ライフサイエンスコーパス: spermine

1 to the CP-AMPAR antagonist 1-naphthyl acetyl spermine.

2 with respect to the reaction spermidine --> spermine.

3 which function is to convert spermidine into spermine.

4 nd decreases only an order of magnitude with spermine.

5 rescine and cadaverine but not spermidine or spermine.

6 recorded in situ but blocked the effects of spermine.

7 itive with respect to the substrates DAP and spermine.

8 le changes in gene expression in response to spermine.

9 r than those formed in buffer or buffer plus spermine.

10 induction and gene regulation in response to spermine.

11 s adjacent to these elements were induced by spermine.

12 the side chain of Glu92 and the N1 amine of spermine.

13 chains of Glu92, Asp93, and the N4 amine of spermine.

14 hate, nicotinamide adenine dinucleotide, and spermine.

15 ally through catabolism of spermidine and/or spermine.

16 plex with coenzyme A, with and without bound spermine.

17 cine, spermidine, acetylated spermidine, and spermine.

18 re isolated from selection plates containing spermine.

19 ase, and spermine synthase) and reduction of spermine.

20 These plants also contain high levels of spermine.

21 rae showed that it acetylates spermidine and spermine.

22 eroxide from the catabolism of the polyamine spermine.

23 nzyme A to polyamines such as spermidine and spermine.

24 (0.1-1.8), N(1),N(14)-bis-(dihydrocaffeoyl) spermine (0.2-1.7), N(1),N(10)-bis-(dihydrocaffeoyl) spe

25 ed the PIP(2)-induced inward current by 69%; spermine (100 microM) reduced the current by 97%.

26 With the exception of spermidine and spermine a wide variation of BA levels was observed amon

27 ctions between duplex DNA in the presence of spermine, a biological polycation.

28 y in cells was also shown to be inhibited by spermine, a porin inhibitor, although in an in vitro ass

29 tabolic enzymes of the polyamine pathway and spermine abundance in 120 well-characterized cases of hu

30 and 19F NMR data show that 1 mM SDS and 1 mM spermine accelerate aggregation compared to buffer alone

31 The structure of the SSAT-spermine-acetyl-coenzyme A complex suggested that Tyr140

32 The bisubstrate analogue, N1-spermine-acetyl-coenzyme A, exhibited linear, competitiv

33 ion of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) is a crucial step in t

34 cell migration through binding of spermidine/spermine acetyltransferase (SSAT) to the alpha9 cytoplas

35 egulation of the degrading enzyme spermidine/spermine acetyltransferase.

36 Here, we report that spermine acts as an exogenous cue that inhibits V. chole

37 ed NspS protein could bind spermine in vitro Spermine also inhibited biofilm formation by altering th

38 Binding of spermine, an allosteric potentiator, opens the amino-ter

39 Remarkably, slightly longer synthetic spermine analogs (BE-spermine, CGC-11098) significantly

40 noparticles compared to their non-degradable spermine analogues.

41 bove a critical concentration of tetravalent spermine and are stable over long times at room temperat

42 non-competitive manner with respect to both spermine and DAP.

43 -reaction depend on the aging time after the spermine and enzyme are mixed in a double-mixing experim

44 ture than the molecular aggregation inducers spermine and heparin.

45 sensitivity to blockade by 1-naphthyl-acetyl-spermine and large single-channel conductances.

46 With both spermine and N(1)-acetylspermine as the amine substrate,

47 omyces cerevisiae catalyzes the oxidation of spermine and N(1)-acetylspermine to spermidine and 3-ami

48 Interactions between the polyamine spermine and nucleic acids drive important cellular proc

49 tation experiments on DNA in the presence of spermine and other condensing agents.

50 hich the ratio between the concentrations of spermine and oxygen is kept constant establishes the ste

51 eby flux is initiated by SSAT acetylation of spermine and particularly spermidine followed by a marke

52 Spermine and putrescine, the endogenous polyamine and me

53 idine, Triquat A, and Triquat 7; tetravalent spermine and Quatro-quat; and hexavalent Quatro-diquat.

54 gnificant positive effect of storage time on spermine and serotonin levels.

55 resent study, polyamine oxidase specific for spermine and spermidine and diamine oxidase specific for

56 Because spermine and spermidine are effective blockers of K(+) i

57 Here, we demonstrate that the polyamines spermine and spermidine are environmental signals that a

58 Our results indicate that spermine and spermidine are novel triggers to alert F. t

59 orimetric and fluorescence turn-on assays of spermine and spermidine in biological samples.

60 ive detection of prostatic cancer biomarkers spermine and spermidine in real clinical applications wi

61 at low Mg(2+) concentrations, the polyamines spermine and spermidine stimulate codon recognition by t

62 The contents of spermine and spermidine were low and did not exceed the

63 Increasing concentrations of putrescine, spermine and spermidine were observed with chilled agein

64 Spermine and spermidine were the prevalent amines (100%)

65 unknown substrates, such as polyamines (e.g. spermine and spermidine).

66 Upon addition of spermine and spermidine, the characteristic surface plas

67 ing the aggregation of Tyr-Au NPs induced by spermine and spermidine, which results to restore fluore

68 a product of polyamine oxidase metabolism of spermine and spermidine.

69 veral of the intermolecular contacts between spermine and the enzyme and form a "proton wire" between

70 natural polyamines (putrescine, spermidine, spermine) and polyamine-like potent OCT1 blockers (1,10-

71 e AMPAR antagonist [NASPM (1-naphthyl acetyl spermine)] and a specific phosphoinositide 3 kinase (PI3

72 nst the substrates 1,5-diaminopentane (DAP), spermine, and fibrillar type I collagen.

73 al mucosal levels of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens,

74 ion, conformational changes induced by urea, spermine, and sodium dodecyl sulfate (SDS), its interact

75 nary complexes with CoA, acetyl-CoA (AcCoA), spermine, and the inhibitor N1,N11bis-(ethyl)-norspermin

76 We find that both DAP and spermine are capable of activating LOXL2 to the same ext

77 Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they regu

78 When small numbers of spermine are introduced, RNA with a designed sequence co

79 Putrescine, spermidine, and spermine are the polyamines required for human cell grow

80 Polyamines (putrescine, spermidine, and spermine) are major organic polycations essential for a

81 The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved

82 ease in MPS patients, and support the use of spermine as a new biomarker to facilitate the developmen

83 50-fold for both mutations; the effects with spermine as the substrate are smaller, 20-40-fold.

84 tamine, serotonine, tyramine, spermidine and spermine), as well as microbiological profile (lactic ac

85 oups from acetylcoenzyme A to spermidine and spermine, as part of a polyamine degradation pathway.

86 ication, which was enhanced by intracellular spermine, as was UDU.

87 tional KCl electrodiffusion potential on the spermine association and dissociation rates.

88 olecules in the cell despite the presence of spermine at concentrations high enough to precipitate DN

89 involved in the conversion of spermidine and spermine back to putrescine.

90 st likely due to depletion of spermidine and spermine, because stable polyamine analogs that are not

91 tic scheme in which weakly voltage-dependent spermine binding to a "shallow" site in the pore (presum

92 Here, we study the effect of spermine binding to short duplex RNA and DNA, and compar

93 contrast, for DNA, simulations suggest that spermine binds externally to the duplex, offering opport

94 inding sites in a Kir pore, and confirm that spermine binds stably at a deep site in the inner cavity

95 constants (K(d)) and kinetics of unilateral spermine block on wild-type Cx40 gap junctions were dete

96 Spermine, but not spermidine, enhanced NMDA-induced depo

97 Putrescine and spermine, but not spermidine, showed evidence of co-oper

98 of the polyamines putrescine, spermidine and spermine by controlling stability of the polyamine biosy

99 The N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT)

100 idence that 3'ddR5p derivatives generated by spermine-catalyzed strand cleavage at Ap sites in duplex

101 ightly longer synthetic spermine analogs (BE-spermine, CGC-11098) significantly increased the protect

102 tant for the slow step is independent of the spermine concentration, with a value of 5.5 s(-1), compa

103 In the absence of IHF, spermidine and spermine condense DNA primarily into toroidal structures

104 Spermine condenses DNA and some RNAs, such as poly(rA):p

105 been explored for the sensitive detection of spermine (considered as an excellent biomarker for early

106 ophenylhydrazone and methylamine, but not by spermine, consistent with an active transport process.

107 reduced by 25%, 50%, or 75% relative to the spermine-containing side, the transjunctional voltage (V

108 ree polyamines showed that only the triamine spermine could specifically rescue the S-dependent repro

109 examethasone spermine (DS) and disubstituted spermine (D(2)S), were tested as individual components a

110 15 h and then decreased after 24 h, whereas spermine decreased by 3.9-fold after 15 h.

111 after the onset of diabetes, an increase in spermine-dependent oxidation at proximal microvascular s

112 We conclude that spermine-dependent oxidation is a previously unrecognize

113 annels; in addition to a physiological role, spermine-dependent oxidation may also contribute to micr

114 In addition, our observation that spermine-dependent oxidation occurs predominately in the

115 electrophysiologically, based on measures of spermine-dependent rectification and CP-AMPAR blockade b

116 facilitation that arose from an activity and spermine-dependent unblock of GluR2-lacking receptors an

117 henolic glycosides, a monoterpene lactone, a spermine derivative, and fatty acids, could be identifie

118 ed macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and

119 M), but the related compounds cadaverine and spermine did not bind.

120 Polyamines spermidine and spermine did not show statistically significant changes

121 The polyamines spermidine and spermine did not show statistically significant changes

122 Polyamines spermidine and spermine did not show statistically significant changes

123 anine from malonate semialdehyde, l-alanine, spermine, dihydrouracil, and acryloyl-coenzyme A (CoA).

124 Hill coefficients for the spermine dose-response curves were approximately 0.58, i

125 vities of two cationic lipids, dexamethasone spermine (DS) and disubstituted spermine (D(2)S), were t

126 ompetitive inhibitor, and two do not contain spermine (E(ox)).

127 Four of the active sites contain spermine (EI), a weak competitive inhibitor, and two do

128 At lower concentrations, spermine enhanced capsaicin-evoked currents with an EC50

129 Synthalin did not block spermine enhancement of NMDA-induced depolarization of m

130 and its complexes with p-xylylenediamine and spermine establish the flexibility of the methylene brid

131 The k(cat)/K(M) value for spermine exhibits a bell-shaped pH profile, with an aver

132 of the CP-AMPAR antagonist 1-naphthyl acetyl spermine followed by a seeking test, or 3) systemic admi

133 nteractions are similar to those of the pure-spermine form of the d(CGCGCG)(2) structure.

134 f thymine acts as a steric block, relocating spermine from major grooves to interhelical regions, the

135 n at intermediate voltages, and exclusion of spermine from the pore at negative voltages.

136 this was also reversed by the production of spermine from the spermine synthase transgene.

137 tate the direct and noninvasive detection of spermine from urine rapidly and is likely to have great

138 The tetramine spermine has been reported to be present at nearly 50 mu

139 rofile is consistent with the active form of spermine having three charged nitrogens.

140 amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine and tryptamine) were deter

141 amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine, tryptamine and phenylethy

142 amines (putrescine, cadaverine, spermidine, spermine, histamine, tyramine, tryptamine and phenylethy

143 Putrescine, spermidine, and spermine (i.e., polyamines) are small cationic amines sy

144 sphorylation was stimulated by the polyamine spermine in a dose-dependent manner.

145 rimetric assay to detect nanomolar levels of spermine in human urine (healthy donors, cancer patients

146 The content of spermidine and spermine in mammalian cells has important roles in prote

147 f the polyamines putrescine, spermidine, and spermine in mutant inflorescences.

148 Reduction of SMO by spermine in the absence of oxygen is biphasic.

149 omyces cerevisiae catalyzes the oxidation of spermine in the biosynthetic pathway for pantothenic aci

150 th NspS, as purified NspS protein could bind spermine in vitro Spermine also inhibited biofilm format

151 daverine) and two polyamines (spermidine and spermine) in 112 samples of dairy products purchased in

152 evealed a marked elevation of the polyamine, spermine, in affected animals, and gene therapy studies

153 imary function of polyamines, spermidine and spermine, in translation in mammalian cells.

154 2-lacking AMPAR antagonist, 1-naphthylacetyl spermine, indicative of an increased contribution of Glu

155 hodamine (TAMRA) with a metal surface, using spermine induced aggregated silver nanoparticles as the

156 e (D646N) or glutamate 648 (E648A) inhibited spermine-induced sensitization.

157 negative cooperativity and possible multiple spermine inhibitory sites.

158 We determined if spermine inhibits iNOS-mediated immunity by reducing L-A

159 Spermine inhibits rat connexin40 (Cx40) gap junctions.

160 ecreased by intra-NAc core 1-naphthyl acetyl spermine injection or systemic mGluR1 positive allosteri

161 mine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2), which c

162 SMO/PAOh1 oxidizes spermine into spermidine, 3-aminopropanal, and H(2)O(2).

163 packaged DNA length and through addition of spermine ions, we transform the interaction energy from

164 Hence, spermine is a candidate for mediating the effect of diab

165 The observed protection profile of spermine is identical to that previously reported, with

166 ofiles with simulation results suggests that spermine is sequestered deep within the major groove of

167 l] resulted in intermediate decreases in the spermine K(d)s, indicative of a minor electrostatic effe

168 Low spermine levels were found in milk irrespective of SCC.

169 These data are consistent with a single spermine molecule being sufficient to occlude the Cx40 g

170 The enzyme spermidine/spermine N (1)-acetyltransferase (SSAT) catalyzes the tr

171 Spermidine/spermine N(1)-acetyltransferase (SAT1) was co-immunoprec

172 permine (DENSpm), an activator of spermidine/spermine N(1)-acetyltransferase (SAT1).

173 ng with a concomitant increase in spermidine/spermine N(1)-acetyltransferase (SSAT) expression in A54

174 the polyamine-acetylating enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) significantly inc

175 ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1)

176 in a rapid induction of host cell spermidine/spermine N(1)-acetyltransferase 1 (hSSAT-1) mRNA, causin

177 ession of a key catabolic enzyme, spermidine/spermine N(1)-acetyltransferase 1 (SAT1) in mammalian ce

178 Spermidine/spermine N(1)-acetyltransferase 1 (SSAT1), which catalyz

179 Here, we identified the SAT1 (spermidine/spermine N(1)-acetyltransferase 1) gene as a transcripti

180 Spermidine/spermine N(1)-acetyltransferase 2 (SSAT2) or inactive SS

181 Moreover, P-S induces spermidine/spermine N(1)-acetyltransferase enzymatic activity, and

182 thaliana an early drought-induced spermidine spermine-N(1) -acetyltransferase homolog, which can slow

183 n this study, we demonstrate that spermidine/spermine-N(1)-acetyltransferase (SSAT) 2 plays an essent

184 of the polyamine catabolic enzyme spermidine/spermine-N(1)-acetyltransferase (SSAT) in response to in

185 s the first and regulatory enzyme spermidine/spermine N1-acetyltransferase (SSAT) in a polyamine cata

186 the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity

187 Spermidine/spermine N1-acetyltransferase (SSAT) is a key enzyme in

188 of the catabolic polyamine enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1).

189 ow that the blood levels of SAT1 (spermidine/spermine N1-acetyltransferase 1), the top biomarker iden

190 whereby the expression status of spermidine/spermine N1-acetyltransferase alters body fat accumulati

191 systemically overexpressed and in spermidine/spermine N1-acetyltransferase knock-out mice.

192 e investigate this possibility in spermidine/spermine N1-acetyltransferase transgenic mice in which t

193 The acetylating enzyme, spermidine/spermine N1-acetyltransferase, participates in polyamine

194 ogen induces an overexpression of spermidine/spermine N1-acetyltransferase, the rate-limiting enzyme

195 GluR2-lacking AMPARs with 1-naphthyl acetyl spermine (NAS) caused a greater reduction in the AMPAR-E

196 ith a specific antagonist, 1-naphthyl acetyl spermine (NASPM), reversed the apparent increase in AMPA

197 the presence of nitric oxide, delivered from spermine NONOate, or increased ectonucleotidase levels (

198 Questions remain as to whether spermine occludes the channel within the ion permeation

199 identical to that previously reported, with spermine occupancy inhibiting MTSEA modification of resi

200 hough in an in vitro assay, the influence of spermine on the activity of isolated NDM-1 protein is mi

201 olyamine analogs that are similar in size to spermine on the rate of MTSEA modification.

202 The spermine on-rates and off-rates, calculated from the jun

203 ontrol airways by the higher-order polyamine spermine or by cell-permeable PIP2, but these interventi

204 Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO

205 and polyamine precursors, supplementation of spermine or spermidine in the borrelial growth medium in

206 ing: (i) addition of putrescine, spermidine, spermine, or N(1)-AcSpd did not restore the expression o

207 Spermidine and spermine originate mainly from raw materials.

208 In mammalian cells, the flavoprotein spermine oxidase (SMO) catalyzes the oxidation of spermi

209 Spermine oxidase (SMO) is a polyamine catabolic enzyme t

210 th H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.

211 Spermine oxidase (SMO) metabolizes the polyamine spermin

212 all interfering RNA (siRNA) strategies to be spermine oxidase (SMO/PAOh1).

213 ng pathogen Helicobacter pylori up-regulates spermine oxidase (SMOX) in gastric epithelial cells, cau

214 The polyamine catabolic enzyme spermine oxidase (SMOX) is induced in chronic inflammato

215 During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydr

216 In contrast, host cell SSAT-2, spermine oxidase, and acetylpolyamine oxidase (hAPAO) re

217 is catalyzed by the mammalian polyamine and spermine oxidases.

218 Dietary polyamines spermidine and spermine participate in an array of physiological roles

219 Spermine, poly-D-lysine, and neomycin all reduced the ba

220 At 24 h, 56% of the spermine pool in the induced SSAT cells was fluorine-lab

221 A large fraction of the spermine present in cells is bound to RNA but apparently

222 Spermine promoted the accumulation of camalexin by induc

223 The complex with spermine provides a direct view of substrate binding by

224 The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential cla

225 p that received DFMO/sulindac, spermidine-to-spermine ratio (Spd:Spm) in rectal mucosa decreased betw

226 mphasize the importance of normal spermidine:spermine ratio in the hearing and balance functions of t

227 y studies demonstrated that reduction of CSF spermine reflects correction of brain lesions in these a

228 Polyamines, including spermine, regulate the interactions of F. tularensis wit

229 Growth of Pseudomonas aeruginosa on spermine requires a functional gamma-glutamylpolyamine s

230 Accumulation of polyphosphate granules and spermine resistance in the suppressor were reversed conc

231 es (75-124 and 11-24 mg/kg of spermidine and spermine, respectively).

232 mechanism of gene regulation controlled by a spermine-responsive promoter contained within IS element

233 identified FTL_0883 as a gene important for spermine responsiveness.

234 Here we report that at concentrations of spermine several-fold higher the MT bundles (B(MT)) quic

235 sociated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modul

236 d in frog motoneurons in situ and also for a spermine specific polyamine site on native NMDA receptor

237 hich have aliphatic (putrescine, cadaverine, spermine, spermidine), aromatic (tyramine, phenylethylam

238 Multicationic amines (spermine, spermidine, and neomycin) were found to effect

239 Extracellular spermine, spermidine, and putrescine directly activated

240 Eight biogenic amines (spermine, spermidine, putrescine, histamine, tyramine, p

241 ne, histamine, phenylethylamine, putrescine, spermine, spermidine, tyramine and tryptamine) in fish t

242 The spermine/spermidine ratio in lymphoblasts was 0.53, sign

243 rmine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth

244 Simulations carried out with Mg(2+) or spermine (SPM(4+)) show that these ions interact with po

245 Polyamines, including spermine (Spm) and spermidine (Spd), are aliphatic catio

246 e (Put) and polyamines; spermidine (Spd) and spermine (Spm) are essential component of every cell bec

247 Finally, we determined spermine (SPM) sensitivity of these uncharacterized SNPs

248 PAO) was found to catalyse the conversion of spermine (Spm) to spermidine (Spd) in vitro.

249 ines: putrescine (Put), spermidine (Spd) and spermine (Spm), and their derivatives.

250 The effects of methyl jasmonate (MeJA), spermine (Spm), epibrassinolide (EBL) and l-phenylalanin

251 e of the most important biogenic polyamines; spermine (SPM), spermidine (SPD) and putrescine (PUT), o

252 DC and two metabolite ratios (citrate [Cit], spermine [Spm], and creatine [Cr] to choline [Cho] and C

253 presence of cobalt hexammine, spermidine, or spermine, stretched DNA exhibits an abrupt configuration

254 Uptake of unchelated Cu is inhibited by spermine, suggesting a porin-dependent passive transport

255 onductance and strong block by intracellular spermine, suggesting that they were 'TARPless'.

256 Global c-di-GMP levels were unaffected by spermine supplementation, suggesting that biofilm format

257 caused by a significant decrease or loss of spermine synthase (SMS) activity.

258 Spermine synthase (SMS) is an enzyme which function is t

259 Loss-of-function mutations in spermine synthase (SMS), a polyamine biosynthesis enzyme

260 tion Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine

261 ersed by the production of spermine from the spermine synthase transgene.

262 transgenic line that ubiquitously expresses spermine synthase under the control of a composite cytom

263 nzymes analyzed (ODC, polyamine oxidase, and spermine synthase) and reduction of spermine.

264 n in polyamine content due to the absence of spermine synthase, the product of the SpmS gene.

265 so prevented by the transgenic expression of spermine synthase.

266 clic polyamine disulfide was shown to be the spermine tetra-amine disulfide (TetraN-3,4,3).

267 mean concentrations showed greater levels of spermine than spermidine, except for the 5th day post-pa

268 We show, using sensitivity to intracellular spermine, that a similar switch occurs between P12 and P

269 N1-acetylspermine, N1-acetylspermidine, and spermine, the k(cat)/K(amine)-pH profiles are bell-shape

270 Not only subjected to growth inhibition by spermine, the pauA2 mutant became more sensitive to beta

271 no effect on the k(cat)/K(amine) profile for spermine; the k(red) value with N1-acetylspermine is onl

272 lyzes the N(1)-acetylation of spermidine and spermine to form acetyl derivatives, is a rate-limiting

273 ine oxidase (SMO) catalyzes the oxidation of spermine to spermidine and 3-aminopropanal.

274 cs defect can be partially rescued by adding spermine to the growth medium, whereas the defects in ca

275 nd scavenging capacity; ii) high contents of spermine, total biogenic amines and total polyamines; an

276 o rapid depletion of cellular spermidine and spermine, total inhibition of protein synthesis, and gro

277 as a potential protection mechanism against spermine toxicity.

278 , and N(1),N(5),N(14)-tris-(dihydrocaffeoyl) spermine (trace - 11.1).

279 sed amino acid, lysine-trimethylene(diNosyl)-spermine(triBoc) with Dde or Fmoc orthogonal protecting

280 transformation pathway, which results from a spermine-triggered conformation switch from straight to

281 uman cells, as acetylation of spermidine and spermine triggers export or degradation.

282 Consistent with this, 1-naphthylacetyl spermine trihydrochloride (NASPM), an antagonist of GluA

283 aying inward tail currents are elicited upon spermine unbinding.

284 rmine derivative 26 was shown to inhibit 14C-spermine uptake (IC50 approximately 10 microM), which im

285 on and CP-AMPAR blockade by 1-naphtyl acetyl spermine using recordings from synaptically connected ce

286 The threshold for activation by spermine was approximately 500 microm at room temperatur

287 In humans, CSF spermine was elevated in neuropathic subtypes of MPS (MP

288 neurons from MPS I mice showed that elevated spermine was essential for the abnormal neurite overgrow

289 In MPS I patients, elevated CSF spermine was restricted to patients with genotypes assoc

290 Spermine was sufficient to activate transcription of the

291 ryptamine, beta-phenylethylamine spermidine, spermine were analysed by UV detection after pre-column

292 Putrescine, spermidine and spermine were measured as dansylated derivatives by high

293 tyramine) and two polyamines (spermidine and spermine) were detected in cocoa beans during fermentati

294 dine and phenylethylamine to 0.2mgkg(-1) for spermine) when compared to FD (from 1mgkg(-1) for putres

295 e 646 (D646N) abolished direct activation by spermine, whereas neutralization of this same aspartate

296 Cheese from all SCC categories contained spermine; whereas tyramine and tryptamine were only dete

297 und for putrescine (and hence spermidine and spermine), which was proposed to convert into 4-aminobut

298 Spermidine and spermine, which enhance duplex stability, inhibited tran

299 of these channels is driven by the polyamine spermine, whose catabolism produces oxidants.

300 polyamine synthesis and could be mimicked by spermine, whose concentration is elevated in the diabeti

301 bably occurs through a direct interaction of spermine with NspS, as purified NspS protein could bind