ライフサイエンスコーパス: spindle cell

1 r composed of endothelial, inflammatory, and spindle cells.

2 show that LNA is extensively expressed in KS spindle cells.

3 nt in the predominant tumor cells of KS, the spindle cells.

4 B-45 positivity is often weaker or absent in spindle cells.

5 nt proliferation of endothelial-cell-derived spindle cells.

6 a cobblestone-like monolayer to foci-forming spindle cells.

7 cterized by angiogenesis and the presence of spindle cells.

8 The main KS tumor cell is the spindle cell, a cell of endothelial origin that maintain

9 many cell types, the predominant cell is the spindle cell, a cell of endothelial origin that maintain

10 vFLIP expression in spindle cells also induces the production of a variety o

11 Spindle cell and mucoepidermoid variants of squamous cel

12 confluent proliferation and the formation of spindle cells and foci of dermal microvascular endotheli

13 edominantly during viral latency, in most KS spindle cells and in cell lines established from body-ca

14 ption factor Ets-1 is highly expressed in KS spindle cells and is upregulated during KSHV infection o

15 Cytologic features such as spindle cells and melanin granules, present in 98% and 8

16 ed skin showed thickening of collagen, CD34+ spindle cells, and increased mucin in the dermis, suppor

17 KS spindle cells are believed to be of the lymphatic endoth

18 Whereas spindle cells are most likely endothelial in origin, it

19 Multiple lesions, in which spindle cells are prominent, often arise synchronously o

20 Of those five, two had high-grade spindle cell areas and one had granular cell histology i

21 ne-arrested cells have nearly normal bipolar spindles, cells arrested by 5-Br-nosc and Rd 5-Br-nosc f

22 carcinoma (SCC) to a more advanced malignant spindle cell carcinoma (SPCC) were determined by differe

23 rkedly decreased or lost in invasive SCC and spindle cell carcinoma cell lines.

24 inoma), and an ultraviolet radiation-induced spindle cell carcinoma were tested, and the results supp

25 ing in epithelial-mesenchymal transitions to spindle cell carcinomas and lung metastases.

26 advanced malignancy, i.e., undifferentiated spindle cell carcinomas, were exclusively observed in p5

27 entiated with a high frequency of anaplastic spindle cell carcinomas.

28 nchymal transition (EMT), i.e., formation of spindle cell carcinomas.

29 ies of renal cell carcinomas (clear/granular/spindle cell, chromophilic cell, chromophobic cell, and

30 The formation of spindle cell colonies and plaques in DMVEC cultures prov

31 om all three cell lines produced distinctive spindle cell colonies and plaques without affecting the

32 The tumors were highly vascularized, had a spindle cell component, expressed VEGF-C mRNA, and conta

33 with pleomorphic or round cells rather than spindle cells, contained an unidentified phosphodiester

34 nclude that de novo KSHV infection induces a spindle cell conversion phenotype in primary DMVEC cultu

35 suggesting that infection of endothelial and spindle cells could induce cellular transformation and t

36 e cells of primary KS lesions and KS-derived spindle cell cultures express high levels of basic fibro

37 that carry mutant p53 undermines the mitotic spindle cell cycle checkpoint and facilitates the develo

38 ontrol of cyclin B metabolism by the mitotic spindle cell cycle checkpoint and resulted in a higher t

39 re the identification of a defective mitotic spindle cell cycle checkpoint in VSMC isolated from capa

40 f Cks1 was sufficient to alter their mitotic spindle cell cycle checkpoint status and promote unsched

41 ient to abrogate the activity of the mitotic spindle cell-cycle checkpoint, promoting polyploidizatio

42 h function in centrosome duplication and the spindle cell-cycle checkpoint.

43 Within KS lesions, KSHV-infected spindle cells displayed features compatible with KSHV-in

44 t by segregation of latent viral episomes as spindle cells divide.

45 mposed of compacted elongated, GFAP-positive spindle cells (due to intermediate filaments identified

46 cells generated spheres in 3D Matrigel, but spindle cells emerged on 2D or coated Matrigel.

47 Spindle cells exhibited cyclin, Ki-67, and Mib-1 immunor

48 2, and more holoclones than those mixed with spindle cells expanded in DF.

49 Resultant epithelial spheres mixed with spindle cells expanded in MESCM expressed more p63alpha,

50 ior faithfully recapitulates the behavior of spindle cells explanted from primary KS biopsies, strong

51 primary human endothelial cells, and that KS spindle cells express A20 in KS tissue.

52 Spindle cells express markers of lymphatic endothelium a

53 formed poorly differentiated carcinomas with spindle cell features.

54 fflicting AIDS patients, is characterized by spindle cell formation and vascularization.

55 Spindle cell formation can be replicated in vitro by inf

56 s showed that c-Kit was sufficient to induce spindle cell formation.

57 We obtained early-passage spindle cells from skin lesions of patients with the acq

58 Kaposi's sarcoma (KS) spindle cell growth and spread have been reported to be

59 e of bFGF, which stimulates angiogenesis and spindle cell growth in an autocrine fashion.

60 growth factor, an angiogenesis and Kaposi's-spindle-cell growth factor.

61 Spindle cell hemangioma (SCH) is a rare, benign vascular

62 The 32 patients with spindle-cell histology had a 49% +/- 7% 5-year recurrenc

63 ies, including each of 12 mesotheliomas with spindle-cell histology.

64 Tumor spindle cells in all clinical types of Kaposi's sarcoma

65 s prior to lytic induction and in >70% of KS spindle cells in primary KS tumors.

66 virus 8 (HHV8) infects Kaposi's sarcoma (KS) spindle cells in situ, as well as the lesional endotheli

67 and CDH11 rearrangements were restricted to spindle cells in the ABC and were not found in multinucl

68 We tested the hypothesis that the spindle cells in these multicentric lesions originate fr

69 al cells that resemble characteristics of KS spindle cells in vivo.

70 Some RCCs had a sarcomatoid morphology of spindle cells in whorled patterns and metastasized to th

71 80 genes, only a few are expressed in tumor spindle cells, including latency-associated nuclear anti

72 KS-derived spindle cells induce vascular lesions and display enhanc

73 It is characterized by the proliferation of spindle cells, inflammatory infiltrate, and aberrant ang

74 main cell type found within a KS lesion, the spindle cell, is latently infected with KSHV and has mar

75 othelial cells to acquire the features of KS spindle cells (KS cells) including spindle morphology, m

76 resent a clinical challenge along with other spindle cell lesions of the prostate in terms of both di

77 litary fibrous tumors, epithelioid sarcomas, spindle cell lipomas, dermatofibrosarcoma protuberans, a

78 ma, epididymal leiomyosarcoma, and recurrent spindle cell malignancy of the spermatic cord.

79 y downregulated in clinical samples of human spindle cell metaplastic breast carcinoma.

80 ) from cell junctions and the acquisition of spindle cell morphology.

81 rs (SFTs) of the prostate are a rare type of spindle cell neoplasm that can demonstrate either a beni

82 osarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm.

83 e gastrointestinal stromal tumors from other spindle cell neoplasms.

84 oscopically, including Spitz nevi, pigmented spindle cell nevi, deep-penetrating nevi, and Monsel's r

85 changes that permit the clonal outgrowth of spindle cells occur before the disease spreads.

86 vealed that Rac1 is overexpressed in KSHV(+) spindle cells of AIDS-KS biopsies.

87 S lesions are characterized by proliferating spindle cells of endothelial cell (EC) origin.

88 sclerotic plaques and in endothelial-derived spindle cells of Kaposi sarcoma.

89 cal staining for CD34 and procollagen in the spindle cells of NFD suggest that the dermal cells of NF

90 We have previously reported that spindle cells of primary KS lesions and KS-derived spind

91 ated Matrigel resulted in rapid expansion of spindle cells, of which the expression of ESC markers ha

92 BCAC versus BCA, as well as the presence of spindle cell/ovarian stroma (both P < 0.05).

93 of HHV8 is sufficient for the acquisition of spindle cell phenotype by vascular endothelial cells and

94 hibitory protein K13 is sufficient to induce spindle cell phenotype in human umbilical vein endotheli

95 s, such as fibronectin, and acquisition of a spindle cell phenotype.

96 Ninety-three percent of mice developed spindle cell/pleomorphic sarcomas after a single subcuta

97 lesional endothelial cells considered to be spindle cell precursors.

98 ology that was strikingly similar to that of spindle cells present in KS lesions.

99 is a primary malignancy of the bone in which spindle cells produce osteoid.

100 ese findings may explain why LANA-expressing spindle cells proliferate within KS tumors, yet most oft

101 re pronounced peribronchial and perivascular spindle cell proliferation accompanied by collagen depos

102 he features of KS, including transformation, spindle cell proliferation, and angiogenesis.

103 atients characterized histopathologically by spindle cell proliferation, angiogenesis, and leukocyte

104 f Kaposi's sarcoma (KS) are characterized by spindle cell proliferation, angiogenesis, inflammatory c

105 the vGCR protein's playing a direct role in spindle cell proliferation, transformation, or latency,

106 S is characterized by neovascularization and spindle cell proliferation.

107 growth factor (VEGF)-driven angiogenesis and spindle cell proliferation.

108 tive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltra

109 cted culture displaying aggregated swirls of spindle cells resembling those in KS lesions.

110 We observed that stimulation in KS 38 spindle cells resulted in tyrosine phosphorylation and a

111 Synovial sarcoma is an aggressive spindle cell sarcoma with two major histological subtype

112 onfirmed PR (two with osteosarcoma, one with spindle cell sarcoma, and one with malignant fibrous his

113 evated the incidence of lung adenocarcinoma, spindle cell sarcoma, and thymic lymphoma in p53 heteroz

114 fered from both a renal cell carcinoma and a spindle-cell sarcoma of the ascending aorta, which had m

115 Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of

116 null mice it leads to increased incidence of spindle cell sarcomas, including RMS.

117 It is composed of spindle cells similar to fibroblasts and derives probabl

118 mor showed invasive squamous cell carcinoma, spindle cell subtype.

119 mitogenic to endothelial cells but not to KS spindle cells, suggesting a prevailing paracrine effect

120 However, a percentage of spindle cells support lytic replication and production o

121 ization signals were detected in most of the spindle cells surrounding the atypical slit-like vascula

122 specialized cells in the neocortex, that is, spindle cells that have been associated with self-consci

123 KS spindle cells, the main tumor cells, all contain KSHV, m

124 ction to isolate areas composed primarily of spindle cells, the putative tumor cells.

125 with multiple skin lesions characterized by "spindle cells," the vast majority of which are infected

126 y expressed in KSHV-infected B cells, not KS spindle cells, this study suggests that vIRF is a transf

127 SLK spindle cells transfected with such constructs efficient

128 Furthermore, similar to K13, HHV8-induced spindle cell transformation of HUVEC is associated with

129 Although HHV8 can induce spindle cell transformation of vascular endothelial cell

130 ntation in a model of immunity to the S1509a spindle cell tumor (H-2a).

131 al cellular RNA was isolated from the S1509a spindle cell tumor and used to pulse CAF1 epidermal cell

132 lopment of Kaposi's sarcoma (KS), a vascular spindle cell tumor primarily consisting of proliferating

133 r immunity against challenge with the S1509a spindle-cell tumor whereas null vector-infected cells we

134 m with the expression profiles of a group of spindle cell tumors from locations outside the gastroint

135 and immunohistochemistry, we showed that the spindle cell tumors in the Snai2-null mice demonstrated

136 Synovial sarcomas are high grade spindle cell tumors that are divided into two major hist

137 R-mediated skin tumors including papillomas, spindle cell tumors, and squamous cell carcinomas, relat

138 dition, null mice developed fewer aggressive spindle cell tumors, believed to arise from squamous cel

139 all diagnosed as squamous cell carcinoma or spindle cell tumors.

140 during the development of adenocarinoma and spindle cell tumors.

141 heir reclassification as separate from other spindle cell tumors.

142 mal tumors, lung and mammary carcinomas, and spindle cell tumors.

143 ng, results in malignant transformation to a spindle cell-type tumor.

144 xpression within KS lesions may be prolonged spindle cell viability which, when coupled with dysregul

145 These spindle cells were not observed in any other primate spe

146 Among these, spindle cells were observed in 98% (63% mixed and 35% sp

147 Spindle cells, which may be vascular precursor cells, of

148 replication, and proliferate into bundles of spindle cells with KS slit-like spaces.