ライフサイエンスコーパス: spindle formation

1 l nucleus (e.g., DNA replication and mitotic spindle formation).

2 activity are sufficient for initial bipolar spindle formation.

3 totic events, like centrosome maturation and spindle formation.

4 led to microtubule function and thus mitotic spindle formation.

5 try that are essential for cilia and mitotic spindle formation.

6 ification, chromosome lagging and multipolar spindle formation.

7 ts ability to cross-link microtubules during spindle formation.

8 te (S719), which positively enhances bipolar spindle formation.

9 ation failure, mitotic arrest, and monopolar spindle formation.

10 e for the lack of centrosomes during meiotic spindle formation.

11 duce centrosome amplification and multipolar spindle formation.

12 eparation is reduced, resulting in monopolar spindle formation.

13 ikingly, the loss of such contacts abolishes spindle formation.

14 at ch-Tog has at least two distinct roles in spindle formation.

15 erstood organelle proposed to play a role in spindle formation.

16 tic arrest with a profound defect in bipolar spindle formation.

17 s-end tracking proteins and is essential for spindle formation.

18 t not for meiotic histone phosphorylation or spindle formation.

19 nesin-14 (ATK5) reveals defects during early spindle formation.

20 l division, probably because of disorganized spindle formation.

21 m changes in microtubule organization during spindle formation.

22 ossibility that centromeres regulate mitotic spindle formation.

23 ates to the opposite side of the cell before spindle formation.

24 me congression defects, but does not perturb spindle formation.

25 entrosome amplification and abnormal mitotic spindle formation.

26 with Alp14, is a target of Ran in yeast for spindle formation.

27 ects of viral HBx on centrosome dynamics and spindle formation.

28 ic spindle orientation is established before spindle formation.

29 ed the relationship between Rae1 and NuMA in spindle formation.

30 domain of NuMA in HeLa cells led to aberrant spindle formation.

31 duplication, maturation and bipolar mitotic spindle formation.

32 s, but our results suggest a new function in spindle formation.

33 ctivity and plays essential roles in bipolar spindle formation.

34 nctions on the centrosome to promote bipolar spindle formation.

35 opposing force necessary for proper mitotic spindle formation.

36 al functioning of centrosomes and to mitotic spindle formation.

37 f telomere-LINC contacts compromises meiotic spindle formation.

38 Dis1 share an essential function in bipolar spindle formation.

39 bly of microtubules is essential for bipolar spindle formation.

40 KSP, can cause mitotic arrest and monopolar spindle formation.

41 spindles and SPB disintegration 30 min after spindle formation.

42 2 in regulation of centrosome separation and spindle formation.

43 omatin-induced microtubule stabilization and spindle formation.

44 d excessive microtubule growth and inhibited spindle formation.

45 emperature mipAD159 does not inhibit mitotic spindle formation.

46 ut frequent asymmetric failure of meiosis II spindle formation.

47 ve revealed that sub is required for bipolar spindle formation.

48 rax lethal factor delayed GVBD and prevented spindle formation.

49 ant fails to progress towards normal bipolar spindle formation.

50 centrosomes, and an accumulation of abnormal spindle formation.

51 d of telomere-centrosome contact to generate spindle formation.

52 forms within the nucleus before microtubule spindle formation.

53 ture at prophase, which precedes microtubule spindle formation.

54 upport cyclin B accumulation, and to support spindle formation.

55 mes during prophase is crucial for efficient spindle formation.

56 f meiotic chromosome condensation and proper spindle formation.

57 structure of the SPB and the events of early spindle formation.

58 be defective in nuclear migration or bipolar spindle formation.

59 p is more important than motility for proper spindle formation.

60 osome separation and, in some cases, bipolar spindle formation.

61 rafusal fiber differentiation and subsequent spindle formation.

62 ation in both the rate and extent of bipolar spindle formation.

63 ponents into the IMO, which in turn perturbs spindle formation.

64 tion, bud formation, cytokinesis and nuclear spindle formation.

65 osome alignment, centrosome positioning, and spindle formation.

66 calization with motility to ensure efficient spindle formation.

67 the nucleus upon mitotic entry and promotes spindle formation.

68 ule-associated protein important for mitotic spindle formation.

69 at arranges microtubule assembly and mitotic spindle formation.

70 mulates at the centrosome to support mitotic spindle formation.

71 ng from cytoskeletal network disassembly and spindle formation.

72 wth of microtubules and results in monopolar spindle formation.

73 tigate the molecular role of HURP in mitotic spindle formation.

74 osomes, multinucleated cells, and multipolar spindle formation.

75 actin, cortical mechanics, and cell shape in spindle formation.

76 contribute to initiate acentriolar meiosis I spindle formation.

77 n early mitosis, a step necessary for proper spindle formation.

78 ment rates, we find stability parameters for spindle formations.

79 ] and subsequently found to be important for spindle formation [2-5].

80 d has been shown to cause multipolar mitotic spindle formation, a diagnostic hallmark of HPV-associat

81 provides a novel mechanism to arrest mitotic spindle formation, a target of several approved and inve

82 After SPB separation and central spindle formation, a temporal delay in the acquisition o

83 defects in chromatid segregation and mitotic spindle formation accompanied by increased stability of

84 ; cells lacking Aust do not initiate central spindle formation, accumulate anillin or actin at the ce

85 ultiple mitotic processes, including bipolar spindle formation, activation of Cdc25C, actin ring form

86 ws search and capture of kinetochores during spindle formation, an important process for accurate chr

87 once per cell cycle is essential for bipolar spindle formation and accurate chromosome segregation du

88 aphase arrest, as a consequence of defective spindle formation and activation of the spindle checkpoi

89 DCLK controls mitotic division by regulating spindle formation and also determines the fate of neural

90 -tubulin isotypes and resulted in multipolar spindle formation and apoptosis.

91 activity as evidenced by blockade of bipolar spindle formation and appearance of monoasters.

92 amma-tubulin sorting, resulting in monopolar spindle formation and cell cycle arrest in meiosis-1; de

93 endent functions in mitotic cells, including spindle formation and cell cycle checkpoint release.

94 n many cellular processes, including mitotic spindle formation and cell division.

95 crotubules, participates actively in mitotic spindle formation and chromosomal organization during ce

96 lytic or regulatory subunits interferes with spindle formation and chromosome alignment because of in

97 osis and tumor growth is by blocking bipolar spindle formation and chromosome alignment.

98 ned from young females results in perturbing spindle formation and chromosome congression following m

99 In turn, this results in aberrant mitotic spindle formation and chromosome missegregation in tumor

100 n kMT dynamic instability facilitate mitotic spindle formation and chromosome movement.

101 s suppressed, we observed defects in central spindle formation and chromosome segregation during anap

102 ce of alpha-N-methylation for normal bipolar spindle formation and chromosome segregation.

103 ith substantial specificity to affect proper spindle formation and chromosome segregation.

104 through Scd1, but not Byr2, to affect proper spindle formation and chromosome segregation.

105 ole in various cellular processes, including spindle formation and chromosome segregation.

106 1/PRC1 protein family, implicated in central spindle formation and cytokinesis in animals, yeasts, an

107 ng RNA (siRNA) and showed defects in bipolar spindle formation and cytokinesis, growth inhibition, an

108 pression of NT-3 in muscle leads to abnormal spindle formation and deficits in locomotive control.

109 ent of the SPB that is phosphorylated during spindle formation and dephosphorylated as cells enter an

110 n Tubulin polymerization dramatically affect spindle formation and disrupt chromosome segregation.

111 lta N resulted in repeated cycles of bipolar spindle formation and disruption, suggestive of a defect

112 Moreover, this mutant exhibited compromised spindle formation and early mitotic delay.

113 leles of cut7(ts), a KLP that contributes to spindle formation and elongation.

114 pensable for entry into mitosis, its role in spindle formation and exit from mitosis is crucial.

115 uilibrate mitotic phosphorylation for proper spindle formation and faithful genomic transmission.

116 PX2, but how this interaction contributes to spindle formation and function is not established.

117 hich is required to prevent abnormal mitotic spindle formation and genome instability.

118 Centrosome assembly is important for mitotic spindle formation and if defective may contribute to gen

119 Mitotic spindle formation and kinetochore-microtubule (K-MT) cap

120 MCAK and HURP, two key regulators of mitotic spindle formation and known substrates of Aurora A kinas

121 and monocentric chromosomes generated during spindle formation and metaphase both moved towards the c

122 dephosphorylation and activation of cdc2, or spindle formation and migration.

123 FOXM1-KIF20A axis to drive abnormal mitotic spindle formation and mitotic catastrophe and that dereg

124 of centrosome clustering triggers multipolar spindle formation and mitotic catastrophe, offering an a

125 d MT nucleation to accomplish normal bipolar spindle formation and mitotic progression.

126 le, while CDKB is essential specifically for spindle formation and nuclear division, but not for DNA

127 ynein regulates ciliary trafficking, mitotic spindle formation and organelle transport, and dissectin

128 se this motor has been implicated in mitotic spindle formation and orientation as well as chromosome

129 The centrosome modulates spindle formation and plays a critical role in guiding p

130 These studies identify meiotic spindle formation and programmed degradation of the firs

131 t degradation of KIFC1 regulates the bipolar spindle formation and proper cell division.

132 Spindle formation and proper function require that micro

133 A is a mitotic kinase that regulates mitotic spindle formation and segregation.

134 esin related proteins that are necessary for spindle formation and stabilization during mitosis.

135 NuMA is an important contributor to mitotic spindle formation and stabilization.

136 mitosis, likely due to the defect of bipolar spindle formation and subsequent activation of the spind

137 Centrosome separation, critical for bipolar spindle formation and subsequent chromosome segregation

138 RC1 kinase, plays a critical role in mitotic spindle formation and subsequent chromosome segregation

139 sphatase regulating Aurora A activity during spindle formation and suggest the general importance of

140 entrosome separation is critical for bipolar spindle formation and the accurate segregation of chromo

141 deletion of MdmX induces multipolar mitotic spindle formation and the loss of chromosomes from hyper

142 ently, we showed that B-Raf is important for spindle formation and the mitotic spindle checkpoint arr

143 p first forms a diffuse cortical band during spindle formation and then coalesces into a ring before

144 f Schizosaccharomyces pombe are defective in spindle formation and/or chromosome segregation, but the

145 culate that Dim1p may play a role in mitotic spindle formation and/or function.

146 ple centrosomal defects, aberrant multipolar spindle formation, and chromatin missegregation, and the

147 ion between nuclear envelope (NE) breakdown, spindle formation, and chromosomal events.

148 h transcripts associated with cell division, spindle formation, and chromosome function, demonstratin

149 control over mitotic progression, multipolar spindle formation, and cytokinesis defects are all likel

150 mplicated in kinetochore attachment, bipolar spindle formation, and cytokinesis.

151 motes microtubule polymerization and bipolar spindle formation, and decreases the turnover rate of th

152 in-5-mediated centrosome separation, bipolar spindle formation, and equal centrosome/centriole segreg

153 ryos have defects in mitotic progression and spindle formation, and exhibit genome instability.

154 ial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes, leading us t

155 s, Ran targets Alp7-Alp14 to achieve nuclear spindle formation, and might differentiate its targets d

156 ontrols nucleocytoplasmic transport, mitotic spindle formation, and nuclear envelope assembly.

157 sses, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope (NE)

158 ulates mitotic microtubule dynamics, bipolar spindle formation, and subsequent chromosome segregation

159 Surprisingly, in MKLP1(RNAi) embryos, spindle formation appears normal until late anaphase.

160 Proper centrosome duplication and spindle formation are crucial for prevention of chromoso

161 es that the contributions of each pathway to spindle formation are integrated, highlighting the remar

162 e-containing cells, microtubules utilized in spindle formation are thought to be nucleated at the cen

163 including centriole duplication and mitotic spindle formation, are obligatorily linked to the metabo

164 anaphase and chromosome segregation; and 3) spindle formation around chromatin-coated beads.

165 , MOZART1 plays an essential role in mitotic spindle formation as a component of the gamma-tubulin ri

166 TOG5-microtubule binding maintained mitotic spindle formation as deleting or mutating TOG5 compromis

167 aromyces pombe NIMA homologue, Fin1, blocked spindle formation at 37 degrees C.

168 a combination of nondisjunction and unequal spindle formation at first pollen mitosis results in the

169 Because of unequal spindle formation at the first pollen mitosis, nondisjoi

170 me-associated microtubules may contribute to spindle formation, at least when centrosomes are absent.

171 The model shows that spindle formation begins with rapid cross-linking of mic

172 lin, a protein required not only for mitotic spindle formation but also for the overall structural in

173 tin-beta-cargo gradient kinetically promotes spindle formation but is largely dispensable once the sp

174 f the 120-kD isoform correlates with mitotic spindle formation but not with SPB duplication.

175 ion that is normally integrated with mitotic spindle formation but that can function without it.

176 ts, Xkid and Xklp1 are essential for bipolar spindle formation but the functions of the human homolog

177 ome biogenesis, endosome sorting and meiotic spindle formation, but functions for the SF7 AAA protein

178 sitioning, microtubule dynamics, and bipolar spindle formation can all contribute to chromosome segre

179 However, spindle formation can proceed following experimental des

180 Moreover, S12 alters spindle formation, causing mitotic arrest and cell death

181 ll division with apparent defects in mitotic spindle formation, cellular spindle assembly checkpoint

182 y into mitosis, centrosome function, mitotic spindle formation, chromosome biorientation and segregat

183 the PBD function results in improper bipolar spindle formation, chromosome missegregation, and cytoki

184 comprise the cell division cycle, including spindle formation, chromosome segregation, and cytokines

185 e and coordinated cycles of DNA replication, spindle formation, chromosome segregation, and cytoplasm

186 hibit defects in SPB integrity, and hence in spindle formation, chromosome segregation, and SIN local

187 was identified in a screen for mutants with spindle formation defects and a screen for molecules tha

188 nhibition led to either monopolar or bipolar spindle formation, depending on whether centrosomes were

189 at the additional gamma-tubulin required for spindle formation does not accumulate progressively at t

190 kinesin family that is essential for bipolar spindle formation during eukaryotic cell division.

191 Bipolar acentrosomal spindle formation during meiosis in oocytes may be drive

192 known role of Golgi proteins in controlling spindle formation during mitosis and may provide an expl

193 equired for centrosome splitting and bipolar spindle formation during mitosis.

194 organelle positioning during interphase and spindle formation during mitosis.

195 14/Dis1 play a collaborative role in bipolar spindle formation during prometaphase through producing

196 to regulate, variously, proliferation and/or spindle formation during the G2/M transition of the cell

197 some-associated microtubules are utilized in spindle formation, even in the presence of centrosomes.

198 whether a centrosome-independent pathway for spindle formation exists in vertebrate somatic cells, wh

199 oe1, indicating that the function of Moe1 in spindle formation has been conserved substantially durin

200 ansport machinery, but no targets of Ran for spindle formation have been identified in yeast.

201 ys to generate the microtubules required for spindle formation, how these pathways are coordinated wi

202 Meiotic spindle formation, however, is not affected in these emb

203 notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the

204 ange factor) mutants have defects in mitotic spindle formation; (ii) the RanGEF temperature-sensitive

205 icated in chromosome segregation and mitotic spindle formation in a number of organisms.

206 ps essential, role in the control of mitotic spindle formation in A. nidulans.

207 esults in severe growth delays and defective spindle formation in adherent cells and cell death in su

208 served BimC kinesin family are essential for spindle formation in all eukaryotes, and complete loss o

209 rosome-associated microtubules contribute to spindle formation in centrosome-containing cells.

210 the critical role of proteins necessary for spindle formation in CNS development.

211 Aurora B complex), in centrosome-independent spindle formation in Drosophila female meiosis.

212 ve-cell microscopy of GFP-tubulin to examine spindle formation in Drosophila S2 cells after RNAi depl

213 Our work uncovers the possible routes to spindle formation in embryos and establishes the central

214 Spindle formation in female meiosis differs from mitosis

215 ied as an important target for Ran GTPase in spindle formation in fission yeast.

216 centrosome duplication, required for bipolar spindle formation in HeLa human carcinoma cells and prim

217 but also regulates RNA splicing and mitotic spindle formation in its integral capacity as a scaffold

218 Here we visualize spindle formation in living Drosophila embryos to show t

219 somal poles all contribute to robust bipolar spindle formation in meiotic extracts.

220 p61F, which is known for its role in bipolar spindle formation in mitosis, is required for protein tr

221 interaction as a critical element for normal spindle formation in mitosis.

222 to timely centrosome separation and bipolar spindle formation in mitosis.

223 rotubule assembly pathway and favors bipolar spindle formation in most animal cells in which tubulin

224 Although centrosomes contribute to spindle formation in most cell types, oocytes of many sp

225 ed with an increased incidence of multipolar spindle formation in some cancer cells that contain supe

226 e vicinity of chromosomes to mediate bipolar spindle formation in the absence of centrioles.

227 nt motors, and overexpressed Kif15 can drive spindle formation in the absence of Eg5 activity.

228 hat Eg5 function is necessary for multipolar spindle formation in the absence of hTPX2.

229 ent of the Ras1 pathway necessary for proper spindle formation in the nucleus.

230 There was no evidence of mitotic spindle formation in these cells, and expression of ie2

231 ls, inhibited mitosis and induced multipolar spindle formation in these cells.

232 The scd1 deletion worsened the defects of spindle formation in tubulin mutants; by contrast, it di

233 its cell proliferation and induces monopolar-spindle formation in tumor cells.

234 preformed K-fibers were also observed during spindle formation in untreated cells.

235 n plays an important role for proper bipolar spindle formation in various eukaryotic organisms.

236 lus-end capture mechanism and contributes to spindle formation in vertebrates.

237 Importin beta inhibits spindle formation in vitro and in vivo and sequesters an

238 ential for centrosome separation and bipolar spindle formation in vitro and in vivo.

239 Kif15-dependent bipolar spindle formation in vivo requires the C-terminal domain

240 Monastrol also inhibits bipolar spindle formation in Xenopus egg extracts.

241 extensive cell death arising from defective spindle formation, incomplete chromosome condensation, a

242 Spindle formation initiates around chromosomes, but the

243 Thus, spindle formation involves a previously overlooked stage

244 est that, in female meiotic systems in which spindle formation is based on the action of multiple mic

245 Anaphase central spindle formation is controlled by the microtubule-stabi

246 Faithful chromosome segregation with bipolar spindle formation is critical for the maintenance of gen

247 In the absence of Subito, central spindle formation is defective and AurB and Incenp fail

248 Mitotic spindle formation is defective in patient-derived fibrob

249 Bipolar spindle formation is essential for the accurate segregat

250 mitotic spindle, but how the APC/C regulates spindle formation is not understood.

251 Bipolar spindle formation is pivotal for accurate segregation of

252 However, when spindle formation is prevented and the SAC cannot be sat

253 ever, whether this process is sufficient for spindle formation is unknown.

254 the small GTPase Ran, a regulator of mitotic spindle formation, is differentially overexpressed in hu

255 tabilization of erroneous attachments during spindle formation, is unknown.

256 er of the kinesin-14 family) are crucial for spindle formation; KifC1, MCAK (a member of the kinesin-

257 m defects in centrosome duplication, bipolar spindle formation, kinetochore-microtubule attachment, c

258 Is affecting centrosome position and bipolar spindle formation, likely explaining some of the antican

259 of microtubule-related processes, including spindle formation, migration of the mitotic spindle to t

260 to delay in G(2)/M progression and abnormal spindle formation, mirroring some attributes of Plk1 der

261 ous tumor cell types causes aberrant mitotic spindle formation, mitochondrial dysfunction, and apopto

262 etically interacts with Aurora A to regulate spindle formation, mitotic progression and brain size.

263 Neither bipolar spindle formation nor centrosome functions were affected

264 in noncancer-derived cells disturbs neither spindle formation nor mitotic progression.

265 the events of DNA synthesis, bud emergence, spindle formation, nuclear division, and cell separation

266 is involved in nucleocytoplasmic transport, spindle formation, nuclear envelope (NE) formation, and

267 When hNuf2 is depleted by RNA interference, spindle formation occurs normally as cells enter mitosis

268 sed to metaphase without apparent defects in spindle formation or chromosome alignment to the metapha

269 tic spindle poles is important for efficient spindle formation, orientation, and cell polarity.

270 nction between Eg5 and chromokinesin in this spindle formation pathway.

271 tubule bundlers that are crucial for central spindle formation, PRC1 and centralspindlin.

272 oes not lead to visible impairment of normal spindle formation, recovery from nocodazole-induced spin

273 viral HBx and cellular HBXIP control mitotic spindle formation, regulating centrosome splitting.

274 NA interference, can rescue abnormal mitotic spindle formation, release the G(2)/M cell cycle arrest,

275 MT organization and spindle formation rely on the activity of gamma-tubulin

276 te microtubules, mechanisms for acentrosomal spindle formation remain unclear.

277 uch as centrosome maturation, mitotic entry, spindle formation, sister chromatid cohesion and cytokin

278 Mps1 function show severe defects in mitotic spindle formation, sister kinetochore positioning at met

279 orgotten organelle, its demonstrated role in spindle formation suggests it deserves renewed attention

280 can use a centrosome-independent pathway for spindle formation that is normally masked by the presenc

281 s in centrosome number can promote errors in spindle formation that lead to subsequent chromosome mis

282 spindles, thus resulting in improper bipolar spindle formation that ultimately leads to mitotic arres

283 h such mutants display no defects in mitotic spindle formation, they undergo mitotic specific disasse

284 w stable K-MT attachments only after bipolar spindle formation, thus preventing attachment errors.

285 ncluding (from low to high activity) bipolar spindle formation, timely mitotic entry, and formation o

286 l an active role for the Golgi in regulating spindle formation to ensure faithful organelle inheritan

287 Here, we use controlled monopolar spindle formation to systematically define the requireme

288 plex regulates local MCAK activity to permit spindle formation via stabilization of chromatin-associa

289 s chromatin morphology, and abnormal meiotic spindle formation was observed following oocyte maturati

290 le-severing activity and its role in meiotic spindle formation, we analyzed the MEI-1(A338S) mutant.

291 To investigate its role during spindle formation, we tested spindle assembly in frog eg

292 rates, HURP and NuSAP can be degraded during spindle formation when the spindle checkpoint is active.

293 r pronounced cell cycle arrest nor anomalous spindle formation, which occur in other eukaryotes upon

294 eavages still largely share the mechanism of spindle formation with meiosis, during which the spindle

295 or assembly of the Ndc80 complex and bipolar spindle formation yet defective in proper end-on attachm