ライフサイエンスコーパス: spermine synthase

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1 so prevented by the transgenic expression of spermine synthase.

2 from both spermidine synthase (2.5.1.16) and spermine synthase (2.5.1.22).

3 nt these alterations were due to the loss of spermine synthase activity, since this chromosomal delet

4 This mutant has neither spermine nor spermine synthase activity.

5 e is formed from spermidine by the action of spermine synthase, an aminopropyltransferase, whose gene

6 y-CAG/SpmS mice had extremely high levels of spermine synthase and contained spermine in all tissues

7 to reside in the ACL5 gene, which encodes a spermine synthase and whose expression is specific to pr

8 nzymes analyzed (ODC, polyamine oxidase, and spermine synthase) and reduction of spermine.

9 ertility in male mice and that regulation of spermine synthase content is not required.

10 transgenic mice (CAG/SpmS mice) that express spermine synthase from the ubiquitous CAG promoter.

11 ects of the Gy and Hyp mutations on both the spermine synthase gene and the Pex gene.

12 Four missing introns of the spermine synthase gene were identified in Gy male mice,

13 with a recessively expressed mutation of the spermine synthase gene, leading to spermine deficiency,

14 Since the gene for spermine synthase is immediately upstream of the homolog

15 we identified the SPE4 gene, which codes for spermine synthase, on the right arm of chromosome XII of

16 tion Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine

17 caused by a significant decrease or loss of spermine synthase (SMS) activity.

18 Spermine synthase (SMS) is an enzyme which function is t

19 Loss-of-function mutations in spermine synthase (SMS), a polyamine biosynthesis enzyme

20 mapped and analyzed another gene 5' of PEX, spermine synthase (SpS), which encodes a ubiquitous enzy

21 n in polyamine content due to the absence of spermine synthase, the product of the SpmS gene.

22 ersed by the production of spermine from the spermine synthase transgene.

23 transgenic line that ubiquitously expresses spermine synthase under the control of a composite cytom

24 A pseudogene for spermine synthase was also identified in the mouse genom

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