ライフサイエンスコーパス: spinal interneuron

1 making them a uniquely well-defined class of spinal interneuron.

2 ed to control motoneurons disynaptically via spinal interneurons.

3 r R-interneurons but project rarely to other spinal interneurons.

4 e alpha2C-AR may be expressed by a subset of spinal interneurons.

5 neously manipulating specific populations of spinal interneurons.

6 euromotor modules originates from excitatory spinal interneurons.

7 -expressing nociceptors and pain-modulating spinal interneurons.

8 l projection neurons and genetically labeled spinal interneurons.

9 he way in which corticospinal neurons engage spinal interneurons.

10 ly ordered generation of distinct classes of spinal interneurons.

11 ly shaped by the integrative function of the spinal interneurons.

12 stress-related transcription factor c-Jun in spinal interneurons.

13 rk controlling locomotor activity, including spinal interneurons.

14 cdh-gamma loss also led to apoptosis of many spinal interneurons.

15 r phenotypes of most of the known classes of spinal interneurons.

16 gestion that they originate principally from spinal interneurons.

17 ehaviors are accomplished by a shared set of spinal interneurons activated in different patterns or,

18 Spinal interneuron activity was assessed using the synch

19 ated that the loss of GABA-ergic inputs from spinal interneurones alone is insufficient to produce to

20 However, in EphA4 full knock-outs, spinal interneurons also develop bilateral misprojection

21 Here we show that spinal interneurons also exhibit early pre-movement dela

22 The specification of spinal interneuron and motor neuron identities initiates

23 medium clusters of Kv2.1-IR were observed in spinal interneurones and projection neurones, and some i

24 the transcriptomes of both Ptf1a-expressing spinal interneurons and endogenous cortical interneurons

25 nections to spinal motoneurons, which bypass spinal interneurons and exert a direct (willful) muscle

26 for locomotion by analysing the activity of spinal interneurons and motoneurons during spontaneous d

27 e primate reticulospinal tract can influence spinal interneurons and motoneurons involved in control

28 The neuronal populations examined include spinal interneurons and motor, sensory, and autonomic ne

29 ed axon projection patterns of V2b subset of spinal interneurons and visualized maturation of the neu

30 network level including altered activity of spinal interneurons; and (iii) the increased power outpu

31 Corticospinal tract (CST) connections to spinal interneurons are conserved across species.

32 In the mouse, the V2a spinal interneurons are dispensable for left-right coord

33 We find that assemblies of excitatory spinal interneurons are recruited by sensory input into

34 imulation on RSNA and the discharge rates of spinal interneurons argue against these neurons playing

35 genetics to directly target major classes of spinal interneurons as well as motor neurons during spas

36 ly due to an increase in the excitability of spinal interneurons because short-latency activity in th

37 Certain spinal interneurons (Bhlhb5) inhibit itch pathways withi

38 prominent "C bouton" cholinergic inputs from spinal interneurons, but the source and function of thes

39 The impact of AIH on cervical spinal interneuron (C-IN) discharge and connectivity is

40 colleagues (2017) find that individual Grp+ spinal interneurons can respond to and distinguish betwe

41 known about the identity and function of the spinal interneuron cell types that contribute to these l

42 are thought to be directed by the actions of spinal interneuron circuits collectively referred to as

43 s of preganglionic and somatic efferents and spinal interneurons closely associated with the efferent

44 rs of neurons were then used to identify the spinal interneurons coreleasing the two excitatory trans

45 Prior to MN loss, spinal interneurons degenerate.

46 ting BMP-dependent cellular processes during spinal interneuron development.

47 ed that different populations of commissural spinal interneurons ensure limb alternation at different

48 ebrafish most glycinergic and many GABAergic spinal interneurons express Pax2a, Pax2b and Pax8 and th

49 n5)/Caspr4 coreceptor complex, together with spinal interneuron expression of NrCAM/CHL1, directs the

50 g EphA4-expressing corticospinal neurons and spinal interneurons from crossing the midline.

51 ctates the mode of stem cell division during spinal interneuron generation.

52 aINs), and possibly other types of mammalian spinal interneurons have common embryonic origins within

53 Spinal interneurons help to coordinate motor behavior.

54 One class of spinal interneurons implicated in the control of mammali

55 ect control is attributable to activation of spinal interneurons in a number of locations.

56 We explored the activity of pools of spinal interneurons in larval zebrafish and found that i

57 m imaging of groups of identified excitatory spinal interneurons in larval zebrafish to explore how t

58 ocal microscopy to examine the morphology of spinal interneurons in living larval zebrafish with the

59 Most studies of spinal interneurons in vertebrate motor circuits have fo

60 We recorded miniature EPSCs (mEPSCs) from spinal interneurons in Xenopus embryos and larvae.

61 Many classes of spinal interneurons in zebrafish have been described bas

62 tudy was to determine changes in activity of spinal interneurons, in particular those mediating PLRs,

63 riteria for the functional identification of spinal interneurones involved in the mammalian locomotor

64 Spinal interneurons involved in the UG reflex were found

65 Understanding the organisation of spinal interneurones is no easy task.

66 ell death affects the 13 cardinal classes of spinal interneurons is unclear.

67 Regulation of spinal interneurons is used to switch between motor stat

68 s recovery, we studied a population of mouse spinal interneurons known to receive direct afferent inp

69 Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptid

70 Spinal interneurons mediate much of this influence, yet

71 t has been hypothesized that a common set of spinal interneurons mediates flexion reflex and the flex

72 It was further demonstrated that the spinal interneurons mediating the descending commands fo

73 sh and amphibians led to the hypothesis that spinal interneurons might be shared by these behaviors.

74 Spinal interneurons modulating motor output are highly d

75 and the M1 motor map, increased cholinergic spinal interneurons numbers on the contralateral, relati

76 has a role in the increased excitability of spinal interneurons observed during persistent inflammat

77 Major cold-sensitive areas projecting to spinal interneurons or to regions containing sympathetic

78 ut the extent to which particular classes of spinal interneurons participate in different behaviors.

79 f the present study was to determine whether spinal interneurons play a role in the regulation of sym

80 e for the importance of connections with key spinal interneuron populations in development of motor c

81 opmental apoptosis in molecularly identified spinal interneuron populations, and implicate the adhesi

82 and functional analyses of corticospinal and spinal interneuron projections reveal that loss of alpha

83 ry circuitry based on the classical types of spinal interneurons (propriospinal, monosynaptic Ia-exci

84 Our findings suggest that spinal interneurons show distinct temporal and spatial t

85 ), an anatomically and functionally discrete spinal interneuron subtype.

86 patches located on Renshaw cells, a type of spinal interneuron that receives powerful excitatory and

87 of this review is to describe populations of spinal interneurons that are involved in the control of

88 ing and dye injection to identify a group of spinal interneurons that are strongly activated during f

89 t behavioral roles for particular classes of spinal interneurons that can eventually be tested direct

90 s known about patterns of recruitment in the spinal interneurons that control motoneurons because of

91 This study shows that a subpopulation of spinal interneurons that expresses parvalbumin and have

92 fines a primitive functional organization of spinal interneurons that formed a developmental and evol

93 nt patterns or, instead, involve specialized spinal interneurons that may shape the motor output to p

94 he spinal cord; however, the identity of the spinal interneurons that serve this function is not know

95 motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of

96 tentials were recorded from the VLF and from spinal interneurons that were synchronized, cycle by cyc

97 cted rats, we have described a population of spinal interneurons that, by virtue of correlations betw

98 We find that a kernel of spinal interneurons, the ipsilateral caudal (IC) cells,

99 ugh spinal motoneurons are a major target of spinal interneurons, the loss of motoneurons did not aff

100 guishable from a recently described group of spinal interneurons (transverse interneurons) that are s

101 However, the molecular identity of the spinal interneurons underlying the excitatory drive with

102 Putative spinal interneurons were found from T13 to S1.

103 Putative spinal interneurons were found in the medial cord from T

104 sory neurons in the dorsal root ganglion and spinal interneurons were not affected by any of the pert

105 In both cases, spinal interneurons were preserved but the mice bore dra

106 uthner cells directly activate contralateral spinal interneurons which feed reciprocal inhibition to

107 We show a discrete subset of commissural spinal interneurons, whose fate is controlled by the act

108 Thus, spinal interneurons with distinct behavioral roles may t

109 combine back-filling or genetic labeling of spinal interneurons with in situ staining for markers of

110 reaching and grasping could be mediated via spinal interneurons with input from the motor-cortex and

111 leg flexion reflex circuits likely share key spinal interneurons with locomotion and scratching netwo