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1 sted to stabilise attachment and silence the spindle checkpoint.
2 motor associated, are needed to silence the spindle checkpoint.
3 y and is essential for the activation of the spindle checkpoint.
4 t Aurora B kinase to efficiently silence the spindle checkpoint.
5 te of mitotic slippage and adaptation to the spindle checkpoint.
6 neral role of the APC protein in the mitotic spindle checkpoint.
7 to identify lead compounds that inhibit the spindle checkpoint.
8 l1 targets contribute to segregation and the spindle checkpoint.
9 of the final steps of mitosis--silencing the spindle checkpoint.
10 tive spindle formation and activation of the spindle checkpoint.
11 of bi-oriented attachments and activated the spindle checkpoint.
12 e formation and subsequent activation of the spindle checkpoint.
13 across sister kinetochores and activate the spindle checkpoint.
14 biquitin ligase, Smurf2, is required for the spindle checkpoint.
15 uces mitotic arrest due to activation of the spindle checkpoint.
16 found that E6 expression does not affect the spindle checkpoint.
17 protease 44) as a critical regulator of the spindle checkpoint.
18 o promoting robust activation of the mitotic spindle checkpoint.
19 cells to arrest in mitosis with a functional spindle checkpoint.
20 ing that LCMT-1 and Balpha are important for spindle checkpoint.
21 phase chromosome alignment and activates the spindle checkpoint.
22 elieved to function primarily in the mitotic spindle checkpoint.
23 of APC in U2OS cells compromises the mitotic spindle checkpoint.
24 iple roles in chromosome segregation and the spindle checkpoint.
25 sion of the APC in anaphase, reactivates the spindle checkpoint.
26 ase activity of Aurora B, a regulator of the spindle checkpoint.
27 pindle-kinetochore interaction activates the spindle checkpoint.
28 metaphase plate, and is not detected by the spindle checkpoint.
29 in microtubule binding and regulation of the spindle checkpoint.
30 is known about its functions apart from the spindle checkpoint.
31 hat determines kinetochore activation of the spindle checkpoint.
32 izes to mitotic centrosomes and controls the spindle checkpoint.
33 dination of chromosome biorientation and the spindle checkpoint.
34 re in both the chromosome attachment and the spindle checkpoint.
35 ome segregation, and optimal function of the spindle checkpoint.
36 e attachments and subsequently silencing the spindle checkpoint.
37 itive tumors and associated with the mitotic spindle checkpoint.
38 APC/C(Cdc20) is the target of the spindle checkpoint.
39 ting an interplay between the DNA damage and spindle checkpoints.
40 chores and microtubules are monitored by the spindle checkpoint, a surveillance system that prevents
41 checkpoint proteins to the kinetochore upon spindle checkpoint activation are incompletely understoo
43 st, they are uniquely sensitive to transient spindle checkpoint activation as a result of a failure i
44 unattached kinetochores and is required for spindle checkpoint activation in Caenorhabditis elegans.
47 explanation of how cells die after prolonged spindle checkpoint activation, and thus how microtubule
56 levated in mitosis or upon activation of the spindle checkpoint, although the dynamic range of Mps1 e
58 spond to microtubule drugs by activating the spindle checkpoint and arresting in mitosis with a round
61 gression, as knockdown of Bora activates the spindle checkpoint and delays sister chromatid segregati
63 kinase activity of Mps1 is required for the spindle checkpoint and for kinetochore localization of B
64 induced a mitotic arrest that depends on the spindle checkpoint and induced misalignment of chromosom
65 that is able to alter the properties of the spindle checkpoint and initiate a signal transduction ca
67 that binds weakly to PP1 also activates the spindle checkpoint and suppresses the temperature sensit
69 t that there exists a cross-talk between the spindle checkpoint and the DNA damage checkpoint and tha
70 function generates lesions invisible to the spindle checkpoint and thereby promotes low levels of CI
72 ing G2 permits the optimal activation of the spindle checkpoint, and consequently it is required for
73 of MTs in a kinetochore fiber, activates the spindle checkpoint, and delays the mitotic progression.
74 in shortened mitotic timing and a defective spindle checkpoint, and that abrogation of ATM Ser1403 p
77 on of checkpoint complexes, we conclude that spindle checkpoint arrest can be independent of their ki
79 se activity is directly required to maintain spindle checkpoint arrest, even in the presence of many
85 that B-Raf(V600E) signaling deregulates the spindle checkpoint as a consequence of stabilizing monop
86 cts strictly depends on a functional mitotic spindle checkpoint as well as on intact microtubule pull
88 hk1 depletion leads to the activation of the spindle checkpoint because codepletion of spindle checkp
89 metaphase arrest is mediated by the mitotic spindle checkpoint being dependent on Mad1 and the Auror
91 val of defective nuclei does not require the spindle checkpoint but instead depends on the DNA damage
92 knockdown cells can enter mitosis and retain spindle checkpoint, but fail to complete cytokinesis.
93 in kinase that regulates segregation and the spindle checkpoint, but few of the targets that mediate
94 kinase activity of Mps1 is required for the spindle checkpoint, but how Mps1 is activated during mit
96 dynein binds directly to a component of the spindle checkpoint complex through the DYNLT3 light chai
98 nucleoplasm, yet kinetochore localization of spindle checkpoint components is required for proper rec
101 s a conserved mitotic regulator critical for spindle checkpoint control, kinetochore functionality, a
111 We show that mitotic errors result in a spindle checkpoint-dependent cell-cycle delay, but defec
112 turb spindle dynamics, and induce prolonged, spindle checkpoint-dependent mitotic arrest in cancer ce
120 hore also serves as a regulatory hub for the spindle checkpoint, ensuring that cell cycle progression
121 partial Mps1 inhibition and was required for spindle checkpoint establishment at the beginning of mit
124 or Zwint-1 causes chromosome missegregation, spindle checkpoint failure, and eventually cell death up
127 for kinetochore-microtubule interactions and spindle checkpoint function [3-7]; however, the underlyi
128 lls, Mps1 catalytic activity is required for spindle checkpoint function and recruitment of Mad2.
129 culture or transgenic mice inhibited mitotic spindle checkpoint function because of reduced Rb transc
139 e systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability.
141 ficient) cells, conditions that activate the spindle checkpoint (i.e., cold shock or treatment with n
142 kinase, Mps1, is a critical component of the spindle checkpoint in human cells and regulates the kine
154 an APCCdc20 substrate, is degraded when the spindle checkpoint is active, while other APCCdc20 subst
157 d, bipolar spindles fail to assemble but the spindle checkpoint is inappropriately silenced due to PP
159 d cells exhibit slower mitotic exit when the spindle checkpoint is silenced by inhibition of the chec
165 ciency 2 (Mad2), a critical component of the spindle checkpoint, is overexpressed in many cancer cell
168 yclin E-Cdk2, but not with Mos, requires the spindle-checkpoint kinase monopolar spindles 1 (Mps1), a
171 t responses to two insults that activate the spindle checkpoint: MAD2/mad2Delta cells respond normall
173 ese results suggest that inactivation of the spindle checkpoint may contribute to the development of
175 study, we develop evidence that the mitotic spindle checkpoint molecule BUB1B may offer a predictive
178 malorientations that are not detected by the spindle checkpoint; Ndel1-deficient cells consequently e
184 e arrest and germline apoptosis, placing the spindle checkpoint pathway upstream of the programmed ce
186 ecombination, sister chromatid cohesion, the spindle checkpoint, postreplication repair, and telomere
190 used budding yeast to determine whether the spindle checkpoint promotes segregation of such chromoso
191 w here that PKM2, but not PKM1, binds to the spindle checkpoint protein Bub3 during mitosis and phosp
192 study clarifies the role of APC as a mitotic spindle checkpoint protein in vivo and shows that APC-de
194 of anaphase requires an understanding of how spindle checkpoint protein interaction with the kinetoch
195 d Pdr3; the mRNA processing factor Fir1; the spindle checkpoint protein kinase Mps1; and a protein of
196 Molecular Cell, Cairo et al. report that the spindle checkpoint protein Mad1 shuttles between unattac
197 rotein p31(comet), converts the HORMA-family spindle checkpoint protein MAD2 from a signaling-active
200 the microtubule-sensitive recruitment of the spindle checkpoint protein Mad2, and the segregation beh
202 f a downstream target for cyclin E/Cdk2, the spindle checkpoint protein Mps1, provides insight into h
204 KSHV, can induce the degradation of Bub1, a spindle checkpoint protein that is important for spindle
205 rthermore, our findings suggest that Bub1, a spindle checkpoint protein, serves as a scaffold or mole
207 eficiency 2 (Mad2) is a component of mitotic spindle checkpoint proteins and is essential for accurat
209 er, AEtr cells had reduced levels of several spindle checkpoint proteins including BubR1 and securin
211 ng the dual prometaphase localization of the spindle checkpoint proteins Mad1, Mad2, Bub3, and Cdc20.
213 he spindle checkpoint because codepletion of spindle checkpoint proteins rescues the Chk1 depletion-i
214 This in turn accentuates degradation of spindle checkpoint proteins such as BubR1 and Bub1, cont
215 ractions between the kinetochore and various spindle checkpoint proteins that ensure that sister chro
216 tension triggers recruitment of several key spindle checkpoint proteins to the kinetochore, which de
217 ugh its interaction with one of the critical spindle checkpoint proteins, Bub1, and the resulting deg
218 ts (Apc14 and Apc15) regulate association of spindle checkpoint proteins, in the form of the mitotic
223 the spindle checkpoint by recruiting several spindle-checkpoint proteins, including Mps1, Mad1, Mad2,
224 gue in response to mitotic delay, leading to spindle checkpoint re-activation and lethal mitotic arre
225 -160 complex was depleted from extracts, the spindle checkpoint remained intact, but spindle assembly
226 t cannot bind aurora B, are sufficient for a spindle checkpoint response when microtubules are absent
228 esses microtubule dynamics and activates the spindle checkpoint, revealed a specific switch in kineto
234 e a molecular switch that maintains a robust spindle checkpoint signal at prometaphase kinetochores u
235 associate with kinetochores to generate the spindle checkpoint signal, but they are released when a
237 dle checkpoint protein that is important for spindle checkpoint signaling and chromosome segregation.
239 n of mitotic chromosomes, where it initiates spindle checkpoint signaling and promotes chromosome ali
241 centromeres, outer kinetochore formation, or spindle checkpoint signaling but nevertheless elevates c
242 s activity of BUB-1/BUB-3 was independent of spindle checkpoint signaling but required kinetochore lo
246 teins responsible for lateral attachment and spindle checkpoint signaling expand to form micrometer-s
247 o systematically define the requirements for spindle checkpoint signaling in the Caenorhabditis elega
249 CTD, recruits PP1 to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphas
250 tes kinetochore-microtubule attachments with spindle checkpoint signaling on each mitotic chromosome.
252 east eight protein kinases are implicated in spindle checkpoint signaling, arguing that a traditional
253 veral protein kinases play critical roles in spindle checkpoint signaling, but the mechanism (or mech
267 required for proper assembly of the mitotic spindle, checkpoint signaling, and several other aspects
268 role of spatiotemporal regulation in mitotic spindle checkpoint signalling and fidelity of chromosome
270 The complex is also required to generate spindle checkpoint signals in both yeast and human cells
275 ere consistent with faulty activation of the spindle checkpoint, such as shortened mitosis, premature
276 that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the
277 hore-microtubule attachments to shut off the spindle checkpoint, suggesting that cells regulate the E
280 g of Bub3 to the Spc7 MELT array toggles the spindle checkpoint switch by permitting Mph1 (Mps1)-depe
281 ivate a signaling pathway called the mitotic spindle checkpoint that blocks progression into anaphase
283 isalignment, mitotic catastrophe and loss of spindle checkpoint, that are accompanied by reduced expr
284 fficient execution of their functions in the spindle checkpoint, the self-monitoring system of the eu
285 ility to phosphorylate Bub1 and regulate the spindle checkpoint, thus maintaining genomic integrity.
287 an age-related decline in the ability of the spindle checkpoint to delay separase-mediated cleavage o
288 ely on a surveillance mechanism known as the spindle checkpoint to ensure accurate chromosome segrega
289 ated from these opposing forces silences the spindle checkpoint to ensure accurate chromosome segrega
290 ochore-microtubule attachments and alert the spindle checkpoint to the presence of misaligned chromos
291 At the metaphase-anaphase transition, the spindle checkpoint turns off, and MCC disassembles to al
292 ts the role of MK2 in G(2)/M and the mitotic spindle checkpoints, two mechanisms by which MK2 contrib
293 network plays a major role in silencing the spindle checkpoint when chromosomes are aligned at metap
295 tometric analysis, we found that the mitotic-spindle checkpoint, which helps maintain chromosomal int
296 chromosome segregation is controlled by the spindle checkpoint, which responds to the lack of microt
297 chromosome segregation is controlled by the spindle checkpoint, which senses kinetochore- microtubul
298 However, Tax did not affect the mitotic spindle checkpoint, which was also functional in HTLV-I-
299 deficient-like 1, MAD2L1, a component of the spindle checkpoint whose down-regulation is essential in
300 for how cancer cells can have a compromised spindle checkpoint without corresponding mutations in ch
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