ライフサイエンスコーパス: sphingolipid

1 cumulation of cholesterol, plasmalogens, and sphingolipids.

2 mains, which are enriched in cholesterol and sphingolipids.

3 to lysosomal accumulation of cholesterol and sphingolipids.

4 of major classes of glycerophospholipids and sphingolipids.

5 ension resulting from a gradual depletion of sphingolipids.

6 jasmonate signaling pathway, cell death, and sphingolipids.

7 thesized to be enriched with cholesterol and sphingolipids.

8 ramide, a key step in the synthesis of brain sphingolipids.

9 t produces fundamental precursors of complex sphingolipids.

10 centrations of some glycerophospholipids and sphingolipids.

11 associations between COPD subphenotypes and sphingolipids.

12 novo biosynthesis and recycling of exogenous sphingolipids.

13 balance between proapoptotic and prosurvival sphingolipids.

14 d messengers for metabolism and signaling of sphingolipids.

15 ex, where ceramides are converted to complex sphingolipids.

16 bolic interactions between glycerolipids and sphingolipids.

17 and intercepts Golgi Rab vesicles to acquire sphingolipids.

18 Sphingolipids, a large family of bioactive lipids, are i

19 orferi contains cholesterol lipids, it lacks sphingolipids-a crucial component of rafts in eukaryotes

20 oid plaque formation, neuronal degeneration, sphingolipid, Abeta42 and phospho-tau levels, and memory

21 -22) and glucosylsphingosine (LGL1), 2 major sphingolipids accumulated in GD, can be recognized by a

22 We propose that glucosylsphingosine, a sphingolipid accumulating in GD, mediates PD pathology i

23 NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant

24 ) and picodiscs, which are composed of human sphingolipid activator protein saposin A and a small num

25 We show that sphingolipid acyl-chain length influences the morphology

26 Our results uncover that the sphingolipids acyl-chain length links lipid composition

27 The biosynthetic pathway of the sphingolipids affords many opportunities for therapeutic

28 e report here the 2.6 A crystal structure of sphingolipid alpha-hydroxylase (Scs7p), a yeast homolog

29 nts articles about three novel subspecies of sphingolipids, alpha-galactosylceramides, 4,5-dihydrocer

30 acylcarnitines, acylglycines, phospholipids, sphingolipids, amino acids and derivatives, free fatty a

31 These enzymes convert sphingolipid and lysolipid substrates to cyclic phosphat

32 e sicariid toxins against a diverse panel of sphingolipid and lysolipid substrates.

33 The sphingolipid and phospholipid metabolism were profoundly

34 Sphingosine 1-phosphate (S1P) is a sphingolipid and the natural ligand for five G protein-c

35 nd zaragozic acid to prevent biosynthesis of sphingolipids and cholesterol and analyzed by immunoblot

36 xchange can be used to maximally replace the sphingolipids and phospholipids in the outer leaflet of

37 Lipids such as sphingolipids and sterols have been implicated in polar

38 ns, little is still known about the roles of sphingolipids and their metabolites.

39 almitate to increase synthesis of endogenous sphingolipids and to inhibit insulin signaling and oxida

40 spiration and intramyocellular triglyceride, sphingolipid, and diacylglycerol content were measured i

41 MEK1/extracellular signal-regulated kinase, sphingolipid, and nuclear factor-kappaB.

42 enrichment in hexoses, glycerophospholipids, sphingolipids, and acylcarnitines, while deplete in the

43 ogenesis, including primarily phospholipids, sphingolipids, and bile acids.

44 omic analysis of a variety of phospholipids, sphingolipids, and ceramides among 154 human liver tissu

45 ed imbalance of amino acids, acylcarnitines, sphingolipids, and glycerophospholipids in the liver and

46 aptive response as a result of modulation of sphingolipids, and it demonstrates an immunomodulatory r

47 rophospholipids (both diacyl and aryl-acyl), sphingolipids, and nonpolar lipids (diacyl and triacylgl

48 We further found that phospholipids, sphingolipids, and other membrane lipids were significan

49 ipids, polyketides, prenols, saccharolipids, sphingolipids, and sterols.

50 Sphingolipid- and cholesterol-rich liquid-ordered (Lo) l

51 d stomatin, proteins known to associate with sphingolipid- and cholesterol-rich microdomains.

52 fect in beta-cells, an enhanced level of the sphingolipid antagonizes insulin-mediated cell growth an

53 The traditional backbones of mammalian sphingolipids are 2-amino, 1,3-diols made by serine palm

54 Sphingolipids are a diverse class of essential cellular

55 Sphingolipids are a major component of plant plasma memb

56 Sphingolipids are abundant membrane components and impor

57 ry behavior, because ethanolamine-containing sphingolipids are common in insect prey.

58 Sphingolipids are emerging as second messengers in progr

59 Sphingolipids are essential and ubiquitous components of

60 Sphingolipids are essential components of eukaryotic mem

61 Complex sphingolipids are important components of eukaryotic cel

62 Sphingolipids are major components of the plasma membran

63 Sphingolipids are membrane lipids globally required for

64 Membrane sphingolipids are metabolized to sphingosine-1-phosphate

65 Bioactive sphingolipids are modulators of immune processes and the

66 Sphingolipids are often altered in cancer, though how th

67 We propose a model by which TG-derived sphingolipids are required to activate the protein phosp

68 Sphingolipids are synthesized de novo from very long-cha

69 the plasma membrane rich in cholesterol and sphingolipids, are hot spots for a number of important c

70 ucosylceramides (GlcCer), glucose-conjugated sphingolipids, are major components of the endomembrane

71 Although sphingolipids as a class are implicated in the pathogene

72 e categories-adiponectin as a key adipokine, sphingolipids as critical mediators of insulin sensitivi

73 V, potentially by modulating the response to sphingolipids as mediators of HPV.

74 t glycosylinositol phosphorylceramide (GIPC) sphingolipids as NLP toxin receptors.

75 Ceramide-C16 (CerC16) is a sphingolipid associated with several diseases like diabe

76 cking parallel nutrient access pathways with sphingolipid-based drugs is broadly effective and cancer

77 rine with palmitoyl-CoA, the initial step in sphingolipid biogenesis.

78 in 89/130 identified metabolites, including sphingolipids, biogenic amines, amino acids and urea.

79 ransferase (SPT) catalyzes the first step in sphingolipid biosynthesis and is considered the primary

80 Ceramides are key intermediates in sphingolipid biosynthesis and potent signaling molecules

81 Deregulation of sphingolipid biosynthesis and their recycling has been p

82 virus-induced metabolic rewiring of the host sphingolipid biosynthesis during the chemical "arms race

83 To investigate the requirement for de novo sphingolipid biosynthesis in adipocytes, a cell type wit

84 llectively, these data indicate that de novo sphingolipid biosynthesis is required for adipocyte cell

85 cular to the de novo coccolithovirus-encoded sphingolipid biosynthesis pathway.

86 ration in the metabolism of either sterol or sphingolipid biosynthesis resulted in vacuole traffickin

87 endoplasmic reticulum, regulates endothelial sphingolipid biosynthesis with direct effects on vascula

88 metabolic function and that reduced de novo sphingolipid biosynthesis within adipocytes is associate

89 ted by its functional interaction with BasA (sphingolipid biosynthesis) and StoA (apical sterol-rich

90 at ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 wa

91 s for a set of genes involved in the de novo sphingolipid biosynthesis, not reported in any viral gen

92 se, an enzyme catalyzing the initial step of sphingolipid biosynthesis.

93 bit autophagy, namely the disruption of host sphingolipid biosynthesis.

94 serine palmitoyltransferase, a key enzyme of sphingolipid biosynthesis.

95 e (SPT) is a key enzyme in the first step of sphingolipid biosynthesis.

96 the first and rate-limiting step of de novo sphingolipid biosynthesis.

97 talyzing the first and rate-limiting step in sphingolipid biosynthesis: the condensation of serine an

98 ents, thus counteracting fluctuations in the sphingolipid biosynthetic flow.

99 ase, the rate-limiting enzyme of the de novo sphingolipid biosynthetic pathway, thereby controlling p

100 GPL1 executes the final decisive step of the sphingolipid breakdown pathway, mediating the irreversib

101 ves as an essential building hub for complex sphingolipids, but also as an organizer of membrane doma

102 yotes, with saturated PC taking the place of sphingolipids, but with ACGal being the main lipid compo

103 Cells acquire sphingolipids by both de novo biosynthesis and recycling

104 he turnover rate of glycerophospholipids and sphingolipids by direct analysis of total lipid extracts

105 ificantly increases the accuracy of measured sphingolipids by resolving nearly isobaric and isobaric

106 ulans sphingolipid Delta8-desaturase (SdeA), sphingolipid C9-methyltransferases (SmtA/SmtB) and gluco

107 owth cones, whereas the use of inhibitors of sphingolipid cascade identified S1P as the sphingolipid

108 The bioactive sphingolipid ceramide has emerged as an antitumorigenic

109 The sphingolipid ceramide regulates cellular processes such

110 e, we investigated the potential for another sphingolipid, ceramide 1-phosphate (C1P), to modulate ef

111 tonomous erythrocyte defect secondary to the sphingolipid changes caused by HNF1A deficiency.

112 In vivo systemic administration of F. major sphingolipids changes the proportion of IgT(+) to IgM(+)

113 Rs are plasmalemmal microdomains enriched in sphingolipids, cholesterol and scaffolding proteins; the

114 eral diffusion of IFN-gammaR2 is confined by sphingolipid/cholesterol nanodomains.

115 Because recent researches showed a shift in sphingolipid composition from C24:0 to C16:0 in relation

116 on is detailed here with special emphasis on sphingolipid composition of nutritional interest, determ

117 they exhibited normal myelin content, myelin sphingolipid composition, and full reversal of spongy my

118 Ceramide and more complex sphingolipids constitute a diverse group of lipids that

119 The sphingolipid content varies among endomembranes with pre

120 Due to this different sphingolipid content, pre- and post-Golgi membranes serv

121 Aberrant plasma levels of sphingolipids contribute to metabolic disease, atheroscl

122 neumophila triggers the reduction of several sphingolipids critical for macrophage function in an LpS

123 nd conferred resistance to the antimicrobial sphingolipid D-erythro-sphingosine.

124 es were reduced in type I fibers in CON, and sphingolipids decreased in both groups, with EX showing

125 ted the contribution of Aspergillus nidulans sphingolipid Delta8-desaturase (SdeA), sphingolipid C9-m

126 In addition, sphingolipid-dependent signals control phosphorylation o

127 events required for membrane growth generate sphingolipid-dependent signals.

128 try revealed substantial and tissue-specific sphingolipid disturbances in several tissues including e

129 riched with cholesterol nor colocalized with sphingolipid domains.

130 Sphingolipids, endogenous to brain tissue, influence inf

131 ex lipid species (i.e., phosphatidylcholine, sphingolipids, etc) these FA differences occur.

132 Sphingolipids exhibit extreme functional and chemical di

133 Glycerolipids, glycerophospholipids, and sphingolipids exhibited diurnal oscillations, suggesting

134 Results show that sphingolipid expression in induced sputum significantly

135 PIUMet by analyzing changes in metabolism of sphingolipids, fatty acids and steroids in a Huntington'

136 Of the measured plasma sphingolipids, five sphingomyelins were associated with

137 acids, purines, pyrimidines, phospholipids, sphingolipids, free fatty acids, and glycerolipids) whic

138 sphingolipids were strongly associated with sphingolipid gene expression, and 15 sphingolipid gene/m

139 ed with sphingolipid gene expression, and 15 sphingolipid gene/metabolite pairs were differentially r

140 In particular, mTORC2 stimulated sphingolipid (glucosylceramide) and glycerophospholipid

141 We show that, whereas GD-related sphingolipids (glucosylceramide, glucosylsphingosine, sp

142 present the largest lipid class, followed by sphingolipids, glycerolipids, fatty acyls, sterol lipids

143 glycosyl inositol phosphorylceramide (GIPC) sphingolipids has been slow as a result of challenges as

144 ata show that GARP is essential for cellular sphingolipid homeostasis and suggest a therapeutic strat

145 In this mutant, sphingolipid homeostasis is disrupted via depletion of A

146 ough an as-yet unrecognized link of HNF1A to sphingolipid homeostasis.

147 ide synthase activities as part of a broader sphingolipid homeostatic regulatory network.

148 d biosynthesis and is considered the primary sphingolipid homeostatic regulatory point.

149 f GCase by CBE resulted in elevation of both sphingolipids; however, inhibition of GBA2 by NB-DGJ res

150 nes is exemplified in the total synthesis of sphingolipid HPA-12 and the sedamine alkaloids.

151 hat excessive C20 LCBs or C20 LCB-containing sphingolipids impair protein homeostasis and neural func

152 ese pathways for the generation of essential sphingolipids in differentiated cells is not well unders

153 analogous to the interaction of sterols with sphingolipids in eukaryotic plasma membranes.

154 he key role of the symbiont F. major and its sphingolipids in mucosal homeostasis via the modulation

155 croglia enhance the metabolism of endogenous sphingolipids in neurons and stimulate excitatory transm

156 The accumulation of sphingolipids in obesity leads to impairments in insulin

157 The current study investigates the role of sphingolipids in radiation-induced podocytopathy.

158 glutinin and isotope-labeled cholesterol and sphingolipids in the plasma membranes of fibroblast cell

159 Here we propose a role for F. major and its sphingolipids in the regulation of B cell populations in

160 nbow trout, as well as an essential role for sphingolipids in trout mucosal homeostasis.

161 r concentrations of glycerophospholipids and sphingolipids in vegans.

162 endocannabinoids, N-acyl ethanolamides, and sphingolipids, in human dermis, epidermis, and suction b

163 nalysis also revealed appreciable changes in sphingolipids including ceramides and glucosylceramides

164 try analyses revealed that gammaTE modulated sphingolipids, including enhancement of intracellular di

165 ric dimethylarginine, alongside decreases in sphingolipids, indicate that both the urea cycle and nit

166 Ceramide is a sphingolipid involved in several cellular processes, inc

167 osphate (S1P) is a multifunctional bioactive sphingolipid involved in the development of many autoimm

168 Hindered diffusion of phospholipids and sphingolipids is abolished in the GPMVs, whereas transie

169 nzymes distinguish glycerophospholipids from sphingolipids is not known.

170 The sphingoid base derived class of lipids (sphingolipids) is a family of interconverting molecules

171 ty and substrate affinity, and in specifying sphingolipid LCB chain length in vivo.

172 Furthermore, sphingolipid levels and PDK1 activity are also increased

173 homeostatic regulatory circuit that controls sphingolipid levels at the trans-Golgi network (TGN).

174 e basis for maintaining distinct subcellular sphingolipid levels in the presence of membrane traffick

175 at change conformation depending on cellular sphingolipid levels.

176 teins to domains enriched in cholesterol and sphingolipids (lipid rafts).

177 disease is a rare neurovisceral, cholesterol-sphingolipid lysosomal storage disorder characterized by

178 Sphingolipids make up a family of molecules associated w

179 Sphingolipids make up a highly diverse group of biomolec

180 and revealed several insights, including in sphingolipid-mediated apoptosis, inflammation and energy

181 f sphingolipid cascade identified S1P as the sphingolipid mediating SynI redistribution.

182 ed pathways relevant to asthma pathogenesis: sphingolipid metabolism (P=6.6x10(-5) ), arginine and pr

183 ORMDL proteins regulate sphingolipid metabolism and ceramide homeostasis and par

184 proteins involved in calcium homeostasis and sphingolipid metabolism could indicate shared biological

185 While multiple axes of sphingolipid metabolism have been investigated to deline

186 le of a high-ranked gene in dysregulation of sphingolipid metabolism in the disease and demonstrate t

187 We previously demonstrated that the sphingolipid metabolism is altered in MS lesions.

188 to colon cancer, suggesting that enzymes of sphingolipid metabolism may emerge as novel regulators a

189 The results suggest that AC-controlled sphingolipid metabolism may play an important role in th

190 ordinal clinical measurements to discover a sphingolipid metabolism regulator involving in Huntingto

191 Neutral ceramidase (nCDase), a key enzyme in sphingolipid metabolism that hydrolyzes ceramide into sp

192 acetylases, thus linking our observations in sphingolipid metabolism to a well-characterized Huntingt

193 lysis revealed 4 important genes involved in sphingolipid metabolism to be deregulated in HNF1A defic

194 In the pathway analysis, sphingolipid metabolism was the most significantly enric

195 By analyzing multiple enzymes involved in sphingolipid metabolism, and by observing the effect of

196 Alterations in sphingolipid metabolism, especially ceramide and sphingo

197 ng that Swe1 activity responds to imbalanced sphingolipid metabolism, in the absence of TG degradatio

198 Ceramide, which serves a central role in sphingolipid metabolism, is generated by six ceramide sy

199 achidonic acid and linoleic acid metabolism, sphingolipid metabolism, tryptophan metabolism, phenylal

200 ail to tether the ER and vacuole and perturb sphingolipid metabolism.

201 thesis are important regulated components of sphingolipid metabolism.

202 present a distinct multisystemic disorder of sphingolipid metabolism.

203 hK1), the enzyme that converts the bioactive sphingolipid metabolite sphingosine to sphingosine-1-pho

204 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates a multitude of ph

205 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid metabolite that regulates numerous processe

206 Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the or

207 previously demonstrated that sphingosine, a sphingolipid metabolite, promotes formation of the SNARE

208 New sphingolipid metabolites have been discovered as potenti

209 rt growth while limiting the accumulation of sphingolipid metabolites that induce programmed cell dea

210 Enrichment of sphingolipid metabolites was positively correlated with

211 workflow was benchmarked against an accepted sphingolipid model system, the RAW 264.7 cell line, and

212 F. major sphingolipids modulate the growth of trout total skin an

213 F. major is known to produce sphingolipids of a unique molecular structure.

214 rgent and by copatching with a raft-resident sphingolipid on intact cells.

215 rdered domains enriched with cholesterol and sphingolipids, or from specific binding interactions bet

216 hree showed significantly faster turnover of sphingolipids over lysolipids, and all three showed a st

217 n of DCs caused modulation of enzymes in the sphingolipid pathway and enhanced expression of the endo

218 RNA sequencing implicated the sphingolipid pathway as a target of the TCAs.

219 sphingoid bases in de novo synthesis of the sphingolipid pathway.

220 amic changes in enzyme activities within the sphingolipid pathway.

221 Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA.

222 ervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mech

223 Pathway abnormalities included sphingolipid, phospholipid, purine, cholesterol, microbi

224 Sphingolipids, phospholipids (including lyso- and ether-

225 , fatty acids, amino acids, glucocorticoids, sphingolipids, phospholipids, etc.

226 Our results demonstrate that sphingolipids play an important role in plant defense, e

227 Sphingolipids play prominent roles in cell signaling and

228 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid produced by mast cells (MCs) on cross-linki

229 Here, a direct comparison of sphingolipid profiles in Arabidopsis (Arabidopsis thalia

230 s in the way that cholesterol interacts with sphingolipids promotes the synergistic balance between t

231 ied class of transmembrane G protein-coupled sphingolipid receptors that mediate multiple cellular pr

232 Sphingolipids regulate critical cellular processes inclu

233 ic amines, glycerophospholipids, hexose, and sphingolipids related to lipid, protein, and carbohydrat

234 st-Golgi compartments being poor and rich in sphingolipids, respectively.

235 Cers2b can also function as a sphingolipid-responsive factor to mediate at least part

236 GPI proteins are found in cholesterol- and sphingolipid-rich membrane regions called rafts.

237 water-soluble, orally bioavailable synthetic sphingolipid, SH-BC-893, that triggers nutrient transpor

238 ological conditions involve perturbations in sphingolipid signaling and metabolism, there are specifi

239 s a lysosomal cysteine amidase that controls sphingolipid signaling by lowering the levels of ceramid

240 Our laboratory has previously shown that sphingolipid signaling by sphingosine 1-phosphate decrea

241 study, we evaluated the role of AC-regulated sphingolipid signaling in melanoma.

242 ingolipid synthesis and shows that autocrine sphingolipid signaling within the endothelium is critica

243 Sphingolipid (SL) biosynthesis is negatively regulated b

244 Cellular sphingolipids (SL) constitution and metabolism were eval

245 We have recently shown that serum sphingolipids (SLs) are deregulated in patients with chr

246 A regression model combining the sphingolipid SM C22:3 and the glycerophospholipid lysoPC

247 alyzed with a specific focus on highly polar sphingolipids, so-called glycosyl inositol phosphorylcer

248 in the pathogenesis of COPD, the particular sphingolipid species associated with COPD subphenotypes

249 ers from the COPDGene cohort had 69 distinct sphingolipid species detected in plasma by targeted mass

250 lutinin, cholesterol, and/or the majority of sphingolipid species in the plasma membrane.

251 abolism, there are specific patterns, unique sphingolipid species, enzymes, metabolites, and receptor

252 ay lead to harmful accumulation of lysosomal sphingolipid species, which are associated with a series

253 and (iii) parallel reaction monitoring of a sphingolipid specific fragmentation pattern.

254 De novo synthesis of the sphingolipid sphingomyelin requires non-vesicular transp

255 activity, which generates the main mammalian sphingolipid, sphingomyelin.

256 human follicular thyroid ML-1 cancer cells, sphingolipid sphingosine 1-phosphate (S1P), through S1P

257 The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinas

258 The bioactive sphingolipid sphingosine-1-phosphate (S1P) mediates cell

259 The sphingolipid sphingosine-1-phosphate (S1P) signals throu

260 dministration can ameliorate cholesterol and sphingolipid storage and trafficking defects in NPC1 mut

261 central signaling and metabolic relay among sphingolipids, studies of its involvement in lung health

262 r levels of SMs, which are the most abundant sphingolipids, suggesting that they are not the primary

263 While sphingolipids suppress tumor growth by downregulating nu

264 eads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosp

265 d mutations in SPT1 are known to both reduce sphingolipid synthesis and generate catalytic promiscuit

266 dentifies Nogo-B as a key inhibitor of local sphingolipid synthesis and shows that autocrine sphingol

267 Dampening iron toxicity, inhibiting sphingolipid synthesis by Myriocin, or reducing Pdk1 or

268 GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol

269 Sphingolipid synthesis involves a highly conserved biosy

270 Inhibition of the first step of de novo sphingolipid synthesis is sufficient to mitigate many of

271 Sphingolipid synthesis is tightly regulated in eukaryote

272 Chemical inhibition of de novo sphingolipid synthesis partially reversed gammaTE's indu

273 Inhibition of fatty acid or sphingolipid synthesis prevented tumor development, indi

274 ith the availability of long-chain bases for sphingolipid synthesis.

275 d found that PNPLA1 is crucial for epidermal sphingolipid synthesis.

276 synthesis of sphingomyelin (SM), an abundant sphingolipid that is transported.

277 ucosylceramide (GlcCer) is a fungal-specific sphingolipid that plays an important role in the growth

278 To profile the sphingolipids that accumulate in obesity, we performed l

279 -phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons.

280 e involvement of a novel class of neurotoxic sphingolipids, the 1-deoxysphingolipids.

281 rating alanine or glycine into the precursor sphingolipid to generate a deoxysphingoid base (DSB).

282 owing body of evidence links deregulation of sphingolipids to several diseases, including cancer.

283 This regulation in plants ensures sufficient sphingolipids to support growth while limiting the accum

284 le in signaling by responding to delivery of sphingolipids to the plasma membrane.

285 e PtdIns(4)P is required for cholesterol and sphingolipid transport to the trans-Golgi network, PtdIn

286 reases in MAM regions, resulting in elevated sphingolipid turnover and an altered lipid composition o

287 Sphingolipids typically have an 18-carbon (C18) sphingoi

288 me natural toxin variants, because mammalian sphingolipids use primarily choline as a positively char

289 ost acylcarnitines, glycerophospholipids and sphingolipids were altered in sepsis compared to systemi

290 odel system, the RAW 264.7 cell line, and 61 sphingolipids were quantified over a dynamic range of 7

291 Three sphingolipids were strongly associated with sphingolipid

292 CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in

293 These fractions, rich in phospho- and sphingolipids, were strongly antiproliferative against h

294 Ceramides are bioactive sphingolipids, which are composed of sphingoid bases car

295 d to be involved in the de novo synthesis of sphingolipids, which have been implicated in the pathoge

296 the nervous system enhances the synthesis of sphingolipids, which in turn activates 3-phosphoinositid

297 Ceramide is a pro-apoptotic sphingolipid with unique physical characteristics.

298 Here we demonstrate that sphingolipids with alpha-hydroxylated acyl-chains of at

299 membranes display enrichment in sterols and sphingolipids with very long chain saturated fatty acids

300 The balance between cholesterol and sphingolipids within the plasma membrane has long been i