ライフサイエンスコーパス: spindle assembly checkpoint

1 s, the mitotic checkpoint (also known as the spindle assembly checkpoint).

2 d load-bearing capacity and silencing of the spindle assembly checkpoint.

3 llels with the mode of action of Mad2 in the spindle assembly checkpoint.

4 ubule polymerization and satisfaction of the spindle assembly checkpoint.

5 tive microtubule nucleation pathways and the spindle assembly checkpoint.

6 7(C70R) mutation does not affect the mitotic spindle assembly checkpoint.

7 ts contribution seems to be relevant for the spindle assembly checkpoint.

8 be induced in the mouse by inactivating the spindle assembly checkpoint.

9 d in G2 phase and mitosis, suggesting a weak spindle assembly checkpoint.

10 D2L1) in a screen for genes required for the spindle assembly checkpoint.

11 damage response, whereas Mps1 regulates the spindle assembly checkpoint.

12 re-microtubule associations and regulate the spindle assembly checkpoint.

13 Moreover, a lack of CK2 activates the spindle assembly checkpoint.

14 ule lattice and, thus, the activation of the spindle assembly checkpoint.

15 ids, the tel1 mec1 diploids had a functional spindle assembly checkpoint.

16 Mps1 is an essential component of the spindle assembly checkpoint.

17 t interact with spindle microtubules and the spindle assembly checkpoint.

18 to mitotic stress by abrogating the mitotic spindle assembly checkpoint.

19 actor transmitting the tension status to the spindle assembly checkpoint.

20 has also been implicated in inactivating the spindle assembly checkpoint.

21 hromatin staining, indicative of an extended spindle assembly checkpoint.

22 ssion of Mad2, an essential component of the spindle assembly checkpoint.

23 otein 1 (MAD1) is a component of the mitotic spindle assembly checkpoint.

24 se to microtubule stress, independent of the spindle assembly checkpoint.

25 pole and missegregate in the absence of the spindle assembly checkpoint.

26 ) and control cell-cycle progression via the spindle assembly checkpoint.

27 ining, indicating that DRT/DMC activates the spindle assembly checkpoint.

28 s, causing mitotic arrest and activating the spindle assembly checkpoint.

29 ase and is one of the main components of the spindle assembly checkpoint.

30 hts the contribution of p53 in regulation of spindle assembly checkpoint.

31 hase of the cell cycle, independently of the spindle assembly checkpoint.

32 ndle disruptions cause the engagement of the spindle assembly checkpoint.

33 , thereby resulting in the activation of the spindle assembly checkpoint.

34 ential roles in chromosome alignment and the spindle assembly checkpoint.

35 ependent regulation of MT attachment and the spindle-assembly checkpoint.

36 checkpoints and a recently reported mitotic spindle-assembly checkpoint.

37 ansient activation of the S phase, G2/M, and spindle assembly checkpoints.

38 detailed knowledge of the components of the spindle assembly checkpoint, a molecular explanation of

39 The spindle assembly checkpoint, a surveillance mechanism th

40 kinetochore-microtubule attachment, mitotic/spindle-assembly checkpoint, accurate chromosome segrega

41 y regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling protein

42 vels of KT proteins, including CENP-C(Cnp3), spindle assembly checkpoint activation, and chromosome s

43 itotic progression is halted attributable to spindle assembly checkpoint activation, and chromosomes

44 ly, inhibition of Net1 expression results in spindle assembly checkpoint activation.

45 e mediated by wee1 and are not the result of spindle assembly checkpoint activation.

46 ctured tail region is defective in mediating spindle assembly checkpoint activation.

47 During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stab

48 in p31(comet) is implicated in silencing the spindle assembly checkpoint after all kinetochores are a

49 Additional mechanisms, such as the spindle assembly checkpoint and centromere positioning,

50 fects in mitotic spindle formation, cellular spindle assembly checkpoint and centrosome amplification

51 Besides its role in the spindle assembly checkpoint and chromosome alignment, Bu

52 and interphase microtubule organization, the spindle assembly checkpoint and cytokinesis through its

53 omosomal passenger protein that mediates the spindle assembly checkpoint and cytokinesis, and also fu

54 ur analysis expands our understanding of the spindle assembly checkpoint and identifies new candidate

55 found that FA signaling is essential for the spindle assembly checkpoint and is therefore required fo

56 anaphase is delayed due to activation of the spindle assembly checkpoint and lagging sister chromatid

57 -expression of survivin restores a competent spindle assembly checkpoint and reduces polyploidy.

58 cells undergo normal mitoses with an intact spindle assembly checkpoint and that they are able to co

59 llmark of cancer, due to attenuations in the spindle assembly checkpoint and the post-mitotic checkpo

60 APC(Cdc20), antimitotic agents activate the spindle-assembly checkpoint and induce apoptosis after p

61 arily conserved protein kinase, required for spindle-assembly checkpoint and, in some organisms, for

62 ct chromosome alignment and segregation, the spindle assembly checkpoint, and cytokinesis.

63 on, arrested cells in mitosis, activated the spindle assembly checkpoint, and triggered mitotic catas

64 ched include genes that regulate the mitotic spindle assembly checkpoint, apoptosis, and the cytosoli

65 Whereas the kinetochores and the spindle assembly checkpoint appeared intact in HDAC3-def

66 at DNA damage-induced wild-type p53 leads to spindle assembly checkpoint arrest by repressing UBE2C,

67 The spindle assembly checkpoint arrests mitotic cells by pre

68 The spindle assembly checkpoint arrests mitotic progression

69 metaphase plate, possibly due to a defective spindle-assembly checkpoint, as well as of frayed and un

70 appear to rely on several components of the spindle assembly checkpoint but does require the kinetoc

71 etochore-associated kinase Mps1 controls the spindle assembly checkpoint, but the regulation of its k

72 reviously undescribed regulatory role in the spindle assembly checkpoint by recruiting Plk1 to kineto

73 ), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitoti

74 ng anaphase progression by activation of the spindle assembly checkpoint caused a loss of condensatio

75 INPP5E in human and murine cells impairs the spindle assembly checkpoint, centrosome and spindle func

76 The spindle assembly checkpoint complex (SAC) is essential f

77 me instability (W-CIN) we down-regulated the spindle assembly checkpoint component BUB1 and the mitot

78 Unusually, spindle assembly checkpoint components are required for

79 the Mos-MEK1-MAPK-p90(Rsk) cascade utilizes spindle-assembly-checkpoint components to effect metapha

80 adipogenesis, DNA replication, mitosis, and spindle assembly checkpoint control were all highly repr

81 The spindle assembly checkpoint controls proper chromosome s

82 dle poles, we identified novel roles for the spindle assembly checkpoint, cortical actin cytoskeleton

83 TRIP13 action in vitro, and in cells causes spindle assembly checkpoint defects consistent with loss

84 The spindle assembly checkpoint delays APC/C-Cdc20 activatio

85 The mitotic checkpoint, also known as the spindle assembly checkpoint, delays anaphase onset until

86 proper chromosome alignment, resulting in a spindle assembly checkpoint-dependent mitotic delay.

87 s-activated checkpoint during late G2 or the spindle assembly checkpoint during mitosis.

88 stmitotic checkpoint after adaptation to the spindle assembly checkpoint, E7-expressing cells replica

89 The spindle assembly checkpoint enables this centering mecha

90 The spindle assembly checkpoint ensures the faithful inherit

91 rmation of a bipolar mitotic spindle and the spindle assembly checkpoint, ensuring proper spindle fun

92 Furthermore, Xnf7 was required for spindle assembly checkpoint function in egg extracts.

93 , but maintains kinetochore localization and spindle assembly checkpoint function, indicating that TP

94 By depolymerizing microtubules and mutating spindle assembly checkpoint function, we demonstrate tha

95 troduced into the monopolar spindle 1 (Mps1) spindle-assembly checkpoint gene so that Cre-mediated re

96 sufficiency or heterozygous mutations in the spindle assembly checkpoint genes BUB1 and BUB3 in 2.9%

97 examined the genetic interactions with four spindle assembly checkpoint genes to identify nonessenti

98 ion, to identify the individual roles of the spindle assembly checkpoint genes within the checkpoint,

99 s in the APC co-activator fzy-1 and in three spindle assembly checkpoint genes, mdf-1, mdf-2, and mdf

100 point and unique interactions for all of the spindle assembly checkpoint genes.

101 Spindle assembly checkpoint governs proper chromosomal s

102 Variation in the activity of the spindle assembly checkpoint has been observed in differe

103 of oocyte maturation and maintenance of the spindle assembly checkpoint in extracts.

104 ne H3 plays a crucial role in activating the spindle assembly checkpoint in response to a defect in m

105 rom separase during meiosis I or support the spindle assembly checkpoint in yeast.

106 t with a role for dynein in self-removal and spindle assembly checkpoint inactivation.

107 By treating embryos with a spindle assembly checkpoint inhibitor during the four- t

108 Despite this, the spindle assembly checkpoint is normally silenced and the

109 A key target of the spindle assembly checkpoint is securin, the separase inh

110 The target of the mitotic spindle assembly checkpoint is the anaphase-promoting co

111 findings establish that in mammalian MI, the spindle assembly checkpoint is unable to sustain meiotic

112 ipts also indicated that the strength of the spindle assembly checkpoint is weakened and that higher

113 The mitotic checkpoint (or spindle assembly checkpoint) is a fail-safe mechanism to

114 c arrest deficient 2 (Mad2), a member of the spindle assembly checkpoint, is present on DRT/DMC chrom

115 The spindle assembly checkpoint kinase Mps1 not only inhibit

116 ctivity of DDR kinases ATM and Chk1, and the spindle assembly checkpoint kinase Mps1.

117 ne-121 site on histone H2A, a target of Bub1 spindle assembly checkpoint kinase, sensitizes gammaH2A-

118 with NHEJ deficiency upon disruption are two spindle assembly checkpoint kinases, Bub1 and Bub2.

119 rmal chromosome alignment and activating the spindle assembly checkpoint, leading to arrest in a prom

120 The spindle assembly checkpoint links the onset of anaphase

121 dies provide evidence that components of the spindle assembly checkpoint may regulate the metaphase-t

122 The spindle assembly checkpoint monitors microtubule attachm

123 The spindle assembly checkpoint monitors the integrity of th

124 synthetic genetic array (SGA) analysis using spindle assembly checkpoint mutants mad1, mad2, mad3, an

125 und 228 synthetic interactions with the four spindle assembly checkpoint mutants with substantial ove

126 e found shared interactions between pairs of spindle assembly checkpoint mutants, suggesting addition

127 ed to the spindle, kinetochores activate the spindle assembly checkpoint network, which in turn block

128 eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA recombination/

129 The spindle assembly checkpoint prevents aneuploidy by ensur

130 The spindle assembly checkpoint prevents separation of siste

131 The mitotic checkpoint (also known as the spindle assembly checkpoint) prevents premature anaphase

132 show that mutant mice with low levels of the spindle assembly checkpoint protein BubR1 develop progre

133 We have found that the spindle assembly checkpoint protein BubR1 regulates both

134 xhibit normal kinetochore recruitment of the spindle assembly checkpoint protein BubR1 without restor

135 conserved HORMA domain family, including the spindle assembly checkpoint protein MAD2 and the meiotic

136 Both reduplication responses require the spindle assembly checkpoint protein Mad2.

137 to seven proteins studied here including the spindle assembly checkpoint protein, Bub3.

138 tes the MCC by directly interacting with the spindle assembly checkpoint protein, MAD2.

139 ng than by differences in mitotic spindle or spindle assembly checkpoint proteins and that antimitoti

140 Spindle assembly checkpoint proteins have been thought t

141 ers of the mitotic spindle and by recruiting spindle assembly checkpoint proteins Mad1 and Mad2.

142 accharomyces pombe MCC (a complex of mitotic spindle assembly checkpoint proteins Mad2, Mad3 and APC/

143 rence reflects a more permissive role of the spindle assembly checkpoint, rather than solely reflecti

144 The spindle assembly checkpoint regulates the metaphase-to-a

145 Correspondingly, cyclin B accumulation and spindle assembly checkpoint (SAC) activation were observ

146 r62 depleted cells show spindle instability, spindle assembly checkpoint (SAC) activation, mitotic ar

147 mproperly attached kinetochores activate the spindle assembly checkpoint (SAC) and by an unknown mech

148 resting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Respons

149 The kinase Bub1 functions in the spindle assembly checkpoint (SAC) and in chromosome cong

150 eso1 (eso1-H17) is due to activation of the spindle assembly checkpoint (SAC) and is associated with

151 eveloped surveillance mechanisms such as the spindle assembly checkpoint (SAC) and the DNA damage res

152 Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis

153 The spindle assembly checkpoint (SAC) arrests mitosis until

154 the triple-Glu mutant failed to satisfy the spindle assembly checkpoint (SAC) at metaphase because p

155 The spindle assembly checkpoint (SAC) averts aneuploidy by c

156 The MI arrest is induced by the spindle assembly checkpoint (SAC) because inhibiting the

157 east, both the DNA damage checkpoint and the spindle assembly checkpoint (SAC) block cells prior to a

158 pore complex (NPC) protein implicated in the spindle assembly checkpoint (SAC) by an unknown mechanis

159 When the spindle assembly checkpoint (SAC) cannot be satisfied, c

160 Here, we report that the conserved spindle assembly checkpoint (SAC) component MDF-1/MAD1 i

161 The Bub1-H2Aph-Sgo1 pathway and spindle assembly checkpoint (SAC) components have been i

162 Here, we report that spindle assembly checkpoint (SAC) components MAD-1, MAD-

163 ences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components, but interp

164 e microtubules (MTs) and the accumulation of spindle assembly checkpoint (SAC) components.

165 The spindle assembly checkpoint (SAC) conveys lack of tensio

166 The spindle assembly checkpoint (SAC) delays anaphase onset

167 The spindle assembly checkpoint (SAC) delays anaphase until

168 unattached/weakly attached kinetochores, the spindle assembly checkpoint (SAC) delays exit from mitos

169 The spindle assembly checkpoint (SAC) delays mitotic progres

170 The spindle assembly checkpoint (SAC) delays mitotic progres

171 The Spindle Assembly Checkpoint (SAC) delays the onset of an

172 chore-microtubule (KT-MT) attachment and the spindle assembly checkpoint (SAC) during cell division a

173 Spindle assembly checkpoint (SAC) ensures bipolar attach

174 The spindle assembly checkpoint (SAC) ensures correct chromo

175 The spindle assembly checkpoint (SAC) ensures faithful chrom

176 In mitosis, the spindle assembly checkpoint (SAC) ensures genome stabili

177 The Spindle Assembly Checkpoint (SAC) ensures genomic stabil

178 In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each daug

179 The spindle assembly checkpoint (SAC) ensures that sister ch

180 The spindle assembly checkpoint (SAC) ensures the accurate s

181 The spindle assembly checkpoint (SAC) ensures the faithful s

182 In eukaryotes, the spindle assembly checkpoint (SAC) ensures the fidelity o

183 d by differential display (EDD) in promoting spindle assembly checkpoint (SAC) function.

184 The spindle assembly checkpoint (SAC) functions as a surveil

185 morigenesis model derived from knocking down spindle assembly checkpoint (SAC) genes and preventing a

186 The spindle assembly checkpoint (SAC) guards against chromos

187 The spindle assembly checkpoint (SAC) in mammals uses cytoso

188 DNA damage activates a pathway involving the spindle assembly checkpoint (SAC) in response to chemica

189 hether APC-deficient cells have a functional spindle assembly checkpoint (SAC) in vivo by examining t

190 indle assembly, chromosome misalignment, and spindle assembly checkpoint (SAC) inactivation.

191 Spindle assembly checkpoint (SAC) is a critical cellular

192 The spindle assembly checkpoint (SAC) is activated at unatta

193 The spindle assembly checkpoint (SAC) is an essential safegu

194 correction, chromosome biorientation and the spindle assembly checkpoint (SAC) is complicated by thei

195 ypersensitive to anoxia, suggesting that the spindle assembly checkpoint (SAC) is compromised.

196 The spindle assembly checkpoint (SAC) is essential for ensur

197 The spindle assembly checkpoint (SAC) is essential for prope

198 The spindle assembly checkpoint (SAC) is essential to ensure

199 for MCC dissociation from the APC/C once the spindle assembly checkpoint (SAC) is satisfied.

200 The spindle assembly checkpoint (SAC) is the major surveilla

201 Inhibition of the spindle assembly checkpoint (SAC) kinase, Mps1, during M

202 The spindle assembly checkpoint (SAC) maintains genomic stab

203 ginally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast.

204 The spindle assembly checkpoint (SAC) monitors and promotes

205 The spindle assembly checkpoint (SAC) monitors correct attac

206 The eukaryotic spindle assembly checkpoint (SAC) monitors microtubule a

207 During mitosis, the spindle assembly checkpoint (SAC) monitors the attachmen

208 amage-induced apoptotic response and mitotic spindle assembly checkpoint (SAC) override in human tumo

209 The spindle assembly checkpoint (SAC) plays a critical role

210 ensure accurate chromosome segregation, the spindle assembly checkpoint (SAC) prevents anaphase unti

211 The spindle assembly checkpoint (SAC) prevents aneuploidy by

212 The spindle assembly checkpoint (SAC) prevents chromosome mi

213 , a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produces an inhibitory

214 ole localization of gamma-tubulin and showed spindle assembly checkpoint (SAC) protein Bub3 at the ki

215 Recruitment of spindle assembly checkpoint (SAC) proteins by an unattac

216 itotic roles involving spatial regulation of spindle assembly checkpoint (SAC) proteins.

217 ~1 h, and this is due to an earlier onset of spindle assembly checkpoint (SAC) satisfaction and APC(C

218 premature mitotic exit is due to defects in spindle assembly checkpoint (SAC) signaling, such that c

219 Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accur

220 ched to the spindle; this is achieved by the Spindle Assembly Checkpoint (SAC) that inhibits the Anap

221 rapeutic agents such as taxanes activate the spindle assembly checkpoint (SAC) to arrest anaphase ons

222 hanosensitive signaling cascade known as the spindle assembly checkpoint (SAC) to detect and signal t

223 have evolved a signaling pathway called the spindle assembly checkpoint (SAC) to increase the fideli

224 mproper kinetochore attachments activate the spindle assembly checkpoint (SAC) to prevent anaphase on

225 APC/C coactivator, Cdc20, is targeted by the spindle assembly checkpoint (SAC) to restrict APC/C acti

226 titioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling

227 K protein kinase) is a core component of the spindle assembly checkpoint (SAC), a genome-surveillance

228 (Mps1) is a central component of the mitotic spindle assembly checkpoint (SAC), a sensing mechanism t

229 itors or Plk1-null cells is triggered by the spindle assembly checkpoint (SAC), and can be rescued in

230 e I causes acceleration of MI, bypass of the spindle assembly checkpoint (SAC), and loss of interchro

231 Two key components are centrosomes and the spindle assembly checkpoint (SAC), and mutations affecti

232 urea, leading to secondary activation of the spindle assembly checkpoint (SAC), aneuploidy, and letha

233 PCM, form multipolar spindles, activate the spindle assembly checkpoint (SAC), arrest in mitosis, an

234 MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning m

235 ce phenotype that requires components of the spindle assembly checkpoint (SAC), including Bub3 and Ma

236 RIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rat

237 th Aurora inhibitors still have a functional spindle assembly checkpoint (SAC), since the checkpoint

238 is to cell cycle arrest independently of the spindle assembly checkpoint (SAC), suggesting that while

239 descriptions of the G1-S checkpoint and the spindle assembly checkpoint (SAC), the EGF signalling pa

240 error correction mechanism [1, 2] and by the spindle assembly checkpoint (SAC), which delays cell-cyc

241 In the spindle assembly checkpoint (SAC), which enables errorle

242 ulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to sug

243 opolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anapha

244 The spindle assembly checkpoint (SAC), whose reversal upon c

245 es identical mitotic defects that initiate a spindle assembly checkpoint (SAC)-dependent mitotic dela

246 rometaphase when APC/C is inactivated by the spindle assembly checkpoint (SAC).

247 om mitosis is controlled by silencing of the spindle assembly checkpoint (SAC).

248 degradation and slippage from an unsatisfied spindle assembly checkpoint (SAC).

249 This process is known as the spindle assembly checkpoint (SAC).

250 which maintains chromosome stability at the spindle assembly checkpoint (SAC).

251 tions (K-fibers), a process regulated by the spindle assembly checkpoint (SAC).

252 ity of chromosome segregation depends on the spindle assembly checkpoint (SAC).

253 , sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC).

254 hould be inherently unstable and trigger the spindle assembly checkpoint (SAC).

255 erroneous attachments, and silencing of the spindle assembly checkpoint (SAC).

256 bule attachment as well as activation of the spindle assembly checkpoint (SAC).

257 of chromosome segregation is enhanced by the spindle assembly checkpoint (SAC).

258 s a delay in mitosis that is mediated by the spindle assembly checkpoint (SAC).

259 s in mitotic cells and is a component of the spindle assembly checkpoint (SAC).

260 ression of Polo kinase and components of the spindle assembly checkpoint (SAC).

261 ustered at a monopolar spindle and an active spindle assembly checkpoint (SAC).

262 question from the functional perspectives of spindle assembly checkpoint (SAC).

263 perly attached to the mitotic spindle by the spindle assembly checkpoint (SAC).

264 cipitates with BubR1, a key regulator of the spindle assembly checkpoint (SAC).

265 BubR1 is a key component of the spindle assembly checkpoint (SAC).

266 chromosome congression and regulation by the spindle assembly checkpoint (SAC).

267 n at specific times under the control of the spindle assembly checkpoint (SAC).

268 me (APC/C(Cdc20)) by Cdc20 is delayed by the spindle assembly checkpoint (SAC).

269 ociated dynein (KD) functions to silence the spindle-assembly checkpoint (SAC) [6].

270 This transition is essential to satisfy the spindle-assembly checkpoint (SAC) and couple MT-generate

271 in kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly ove

272 e of at least six proteins that transmit the spindle assembly checkpoint signal.

273 ere impaired, resulting in the activation of spindle assembly checkpoint signaling and, ultimately, e

274 port that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, pro

275 t to promote chromosome alignment and robust spindle assembly checkpoint signaling.

276 h are involved in chromosome congression and spindle assembly checkpoint signaling.

277 compromised bipolar attachment and premature spindle assembly checkpoint silencing in the mutant cell

278 Zw10 but not BubR1 from kinetochores during spindle assembly checkpoint silencing.

279 The mitotic (or spindle assembly) checkpoint system delays anaphase unti

280 The mitotic (or spindle assembly) checkpoint system prevents premature s

281 The mitotic (or spindle assembly) checkpoint system prevents premature s

282 spindle 1 kinase (Mps-1) is a kinase of the spindle assembly checkpoint that controls cell division

283 s mechanism of aneuploidy bypasses the known spindle assembly checkpoint that monitors chromosome seg

284 w the APC/C works, with implications for the spindle assembly checkpoint that regulates it.

285 ding cells use a surveillance mechanism, the spindle assembly checkpoint, that monitors the attachmen

286 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational

287 s possible that a lowered sensitivity of the spindle assembly checkpoint to certain types of chromoso

288 s to the spindle microtubules and signal the spindle assembly checkpoint to delay mitotic exit until

289 tension at the kinetochore that silences the spindle assembly checkpoint to ensure faithful chromosom

290 Mad2 knockdown released the spindle assembly checkpoint triggered when TOG5-microtub

291 on due to erroneous attachment activates the spindle assembly checkpoint, which corrects the mistakes

292 d the kinetochore microtubules activates the spindle assembly checkpoint, which delays anaphase by bl

293 ssociated with defects in DNA repair and the spindle assembly checkpoint, which in turn can lead to p

294 Mitotic cells arrested by the spindle assembly checkpoint, which inactivates APC/C, of

295 The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-p

296 regulation of genes involved in the mitotic spindle assembly checkpoint, which results in inhibition

297 cell cycle as in Opisthokonts; however, the spindle assembly checkpoint, which targets the APC in Op

298 a a Cdk1/MAPK-dependent stabilization of the spindle assembly checkpoint, which when inhibited leads

299 Mps1 is an upstream component of the spindle assembly checkpoint, which, in human cells, is r

300 on leads to a constitutive activation of the spindle-assembly checkpoint, which therefore causes a la