine and its derivative, hypusinated eIF5A, are es

39 Multivalent cations such as spermidine and magnesium induce attraction between packa

40 lysosomal transmembrane protein, as well as spermidine and N-acetylglucosamine biosynthesis, all con

41 ed higher sensitivity (from 0.02mgkg(-1) for spermidine and phenylethylamine to 0.2mgkg(-1) for sperm

42 e amidino acceptor substrate, especially for spermidine and putrescine (Km values of 33 mum and 3.9 m

43 The up-regulation of polyamines (spermidine and putrescine) and potassium may mitigate ox

44 The latter two proteins preferentially bind spermidine and putrescine, respectively.

45 regulated, and the levels of the polyamines, spermidine and putrescine, were found to be increased wh

46 With the exception of spermidine and spermine a wide variation of BA levels wa

47 Cationic polyamines such as spermidine and spermine are critical in all forms of lif

48 ism critically involved in the conversion of spermidine and spermine back to putrescine.

49 ates synthesis of the polyamines putrescine, spermidine and spermine by controlling stability of the

50 The N1-acetylation of spermidine and spermine by spermidine/spermine acetyltra

51 In the absence of IHF, spermidine and spermine condense DNA primarily into toro

52 Polyamines spermidine and spermine did not show statistically signi

53 Polyamines spermidine and spermine did not show statistically signi

54 The polyamines spermidine and spermine did not show statistically signi

55 The content of spermidine and spermine in mammalian cells has important

56 Spermidine and spermine originate mainly from raw materi

57 Dietary polyamines spermidine and spermine participate in an array of physi

58 T1), which catalyzes the N(1)-acetylation of spermidine and spermine to form acetyl derivatives, is a

59 Putrescine, spermidine and spermine were measured as dansylated deri

60 rescine, and cadaverine) and two polyamines (spermidine and spermine) in 112 samples of dairy product

61 tryptamine and tyramine) and two polyamines (spermidine and spermine) were detected in cocoa beans du

62 cadaverine, histamine, serotonine, tyramine, spermidine and spermine), as well as microbiological pro

63 precursor compound for putrescine (and hence spermidine and spermine), which was proposed to convert

64 er of acetyl groups from acetylcoenzyme A to spermidine and spermine, as part of a polyamine degradat

65 T1 effect is most likely due to depletion of spermidine and spermine, because stable polyamine analog

66 idence for a primary function of polyamines, spermidine and spermine, in translation in mammalian cel

67 ent of polyamines (75-124 and 11-24 mg/kg of spermidine and spermine, respectively).

68 denovirus led to rapid depletion of cellular spermidine and spermine, total inhibition of protein syn

69 Spermidine and spermine, which enhance duplex stability,

70 G from V. cholerae showed that it acetylates spermidine and spermine.

71 from acetyl coenzyme A to polyamines such as spermidine and spermine.

72 genous metabolite, N(4)-(N-acetylaminopropyl)spermidine and the use of a novel proteomics based metho

73 Therefore, spermidine and Triquat A each show strong DNA selectivit

74 migration specifically through catabolism of spermidine and/or spermine.

75 brellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to cross fluid liposomal m

76 tions, TryS displays Km values for GSH, ATP, spermidine, and Gsp of 34, 18, 687, and 32 mum, respecti

77 0)-(E)-caffeoyl-N(1),N(5)-di-p-(E)-coumaroyl spermidine, and N(1),N(5),N(10)-tri-p-(E)-coumaroyl sper

78 Multicationic amines (spermine, spermidine, and neomycin) were found to effectively indu

79 bolites, including histidine, phenylalanine, spermidine, and phosphatidylcholine C34:4, has a diagnos

80 Putrescine, spermidine, and spermine (i.e., polyamines) are small ca

81 Putrescine, spermidine, and spermine are the polyamines required for

82 reduced levels of the polyamines putrescine, spermidine, and spermine in mutant inflorescences.

83 Polyamines (putrescine, spermidine, and spermine) are major organic polycations

84 The polyamines, putrescine, spermidine, and spermine, are essential polycations, int

85 uorinated putrescine, spermidine, acetylated spermidine, and spermine.

86 ylarginine/arginine ratio, butyrylcarnitine, spermidine, and the total amount of essential amino acid

87 Because spermine and spermidine are effective blockers of K(+) ion efflux thr

88 demonstrate that the polyamines spermine and spermidine are environmental signals that alter bacteria

89 Both HDAC10 and spermidine are known to promote cellular survival throug

90 Our results indicate that spermine and spermidine are novel triggers to alert F. tularensis of

91 zoyl-AsbD with spermidine, providing the DHB-spermidine arms that are linked to citrate for assembly

92 aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic (tyramine, phenylethylamine) or he

93 These data implicate spermidine as a potential therapeutic agent to treat con

94 sma, levels of the polyamines putrescine and spermidine as well as the collagen breakdown product pro

95 In humans, high levels of dietary spermidine, as assessed from food questionnaires, correl

96 explained by spontaneous release of 1,1/t,t-spermidine at physiological pH.

97 To test this concept, a budding yeast spermidine auxotrophic strain was found to grow almost n

98 The ABHD5/SRM/spermidine axis in TAMs might represent a potential targ

99 COR)(CH 2) 4NH 2]X 2 (R = H, X = Cl (1,1/t,t-spermidine, BBR3571); R = CH 3 , X = Cl ( 2); R = CH 2 C

100 It is striking that, as intracellular spermidine becomes limiting, an increasing portion of it

101 case of trypanothione disulfide (TS2), a GSH-spermidine bioconjugate, involved in the antioxidative s

102 aramecium lost the eukaryotic genes encoding spermidine biosynthesis: S-adenosylmethionine decarboxyl

103 iasis, inhibits the first step in polyamine (spermidine) biosynthesis, a highly regulated pathway in

104 showed that activity of a key trypanosomatid spermidine biosynthetic enzyme, S-adenosylmethionine dec

105 lar metazoan Schistosoma worms have lost the spermidine biosynthetic pathway but retain deoxyhypusine

106 Treatment with putrescine or spermidine blocks myelin-mediated inhibition of neurite

107 so show that putrescine must be converted to spermidine both in culture and in vivo to overcome inhib

108 he chemistry and biology of acetyl-protected spermidine-bridged dinuclear platinum complexes [{ trans

109 ), acetylates polyamines such as putrescine, spermidine, cadaverine, and homospermidine present in bo

110 vivo to overcome inhibition by MAG and that spermidine can promote optic nerve regeneration in vivo.

111 Finally, rapamycin as well as spermidine, carbamazepine, and tamoxifen could also resc

112 (mTOR) and three other autophagy activators (spermidine, carbamazepine, and tamoxifen) in a FTLD-U mo

113 Typhimurium revealed novel latent spermidine catabolic activity producing non-native 1,3-d

114 SMS deficiency leads to excessive spermidine catabolism, which generates toxic metabolites

115 concentration of spermidine is <0.2% of the spermidine concentration present in wild-type cells.

116 er gene (acyltransferase DH29), specific for spermidine conjugation, mediates the initial acylation s

117 e interaction with SPDS2, thereby increasing spermidine content and subsequently PAO activity.

118 d SPDS2 mRNA abundance, significantly higher spermidine content, and increased polyamine oxidase (PAO

119 These results suggest that spermidine could be a useful tool in promoting CNS axon

120 he enzymatic product of spermidine synthase, spermidine, cycles as well.

121 We report here that in a spermidine-deficient B. subtilis mutant, the structural

122 of sinR or ectopic expression of slrR in the spermidine-deficient DeltaspeD background restored biofi

123 eoxyhypusine synthase, which is required for spermidine-dependent hypusine modification of a lysine r

124 ent are thermospermine synthase activity and spermidine-dependent posttranslational modification of e

125 Transcriptomic analysis of a spermidine-depleted B. subtilis speD mutant uncovered a

126 Development in spermidine-depleted gametophytes was arrested before the

127 In spermidine-depleted spermatogenous cells, chromatin fail

128 d a key component in the biosynthesis of DHB-spermidine (DHB-SP), the first isolable intermediate in

129 Spermidine did not affect quantal size, consistent with

130 d increased 8-fold with norC overexpression, spermidine did not induce expression of norC and other p

131 ecifically, the polyamines norspermidine and spermidine enhance and repress V. cholerae biofilm forma

132 Spermine, but not spermidine, enhanced NMDA-induced depolarization of moto

133 tions showed greater levels of spermine than spermidine, except for the 5th day post-partum.

134 ral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardi

135 Spermidine feeding enhanced cardiac autophagy, mitophagy

136 Spermidine feeding failed to provide cardioprotection in

137 pertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, incr

138 SAT acetylation of spermine and particularly spermidine followed by a marked increase in key biosynth

139 CpaN molecules cross-linked by the polyamine spermidine following reaction with the thioester bonds.

140 ain was auxotrophic for polyamines, required spermidine for growth in its insect vector form, and was

141 ulate homospermidine, suggesting it replaces spermidine for growth.

142 s largely mediated through a requirement for spermidine for the downstream posttranslational modifica

143 showed that Hst 5 is a competitive analog of spermidine for uptake into C. albicans cells, and that H

144 onine as the aminopropyl group donor to form spermidine from putrescine by the key enzymes S-adenosyl

145 the novel de novo synthesis of the triamine spermidine from the diamine putrescine by fusion enzymes

146 ilm regulator slrR Our results indicate that spermidine functions in biofilm development by activatin

147 arily optimized with respect to the reaction spermidine --> spermine.

148 -inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by c

149 spermidine analogues to functionally replace spermidine in biofilm formation indicated that the amino

150 fluorescence turn-on assays of spermine and spermidine in biological samples.

151 d for their ability to inhibit the import of spermidine in DFMO-treated Chinese hamster ovary (CHO) a

152 presence of extracellular concentrations of spermidine in growing cultures of R. sphaeroides gave ri

153 of prostatic cancer biomarkers spermine and spermidine in real clinical applications with reduced sa

154 on of eIF5A is a most important function for spermidine in supporting the growth of S. cerevisiae pol

155 e precursors, supplementation of spermine or spermidine in the borrelial growth medium induced synthe

156 and drug treatments were employed to deplete spermidine in the gametophyte at different stages of gam

157 Hydric stress caused accumulation of spermidine in the grains and affected the levels of othe

158 hat the effect of multivalent cations and of spermidine, in particular, on the dynamics of DNA packin

159 ment of T84 and HT29/cl.19A colonocytes with spermidine increased both TCPTP protein levels and enzym

160 S) is an enzyme which function is to convert spermidine into spermine.

161 s observed in the systems with magnesium and spermidine ions compared to the system with only salt.

162 s near normal, the internal concentration of spermidine is <0.2% of the spermidine concentration pres

163 s study demonstrated that the small molecule spermidine is a selective activator of TCPTP in vitro.

164 The polyamine spermidine is absolutely required for growth and cell pr

165 ntration for cobalt hexammine as compared to spermidine is due to a difference in ion binding, not a

166 Spermidine is essential for viability and acts as the pr

167 ion indicated that the aminopropyl moiety of spermidine is more sensitive to C-methylation, which it

168 Ubiquitous polyamine spermidine is not required for normal planktonic growth

169 restored biofilm formation, indicating that spermidine is required for expression of the biofilm reg

170 is essential in T. brucei, and the polyamine spermidine is required for synthesis of a novel cofactor

171 are mixed, AdoMetDC activity is restored and spermidine is synthesized.

172 ey step in the biosynthesis of the polyamine spermidine, is activated by dimerization with an inducib

173 key enzyme for biosynthesis of the polyamine spermidine, is activated by heterodimer formation with a

174 mic acids and two polyamines, putrescine and spermidine, is regulated by this transcription factor.

175 ed preference for putrescine (Kd=10 nM) over spermidine (Kd=430 nM), but the related compounds cadave

176 c analysis also showed that hydroxycinnamoyl spermidines, known components of the pollen coat, were e

177 s and total polyamines; and iii) the highest spermidine levels and total acidity, but the lowest tota

178 Spermidine levels rise first in sterile jacket cells and

179 In untreated gametophytes, spermidine made in the jacket cells moves into the sperm

180 The spermidine N-acetyltransferase SpeG is a dodecameric enz

181 Spermidine N-acetyltransferase, encoded by the gene speG

182 ),N(10)-di-(E)-caffeoyl-N(5)-p-(E)-coumaroyl spermidine, N(1)-(E)-caffeoyl-N(5),N(10)-di-p-(E)-coumar

183 )-(E)-caffeoyl-N(5),N(10)-di-p-(E)-coumaroyl spermidine, N(10)-(E)-caffeoyl-N(1),N(5)-di-p-(E)-coumar

184 contain high levels of polyamines, including spermidine, N1-acetylspermine, and N1-acetylspermidine.

185 The effect of spermidine on the levels of select borrelial proteins wa

186 With spermidine, one round of transcription occurred normally

187 Other autophagy-inducing drugs, such as spermidine or add-on therapy with widely used antiathero

188 We found that treating spores directly with spermidine or other polyamines was sufficient to unmask

189 o produce N-acetyl-3-aminopropanaldehyde and spermidine or putrescine.

190 nized both putrescine and cadaverine but not spermidine or spermine.

191 With 500 microM spermidine or Triquat A, the supernatant DNA could not b

192 In the presence of cobalt hexammine, spermidine, or spermine, stretched DNA exhibits an abrup

193 Here, we show that the polyamine spermidine plays a key role as a morphogenetic determina

194 lvage ornithine and have some access to host spermidine pools, while host putrescine appears to be un

195 ppresses spermidine synthase (SRM)-dependent spermidine production in macrophages by inhibiting the r

196 olytic factor ABHD5 suppresses SRM-dependent spermidine production in TAMs and potentiates the growth

197 On a functional level, spermidine protected barrier function in the setting of

198 uniquely bind with N(4)-(N-acetylaminopropyl)spermidine, provides information on the role of this nov

199 ndensation of 3,4-dihydroxybenzoyl-AsbD with spermidine, providing the DHB-spermidine arms that are l

200 uding reduced levels of dephosphocoenzyme A, spermidine, putrescine, and phosphatidylethanolamines an

201 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, phenylethyl

202 The spermine/spermidine ratio in lymphoblasts was 0.53, significantly

203 thase show clearly that the correct spermine:spermidine ratio is critical for normal growth and devel

204 In addition, the CaSR agonist spermidine reduced synaptic transmission and increased p

205 cells were determined, and it was found that spermidine remained unchanged and putrescine increased b

206 However, the structural features of spermidine required for B. subtilis biofilm formation ar

207 However, the levels of spermidine required to inhibit biofilm formation through

208 Consistent with the spermidine requirement in biofilm formation, single-cell

209 ferirel (relBbu ; bb0198) in the presence of spermidine revealed the interplay of multiple regulatory

210 hibitors N,N'-dibenzylbutane-1,4-diamine and spermidine show that the fully protonated forms of the i

211 Putrescine and spermine, but not spermidine, showed evidence of co-operative stimulation

212 ying of grapevines with putrescine (Put) and spermidine (Spd) (0, 1, 2mM) was evaluated for determini

213 portant biogenic polyamines; spermine (SPM), spermidine (SPD) and putrescine (PUT), or electrochemica

214 Diamine putrescine (Put) and polyamines; spermidine (Spd) and spermine (Spm) are essential compon

215 ved three biogenic amines: putrescine (Put), spermidine (Spd) and spermine (Spm), and their derivativ

216 catalyse the conversion of spermine (Spm) to spermidine (Spd) in vitro.

217 transgenic lines accumulate higher levels of spermidine (Spd) than the wild-type plants and were exam

218 Polyamines, including spermine (Spm) and spermidine (Spd), are aliphatic cations that are reporte

219 AP), putrescine (Put), cadaverine (Cad), and spermidine (Spd), as carbon and/or nitrogen sources.

220 PA model compound, i.e. putrescine (PUT) or spermidine (SPD), or with no addition as controls (CTRs)

221 esence of the triply positively charged base spermidine (Spd).

222 rabidopsis thaliana an early drought-induced spermidine spermine-N(1) -acetyltransferase homolog, whi

223 adaverine, tryptamine, beta-phenylethylamine spermidine, spermine were analysed by UV detection after

224 eractions of natural polyamines (putrescine, spermidine, spermine) and polyamine-like potent OCT1 blo

225 nalyzed rectal mucosal levels of polyamines (spermidine, spermine, and putrescine) and PGE2, treatmen

226 ven biogenic amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine and tryptamine

227 ght biogenic amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine, tryptamine an

228 ght biogenic amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine, tryptamine an

229 f the following: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not restore the

230 The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an e

231 ng enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encode

232 N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) is a crucia

233 ccelerates cell migration through binding of spermidine/spermine acetyltransferase (SSAT) to the alph

234 d by an upregulation of the degrading enzyme spermidine/spermine acetyltransferase.

235 The enzyme spermidine/spermine N (1)-acetyltransferase (SSAT) catal

236 Spermidine/spermine N(1)-acetyltransferase (SAT1) was co

237 diethylnorspermine (DENSpm), an activator of spermidine/spermine N(1)-acetyltransferase (SAT1).

238 pression of the polyamine-acetylating enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) signif

239 m resulted in a rapid induction of host cell spermidine/spermine N(1)-acetyltransferase 1 (hSSAT-1) m

240 by overexpression of a key catabolic enzyme, spermidine/spermine N(1)-acetyltransferase 1 (SAT1) in m

241 Spermidine/spermine N(1)-acetyltransferase 1 (SSAT1), wh

242 Here, we identified the SAT1 (spermidine/spermine N(1)-acetyltransferase 1) gene as a

243 Spermidine/spermine N(1)-acetyltransferase 2 (SSAT2) or

244 Moreover, P-S induces spermidine/spermine N(1)-acetyltransferase enzymatic act

245 ogen induces the first and regulatory enzyme spermidine/spermine N1-acetyltransferase (SSAT) in a pol

246 localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close

247 expression of the catabolic polyamine enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1).

248 urth, we show that the blood levels of SAT1 (spermidine/spermine N1-acetyltransferase 1), the top bio

249 e that androgen induces an overexpression of spermidine/spermine N1-acetyltransferase, the rate-limit

250 In this study, we demonstrate that spermidine/spermine-N(1)-acetyltransferase (SSAT) 2 play

251 synthesis of the polyamine catabolic enzyme spermidine/spermine-N(1)-acetyltransferase (SSAT) in res

252 ntial and emphasize the importance of normal spermidine:spermine ratio in the hearing and balance fun

253 concentrations, the polyamines spermine and spermidine stimulate codon recognition by the ribosome w

254 known and so are the molecular mechanisms of spermidine-stimulated biofilm development.

255 ell as the internal and distal amines in the spermidine substrate.

256 Spermidine supplementation of the medium did not circumv

257 ic flux by treating cells with the polyamine spermidine suppresses prion formation in mutants that no

258 When cyclohexylamine, a spermidine synthase (SPDS) inhibitor, was added at the s

259 parasite virulence, a cell line deficient in spermidine synthase (SPDSYN), the enzyme that converts p

260 nosylmethionine decarboxylase (AdoMetDC) and spermidine synthase (SpdSyn).

261 Mechanistically, ABHD5 suppresses spermidine synthase (SRM)-dependent spermidine productio

262 We have expressed a yeast spermidine synthase (ySpdSyn) gene under constitutive (C

263 num lycopersicum) lines overexpressing yeast spermidine synthase (ySpdSyn), an enzyme involved in pol

264 Treatment of cells with a spermidine synthase inhibitor increased spermidine uptak

265 D (adenosylmethionine decarboxylase), speE (spermidine synthase), speF (inducible ornithine decarbox

266 iling revealed that the enzymatic product of spermidine synthase, spermidine, cycles as well.

267 shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosyn

268 lations, such as ornithine decarboxylase and spermidine synthase.

269 zymes S-adenosylmethionine decarboxylase and spermidine synthase.

270 Using yeast two-hybrid assays, we identified Spermidine Synthase2 (SPDS2), a key enzyme involved in p

271 of stored SPDS mRNAs, leading to substantial spermidine synthesis in the spermatids.

272 ne (Gsp) and trypanothione (bis(glutathionyl)spermidine (T(SH)2)).

273 Upon addition of spermine and spermidine, the characteristic surface plasmon resonance

274 a cells are grown with low concentrations of spermidine, there is a large decrease in the amount of h

275 At high concentrations of spermidine, this condensation significantly increases th

276 FN-gamma signaling, upon coadministration of spermidine to IFN-gamma-treated cells.

277 h this inhibitor reduced the cells' ratio of spermidine to norspermine by decreasing the putrescine p

278 In the group that received DFMO/sulindac, spermidine-to-spermine ratio (Spd:Spm) in rectal mucosa

279 e under stress conditions and for preventing spermidine toxicity.

280 Thus, Dur3p and Dur31p are preferential spermidine transporters used by Hst 5 for its entry into

281 mpaction agents were investigated: trivalent spermidine, Triquat A, and Triquat 7; tetravalent spermi

282 ine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamine) in fish tissues.

283 eG is the enzyme responsible for acetylating spermidine under stress conditions and for preventing sp

284 th a spermidine synthase inhibitor increased spermidine uptake and Hst 5 killing, whereas protonophor

285 We found spermidine uptake and Hst 5 mediated killing were decrea

286 eas protonophores and cold treatment reduced spermidine uptake.

287 train increased Hst 5 sensitivity and higher spermidine uptake.

288 The increase in spermidine was accompanied by reduced levels of nicotina

289 e 2 was found to increase 4- to 10-fold when spermidine was added to the binding reaction.

290 o investigate whether activation of TCPTP by spermidine was capable of alleviating IFN-gamma-induced,

291 ave not been reported before, and dicaffeoyl spermidine was detected in high abundance in the extract

292 Spermidine was the prevailing polyamine in caprine sampl

293 SYN), the enzyme that converts putrescine to spermidine, was created by double-targeted gene replacem

294 gene, CV86, proposed to act on monoacylated spermidines, was isolated and partially characterized.

295 The contents of spermine and spermidine were low and did not exceed the values of 35

296 g concentrations of putrescine, spermine and spermidine were observed with chilled ageing period and

297 Spermine and spermidine were the prevalent amines (100%), followed by

298 aled elevated levels of many amino acids and spermidine, which links the induction of autophagy in Ma

299 gation of Tyr-Au NPs induced by spermine and spermidine, which results to restore fluorescence of Tyr

300 scripts of rpoS were elevated in response to spermidine, which was correlated with increased protein