ライフサイエンスコーパス: spike

1 y epitope on each side of the dimeric capsid spike.

2 minal His tag located at the "bottom" of the spike.

3 uantitatively describe the timing of calcium spikes.

4 action potential: simple spikes and complex spikes.

5 spike latency; FSL) and the number of evoked spikes.

6 or synaptic strengthening by local dendritic spikes.

7 intertwined loops that form the large capsid spikes.

8 action potential: simple spikes and complex spikes.

9 potentials in spike bursts as well as single spikes.

10 in control occurred at both transduction and spiking.

11 l PFC-STN coherence and altered STN neuronal spiking.

12 on, induced antioxidant activity and calcium spiking.

13 or integrating excitatory inputs and promote spiking.

14 ures with subsequent reduction in interictal spiking.

15 ios of 11:1 and 4:1 with and without nitrite spiking (28 mg-N L(-1)).

16 complex spike spikelet number affects simple spike activity (and vice versa) remains poorly understoo

17 ncomitantly, alterations in the task-related spike activity of medial prefrontal neurons correspond w

18 s facilitated the initiation of synchronized spike activity.

19 These oscillations are related to local spiking activity and transiently synchronize with anatom

20 Neuronal spiking activity at seizure initiation was highly hetero

21 he balance between inhibitory and excitatory spiking activity directly.

22 important statistical framework for modeling spiking activity in single-neurons and neuronal networks

23 Neurons in the neocortex exhibit spontaneous spiking activity in the absence of external stimuli, but

24 Here we used MEAs to record neuronal spiking activity in the human middle temporal gyrus (MTG

25 owed that visual latency of the LFP preceded spiking activity in the visual epoch, whereas spiking ac

26 lized linear models were used to predict the spiking activity of cells in both areas as a function of

27 We modeled the spiking activity of neurons as a function of kinematic p

28 piking activity in the visual epoch, whereas spiking activity preceded LFP activity in the saccade ep

29 We demonstrate with large-scale spiking activity recordings a concurrent deregulation of

30 oked spike responses, the slow inhibition of spiking activity required the activation of GABAB recept

31 Stimulation of the mouse hippocampus evoked spiking activity that was readily discerned with bath-ap

32 elta-frequency cortical oscillations entrain spiking activity throughout the entire LGN, in anaesthet

33 imescales, cortical oscillations can entrain spiking activity throughout the entire LGN.

34 al state are selectively linked to K pathway spiking activity, whereas delta-frequency cortical oscil

35 f junctional conductance, thus demonstrating spiking activity-dependent short-term plasticity of elec

36 and how nonlinearities impact the networks' spiking activity.

37 te-of-the-art statistical models of neuronal spiking activity.

38 ivated by action potentials and affected the spike afterhyperpolarization.

39 erence material of human blood serum, by the spike and recovery trials with seawater, tap water, mine

40 link currently exists between this intensity spike and the global field produced by the core geodynam

41 of chloramphenicol were identified in water, spiked and incurred tissues, and were all different.

42 tigations of the interactions between simple spikes and complex spikes have mainly considered complex

43 o distinct types of action potential: simple spikes and complex spikes.

44 o distinct types of action potential: simple spikes and complex spikes.

45 fully excite Purkinje cells, evoking complex spikes and depressing parallel fibre synapses.

46 that the posttranslational processing of the spikes and nucleocapsid is necessary to produce infectio

47 arizing potential (AHP) following a train of spikes and the underlying apamin-sensitive IAHP were blu

48 by a miRNA target mimic resulted in compact spikes and transition from glumes to florets in apical s

49 ve similar somatic half-widths to late burst spikes and undergo similar dendritic attenuation.

50 Interestingly, fast-spiking and non-fast-spiking INs displayed differential

51 le-cell features such as the irregularity of spiking and the frequency dependence of the neuron's tra

52 -cell ribbon size influences the spontaneous spiking and the precise encoding of stimulus onset in af

53 o a larger number of tillers bearing fertile spikes, and increases in seed number and size.

54 uld be relatively uniform in size, number of spikes, and peak firing rate.

55 zation, increased input resistance, enhanced spiking, and slowed decay of excitatory post-synaptic po

56 Quaternary epitopes at the apex of the spike are recognized by some of the most potent and broa

57 Moreover, although spikes are distorted by block, they are regularized duri

58 tes but, following the complex spike, simple spikes are reduced in a manner that is graded with spike

59 The capsids are decorated by large spikes around the 5-fold vertices.

60 omplex spikes have mainly considered complex spikes as unitary events.

61 visual stimulation; SCS cells fired complex spikes associated with learned swimming episodes.

62 search generally, there are variables with a spike at zero, namely variables for which a proportion o

63 Pesticide-free tea powder spiked at 50 and 100mugL(-1).

64 e identified for authenticating buffalo meat spiked at a minimum 0.5% level in sheep meat with high c

65 tability at moderate spike rates but reduced spiking at high rates; and (v) reduced spike clustering

66 ctional form for the positive portion of the spike-at-zero variable distribution has been developed.

67 n (LOD) and dynamic range were determined by spiking B. anthracis DNA into individual PCR mixtures an

68 stochastic functionalities also underlie the spiking behavior of neurons in cortical microcircuits of

69 ubunits eliminates the long-range correlated spiking between RGCs.

70 nt, trimeric mimic of the native HIV-1 viral spike (BG505 SOSIP.664) compared to the corresponding un

71 f infecting mosquitoes after oral feeding of spiked-blood meals, representing an additional safety fe

72 AP clamp experiments showed that spike broadening results from frequency-dependent reduct

73 ation of flying past an elevated object, the spike burst activity is modulated by the height of the o

74 We show that the spike burst coding is size and speed-tuned and is select

75 ther cell type, high-frequency low-threshold spike burst or lower-frequency tonic APs undergo substan

76 lip direction and fires action potentials in spike bursts as well as single spikes.

77 erminal Ca(2+) Increases in Ca(2+) driven by spike bursts last seconds; however, the increases in ner

78 The temporal window of spiking can be delicately controlled by GABAergic inhibi

79 n the most realistic scenario assayed (i.e., spiked chicken meat analysis), only 13% of the AgNPs pre

80 duced spiking at high rates; and (v) reduced spike clustering and rebound potentials.

81 oadening action potentials; and (v) reducing spike clustering.

82 Thus, here we compared simple spike-complex spike interactions both within and across

83 Importantly, we find that HAstV-2 capsid spike containing a serine in this loop is immunogenic an

84 Finally, we measured trial-to-trial spike count variability during stimulus presentation and

85 The spike count, CV(2), and m-FF of spontaneous activity wer

86 ion about identity provided by spike time or spike count.

87 irs of similarly tuned neurons but decreased spike-count correlations between pairs of oppositely tun

88 imulus beside a preferred stimulus increased spike-count correlations between pairs of similarly tune

89 tored inputs and plasticity-inducing complex spikes (CSs) in CA1 neurons while mice explored novel an

90 In comparison, the NO2(-) spiked cultures with COD:N = 4:1 showed significantly hi

91 rpolarization in spinal neurons, mediated by spike-dependent increases in pump activity, which is aff

92 newly formed synapses via dendritic calcium spike-dependent mechanisms.

93 sults compared to the simple threshold-based spike detection.

94 the crystal structure of the capsid protein spike domain from one of these HAstV strains and found t

95 ssociated with increased rheobase, increased spike duration, and reductions in membrane resistance an

96 se Purkinje cells can fire coincident simple spikes during cerebellar behaviours, we varied the propo

97 l but markedly slowed repolarization of late spikes during repetitive firing; (ii) enhanced the after

98 correlated with the frequency of interictal spikes during the last hour of wakefulness preceding sle

99 mework that combines the Hodgkin-Huxley type spiking dynamics, dynamic ion concentrations and glutama

100 s were validated using blank wheat and wheat spiked either at the EC regulated levels (100microg/kg f

101 Based on how many complex spikes emerged during learned swimming, they were classi

102 tanding how sequences of action potentials ("spikes") encode information about sensory signals and mo

103 ensory neurons, trains of action potentials (spikes) encode stimulus intensity within the onset time

104 simian immunodeficiency virus (SIV) envelope spike (Env) mediates viral entry into host cells.

105 nary genetic diversity of the HIV-1 envelope spike [Env; trimeric (gp160)3, cleaved to (gp120/gp41)3]

106 Furthermore, river/sea-spiked environmental samples and samples from a bioreact

107 pendent random inputs which may induce large spiking events propagating through the branches of the t

108 Spiking experiments show that the CARD-SGS method can de

109 rticles have pronounced dimeric blade-shaped spikes extending up to 6 nm from the outer surface of th

110 ye movement (NREM) sleep, LGN neuron overall spike-field coherence (SFC) with V1 delta (0.5-4 Hz) and

111 y discover trial-to-trial variability in the spike-field coherence of a rat primary motor cortical ne

112 s of odorant receptors, inhibiting the basal spike firing in olfactory sensory neurons.

113 ciated with a subsequent reduction in simple spike firing rate.

114 s of spikelets are preceded by higher simple spike firing rates but, following the complex spike, sim

115 ty within the onset time of the first evoked spike (first spike latency; FSL) and the number of evoke

116 low afterhyperpolarization, the sag, and the spike frequency adaptation - split layer 5 barrel cortex

117 lular neurons regulate repetitive firing and spike frequency adaptation but relatively little is know

118 In neurons from CIE-treated mice, spike frequency was nearly doubled and inhibition of fir

119 ory regular-spiking (RS) and inhibitory fast-spiking (FS) V1 cells had similar EPSP characteristics,

120 n surround inhibition mediated by wide-field spiking GABAergic amacrine cells.

121 However, simultaneous M-cell spikes generated through direct current injection were n

122 teractions between simple spikes and complex spikes have mainly considered complex spikes as unitary

123 Tonic spikes have similar somatic half-widths to late burst sp

124 f different kinematic parameters, as well as spike history.

125 ns as a function of kinematic parameters and spike history.

126 a cells and is required for the postprandial spike in insulin secretion.

127 Postprandial dysmetabolism-an exaggerated spike in triglycerides, glucose, and insulin-increases c

128 ance (FO-SPR) biosensor for detection of IFX spiked in 100-fold diluted serum, plasma, and whole bloo

129 00ng/mL for OTA and DON and 3ng/mL for AFB1, spiked in a sample under analysis and simultaneously com

130 s, stimulants, narcotics, and beta-blockers) spiked in human urine and plasma samples.

131 o perform ex vivo analysis of drugs of abuse spiked in urine and OF samples.

132 Spikes in deaths due to heart attacks, strokes and other

133 he stochastic properties of dendritic Ca(2+) spikes in neocortical layer 5 pyramidal neurons.

134 ing into account the spatial distribution of spikes in relation to the seizure onset zone as well as

135 ories involve timing information from neural spikes in the auditory nerve (time code) and the spatial

136 The spikes in the immature virus have a larger radius and ar

137 tic stimulation of PPN axons reliably evoked spiking in SNc dopaminergic neurons.

138 be induced by pairing pre- and postsynaptic spiking in the absence of glutamate signalling.

139 ision of the first evoked action potentials (spikes) in hair-cell afferent neurons of the lateral lin

140 ipt counts without the need for experimental spike-in controls.

141 An exhaustive spike-in experiment with 79 metabolite standards demonst

142 in addition to investigating the effects of spike-in molecular degradation.

143 e to differences in behavior between the two spike-in sets.

144 Inputs driving place field spiking increased in amplitude - often suddenly - during

145 animal studies, both seizures and interictal spikes induce synaptic potentiation.

146 called perineuronal nets (PNNs) around fast-spiking inhibitory interneurons, in a rat model of TBI a

147 ion of L6 CT neurons and subnetworks of fast-spiking inhibitory neurons that reset the phase of low-f

148 Together, these results show that the spiking-initiated mechanisms underlying electrical synap

149 stimuli, somatic EPSP normalization renders spike initiation more sensitive to synapse timing than d

150 the prelimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projectin

151 Interestingly, fast-spiking and non-fast-spiking INs displayed differential modulation by glutama

152 Thus, here we compared simple spike-complex spike interactions both within and across zebrin populat

153 Before song learning, fast-spiking interneurons (FSIs) densely innervated glutamate

154 ded in layer V-VI pyramidal neurons and fast-spiking interneurons in slices from male and female mice

155 emonstrate the selective involvement of fast spiking interneurons in structured temporal sequences du

156 s provide evidence that the function of fast-spiking interneurons is disrupted due to a deficiency in

157 l properties, such as firing rates and inter-spike interval distributions.

158 d was able to detect several species of crab spiked into complex food matrices at levels ranging from

159 100 nm Au ENM were spiked into DI H2O and synthetic and natural leachates.

160 is DNA in buffer or CFU of F. tularensis was spiked into human or macaque blood.

161 We provide evidence that the HAstV capsid spike is a receptor-binding domain and that the antibody

162 scattering measurements indicates that each spike is associated with the collision of a single sub-p

163 umber of spikelets within individual complex spikes is highly variable and the extent to which differ

164 height of the object, and the rate of single spikes is unaffected.

165 Moreover, we discovered that the noisy spiking is linked to a high level of binocular suppressi

166 rominent Purkinje neuron atrophy, repetitive spiking is restored, although at a greatly reduced firin

167 lamocortical input layer 4, and sound-evoked spike latencies were longer in layer 4 than in subplate,

168 onset time of the first evoked spike (first spike latency; FSL) and the number of evoked spikes.

169 After analysis of blood lead data revealed spiking lead in blood of Flint children in September 201

170 s applied to the analysis of fumonisin B1 in spiked maize and wheat samples.

171 New ultrahigh precision, double-spike mass spectrometry stable Pb isotope data allow cle

172 ssified as multiple, single, or zero complex spike (MCS, SCS, ZCS) cells.

173 articles added, while particle recovery in a spiked method blank is approximately 100%, indicating th

174 It is widely believed that this spiking mode depends upon an interaction between synapti

175 l spike shape as deletion of Kv1.1; however, spike modulation by somatic prepulses was abolished.

176 The amplitudes of the pre- and post-complex spike modulation phases were correlated across PCs.

177 These predictions are validated in a spiking neural network model of the OB-PC pathway that s

178 acts to motor commands, but how a network of spiking neurons can learn non-linear body dynamics using

179 , a high-threshold channel expressed in fast-spiking neurons throughout the central auditory pathway.

180 nt connections in a network of heterogeneous spiking neurons.

181 Most spikes occurred within repeats and reoccurred with a pre

182 aser pulses by MGNCs can produce temperature spikes of nearly 1000 degrees C, which is sufficient for

183 cortical lamina and averaged on spontaneous spikes of thalamocortical (TC) cells.

184 The spikes of the entropy per particles can be considered as

185 Our results suggest that Nav1.2-driven spiking of pre-OLs is an integral component of axon-glia

186 Thus, PPN-evoked burst spiking of SNc dopaminergic neurons in vivo may not only

187 Levels of spikes on cells correlated well with those on progeny vi

188 In this study, we investigated the effect of spikes on memory encoding and retrieval, taking into acc

189 Assay was validated by spiking OTC to antibiotic free milk samples and results

190 presence of a low threshold Ca(2+) channel, spike output functions are strongly modulated by the pre

191 ce to examine both subthreshold activity and spiking output in single neurons.

192 rifiable at the lowest increase (1%) through spiked oxidized IgG1.

193 eptibility to potentiation by fewer pre-post spike pairs, indicating a reduced t-LTP induction thresh

194 rons of the hippocampus and cortex with fast-spiking parvalbumin (PV) interneurons that control netwo

195 hippocampus and neocortex, particularly fast-spiking parvalbumin-positive (PV+) basket cells.

196 model reproduced the regular pacemaker-like spiking pattern, action potential shape, and most of the

197 r behaviors, but whether and how appropriate spike patterns could drive long-term synaptic plasticity

198 ermines the precise responses of synapses to spike patterns in a neuron and circuit and which is vuln

199 Spiking patterns of single neurons in both core and shel

200 a low number of envelope glycoprotein (Env) spikes per virion, i.e., approximately 7 to 14.

201 Y (NPY) interneurons, plateau low threshold spike (PLTS) and NPY-neurogliaform (NGF) cells.

202 nsfer function determine whether synchronous spikes possess a distinct meaning for the encoding of ti

203 that deletion of this 197-aa fragment in the spike protein can attenuate a highly virulent PEDV, but

204 ture elements in the capsid shell from which spikes protrude, and a decreased dynamics in the long in

205 equences were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed un

206 In spiked quality control (QC) samples 82% of metabolite me

207 between excitation and inhibition determines spike rate and local spike train variability.

208 espond to touch and also show an increase in spike rate with whisker movement.

209 SR in scale-free networks, where the average spiking rate is calculated over the neuronal population.

210 alamus (VPM), respond to touch, but have low spike rates and low sensitivity to the movement of whisk

211 iring and increased excitability at moderate spike rates but reduced spiking at high rates; and (v) r

212 easing excitability and bursting at moderate spike rates but reducing firing at high rates; (ii) enha

213 e show that Gaussian processes model calcium spike rates with high fidelity and perform better than s

214 rged ribbons resulted in reduced spontaneous spike rates.

215 g short-term plasticity from multi-electrode spike recordings in vivo.

216 e analyzed as real samples and good relative spiked recoveries (95-106%) were obtained.

217 resolution needed to distinguish individual spikes reliably and does not measure local field potenti

218 Spikes reminiscent of exocytotic events in secretory ani

219 endent reduction of potassium current during spike repolarization.

220 for frequency-dependent reduction of overall spike-repolarizing potassium current was identified as K

221 the skin is deformed and then simulates the spiking response that would be produced in the nerve fib

222 le for the direct inhibition of light-evoked spike responses, the slow inhibition of spiking activity

223 topographic maps emerge before the onset of spiking responses in layer 4.

224 Putative excitatory regular-spiking (RS) and inhibitory fast-spiking (FS) V1 cells h

225 hibitory inputs, along with the rates (0-100 spikes s(-1) ) and number (0-800) of excitatory inputs.

226 reakpoint located near 5' and 3' ends of the spike (S) protein gene.

227 aa) deletion in the N-terminal domain of the spike (S) protein.

228 fication of different hIgG1s within the same spiked sample were also exemplified.

229 A spiked-sample recovery analysis shows that 96% +/- 2% of

230 The average recoveries from spiked samples ranged from 97.25% to 105%.

231 IL-8 spiked serum samples were measured with a high reproduci

232 ion had a similar broadening effect on basal spike shape as deletion of Kv1.1; however, spike modulat

233 roscopy (EM) and tomography reveal monomeric spikes similar to one of the crystal conformations.

234 pike firing rates but, following the complex spike, simple spikes are reduced in a manner that is gra

235 ence by imposing a constraint on the minimum spike size.

236 d the extent to which differences in complex spike spikelet number affects simple spike activity (and

237 We focus on the spiking statistics of the central node, which fires in r

238 It was also found that effective spike-stimulus delays are consistent with experimentally

239 In the limit of slow synaptic kinetics the spike-synchrony mechanism is suppressed and the standard

240 al matrix interference on the immunoassay by spiking the test sample itself.

241 n addition to the daily rate of epileptiform spikes, the relative power of five frequency bands (thet

242 in single collaterals and variable times to spike threshold in converging afferents.

243 ional information about identity provided by spike time or spike count.

244 Most of the previous studies focus on the spike time, pulse number and material species: however,

245 eaving it unclear whether the information in spike timing actually plays a role in brain function.

246 unknown whether or how subtle differences in spike timing drive differences in perception or behavior

247 sponses to pharmacological manipulations and spike timing statistics.

248 ipheral pitch coding involve stimulus-driven spike timing, or phase locking, in the auditory nerve (t

249 Spike timing-dependent long-term potentiation and depres

250 Hence, we propose that spike timing-dependent plasticity enables this microcirc

251 odes emerge in this microcircuit motif under spike timing-dependent plasticity.

252 an important computational function through spike timing-dependent plasticity: The capability to dis

253 Spike timing-dependent synaptic plasticity (STDP) serves

254 xpressing dopamine D1 receptors shifted from spike-timing-dependent long-term depression (tLTD), the

255 nt form of plasticity in naive male mice, to spike-timing-dependent long-term potentiation (tLTP) in

256 indow and lowers the induction threshold for spike-timing-dependent LTP (t-LTP).

257 Classic in vitro studies have described spike-timing-dependent plasticity (STDP) at a synapse: t

258 at this can actually occur through a form of spike-timing-dependent plasticity (STDP) at the cerebell

259 s are consistent with experimentally derived spike-timing-dependent plasticity (STDP) rules, suggesti

260 Cellular mechanisms underlying spike-timing-dependent plasticity have been studied exte

261 d analyses of an abundant Lh VLP surface and spike-tip protein, p40, reveal similarities to the needl

262 e for phase-dependent binding of mossy fiber spikes to repetitive theta-frequency cycles of granule c

263 Decoupling of spiking to slow oscillations using optogenetic methods e

264 lated conductance was removed, the ON cell's spike train exhibited an increase in SNR.

265 how that by varying the network topology the spike train statistics of the central node can be tuned

266 d inhibition determines spike rate and local spike train variability.

267 for the high coefficient of variation in CN spike trains, while the balance between excitation and i

268 ptimum frequency of presynaptic activity for spike transfer at approximately 10 Hz.

269 Each spike triggered Ca(2+)-induced Ca(2+) release (CICR) fro

270 receptive field (RF) center sizes decrease, spike-triggered averaged responses to white noise become

271 ulate predictions concerning the efficacy of spike-triggered conditioning in different regimes of cor

272 Experiments show that spike-triggered stimulation performed with Bidirectional

273 The temporal order of spikes turned out to be crucial.

274 Spiked virus-like particles (VLPs) in wasp venom have cl

275 etic studies identified five major SIX-ROWED SPIKE (VRS) genes, with four now known to encode transcr

276 Spiking was also inhibited by the direct GIRK channel ac

277 Conversely, spiking was most effectively suppressed when inhibition

278 seconds) spontaneous seizures, which involve spike-wave discharges (SWDs) in the EEG and interruption

279 the latent pre-seizure period, epileptiform spikes were more frequent in epileptic compared with non

280 effective at increasing the rate of CbN cell spiking when the coherence (synchrony) of convergent inh

281 mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies.

282 imulation results also revealed that voltage spikes, which develop between neighboring cells during t

283 Y+ cells and the factors that regulate their spiking, which could pave the way for new therapeutic ta

284 Larvae were reared on artificial diets spiked with contaminants of emerging concern (CECs) at e

285 Validation on tap water samples spiked with different concentrations of malathion shows

286 115-component test mixture and a diesel fuel spiked with several compounds, for the purpose of illust

287 for the production of olive oil from olives spiked with the 104 pesticides studied, three different

288 milled toasted maize and wheat samples were spiked with the pesticides, and they were then stored in

289 The samples were spiked with up to 20 metals at concentrations ranging fr

290 ation experiments were conducted in seawater spiked with UV filters to investigate the reactivity of

291 l fish tissue from multiple "common" species spiked with varying proportions of tissue from an additi

292 In addition, complex spikes with a greater number of spikelets were associate

293 We found that complex spikes with greater numbers of spikelets are preceded by

294 The challenge to evoke spikes with high spatial and temporal complexity necessi

295 ic calcium signals, we observed fewer evoked spikes with longer latencies from stimulus onset.

296 the LSL was predicted to result in releasing spikes with significantly high concentrations of particu

297 error rates in the identification of evoked spikes, with a computational complexity that is compatib

298 dent superposition of pre- and post-synaptic spikes within a hybrid one-transistor/one-resistor (1T1R

299 illisecond-scale variations in the timing of spikes within multispike patterns to control a vertebrat

300 Spiking Yellowstone Lake PMEZ samples with (13) C-labele